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Aliases for ZNF280D Gene

Aliases for ZNF280D Gene

  • Zinc Finger Protein 280D 2 3 5
  • Suppressor Of Hairy Wing Homolog 4 3 4
  • Zinc Finger Protein 634 3 4
  • ZNF634 3 4
  • SUHW4 3 4
  • Suppressor Of Hairy Wing Homolog 4 (Drosophila) 2
  • KIAA1584 4

External Ids for ZNF280D Gene

Previous HGNC Symbols for ZNF280D Gene

  • SUHW4

Previous GeneCards Identifiers for ZNF280D Gene

  • GC15M054710
  • GC15M056922
  • GC15M033745

Summaries for ZNF280D Gene

GeneCards Summary for ZNF280D Gene

ZNF280D (Zinc Finger Protein 280D) is a Protein Coding gene. An important paralog of this gene is POGZ.

UniProtKB/Swiss-Prot for ZNF280D Gene

  • May function as a transcription factor.

Gene Wiki entry for ZNF280D Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280D Gene

Genomics for ZNF280D Gene

Regulatory Elements for ZNF280D Gene

Promoters for ZNF280D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF280D on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF280D Gene

Chromosome:
15
Start:
56,630,176 bp from pter
End:
56,918,571 bp from pter
Size:
288,396 bases
Orientation:
Minus strand

Genomic View for ZNF280D Gene

Genes around ZNF280D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280D Gene

Proteins for ZNF280D Gene

  • Protein details for ZNF280D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N043-Z280D_HUMAN
    Recommended name:
    Zinc finger protein 280D
    Protein Accession:
    Q6N043
    Secondary Accessions:
    • A1L495
    • B2RMT6
    • Q6MZM6
    • Q6N085
    • Q6P2R6
    • Q7Z6J5
    • Q9H0U5
    • Q9HCI8
    • Q9NXS0

    Protein attributes for ZNF280D Gene

    Size:
    979 amino acids
    Molecular mass:
    109285 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13410.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAE46003.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF280D Gene

neXtProt entry for ZNF280D Gene

Proteomics data for ZNF280D Gene at MOPED

Post-translational modifications for ZNF280D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF280D Gene

Domains & Families for ZNF280D Gene

Protein Domains for ZNF280D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF280D Gene

Graphical View of Domain Structure for InterPro Entry

Q6N043

UniProtKB/Swiss-Prot:

Z280D_HUMAN :
  • Contains 5 C2H2-type zinc fingers.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF280D: view

No data available for Gene Families for ZNF280D Gene

Function for ZNF280D Gene

Molecular function for ZNF280D Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Animal Model Products

CRISPR Products

miRNA for ZNF280D Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280D Gene

Localization for ZNF280D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF280D Gene COMPARTMENTS Subcellular localization image for ZNF280D gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF280D Gene

Pathways & Interactions for ZNF280D Gene

SuperPathways for ZNF280D Gene

No Data Available

Interacting Proteins for ZNF280D Gene

Gene Ontology (GO) - Biological Process for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280D Gene

Drugs & Compounds for ZNF280D Gene

No Compound Related Data Available

Transcripts for ZNF280D Gene

Unigene Clusters for ZNF280D Gene

Zinc finger protein 280D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280D Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for ZNF280D Gene

GeneLoc Exon Structure for
ZNF280D
ECgene alternative splicing isoforms for
ZNF280D

Expression for ZNF280D Gene

mRNA expression in normal human tissues for ZNF280D Gene

Protein differential expression in normal tissues from HIPED for ZNF280D Gene

This gene is overexpressed in Fetal Brain (24.8), Plasma (20.8), and Pancreatic juice (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF280D Gene



SOURCE GeneReport for Unigene cluster for ZNF280D Gene Hs.511477

genes like me logo Genes that share expression patterns with ZNF280D: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF280D Gene

Orthologs for ZNF280D Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF280D 35
  • 91.37 (n)
  • 88.44 (a)
ZNF280D 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF280D 35
  • 92.47 (n)
  • 91.82 (a)
ZNF280D 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp280d 35
  • 83.77 (n)
  • 77.32 (a)
Zfp280d 16
Zfp280d 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF280D 35
  • 99.63 (n)
  • 99.49 (a)
ZNF280D 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp280d 35
  • 83.8 (n)
  • 76.37 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF280D 35
  • 71.45 (n)
  • 64.41 (a)
-- 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf280d 35
  • 61.52 (n)
  • 53.53 (a)
zebrafish
(Danio rerio)
Actinopterygii znf280d 35
  • 53.92 (n)
  • 49.25 (a)
znf280d 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta row 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37D6.2 36
  • 21 (a)
OneToMany
Species with no ortholog for ZNF280D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF280D Gene

ENSEMBL:
Gene Tree for ZNF280D (if available)
TreeFam:
Gene Tree for ZNF280D (if available)

Paralogs for ZNF280D Gene

Paralogs for ZNF280D Gene

(4) SIMAP similar genes for ZNF280D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF280D: view

Variants for ZNF280D Gene

Sequence variations from dbSNP and Humsavar for ZNF280D Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs28620278 - 56,666,830(+) TTTGA(C/T)TGTAT nc-transcript-variant, downstream-variant-500B, reference, missense
rs12900993 - 56,632,105(+) AAGAA(A/C/G)CAGCT reference, missense
rs12901843 - 56,632,096(+) TTTCT(A/T)TTGAA reference, missense
rs12900729 - 56,632,084(+) TACAT(C/G)CATTT reference, missense
rs2148 -- 56,696,651(+) AAAAT(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280D Gene

Variant ID Type Subtype PubMed ID
esv2661684 CNV Deletion 23128226
esv2749732 CNV Deletion 23290073

Variation tolerance for ZNF280D Gene

Residual Variation Intolerance Score: 6.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF280D Gene

HapMap Linkage Disequilibrium report
ZNF280D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280D Gene

Disorders for ZNF280D Gene

Relevant External Links for ZNF280D

Genetic Association Database (GAD)
ZNF280D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF280D

No disorders were found for ZNF280D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280D Gene

Publications for ZNF280D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  3. A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1. (PMID: 20798984) Buonincontri R. … Tommerup N. (Behav. Genet. 2011) 3
  4. Analysis of the human HP1 interactome reveals novel binding partners. (PMID: 21888893) Rosnoblet C. … Angrand P.O. (Biochem. Biophys. Res. Commun. 2011) 3
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for ZNF280D Gene

Sources for ZNF280D Gene

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