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Aliases for ZNF280D Gene

Aliases for ZNF280D Gene

  • Zinc Finger Protein 280D 2 3
  • Suppressor Of Hairy Wing Homolog 4 3 4
  • Zinc Finger Protein 634 3 4
  • ZNF634 3 4
  • SUHW4 3 4
  • Suppressor Of Hairy Wing Homolog 4 (Drosophila) 2
  • KIAA1584 4

External Ids for ZNF280D Gene

Previous Symbols for ZNF280D Gene

  • SUHW4

Summaries for ZNF280D Gene

GeneCards Summary for ZNF280D Gene

ZNF280D (Zinc Finger Protein 280D) is a Protein Coding gene. Diseases associated with ZNF280D include articulation disorder and doid:4019. An important paralog of this gene is POGZ.

UniProtKB/Swiss-Prot for ZNF280D Gene

  • May function as a transcription factor

Gene Wiki entry for ZNF280D Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280D Gene

Genomics for ZNF280D Gene

Genomic Location for ZNF280D Gene

Start:
56,630,176 bp from pter
End:
56,918,571 bp from pter
Size:
288,396 bases
Orientation:
Minus strand

Genomic View for ZNF280D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF280D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280D Gene

Regulatory Elements for ZNF280D Gene

Proteins for ZNF280D Gene

  • Protein details for ZNF280D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N043-Z280D_HUMAN
    Recommended name:
    Zinc finger protein 280D
    Protein Accession:
    Q6N043
    Secondary Accessions:
    • A1L495
    • B2RMT6
    • Q6MZM6
    • Q6N085
    • Q6P2R6
    • Q7Z6J5
    • Q9H0U5
    • Q9HCI8
    • Q9NXS0

    Protein attributes for ZNF280D Gene

    Size:
    979 amino acids
    Molecular mass:
    109285 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13410.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAE46003.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF280D Gene

neXtProt entry for ZNF280D Gene

Proteomics data for ZNF280D Gene at MOPED

Post-translational modifications for ZNF280D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF280D Gene

Domains for ZNF280D Gene

Protein Domains for ZNF280D Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

Z280D_HUMAN
Similarity:
  • Contains 5 C2H2-type zinc fingers.:
    • Q6N043
genes like me logo Genes that share domains with ZNF280D: view

No data available for Gene Families for ZNF280D Gene

Function for ZNF280D Gene

Molecular function for ZNF280D Gene

UniProtKB/Swiss-Prot Function: May function as a transcription factor

Gene Ontology (GO) - Molecular Function for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

miRNA for ZNF280D Gene

miRTarBase miRNAs that target ZNF280D

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF280D Gene

Localization for ZNF280D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF280D Gene COMPARTMENTS Subcellular localization image for ZNF280D gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

Pathways for ZNF280D Gene

SuperPathways for ZNF280D Gene

No Data Available

Interacting Proteins for ZNF280D Gene

Gene Ontology (GO) - Biological Process for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

No data available for Pathways by source for ZNF280D Gene

Transcripts for ZNF280D Gene

Unigene Clusters for ZNF280D Gene

Zinc finger protein 280D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280D Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for ZNF280D Gene

GeneLoc Exon Structure for
ZNF280D
ECgene alternative splicing isoforms for
ZNF280D

Expression for ZNF280D Gene

mRNA expression in normal human tissues for ZNF280D Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF280D Gene

SOURCE GeneReport for Unigene cluster for ZNF280D Gene Hs.511477

genes like me logo Genes that share expressions with ZNF280D: view

Orthologs for ZNF280D Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF280D 36
  • 99.63 (n)
  • 99.49 (a)
ZNF280D 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF280D 36
  • 91.37 (n)
  • 88.44 (a)
ZNF280D 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF280D 36
  • 92.47 (n)
  • 91.82 (a)
ZNF280D 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp280d 36
  • 83.77 (n)
  • 77.32 (a)
Zfp280d 16
Zfp280d 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp280d 36
  • 83.8 (n)
  • 76.37 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 62 (a)
OneToMany
ZNF280D 36
  • 71.45 (n)
  • 64.41 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf280d 36
  • 61.52 (n)
  • 53.53 (a)
zebrafish
(Danio rerio)
Actinopterygii znf280d 36
  • 53.92 (n)
  • 49.25 (a)
znf280d 37
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta row 37
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37D6.2 37
  • 21 (a)
OneToMany
Species with no ortholog for ZNF280D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF280D Gene

ENSEMBL:
Gene Tree for ZNF280D (if available)
TreeFam:
Gene Tree for ZNF280D (if available)

Paralogs for ZNF280D Gene

Paralogs for ZNF280D Gene

Selected SIMAP similar genes for ZNF280D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF280D: view

Variants for ZNF280D Gene

Sequence variations from dbSNP and Humsavar for ZNF280D Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2148 -- 56,696,651(+) AAAAT(A/C)AAAAA intron-variant
rs3199 -- 56,637,578(+) GCAGA(C/T)TGTGC intron-variant
rs475512 -- 56,696,358(+) TATCA(A/T)GCAGC intron-variant
rs479060 -- 56,706,217(+) cacct(A/G)taatc intron-variant
rs480701 -- 56,691,656(+) TTTTC(G/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280D Gene

Variant ID Type Subtype PubMed ID
esv2661684 CNV Deletion 23128226
esv2749732 CNV Deletion 23290073

Relevant External Links for ZNF280D Gene

HapMap Linkage Disequilibrium report
ZNF280D

Disorders for ZNF280D Gene

(4) University of Copenhagen DISEASES for ZNF280D Gene

Relevant External Links for ZNF280D

Genetic Association Database (GAD)
ZNF280D
genes like me logo Genes that share disorders with ZNF280D: view

No data available for UniProtKB/Swiss-Prot for ZNF280D Gene

Publications for ZNF280D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for ZNF280D Gene

Sources for ZNF280D Gene

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