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Aliases for ZNF280D Gene

Aliases for ZNF280D Gene

  • Zinc Finger Protein 280D 2 3 5
  • Suppressor Of Hairy Wing Homolog 4 3 4
  • Zinc Finger Protein 634 3 4
  • ZNF634 3 4
  • SUHW4 3 4
  • Suppressor Of Hairy Wing Homolog 4 (Drosophila) 2
  • KIAA1584 4

External Ids for ZNF280D Gene

Previous HGNC Symbols for ZNF280D Gene

  • SUHW4

Previous GeneCards Identifiers for ZNF280D Gene

  • GC15M054710
  • GC15M056922
  • GC15M033745

Summaries for ZNF280D Gene

GeneCards Summary for ZNF280D Gene

ZNF280D (Zinc Finger Protein 280D) is a Protein Coding gene. Diseases associated with ZNF280D include Reading Disorder. An important paralog of this gene is ZNF280C.

UniProtKB/Swiss-Prot for ZNF280D Gene

  • May function as a transcription factor.

Gene Wiki entry for ZNF280D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280D Gene

Genomics for ZNF280D Gene

Regulatory Elements for ZNF280D Gene

Enhancers for ZNF280D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G056885 1.1 ENCODE 11.6 +31.2 31189 3.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 TCF12 ZNF280D LINC00926 LOC105370833 PIR32785
GH15G056736 1.5 Ensembl ENCODE dbSUPER 4.5 +181.3 181315 1.5 PKNOX1 FOXA2 ATF1 ARNT FEZF1 TCF12 ELK1 GATA2 FOS ZHX2 LINC00926 ZNF280D ENSG00000274667 GC15M056742
GH15G056793 0.6 ENCODE 10.8 +124.1 124068 1.1 ZNF202 ZNF121 ZNF169 CEBPB FEZF1 NFE2 CEBPG NFE2L2 ZNF280D ENSG00000279683 PIR39629
GH15G056870 0.9 Ensembl ENCODE 7 +47.3 47254 1.3 FOXA2 TEAD1 JUN CEBPB ZNF384 EP300 JUND SMARCA4 CEBPA STAT3 TCF12 ZNF280D LINC00926 LOC105370833 GC15P056859
GH15G057038 0.9 dbSUPER 6.7 -122.6 -122608 5.5 YBX3 PTBP1 CBX3 ZNF335 TCF12 GATA2 EGR1 FOS SMARCA5 ZBTB2 LINC00926 ZNF280D TCF12 GC15P057009 GC15M057107
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF280D on UCSC Golden Path with GeneCards custom track

Promoters for ZNF280D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076956 -629 2801 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF610
ENSR00000076923 886 1601 CREB3L1 AGO1 SIN3A FEZF1 DMAP1 YY1 ZNF766 CBX5 ZNF143 FOS
ENSR00000277670 1071 201 ZBTB11 ZNF175 ZNF623 SMARCB1 YY1 CREB3 FOSL1 HMBOX1

Genomic Location for ZNF280D Gene

Chromosome:
15
Start:
56,630,176 bp from pter
End:
56,918,571 bp from pter
Size:
288,396 bases
Orientation:
Minus strand

Genomic View for ZNF280D Gene

Genes around ZNF280D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280D Gene

Proteins for ZNF280D Gene

  • Protein details for ZNF280D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N043-Z280D_HUMAN
    Recommended name:
    Zinc finger protein 280D
    Protein Accession:
    Q6N043
    Secondary Accessions:
    • A1L495
    • B2RMT6
    • Q6MZM6
    • Q6N085
    • Q6P2R6
    • Q7Z6J5
    • Q9H0U5
    • Q9HCI8
    • Q9NXS0

    Protein attributes for ZNF280D Gene

    Size:
    979 amino acids
    Molecular mass:
    109285 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13410.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAE46003.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF280D Gene

neXtProt entry for ZNF280D Gene

Post-translational modifications for ZNF280D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF280D Gene

Domains & Families for ZNF280D Gene

Protein Domains for ZNF280D Gene

Suggested Antigen Peptide Sequences for ZNF280D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF280D: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZNF280D Gene

Function for ZNF280D Gene

Molecular function for ZNF280D Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Gene Ontology (GO) - Molecular Function for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

Phenotypes for ZNF280D Gene

GenomeRNAi human phenotypes for ZNF280D:
genes like me logo Genes that share phenotypes with ZNF280D: view

Animal Model Products

CRISPR Products

miRNA for ZNF280D Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280D Gene

Localization for ZNF280D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF280D gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

Pathways & Interactions for ZNF280D Gene

SuperPathways for ZNF280D Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280D Gene

Transcripts for ZNF280D Gene

Unigene Clusters for ZNF280D Gene

Zinc finger protein 280D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280D Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for ZNF280D Gene

GeneLoc Exon Structure for
ZNF280D
ECgene alternative splicing isoforms for
ZNF280D

Expression for ZNF280D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF280D Gene

Protein differential expression in normal tissues from HIPED for ZNF280D Gene

This gene is overexpressed in Fetal Brain (24.8), Plasma (20.8), and Pancreatic juice (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF280D Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF280D Gene:

ZNF280D

SOURCE GeneReport for Unigene cluster for ZNF280D Gene:

Hs.511477

Evidence on tissue expression from TISSUES for ZNF280D Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF280D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280D Gene

Orthologs for ZNF280D Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF280D 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia ZNF280D 34 35
  • 92.47 (n)
cow
(Bos Taurus)
Mammalia ZNF280D 34 35
  • 91.37 (n)
rat
(Rattus norvegicus)
Mammalia Zfp280d 34
  • 83.8 (n)
mouse
(Mus musculus)
Mammalia Zfp280d 34 16 35
  • 83.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF280D 34
  • 71.45 (n)
-- 35
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf280d 34
  • 61.52 (n)
zebrafish
(Danio rerio)
Actinopterygii znf280d 34 35
  • 53.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta row 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37D6.2 35
  • 21 (a)
OneToMany
Species where no ortholog for ZNF280D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF280D Gene

ENSEMBL:
Gene Tree for ZNF280D (if available)
TreeFam:
Gene Tree for ZNF280D (if available)

Paralogs for ZNF280D Gene

Paralogs for ZNF280D Gene

(4) SIMAP similar genes for ZNF280D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF280D: view

Variants for ZNF280D Gene

Sequence variations from dbSNP and Humsavar for ZNF280D Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000017458 -- 56,714,578(+) CTAGA(A/C)TAGGG intron-variant
rs1000045104 -- 56,673,900(+) GACCA(C/T)TCCTG intron-variant
rs1000049994 -- 56,714,335(+) CTGAA(A/G)GATTC intron-variant
rs1000083120 -- 56,684,598(+) ACATT(C/G)CAAGG intron-variant
rs1000114549 -- 56,637,164(+) TCCAG(A/C)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280D Gene

Variant ID Type Subtype PubMed ID
esv2661684 CNV deletion 23128226
esv2749732 CNV deletion 23290073
esv3636598 CNV loss 21293372
esv3892699 CNV gain 25118596
nsv1041239 CNV gain 25217958
nsv1133217 CNV tandem duplication 24896259
nsv569576 CNV loss 21841781

Variation tolerance for ZNF280D Gene

Residual Variation Intolerance Score: 6.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF280D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF280D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280D Gene

Disorders for ZNF280D Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF280D Gene - From: DISEASES

Disorder Aliases PubMed IDs
reading disorder
  • dyslexia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF280D

Genetic Association Database (GAD)
ZNF280D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF280D
genes like me logo Genes that share disorders with ZNF280D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF280D Gene

Publications for ZNF280D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  4. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64
  5. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 64

Products for ZNF280D Gene

Sources for ZNF280D Gene

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