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Aliases for PPIA Gene

Aliases for PPIA Gene

  • Peptidylprolyl Isomerase A (Cyclophilin A) 2 3
  • Cyclosporin A-Binding Protein 3 4
  • Rotamase A 3 4
  • EC 4 63
  • PPIase A 3 4
  • CYPA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 69p 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A 3
  • T Cell Cyclophilin 3
  • Cyclophilin A 4
  • HEL-S-69p 3
  • CYPH 3

External Ids for PPIA Gene

Previous GeneCards Identifiers for PPIA Gene

  • GC07P044482
  • GC07P044543
  • GC07P044577
  • GC07P044609
  • GC07P044803
  • GC07P044841

Summaries for PPIA Gene

Entrez Gene Summary for PPIA Gene

  • This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIA Gene

PPIA (Peptidylprolyl Isomerase A (Cyclophilin A)) is a Protein Coding gene. Diseases associated with PPIA include in situ carcinoma and hiv-1. Among its related pathways are Disease and Hemostasis. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot for PPIA Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for PPIA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIA Gene

Genomics for PPIA Gene

Regulatory Elements for PPIA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPIA Gene

44,796,642 bp from pter
44,824,564 bp from pter
27,923 bases
Plus strand

Genomic View for PPIA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIA Gene

Proteins for PPIA Gene

  • Protein details for PPIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A
    Protein Accession:
    Secondary Accessions:
    • A8K220
    • P05092
    • Q3KQW3
    • Q567Q0
    • Q6IBU5
    • Q96IX3
    • Q9BRU4
    • Q9BTY9
    • Q9UC61

    Protein attributes for PPIA Gene

    165 amino acids
    Molecular mass:
    18012 Da
    Quaternary structure:
    • Interacts with HIV-1 Capsid protein.

    Three dimensional structures from OCA and Proteopedia for PPIA Gene

    Alternative splice isoforms for PPIA Gene


neXtProt entry for PPIA Gene

Proteomics data for PPIA Gene at MOPED

Post-translational modifications for PPIA Gene

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
  • Ubiquitination at Lys31, Lys44, Lys49, Lys76, Lys82, Lys91, Lys118, Lys125, Lys131, Lys133, and Lys155
  • Glycosylation at Asn108
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPIA (PPIA)

Domains for PPIA Gene

Gene Families for PPIA Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIA: view

Function for PPIA Gene

Molecular function for PPIA Gene

GENATLAS Biochemistry:
cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for PPIA Gene

Gene Ontology (GO) - Molecular Function for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 14993672
GO:0005515 protein binding IPI 12730686
GO:0042277 peptide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046790 virion binding NAS 11250896
genes like me logo Genes that share ontologies with PPIA: view
genes like me logo Genes that share phenotypes with PPIA: view

Animal Models for PPIA Gene

MGI Knock Outs for PPIA:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for PPIA Gene

Localization for PPIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene

Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Subcellular locations from

Jensen Localization Image for PPIA Gene COMPARTMENTS Subcellular localization image for PPIA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 16780588
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PPIA: view

Pathways for PPIA Gene

genes like me logo Genes that share pathways with PPIA: view

Pathways by source for PPIA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 14993672
GO:0002576 platelet degranulation TAS --
GO:0006278 RNA-dependent DNA replication TAS --
GO:0006457 protein folding TAS 2179953
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PPIA: view

Drugs for PPIA Gene

(5) Drugbank Compounds for PPIA Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Ciclosporin
59865-13-3 Target approved, investigational
  • (-)-(S)-Proline
147-85-3 145742 Target binder approved, nutraceutical
449120 Target experimental
46936659 Target experimental
Ethyl Oxo(Piperidin-1-Yl)Acetate
53074-96-7 104406 Target experimental

(1) ApexBio Compounds for PPIA Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent [59865-13-3]

(1) HMDB Compounds for PPIA Gene

Compound Synonyms Cas Number PubMed IDs
  • (-)-(S)-Proline

(10) Novoseek inferred chemical compound relationships for PPIA Gene

Compound -log(P) Hits PubMed IDs
cyclosporin a 76.1 49
glyceraldehyde 3-phosphate 56.1 5
heparan sulfate 34 1
tacrolimus 30.3 2
proline 7.47 2
genes like me logo Genes that share compounds with PPIA: view

Transcripts for PPIA Gene

Unigene Clusters for PPIA Gene

Peptidylprolyl isomerase A (cyclophilin A):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PPIA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIA Gene

mRNA expression in normal human tissues for PPIA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIA Gene

SOURCE GeneReport for Unigene cluster for PPIA Gene Hs.356331

genes like me logo Genes that share expressions with PPIA: view

Expression partners for PPIA Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIA Gene

Orthologs for PPIA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100337215 35
  • 94.51 (n)
  • 97.56 (a)
  • 93 (a)
(Canis familiaris)
Mammalia PPIA 35
  • 88.28 (n)
  • 95.86 (a)
  • 75 (a)
(Mus musculus)
Mammalia Ppia 35
  • 92.48 (n)
  • 96.34 (a)
Ppia 16
Gm10123 36
  • 96 (a)
Gm5160 36
  • 85 (a)
Ppia 36
  • 96 (a)
(Pan troglodytes)
Mammalia PPIA 35
  • 99.39 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppia 35
  • 92.68 (n)
  • 96.34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
(Gallus gallus)
Aves PPIA 35
  • 81.71 (n)
  • 90.85 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496569 35
  • 67.27 (n)
  • 72.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398630 35
(Danio rerio)
Actinopterygii ppiaa 35
  • 69.92 (n)
  • 73.78 (a)
wufd61c06 35
  • 1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7768 37
  • 74 (a)
Cyp1 37
  • 74 (a)
CG5071 36
  • 7 (a)
(Caenorhabditis elegans)
Secernentea cyp-3 37
  • 67 (a)
cyp-7 37
  • 64 (a)
cyp-8 37
  • 52 (a)
cyn-1 35
  • 65.43 (n)
  • 72.84 (a)
T22F3.12 36
  • 45 (a)
Y17G9B.4 36
  • 22 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER156C 35
  • 63.96 (n)
  • 64.37 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04565g 35
  • 61.62 (n)
  • 63.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR3 35
  • 59.33 (n)
  • 65.41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC2 35
  • 66.46 (n)
  • 73.33 (a)
(Glycine max)
eudicotyledons Gma.12280 35
(Oryza sativa)
Liliopsida Os09g0571400 35
  • 66.05 (n)
  • 72.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 36
  • 5 (a)
Species with no ortholog for PPIA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIA Gene

Gene Tree for PPIA (if available)
Gene Tree for PPIA (if available)

Paralogs for PPIA Gene Pseudogenes for PPIA Gene

genes like me logo Genes that share paralogs with PPIA: view

Variants for PPIA Gene

Sequence variations from dbSNP and Humsavar for PPIA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6904 -- 44,802,822(-) TTAGA(C/T)TGTCC utr-variant-3-prime
rs6850 -- 44,796,715(+) CGTGT(A/G)CTATT utr-variant-5-prime
rs4205 -- 44,802,834(-) AGGGG(-/TT)TTCTC utr-variant-3-prime
rs200534700 -- 44,796,709(+) GAAAA(C/T)CGTGT utr-variant-5-prime
rs199872473 -- 44,799,654(+) GCACA(C/G)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIA Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV Loss 17160897

Relevant External Links for PPIA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene

Disorders for PPIA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPIA Gene in MalaCards »

(2) Diseases for PPIA Gene

(10) Novoseek inferred disease relationships for PPIA Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 44 12
pancreatic cancer 5.67 11
virus infection 2.66 1
lupus erythematosus systemic 0 2
leukemia 0 2

Relevant External Links for PPIA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PPIA: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PPIA Gene

Publications for PPIA Gene

  1. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B. … Hofer E. (Eur. J. Biochem. 1990) 2 3 4
  2. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P. … Winkler C.A. (PLoS Pathog. 2007) 3 23 48
  3. Oligo-microarray analysis reveals the role of cyclophilin A in drug resistance. (PMID: 17520256) Chen S. … Yu L. (Cancer Chemother. Pharmacol. 2008) 3 23
  4. A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA. (PMID: 17267487) Yang R. … Aiken C. (J. Virol. 2007) 3 23
  5. Cyclophilin, TRIM5, and innate immunity to HIV-1. (PMID: 16815734) Sokolskaja E. … Luban J. (Curr. Opin. Microbiol. 2006) 3 23

Products for PPIA Gene

Sources for PPIA Gene

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