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Aliases for PPIA Gene

Aliases for PPIA Gene

  • Peptidylprolyl Isomerase A 2 3 5
  • Cyclosporin A-Binding Protein 3 4
  • Cyclophilin A 2 4
  • Rotamase A 3 4
  • EC 5.2.1.8 4 61
  • PPIase A 3 4
  • CYPA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 69p 3
  • Peptidylprolyl Isomerase A (Cyclophilin A) 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A 3
  • T Cell Cyclophilin 3
  • HEL-S-69p 3
  • CYPH 3

External Ids for PPIA Gene

Previous GeneCards Identifiers for PPIA Gene

  • GC07P044482
  • GC07P044543
  • GC07P044577
  • GC07P044609
  • GC07P044803
  • GC07P044841
  • GC07P044798
  • GC07P044799
  • GC07P044800
  • GC07P044801
  • GC07P044804

Summaries for PPIA Gene

Entrez Gene Summary for PPIA Gene

  • This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIA Gene

PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Diffuse Intrinsic Pontine Glioma and Nodular Nonsuppurative Panniculitis. Among its related pathways are HIV Life Cycle and Innate Immune System. GO annotations related to this gene include poly(A) RNA binding and peptide binding. An important paralog of this gene is PPIAL4C.

UniProtKB/Swiss-Prot for PPIA Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for PPIA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIA Gene

Genomics for PPIA Gene

Regulatory Elements for PPIA Gene

Enhancers for PPIA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G044880 1.4 ENCODE dbSUPER 9.2 +88.5 88460 9.8 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 SIN3A ARID4B DMAP1 ZNF2 H2AFV LINC01952 SNHG15 MYO1G ENSG00000228596 PPIA ZMIZ2 ENSG00000272768 PIR54023
GH07G044795 1.2 ENCODE 9.2 +0.8 806 4.1 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21 ZMIZ2 H2AFV SEPT7P2 SNORA5C LINC01952 SNORA5B DDX56 SNHG15 PPIA GC07P044796
GH07G044866 1.2 ENCODE dbSUPER 9.2 +70.9 70915 1.6 PKNOX1 ATF1 SIN3A KLF17 ZEB1 GATA2 ZNF366 SCRT2 FOS CREM ENSG00000228596 PPIA H2AFV GC07P044861 GC07M044876
GH07G044628 2 FANTOM5 Ensembl ENCODE dbSUPER 5 -161.4 -161432 13.6 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A ARID4B FEZF1 YY1 ZNF766 ZNF143 PURB OGDH NACAD MYO1G ENSG00000228596 H2AFV LINC01952 DDX56 NUDCD3 PPIA
GH07G044893 1.4 FANTOM5 ENCODE dbSUPER 6.9 +98.1 98134 3.0 HDAC1 PKNOX1 RAD21 YY1 TCF12 GATA2 SCRT2 HMG20B CEBPB PBX2 H2AFV LINC01952 MYO1G ENSG00000228596 PPIA PURB ZMIZ2 OGDH PIR53562 LOC105375262
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPIA on UCSC Golden Path with GeneCards custom track

Promoters for PPIA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211874 464 3001 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC

Genomic Location for PPIA Gene

Chromosome:
7
Start:
44,796,636 bp from pter
End:
44,824,564 bp from pter
Size:
27,929 bases
Orientation:
Plus strand

Genomic View for PPIA Gene

Genes around PPIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIA Gene

Proteins for PPIA Gene

  • Protein details for PPIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62937-PPIA_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A
    Protein Accession:
    P62937
    Secondary Accessions:
    • A8K220
    • P05092
    • Q3KQW3
    • Q567Q0
    • Q6IBU5
    • Q96IX3
    • Q9BRU4
    • Q9BTY9
    • Q9UC61

    Protein attributes for PPIA Gene

    Size:
    165 amino acids
    Molecular mass:
    18012 Da
    Quaternary structure:
    • Interacts with HIV-1 Capsid protein.

    Three dimensional structures from OCA and Proteopedia for PPIA Gene

    Alternative splice isoforms for PPIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIA Gene

Selected DME Specific Peptides for PPIA Gene

P62937:
  • FMCQGGDF
  • LSMANAG
  • DGEPLGRV
  • KFEDENF
  • TNGSQFF
  • TAENFRAL
  • TGEKGFGY
  • SIYGEKF
  • GPNTNGSQ
  • GFGYKGS
  • PKTAENF
  • GILSMAN
  • GGKSIYG
  • LDGKHVVFG
  • KTEWLDG
  • IVEAMERFGSRNGKTSKKITI

Post-translational modifications for PPIA Gene

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
  • Ubiquitination at Lys31, Lys49, Lys82, posLast=9191, posLast=131131, Lys133, and posLast=155155
  • Glycosylation at posLast=108108
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPIA (PPIA)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PPIA

Domains & Families for PPIA Gene

Gene Families for PPIA Gene

Graphical View of Domain Structure for InterPro Entry

P62937

UniProtKB/Swiss-Prot:

PPIA_HUMAN :
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIA: view

Function for PPIA Gene

Molecular function for PPIA Gene

GENATLAS Biochemistry:
cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIA Gene

Gene Ontology (GO) - Molecular Function for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 14993672
GO:0005515 protein binding IPI 12357034
GO:0016018 cyclosporin A binding IDA 12357034
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIA: view
genes like me logo Genes that share phenotypes with PPIA: view

Animal Models for PPIA Gene

MGI Knock Outs for PPIA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIA Gene

Localization for PPIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene

Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 16780588
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPIA: view

Pathways & Interactions for PPIA Gene

genes like me logo Genes that share pathways with PPIA: view

Pathways by source for PPIA Gene

Gene Ontology (GO) - Biological Process for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 14993672
GO:0006278 RNA-dependent DNA biosynthetic process TAS --
GO:0006457 protein folding TAS 2179953
GO:0016032 viral process IEA --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with PPIA: view

No data available for SIGNOR curated interactions for PPIA Gene

Drugs & Compounds for PPIA Gene

(13) Drugs for PPIA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist, inhibitor, Target Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
L-Proline Approved Nutra Target, binder 0
(3r)-1-Acetyl-3-Methylpiperidine Experimental Pharma Target 0
(3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl- Experimental Pharma Target 0
Ethyl Oxo(Piperidin-1-Yl)Acetate Experimental Pharma Target 0

(3) Additional Compounds for PPIA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for PPIA Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
TMN 355 cyclophilin A inhibitor 1186372-20-2
genes like me logo Genes that share compounds with PPIA: view

Drug Products

Transcripts for PPIA Gene

Unigene Clusters for PPIA Gene

Peptidylprolyl isomerase A (cyclophilin A):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIA

Alternative Splicing Database (ASD) splice patterns (SP) for PPIA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PPIA Gene

GeneLoc Exon Structure for
PPIA
ECgene alternative splicing isoforms for
PPIA

Expression for PPIA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIA Gene



Protein tissue co-expression partners for PPIA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIA Gene:

PPIA

SOURCE GeneReport for Unigene cluster for PPIA Gene:

Hs.356331

Evidence on tissue expression from TISSUES for PPIA Gene

  • Liver(5)
  • Nervous system(5)
  • Lung(4.9)
  • Blood(4.8)
  • Skin(4.8)
  • Intestine(4.7)
  • Pancreas(4.7)
  • Kidney(4.5)
  • Eye(4.4)
  • Stomach(4.1)
  • Muscle(3.7)
  • Heart(3.3)
  • Bone(3.1)
  • Spleen(3)
  • Lymph node(2.7)
  • Bone marrow(2.5)
  • Adrenal gland(2.1)
  • Gall bladder(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PPIA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIA Gene

Orthologs for PPIA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIA 34 35
  • 99.39 (n)
mouse
(Mus musculus)
Mammalia Gm10123 35
  • 96 (a)
OneToMany
Ppia 34 16 35
  • 92.48 (n)
Gm5160 35
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LOC100337215 34
  • 94.51 (n)
PPIA 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ppia 34
  • 92.68 (n)
dog
(Canis familiaris)
Mammalia PPIA 34 35
  • 88.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves PPIA 34 35
  • 81.71 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496569 34
  • 67.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398630 34
zebrafish
(Danio rerio)
Actinopterygii ppiaa 34
  • 69.92 (n)
PPIA 35
  • 1 (a)
OneToMany
wufd61c06 34
fruit fly
(Drosophila melanogaster)
Insecta CG7768 36
  • 74 (a)
Cyp1 36
  • 74 (a)
CG5071 35
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-3 36
  • 67 (a)
cyn-1 34
  • 65.43 (n)
cyp-7 36
  • 64 (a)
cyp-8 36
  • 52 (a)
T22F3.12 35
  • 45 (a)
ManyToMany
Y17G9B.4 35
  • 22 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER156C 34
  • 63.96 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04565g 34
  • 61.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR3 34
  • 59.33 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC2 34
  • 66.46 (n)
soybean
(Glycine max)
eudicotyledons Gma.12280 34
rice
(Oryza sativa)
Liliopsida Os09g0571400 34
  • 66.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 35
  • 5 (a)
OneToMany
Species where no ortholog for PPIA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIA Gene

ENSEMBL:
Gene Tree for PPIA (if available)
TreeFam:
Gene Tree for PPIA (if available)

Paralogs for PPIA Gene

Pseudogenes.org Pseudogenes for PPIA Gene

genes like me logo Genes that share paralogs with PPIA: view

Variants for PPIA Gene

Sequence variations from dbSNP and Humsavar for PPIA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000118396 -- 44,794,786(+) GAGTC(C/T)AGGAG upstream-variant-2KB
rs1000249398 -- 44,802,504(+) AAGCA(G/T)ATTGG utr-variant-3-prime
rs1000292328 -- 44,799,505(+) TTATT(C/T)TATTT intron-variant
rs1000444121 -- 44,797,562(+) CCGAT(C/T)GTCCC intron-variant, upstream-variant-2KB
rs1000628094 -- 44,797,306(+) AGCCC(A/G/T)TCCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPIA Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV loss 17160897
nsv970472 CNV duplication 23825009

Variation tolerance for PPIA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIA Gene

Human Gene Mutation Database (HGMD)
PPIA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene

Disorders for PPIA Gene

MalaCards: The human disease database

(7) MalaCards diseases for PPIA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diffuse intrinsic pontine glioma
  • dipg
nodular nonsuppurative panniculitis
  • nodular non-suppurative febrile panniculitis
in situ carcinoma
  • carcinoma in situ
wolfram syndrome 2
  • wfs2
retinitis pigmentosa 14
  • rp14
- elite association - COSMIC cancer census association via MalaCards
Search PPIA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPIA

Genetic Association Database (GAD)
PPIA
Human Genome Epidemiology (HuGE) Navigator
PPIA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIA
genes like me logo Genes that share disorders with PPIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIA Gene

Publications for PPIA Gene

  1. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P. … Winkler C.A. (PLoS Pathog. 2007) 3 22 46 64
  2. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B. … Hofer E. (Eur. J. Biochem. 1990) 2 3 4 64
  3. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. (PMID: 20364129) Lammers M. … James L.C. (Nat. Chem. Biol. 2010) 3 4 64
  4. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. (PMID: 19758589) Seizer P. … May A.E. (Atherosclerosis 2010) 3 22 64
  5. Cyclophilin A: potential functions and therapeutic target for human cancer. (PMID: 19865066) Obchoei S. … Chen C. (Med. Sci. Monit. 2009) 3 22 64

Products for PPIA Gene

  • Addgene plasmids for PPIA

Sources for PPIA Gene

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