Aliases for PPIA Gene
External Ids for PPIA Gene
Previous GeneCards Identifiers for PPIA Gene
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPIA Gene
PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Diffuse Intrinsic Pontine Glioma and Wolfram Syndrome 2. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. GO annotations related to this gene include poly(A) RNA binding and peptide binding. An important paralog of this gene is PPIAL4C.
UniProtKB/Swiss-Prot for PPIA Gene
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.