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Aliases for PPARG Gene

Aliases for PPARG Gene

  • Peroxisome Proliferator Activated Receptor Gamma 2 3
  • Peroxisome Proliferator-Activated Receptor Gamma 2 5
  • Nuclear Receptor Subfamily 1 Group C Member 3 3 4
  • PPAR-Gamma 3 4
  • NR1C3 3 4
  • Peroxisome Proliferator-Activated Nuclear Receptor Gamma Variant 1 3
  • Peroxisome Proliferative Activated Receptor, Gamma 2
  • PPARgamma 3
  • PPARG1 3
  • PPARG2 3
  • CIMT1 3
  • GLM1 3

External Ids for PPARG Gene

Previous GeneCards Identifiers for PPARG Gene

  • GC03P012258
  • GC03P012304
  • GC03P012305
  • GC03P012263

Summaries for PPARG Gene

Entrez Gene Summary for PPARG Gene

  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPARG Gene

PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include lipodystrophy, familial partial, type 3 and obesity. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is NR1D2.

UniProtKB/Swiss-Prot for PPARG Gene

  • Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

Tocris Summary for PPARG Gene

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Gene Wiki entry for PPARG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARG Gene

Genomics for PPARG Gene

Regulatory Elements for PPARG Gene

Genomic Location for PPARG Gene

Chromosome:
3
Start:
12,287,368 bp from pter
End:
12,471,013 bp from pter
Size:
183,646 bases
Orientation:
Plus strand

Genomic View for PPARG Gene

Genes around PPARG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPARG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPARG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARG Gene

Proteins for PPARG Gene

  • Protein details for PPARG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37231-PPARG_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor gamma
    Protein Accession:
    P37231
    Secondary Accessions:
    • A8K3G6
    • B5BUA1
    • O00684
    • O00710
    • O14515
    • Q0QJH8
    • Q15178
    • Q15179
    • Q15180
    • Q15832
    • Q86U60
    • Q96J12

    Protein attributes for PPARG Gene

    Size:
    505 amino acids
    Molecular mass:
    57620 Da
    Quaternary structure:
    • Interacts with FOXO1 (acetylated form) (By similarity). Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with NOCT. Interacts with ACTN4.
    SequenceCaution:
    • Sequence=AAN38992.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA23354.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAF83270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA62153.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPARG Gene

    Alternative splice isoforms for PPARG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPARG Gene

Proteomics data for PPARG Gene at MOPED

Post-translational modifications for PPARG Gene

  • O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.
  • Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity).
  • Glycosylation at Thr 84
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PPARG (PPAR gamma/NR1C3)
  • Cell Signaling Technology (CST) Antibodies for PPARG (PPAR-gamma)

No data available for DME Specific Peptides for PPARG Gene

Domains & Families for PPARG Gene

Graphical View of Domain Structure for InterPro Entry

P37231

UniProtKB/Swiss-Prot:

PPARG_HUMAN :
  • Contains 1 nuclear receptor DNA-binding domain.
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with PPARG: view

Function for PPARG Gene

Molecular function for PPARG Gene

GENATLAS Biochemistry:
peroxisome proliferator-activated receptor,steroid/thyroid hormone coactivator receptor superfamily,heterodimerizing with RXR*,coactivated by SRCO1,expressed (isoform 1) in the diploid trophoblast lineages and required for placental development,expressed at low levels in preadipocytes,induced by CEBPB and CEBPD,coexpressed with and coregulated by PPARG,jointly required for full adipocyte differentiation and fat deposition with variability influencing plasma leptin levels in obese humans,modulator of insulin sensitivity and control of glucose homostasis and blood pressure and activation of antidiabetic effect of thiazolidinediones,negative regulator of macrophage activation,inhibiting production of monocyte inflammatory cytokines,increasing PAI1 expression in endothelial cells.
UniProtKB/Swiss-Prot EnzymeRegulation:
PDPK1 activates its transcriptional activity independently of its kinase activity.
UniProtKB/Swiss-Prot Function:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

Gene Ontology (GO) - Molecular Function for PPARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008144 drug binding IDA 9113987
GO:0033613 activating transcription factor binding IDA 10622252
GO:0050544 arachidonic acid binding ISS 9568715
GO:0051393 alpha-actinin binding IPI 22351778
genes like me logo Genes that share ontologies with PPARG: view
genes like me logo Genes that share phenotypes with PPARG: view

Human Phenotype Ontology for PPARG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPARG Gene

MGI Knock Outs for PPARG:

Animal Model Products

Targeted motifs for PPARG Gene
HOMER Transcription Factor Regulatory Elements motif PPARG
  • Consensus sequence: TGACCTTTGCCCCA Submotif: DR1 Cell Type: 3T3L1 GEO ID: GSE13511

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for PPARG Gene

Localization for PPARG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARG Gene

Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARG Gene COMPARTMENTS Subcellular localization image for PPARG gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
peroxisome 4
extracellular 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 2
vacuole 2
lysosome 1

No data available for Gene Ontology (GO) - Cellular Components for PPARG Gene

Pathways & Interactions for PPARG Gene

genes like me logo Genes that share pathways with PPARG: view

SIGNOR curated interactions for PPARG Gene

Gene Ontology (GO) - Biological Process for PPARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002674 negative regulation of acute inflammatory response IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006629 lipid metabolic process TAS 9568716
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 18293083
genes like me logo Genes that share ontologies with PPARG: view

Drugs & Compounds for PPARG Gene

(169) Drugs for PPARG Gene - From: Novoseek, DGIdb, IUPHAR, DrugBank, Tocris, ApexBio, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pioglitazone Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 419
Rosiglitazone Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Potent PPARγ agonist 220
Bezafibrate Approved Pharma Agonist, Target, agonist 12
Indomethacin Approved, Investigational Pharma Partial agonist, Agonist, inhibitor, Target, activator Cox inhibitor 106
Balsalazide Approved, Investigational Pharma inhibitor, Target, agonist 7

(95) Additional Compounds for PPARG Gene - From: Novoseek, HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-deoxy-delta-12,14-prostaglandin j2
87893-55-8
15-deoxy-delta 12 14-prostaglandin J2
Full agonist, Agonist
CDDO
Partial agonist, Agonist
thiazolidinone
Partial agonist, Agonist
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8

(5) Tocris Compounds for PPARG Gene

Compound Action Cas Number
15-deoxy-delta-12,14-Prostaglandin J2 Endogenous PPARgamma agonist 87893-55-8
Ciglitazone Selective PPARgamma agonist 74772-77-3
GW 1929 hydrochloride Selective PPARgamma agonist. Orally active 1217466-21-1
nTZDpa Potent, selective PPARgamma partial agonist 118414-59-8
Troglitazone Selective PPARgamma agonist; antidiabetic agent 97322-87-7

(13) ApexBio Compounds for PPARG Gene

Compound Action Cas Number
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid 317318-70-0
Balaglitazone PPAR-γ partial agonist 199113-98-9
Bezafibrate 41859-67-0
Ciprofibrate 52214-84-3
Fenofibrate 49562-28-9
Gemfibrozil 25812-30-0
GW9662 PPARγ antagonist 22978-25-2
Pioglitazone 111025-46-8
Pioglitazone HCl PPARγ agonist 112529-15-4
Rosiglitazone Potent PPARγ agonist 122320-73-4
Rosiglitazone HCl 302543-62-0
Rosiglitazone maleate PPARγ agonist,high-affinity and selective,potent insulin sensitizer 155141-29-0
T0070907 Human PPARγ antagonist,potent and selective 313516-66-4
genes like me logo Genes that share compounds with PPARG: view

Drug Products

Transcripts for PPARG Gene

Unigene Clusters for PPARG Gene

Peroxisome proliferator-activated receptor gamma:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPARG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: - - - - - - -
SP9: - - - - -

Relevant External Links for PPARG Gene

GeneLoc Exon Structure for
PPARG
ECgene alternative splicing isoforms for
PPARG

Expression for PPARG Gene

mRNA expression in normal human tissues for PPARG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPARG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x9.0), Adipose - Subcutaneous (x8.6), and Breast - Mammary Tissue (x5.0).

Protein differential expression in normal tissues from HIPED for PPARG Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPARG Gene



SOURCE GeneReport for Unigene cluster for PPARG Gene Hs.162646

mRNA Expression by UniProt/SwissProt for PPARG Gene

P37231-PPARG_HUMAN
Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
genes like me logo Genes that share expression patterns with PPARG: view

Protein tissue co-expression partners for PPARG Gene

- Elite partner

In Situ Assay Products

Orthologs for PPARG Gene

This gene was present in the common ancestor of animals.

Orthologs for PPARG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPARG 35
  • 91.02 (n)
  • 95.84 (a)
PPARG 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPARG 35
  • 92.34 (n)
  • 98.22 (a)
PPARG 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pparg 35
  • 90.1 (n)
  • 96.24 (a)
Pparg 16
Pparg 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPARG 35
  • 99.54 (n)
  • 99.8 (a)
PPARG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pparg 35
  • 89.83 (n)
  • 95.84 (a)
oppossum
(Monodelphis domestica)
Mammalia PPARG 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARG 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPARG 35
  • 82.25 (n)
  • 92.84 (a)
PPARG 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPARG 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16633 35
African clawed frog
(Xenopus laevis)
Amphibia PPARg 35
zebrafish
(Danio rerio)
Actinopterygii pparg 35
  • 67.02 (n)
  • 69.34 (a)
pparg 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip75B 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea sex-1 37
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.186 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for PPARG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPARG Gene

ENSEMBL:
Gene Tree for PPARG (if available)
TreeFam:
Gene Tree for PPARG (if available)

Paralogs for PPARG Gene

Paralogs for PPARG Gene

genes like me logo Genes that share paralogs with PPARG: view

Variants for PPARG Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PPARG Gene

P37231-PPARG_HUMAN
Genetic variations in PPARG define the body mass index quantitative trait locus 1 (BMIQ1) [MIM:606641]. The body max index (BMI) reflects the amount of fat, lean mass, and body build.

Sequence variations from dbSNP and Humsavar for PPARG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1801282 - 12,351,626(+) TTGAC(C/G)CAGAA intron-variant, reference, missense
rs1800571 Obesity (OBESITY) 12,381,349(+) ATCTC(A/C)ACCTT reference, missense
rs28936407 Colon cancer, Colon cancer 12,416,831(+) GTTTC(A/G)CTCCG intron-variant, reference, missense
VAR_010727 -
VAR_010728 -

Structural Variations from Database of Genomic Variants (DGV) for PPARG Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
nsv3702 CNV Loss 18451855
esv4138 CNV Deletion 18987735
esv2724933 CNV Deletion 23290073
esv7808 CNV Loss 19470904
esv2669014 CNV Deletion 23128226
esv2661678 CNV Deletion 23128226

Variation tolerance for PPARG Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPARG Gene

HapMap Linkage Disequilibrium report
PPARG
Human Gene Mutation Database (HGMD)
PPARG

Disorders for PPARG Gene

MalaCards: The human disease database

(53) MalaCards diseases for PPARG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lipodystrophy, familial partial, type 3
  • insulin resistance, severe, digenic
obesity
  • obesity, association with
carotid intimal medial thickness 1
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards
Search PPARG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PPARG_HUMAN
  • Glioma 1 (GLM1) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269 PubMed:10851250}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
  • Lipodystrophy, familial partial, 3 (FPLD3) [MIM:604367]: A form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. {ECO:0000269 PubMed:11788685, ECO:0000269 PubMed:12453919}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. {ECO:0000269 PubMed:10394368}.
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:9753710}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Genatlas disease for PPARG Gene

marked obesity with a high body-mass index and a defect in the regulation of adipocyte differentiation associated with type 2 diabetes

Relevant External Links for PPARG

Genetic Association Database (GAD)
PPARG
Human Genome Epidemiology (HuGE) Navigator
PPARG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPARG
genes like me logo Genes that share disorders with PPARG: view

Publications for PPARG Gene

  1. A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. (PMID: 19147680) Tagami T. … Naruse M. (Endocrinology 2009) 3 23 25 26
  2. Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects. (PMID: 15562396) Kim K.S. … Yoon Y. (Metabolism 2004) 3 4 48 67
  3. Mesalazine in inflammatory bowel disease: a trendy topic once again? (PMID: 20151072) Iacucci M. … Ghosh S. (Can. J. Gastroenterol. 2010) 23 25 26
  4. PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. (PMID: 18544567) Schwab M. … Stein J. (Carcinogenesis 2008) 23 25 26
  5. Beyond the classic angiotensin-receptor-blocker profile. (PMID: 18580862) Kurtz T.W. (Nat Clin Pract Cardiovasc Med 2008) 23 25 26

Products for PPARG Gene

  • Addgene plasmids for PPARG

Sources for PPARG Gene

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