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UGT1A3 Gene(Protein Coding)

UDP Glucuronosyltransferase Family 1 Member A3

GCID:
GC02P233729
GIFtS:
54
Genes Participants
UDN Logo

Aliases for UGT1A3 Gene

Aliases for UGT1A3 Gene

  • UDP Glucuronosyltransferase Family 1 Member A3 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A3 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A3 2 3
  • UDP-Glucuronosyltransferase 1-C 3 4
  • UDP-Glucuronosyltransferase 1A3 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 1-3 3 4
  • UGT1-03 3 4
  • UGT-1C 3 4
  • UGT1*3 3 4
  • UGT1.3 3 4
  • UGT1C 3 4
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A3s 3
  • UGT1A3S 3
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A3 Gene

Previous GeneCards Identifiers for UGT1A3 Gene

  • GC02U990254
  • GC02P234816
  • GC02P234879
  • GC02P234364
  • GC02P234419
  • GC02P234194
  • GC02P234204
  • GC02P234214
  • GC02P234224
  • GC02P234302
  • GC02P234637
  • GC02P226437

Summaries for UGT1A3 Gene

Entrez Gene Summary for UGT1A3 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A3 Gene

UGT1A3 (UDP Glucuronosyltransferase Family 1 Member A3) is a Protein Coding gene. Diseases associated with UGT1A3 include Gilbert Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Glucose / Energy Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A3 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A3 Gene

Genomics for UGT1A3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for UGT1A3 Gene

Enhancers for UGT1A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UGT1A3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UGT1A3 gene promoter:

Genomic Location for UGT1A3 Gene

Chromosome:
2
Start:
233,729,108 bp from pter
End:
233,773,299 bp from pter
Size:
44,192 bases
Orientation:
Plus strand

Genomic View for UGT1A3 Gene

Genes around UGT1A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UGT1A3 Gene

Proteins for UGT1A3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for UGT1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35503-UD13_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-3
    Protein Accession:
    P35503
    Secondary Accessions:
    • B8K287

    Protein attributes for UGT1A3 Gene

    Size:
    534 amino acids
    Molecular mass:
    60338 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A3 Gene

Proteomics data for UGT1A3 Gene at MOPED

Protein Expression for UGT1A3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for UGT1A3 Gene

P35503:

Post-translational modifications for UGT1A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UGT1A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A3 Gene

Gene Families for UGT1A3 Gene

HGNC:

Protein Domains for UGT1A3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UGT1A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35503

UniProtKB/Swiss-Prot:

UD13_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A3: view

Function for UGT1A3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for UGT1A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A3 Gene

Gene Ontology (GO) - Molecular Function for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
genes like me logo Genes that share ontologies with UGT1A3: view

Phenotypes for UGT1A3 Gene

GenomeRNAi human phenotypes for UGT1A3:
genes like me logo Genes that share phenotypes with UGT1A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A3 Gene

Localization for UGT1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A3 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A3 Gene COMPARTMENTS Subcellular localization image for UGT1A3 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
peroxisome 2
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for UGT1A3 Gene

Pathways & Interactions for UGT1A3 Gene

genes like me logo Genes that share pathways with UGT1A3: view

Interacting Proteins for UGT1A3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418532%0d%0a9606.ENSP00000303174%0d%0a9606.ENSP00000362525%0d%0a9606.ENSP00000362549%0d%0a9606.ENSP00000362508%0d%0a9606.ENSP00000304845%0d%0a
Selected Interacting proteins: ENSP00000418532 for UGT1A3 Gene via STRING

Gene Ontology (GO) - Biological Process for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA,TAS 9295054
GO:0052696 flavonoid glucuronidation IDA 20056724
GO:1904224 negative regulation of glucuronosyltransferase activity ISS 20610558
genes like me logo Genes that share ontologies with UGT1A3: view

No data available for SIGNOR curated interactions for UGT1A3 Gene

Drugs & Compounds for UGT1A3 Gene

Products:

  1. Drug

(48) Drugs for UGT1A3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Morphine Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate 889
atorvastatin Approved Pharma Competitive, Inhibitor, Enzyme, substrate 0
Eltrombopag Approved Pharma Enzyme, substrate 0
Cyproheptadine Approved Pharma Antagonist, Enzyme, substrate 20
Ezetimibe Approved Pharma Enzyme, substrate Cholesterol transport inhibitor 267

(90) Additional Compounds for UGT1A3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
 115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
 77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A3: view

Transcripts for UGT1A3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for UGT1A3 Gene

(1) REFSEQ mRNAs :
(271) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A3 Gene

No ASD Table

Relevant External Links for UGT1A3 Gene

GeneLoc Exon Structure for
UGT1A3
ECgene alternative splicing isoforms for
UGT1A3

Expression for UGT1A3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for UGT1A3 Gene

mRNA expression in normal human tissues for UGT1A3 Gene
mRNA expression by BioGPS for UGT1A3 Gene

Protein differential expression in normal tissues from HIPED for UGT1A3 Gene

This gene is overexpressed in Liver (43.9) and Gallbladder (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UGT1A3 Gene



mRNA Expression by UniProt/SwissProt for UGT1A3 Gene

P35503-UD13_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus.
genes like me logo Genes that share expression patterns with UGT1A3: view

Protein tissue co-expression partners for UGT1A3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UGT1A3 Gene

Orthologs for UGT1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
 Mammalia Ugt1a2 35
  • 79.61 (n)
  • 75.8 (a)
Ugt1a2 16
Ugt1a2 36
  • 76 (a)
 ManyToMany
Ugt1a5 36
  • 76 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia Ugt1a2 35
  • 81.11 (n)
  • 77.49 (a)
cow
(Bos Taurus)
 Mammalia -- 36
  • 66 (a)
 ManyToMany
-- 36
  • 66 (a)
 ManyToMany
-- 36
  • 70 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 60 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii ugt1a7 36
  • 51 (a)
 ManyToMany
ugt1b1 36
  • 48 (a)
 ManyToMany
ugt1b2 36
  • 46 (a)
 ManyToMany
ugt1b3 36
  • 46 (a)
 ManyToMany
ugt1b4 36
  • 46 (a)
 ManyToMany
ugt1b5 36
  • 46 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta BEST:GH06505 37
  • 28 (a)
CG10178 37
  • 26 (a)
CG16732 37
  • 24 (a)
CG17323 37
  • 29 (a)
CG5724 37
  • 29 (a)
CG5999 37
  • 23 (a)
Dot 37
  • 26 (a)
Ugt36Ba 37
  • 29 (a)
Ugt37a1 37
  • 29 (a)
Ugt37b1 37
  • 26 (a)
Ugt37c1 37
  • 30 (a)
Ugt36Bb 35
  • 44.03 (n)
  • 33.19 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP011564 35
  • 43 (n)
  • 31.39 (a)
worm
(Caenorhabditis elegans)
 Secernentea AC3.2 37
  • 28 (a)
C03A7.11 37
  • 24 (a)
C08B6.1 37
  • 24 (a)
C08F11.8 37
  • 27 (a)
C10H11.5 37
  • 26 (a)
C10H11.6 37
  • 24 (a)
C17G1.3 37
  • 25 (a)
C33A12.6 37
  • 25 (a)
C44H9.1 37
  • 24 (a)
F01D4.1 37
  • 23 (a)
F01D4.2 37
  • 23 (a)
F09G2.6 37
  • 25 (a)
F10D2.5 37
  • 27 (a)
F35H8.6 37
  • 28 (a)
F39G3.1 37
  • 30 (a)
F47C10.6 37
  • 23 (a)
K08B4.4 37
  • 25 (a)
R04B5.9 37
  • 23 (a)
T01G5.2 37
  • 23 (a)
T07C5.1a 37
  • 26 (a)
ZC443.5 37
  • 26 (a)
Species with no ortholog for UGT1A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT1A3 Gene

ENSEMBL:
Gene Tree for UGT1A3 (if available)
TreeFam:
Gene Tree for UGT1A3 (if available)

Paralogs for UGT1A3 Gene

Paralogs for UGT1A3 Gene

(31) SIMAP similar genes for UGT1A3 Gene using alignment to 18 proteins:

Pseudogenes.org Pseudogenes for UGT1A3 Gene

genes like me logo Genes that share paralogs with UGT1A3: view

Variants for UGT1A3 Gene

Sequence variations from dbSNP and Humsavar for UGT1A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_052445 -
VAR_052446 -
VAR_052447 -
VAR_052448 -
VAR_052449 -

Structural Variations from Database of Genomic Variants (DGV) for UGT1A3 Gene

Variant ID Type Subtype PubMed ID
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Variation tolerance for UGT1A3 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A3 Gene

Human Gene Mutation Database (HGMD)
UGT1A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A3 Gene

Disorders for UGT1A3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for UGT1A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gilbert syndrome
  • constitutional hyperbilirubinemia
stevens-johnson syndrome/toxic epidermal necrolysis
  • toxic epidermal necrolysis
drug-induced hepatitis
  • drug-induced chronic hepatitis
pericholangitis
cholelithiasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A3

Genetic Association Database (GAD)
UGT1A3
Human Genome Epidemiology (HuGE) Navigator
UGT1A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT1A3
genes like me logo Genes that share disorders with UGT1A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A3 Gene

Publications for UGT1A3 Gene

  1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Menard V. … Guillemette C. (Hum. Mutat. 2009) 3 4 23 48 67
  2. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. (PMID: 9616184) Green M.D. … Tephly T.R. (Drug Metab. Dispos. 1998) 3 23 25 26
  3. Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. (PMID: 21368751) Oswald S. … Siegmund W. (Clin. Pharmacol. Ther. 2011) 25 26
  4. The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver. (PMID: 19889628) Trottier J. … Barbier O. (J. Biol. Chem. 2010) 3 23
  5. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. (PMID: 20056724) Brand W. … Rietjens I.M. (Drug Metab. Dispos. 2010) 3 23

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