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Aliases for UGT1A5 Gene

Aliases for UGT1A5 Gene

  • UDP Glucuronosyltransferase Family 1 Member A5 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A5 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A5 2 3
  • UDP-Glucuronosyltransferase 1-E 3 4
  • UDP-Glucuronosyltransferase 1A5 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 1-5 3 4
  • UGT-1E 3 4
  • UGT1*5 3 4
  • UGT1E 3 4
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A5s 3
  • UGT1-05 4
  • UGT1.5 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A5 Gene

Previous GeneCards Identifiers for UGT1A5 Gene

  • GC02U990249
  • GC02P234818
  • GC02P234881
  • GC02P234366
  • GC02P234403
  • GC02P234196
  • GC02P234206
  • GC02P234216
  • GC02P234286
  • GC02P234621
  • GC02P226422

Summaries for UGT1A5 Gene

Entrez Gene Summary for UGT1A5 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A5 Gene

UGT1A5 (UDP Glucuronosyltransferase Family 1 Member A5) is a Protein Coding gene. Diseases associated with UGT1A5 include pericholangitis and cholelithiasis. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A5 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).

Gene Wiki entry for UGT1A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A5 Gene

Genomics for UGT1A5 Gene

Regulatory Elements for UGT1A5 Gene

Genomic Location for UGT1A5 Gene

Chromosome:
2
Start:
233,712,992 bp from pter
End:
233,773,299 bp from pter
Size:
60,308 bases
Orientation:
Plus strand

Genomic View for UGT1A5 Gene

Genes around UGT1A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A5 Gene

Proteins for UGT1A5 Gene

  • Protein details for UGT1A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35504-UD15_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-5
    Protein Accession:
    P35504
    Secondary Accessions:
    • B8K294

    Protein attributes for UGT1A5 Gene

    Size:
    534 amino acids
    Molecular mass:
    60071 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A5 Gene

Proteomics data for UGT1A5 Gene at MOPED

Post-translational modifications for UGT1A5 Gene

  • Glycosylation at Asn 119, Asn 296, and Asn 348
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UGT1A5 (UGT1A5)

Domains & Families for UGT1A5 Gene

Gene Families for UGT1A5 Gene

Protein Domains for UGT1A5 Gene

Graphical View of Domain Structure for InterPro Entry

P35504

UniProtKB/Swiss-Prot:

UD15_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A5: view

Function for UGT1A5 Gene

Molecular function for UGT1A5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).

Enzyme Numbers (IUBMB) for UGT1A5 Gene

Gene Ontology (GO) - Molecular Function for UGT1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT1A5: view
genes like me logo Genes that share phenotypes with UGT1A5: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A5 Gene

Localization for UGT1A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A5 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A5 Gene COMPARTMENTS Subcellular localization image for UGT1A5 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 2
nucleus 2
peroxisome 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UGT1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 NOT endoplasmic reticulum membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT1A5: view

Pathways & Interactions for UGT1A5 Gene

genes like me logo Genes that share pathways with UGT1A5: view

Interacting Proteins for UGT1A5 Gene

Gene Ontology (GO) - Biological Process for UGT1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052696 flavonoid glucuronidation IBA --
genes like me logo Genes that share ontologies with UGT1A5: view

No data available for SIGNOR curated interactions for UGT1A5 Gene

Drugs & Compounds for UGT1A5 Gene

(13) Drugs for UGT1A5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 68
Estradiol Approved, Investigational Pharma Sex hormone 1094
Estriol Approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 19
Morphine Approved, Investigational Pharma Full agonist, Agonist 855

(82) Additional Compounds for UGT1A5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A5: view

Transcripts for UGT1A5 Gene

mRNA/cDNA for UGT1A5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A5 Gene

No ASD Table

Relevant External Links for UGT1A5 Gene

GeneLoc Exon Structure for
UGT1A5
ECgene alternative splicing isoforms for
UGT1A5

Expression for UGT1A5 Gene

mRNA expression in normal human tissues for UGT1A5 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.0) and Bladder (x5.7).

mRNA Expression by UniProt/SwissProt for UGT1A5 Gene

P35504-UD15_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus.
genes like me logo Genes that share expression patterns with UGT1A5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for UGT1A5 Gene

Orthologs for UGT1A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UGT1A5 Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Ugt1a3 35
  • 78.87 (n)
  • 76.04 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt1a2 36
  • 74 (a)
ManyToMany
Ugt1a5 36
  • 75 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ugt1a7 36
  • 50 (a)
ManyToMany
ugt1b1 36
  • 48 (a)
ManyToMany
ugt1b2 36
  • 45 (a)
ManyToMany
ugt1b3 36
  • 46 (a)
ManyToMany
ugt1b4 36
  • 46 (a)
ManyToMany
ugt1b5 36
  • 46 (a)
ManyToMany
Species with no ortholog for UGT1A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT1A5 Gene

ENSEMBL:
Gene Tree for UGT1A5 (if available)
TreeFam:
Gene Tree for UGT1A5 (if available)

Paralogs for UGT1A5 Gene

genes like me logo Genes that share paralogs with UGT1A5: view

Variants for UGT1A5 Gene

Sequence variations from dbSNP and Humsavar for UGT1A5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_052455 -
VAR_052456 -
VAR_052457 -
VAR_052458 -
VAR_052459 -

Structural Variations from Database of Genomic Variants (DGV) for UGT1A5 Gene

Variant ID Type Subtype PubMed ID
nsv876017 CNV Loss 21882294
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv2721668 CNV Deletion 23290073
esv2661542 CNV Deletion 23128226
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Variation tolerance for UGT1A5 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.03; 90.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A5 Gene

HapMap Linkage Disequilibrium report
UGT1A5
Human Gene Mutation Database (HGMD)
UGT1A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A5 Gene

Disorders for UGT1A5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UGT1A5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pericholangitis
cholelithiasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A5

Genetic Association Database (GAD)
UGT1A5
Human Genome Epidemiology (HuGE) Navigator
UGT1A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT1A5
genes like me logo Genes that share disorders with UGT1A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A5 Gene

Publications for UGT1A5 Gene

  1. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. (PMID: 1339448) Ritter J.K. … Owens I.S. (J. Biol. Chem. 1992) 2 3 4 67
  2. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PMID: 9295054) Mackenzie P.I. … Nebert D.W. (Pharmacogenetics 1997) 2 3
  3. Genome-wide analysis of hepatic lipid content in extreme obesity. (PMID: 25246029) DiStefano J.K. … Gerhard G.S. (Acta Diabetol 2015) 3
  4. Genetic determinants influencing human serum metabolome among African Americans. (PMID: 24625756) Yu B. … Boerwinkle E. (PLoS Genet. 2014) 3
  5. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3

Products for UGT1A5 Gene

Sources for UGT1A5 Gene

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