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Aliases for UGT1A6 Gene

Aliases for UGT1A6 Gene

  • UDP Glucuronosyltransferase 1 Family, Polypeptide A6 2 3
  • UDP Glycosyltransferase 1 Family, Polypeptide A6 2 3
  • Phenol-Metabolizing UDP-Glucuronosyltransferase 3 4
  • UDP-Glucuronosyltransferase 1-F 3 4
  • UDP-Glucuronosyltransferase 1A6 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 1-6 3 4
  • UGT1-06 3 4
  • UGT-1F 3 4
  • UGT1*6 3 4
  • UGT1.6 3 4
  • UGT1F 3 4
  • UGT1 3 4
  • GNT1 3 4
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A6s 3
  • UDP-Glucuronosyltransferase 1-6 3
  • UGT1A6S 3
  • HLUGP1 3
  • UDPGT 3
  • HLUGP 3

External Ids for UGT1A6 Gene

Previous GeneCards Identifiers for UGT1A6 Gene

  • GC02U990248
  • GC02P234819
  • GC02P234882
  • GC02P234367
  • GC02P234382
  • GC02P234197
  • GC02P234208
  • GC02P234217
  • GC02P234265
  • GC02P234600
  • GC02P226400

Summaries for UGT1A6 Gene

Entrez Gene Summary for UGT1A6 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A6 Gene

UGT1A6 (UDP Glucuronosyltransferase 1 Family, Polypeptide A6) is a Protein Coding gene. Diseases associated with UGT1A6 include colorectal adenoma and crigler-najjar syndrome, type i. Among its related pathways are AhR pathway (WikiPathways) and Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A6 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).

Gene Wiki entry for UGT1A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A6 Gene

Genomics for UGT1A6 Gene

Regulatory Elements for UGT1A6 Gene

Transcription factor binding sites by QIAGEN in the UGT1A6 gene promoter:

Genomic Location for UGT1A6 Gene

Start:
233,691,607 bp from pter
End:
233,773,305 bp from pter
Size:
81,699 bases
Orientation:
Plus strand

Genomic View for UGT1A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT1A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A6 Gene

Proteins for UGT1A6 Gene

  • Protein details for UGT1A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19224-UD16_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-6
    Protein Accession:
    P19224
    Secondary Accessions:
    • A6NKK6
    • B8K289
    • Q96TE7

    Protein attributes for UGT1A6 Gene

    Size:
    532 amino acids
    Molecular mass:
    60751 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 3/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 3. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity
    SequenceCaution:
    • Sequence=BM924331; Type=Erroneous termination; Positions=420; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BM924331; Type=Frameshift; Positions=451, 463; Evidence={ECO:0000305}; Sequence=BM924331; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for UGT1A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A6 Gene

Proteomics data for UGT1A6 Gene at MOPED

Post-translational modifications for UGT1A6 Gene

  • Glycosylation at Asn294 and Asn346
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UGT1A6 (Ugt1a6a)

Domains for UGT1A6 Gene

Gene Families for UGT1A6 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT1A6 Gene

Graphical View of Domain Structure for InterPro Entry

P19224

UniProtKB/Swiss-Prot:

UD16_HUMAN :
  • P19224
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A6: view

Function for UGT1A6 Gene

Molecular function for UGT1A6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
UniProtKB/Swiss-Prot Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).

Enzyme Numbers (IUBMB) for UGT1A6 Gene

Gene Ontology (GO) - Molecular Function for UGT1A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity ISS 20610558
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0019899 enzyme binding IPI 20610558
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with UGT1A6: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT1A6 Gene

Localization for UGT1A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A6 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A6 Gene COMPARTMENTS Subcellular localization image for UGT1A6 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
nucleus 2
plasma membrane 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UGT1A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum NAS 20610558
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UGT1A6: view

Pathways for UGT1A6 Gene

genes like me logo Genes that share pathways with UGT1A6: view

Interacting Proteins for UGT1A6 Gene

Gene Ontology (GO) - Biological Process for UGT1A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0009813 flavonoid biosynthetic process IBA --
GO:0017144 NOT drug metabolic process IKR 20610558
genes like me logo Genes that share ontologies with UGT1A6: view

Compounds for UGT1A6 Gene

(85) HMDB Compounds for UGT1A6 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available

(34) Novoseek inferred chemical compound relationships for UGT1A6 Gene

Compound -log(P) Hits PubMed IDs
4-methylumbelliferone 88.9 7
udp glucuronic acid 86.1 2
1-naphthol 83.9 9
uridine diphosphate 81.8 5
glucuronide 74.2 4

(3) PharmGKB related drug/compound annotations for UGT1A6 Gene

Drug/compound Annotation
clobazam
eltrombopag
valproic acid CA
genes like me logo Genes that share compounds with UGT1A6: view

Transcripts for UGT1A6 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UGT1A6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: -
SP8:
SP9: - - - - -
SP10: - - - - - - - -
SP11: -

Relevant External Links for UGT1A6 Gene

GeneLoc Exon Structure for
UGT1A6
ECgene alternative splicing isoforms for
UGT1A6

Expression for UGT1A6 Gene

mRNA expression in normal human tissues for UGT1A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT1A6 Gene

This gene is overexpressed in Liver (13.5), Kidney - Cortex (11.0), Bladder (10.2), and Testis (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UGT1A6 Gene

mRNA Expression by UniProt/SwissProt for UGT1A6 Gene

P19224-UD16_HUMAN
Tissue specificity: Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine.
genes like me logo Genes that share expressions with UGT1A6: view

In Situ Assay Products

Orthologs for UGT1A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT1A6 35
  • 99.44 (n)
  • 99.44 (a)
UGT1A6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGT1A6 35
  • 80.03 (n)
  • 80.34 (a)
dog
(Canis familiaris)
Mammalia UGT1A6 35
  • 83.9 (n)
  • 81.63 (a)
UGT1A6 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ugt1a6a 35
  • 81.48 (n)
  • 79.66 (a)
Ugt1a6a 16
Ugt1a6a 36
  • 75 (a)
OneToMany
Ugt1a6b 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt1a6 35
  • 81.7 (n)
  • 80.57 (a)
lizard
(Anolis carolinensis)
Reptilia UGT1A6 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ugt1a7 36
  • 50 (a)
ManyToMany
ugt1b1 36
  • 47 (a)
ManyToMany
ugt1b2 36
  • 47 (a)
ManyToMany
ugt1b3 36
  • 46 (a)
ManyToMany
ugt1b4 36
  • 47 (a)
ManyToMany
ugt1b5 36
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10178 37
  • 30 (a)
Dot 37
  • 26 (a)
CG11289 37
  • 35 (a)
Ugt36Bc 37
  • 30 (a)
Ugt37c1 37
  • 31 (a)
Ugt36Ba 37
  • 29 (a)
Ugt86Dc 37
  • 32 (a)
CG5724 37
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea F56B3.7 37
  • 29 (a)
C08F11.8 37
  • 25 (a)
C17G1.3 37
  • 27 (a)
C49A9.8 37
  • 22 (a)
ZC443.5 37
  • 25 (a)
F10D2.5 37
  • 25 (a)
T03D3.1 37
  • 26 (a)
C10H11.6 37
  • 23 (a)
F35H8.6 37
  • 29 (a)
F09G2.6 37
  • 24 (a)
K08B4.4 37
  • 23 (a)
F01D4.2 37
  • 22 (a)
C35A5.2 37
  • 28 (a)
R04B5.9 37
  • 25 (a)
AC3.2 37
  • 25 (a)
AC3.7 37
  • 24 (a)
C03A7.11 37
  • 24 (a)
T01G5.2 37
  • 23 (a)
T25B9.7 37
  • 27 (a)
C10H11.4 37
  • 23 (a)
AC3.8 37
  • 23 (a)
C33A12.6 37
  • 25 (a)
C10H11.5 37
  • 25 (a)
Species with no ortholog for UGT1A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT1A6 Gene

ENSEMBL:
Gene Tree for UGT1A6 (if available)
TreeFam:
Gene Tree for UGT1A6 (if available)

Paralogs for UGT1A6 Gene

genes like me logo Genes that share paralogs with UGT1A6: view

Variants for UGT1A6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A6 Gene

P19224-UD16_HUMAN
Polymorphisms in the UGT1A6 gene define four common haplotypes: UGT1A6*1, UGT1A6*2, UGT1A6*3 and UGT1A6*4. Liver tissue samples that were homozygous for UGT1A6*2 exhibited a high rate of glucuronidation relative to tissues with other genotypes. Biochemical kinetic studies indicate that the UGT1A6*2 allozyme, expressed homozygously, had almost two-fold greater activity toward p-nitrophenol than UGT1A6*1 and when expressed heterozygously (UGT1A6*1/*2) it is associated with low enzyme activity. Common genetic variation in UGT1A6 confers functionally significant differences in biochemical phenotype. This genetic variation might impact clinical efficacy or toxicity of drugs metabolized by UGT1A6

Sequence variations from dbSNP and Humsavar for UGT1A6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_014784 -
VAR_015559 -
VAR_024685 -
VAR_026628 -
VAR_026629 -

Structural Variations from Database of Genomic Variants (DGV) for UGT1A6 Gene

Variant ID Type Subtype PubMed ID
nsv876016 CNV Gain 21882294
nsv876017 CNV Loss 21882294
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv2721668 CNV Deletion 23290073
esv2661542 CNV Deletion 23128226
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Relevant External Links for UGT1A6 Gene

HapMap Linkage Disequilibrium report
UGT1A6
Human Gene Mutation Database (HGMD)
UGT1A6

Disorders for UGT1A6 Gene

(6) Novoseek inferred disease relationships for UGT1A6 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 48.6 4
colon adenocarcinoma 24.2 1
adenoma 18.5 9
lung carcinoma 9.04 1
tumors 2.04 3

Relevant External Links for UGT1A6

Genetic Association Database (GAD)
UGT1A6
Human Genome Epidemiology (HuGE) Navigator
UGT1A6
genes like me logo Genes that share disorders with UGT1A6: view

No data available for UniProtKB/Swiss-Prot for UGT1A6 Gene

Publications for UGT1A6 Gene

  1. Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. (PMID: 15284531) Nagar S. … Blanchard R.L. (Pharmacogenetics 2004) 3 4 23 48
  2. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Menard V. … Guillemette C. (Hum. Mutat. 2009) 3 4 23 48
  3. Effect of genetic polymorphisms in UDP-glucuronosyltransferase 1A6 (UGT1A6) on acetylsalicylic acid metabolism in healthy female volunteers. (PMID: 19262071) van Oijen M.G. … Jansen J.B. (Pharmacology 2009) 3 23 48
  4. Characterizing the effects of common UDP glucuronosyltransferase (UGT) 1A6 and UGT1A1 polymorphisms on cis- and trans-resveratrol glucuronidation. (PMID: 19406951) Iwuchukwu O.F. … Nagar S. (Drug Metab. Dispos. 2009) 3 23 48
  5. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) (Breast Cancer Res. Treat. 2010) 3 23 48

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