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Aliases for UGT1A8 Gene

Aliases for UGT1A8 Gene

  • UDP Glucuronosyltransferase 1 Family, Polypeptide A8 2 3
  • UDP Glycosyltransferase 1 Family, Polypeptide A8 2 3
  • UDP-Glucuronosyltransferase 1-H 3 4
  • UDP-Glucuronosyltransferase 1A8 3 4
  • EC 2.4.1.17 4 64
  • UDPGT 1-8 3 4
  • UGT1-08 3 4
  • UGT-1H 3 4
  • UGT1.8 3 4
  • UGT1H 3 4
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A8s 3
  • UDP-Glucuronosyltransferase 1-8 3
  • UGT1A8S 3
  • UGT1*8 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A8 Gene

Summaries for UGT1A8 Gene

Entrez Gene Summary for UGT1A8 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A8 Gene

UGT1A8 (UDP Glucuronosyltransferase 1 Family, Polypeptide A8) is a Protein Coding gene. Diseases associated with UGT1A8 include kernicterus. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A8 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A8 Gene

Genomics for UGT1A8 Gene

Genomic Location for UGT1A8 Gene

Start:
233,617,645 bp from pter
End:
233,773,299 bp from pter
Size:
155,655 bases
Orientation:
Plus strand

Genomic View for UGT1A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UGT1A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A8 Gene

Regulatory Elements for UGT1A8 Gene

Proteins for UGT1A8 Gene

  • Protein details for UGT1A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW9-UD18_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-8
    Protein Accession:
    Q9HAW9
    Secondary Accessions:
    • B2R8S3
    • B8K290
    • O14928
    • Q8TEX4
    • Q8WTQ9
    • Q8WX85

    Protein attributes for UGT1A8 Gene

    Size:
    530 amino acids
    Molecular mass:
    59742 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity

    Alternative splice isoforms for UGT1A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A8 Gene

Proteomics data for UGT1A8 Gene at MOPED

Post-translational modifications for UGT1A8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn71, Asn292, and Asn344

Other Protein References for UGT1A8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UGT1A8 Gene

Gene Families for UGT1A8 Gene

HGNC:
  • UGT :UDP glucuronosyltransferases

Protein Domains for UGT1A8 Gene

UniProtKB/Swiss-Prot:

UD18_HUMAN
Family:
  • Belongs to the UDP-glycosyltransferase family.:
    • Q9HAW9
genes like me logo Genes that share domains with UGT1A8: view

Function for UGT1A8 Gene

Molecular function for UGT1A8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A8 Gene

Gene Ontology (GO) - Molecular Function for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IC 20308471
GO:0004857 enzyme inhibitor activity IGI 20610558
GO:0005496 steroid binding IDA 19996319
GO:0005504 fatty acid binding IDA 19996319
GO:0008144 drug binding IDA 20610558
genes like me logo Genes that share ontologies with UGT1A8: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UGT1A8 Gene

Localization for UGT1A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A8 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A8 Gene COMPARTMENTS Subcellular localization image for UGT1A8 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 2
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum NAS 20610558
GO:0005789 endoplasmic reticulum membrane NAS 20610558
GO:0005887 integral component of plasma membrane --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with UGT1A8: view

Pathways for UGT1A8 Gene

genes like me logo Genes that share pathways with UGT1A8: view

Interacting Proteins for UGT1A8 Gene

Gene Ontology (GO) - Biological Process for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development --
GO:0005975 carbohydrate metabolic process --
GO:0006631 fatty acid metabolic process IDA 20610558
GO:0006778 porphyrin-containing compound metabolic process --
GO:0006789 bilirubin conjugation --
genes like me logo Genes that share ontologies with UGT1A8: view

Compounds for UGT1A8 Gene

(84) HMDB Compounds for UGT1A8 Gene

Compound Synonyms Cas Number PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
Not Available
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • Ibuprofen acyl glucuronide
115075-59-7
11-beta-hydroxyandrosterone-3-glucuronide
  • 11-beta-hydroxyetiocholanolone-3-glucuronide
Not Available
11-Hydroxyprogesterone 11-glucuronide
  • 11-hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-etiocholanolone glucuronide
Not Available

(6) Drugbank Compounds for UGT1A8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Diflunisal
22494-42-4 enzyme substrate
Morphine
  • (-)-Heroin hydrochloride
57-27-2 enzyme substrate
Mycophenolate mofetil
  • MMF
128794-94-5 enzyme substrate
Propofol
  • 2,6-Diisopropylphenol
2078-54-8 enzyme substrate
Troglitazone
97322-87-7 enzyme substrate

(12) Novoseek inferred chemical compound relationships for UGT1A8 Gene

Compound -log(P) Hits PubMed IDs
udp glucuronic acid 86.9 1
n-hydroxy phip 77.4 1
mycophenolic acid 66.8 7
imipramine 51 1
mycophenolate mofetil 38.2 3

(6) PharmGKB related drug/compound annotations for UGT1A8 Gene

Drug/compound Annotation
ABT-751 CA
cyclosporine CA
mycophenolate mofetil CA
sirolimus CA
tacrolimus CA
valproic acid CA
genes like me logo Genes that share compounds with UGT1A8: view

Transcripts for UGT1A8 Gene

mRNA/cDNA for UGT1A8 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A8 Gene

No ASD Table

Relevant External Links for UGT1A8 Gene

GeneLoc Exon Structure for
UGT1A8
ECgene alternative splicing isoforms for
UGT1A8

Expression for UGT1A8 Gene

mRNA expression in normal human tissues for UGT1A8 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A8 Gene

This gene is overexpressed in Liver (49.3).

mRNA Expression by UniProt/SwissProt for UGT1A8 Gene

Q9HAW9-UD18_HUMAN
Tissue specificity: Colon specific. Isoform 1 and 2 are expressed in liver, kidney, colon and small intestine; isoform 2 but not isoform 1 is expressed in liver (PubMed:18004212).
genes like me logo Genes that share expressions with UGT1A8: view

Orthologs for UGT1A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 32 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 66 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ugt1a2 37
  • 76 (a)
ManyToMany
Ugt1a5 37
  • 76 (a)
ManyToMany
Ugt1a8 16
Ugt1a9 36
  • 80.59 (n)
  • 80.08 (a)
rat
(Rattus norvegicus)
Mammalia Ugt1a8 36
  • 81.57 (n)
  • 79.43 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15808 36
zebrafish
(Danio rerio)
Actinopterygii fads2 36
ugt1a7 37
  • 51 (a)
ManyToMany
ugt1b1 37
  • 48 (a)
ManyToMany
ugt1b2 37
  • 46 (a)
ManyToMany
ugt1b3 37
  • 46 (a)
ManyToMany
ugt1b4 37
  • 46 (a)
ManyToMany
ugt1b5 37
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10178 38
  • 26 (a)
BEST:GH09393 38
  • 31 (a)
Ugt86Da 38
  • 33 (a)
Dot 38
  • 25 (a)
CG16732 38
  • 25 (a)
Ugt36Bb 38
  • 29 (a)
Ugt86De 38
  • 30 (a)
CG11289 38
  • 35 (a)
CG10170 38
  • 24 (a)
Ugt86Di 38
  • 33 (a)
Ugt37c1 38
  • 30 (a)
Ugt86Dh 38
  • 27 (a)
Ugt36Ba 38
  • 28 (a)
Ugt37b1 38
  • 27 (a)
BEST:GH06505 38
  • 28 (a)
Ugt86Dc 38
  • 34 (a)
CG5724 38
  • 27 (a)
CG6475 38
  • 32 (a)
CG17323 38
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea C08F11.8 38
  • 26 (a)
C17G1.3 38
  • 24 (a)
Y37E11AR.5 38
  • 26 (a)
C49A9.8 38
  • 24 (a)
ZC443.5 38
  • 27 (a)
C10H11.6 38
  • 24 (a)
C08B6.1 38
  • 25 (a)
F09G2.6 38
  • 25 (a)
K08B4.4 38
  • 23 (a)
F01D4.2 38
  • 22 (a)
AC3.2 38
  • 25 (a)
ZC455.3 38
  • 22 (a)
T01G5.2 38
  • 25 (a)
C10H11.4 38
  • 24 (a)
AC3.8 38
  • 22 (a)
C33A12.6 38
  • 24 (a)
F39G3.1 38
  • 28 (a)
M88.1 38
  • 28 (a)
C10H11.5 38
  • 26 (a)
F01D4.1 38
  • 23 (a)
Species with no ortholog for UGT1A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT1A8 Gene

ENSEMBL:
Gene Tree for UGT1A8 (if available)
TreeFam:
Gene Tree for UGT1A8 (if available)

Paralogs for UGT1A8 Gene

genes like me logo Genes that share paralogs with UGT1A8: view

Variants for UGT1A8 Gene

Sequence variations from dbSNP and Humsavar for UGT1A8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1042590 -- 233,618,139(+) GATGC(A/G)GTGTT synonymous-codon, reference
rs1042591 -- 233,618,148(+) TTTCT(G/T)GATCC synonymous-codon, reference
rs1042593 -- 233,618,161(+) TTGAT(A/G)CCTGT missense, reference
rs1042597 -, - 233,618,225(+) AATAG(C/G/T)TTGCC reference, missense
rs1042605 -- 233,618,472(+) CGAAC(A/G)GACTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UGT1A8 Gene

Variant ID Type Subtype PubMed ID
nsv876013 CNV Gain 21882294
nsv7336 OTHER Inversion 18451855
nsv876014 CNV Gain 21882294
nsv876015 CNV Loss 21882294
esv2721663 CNV Deletion 23290073
esv2721664 CNV Deletion 23290073
esv2657145 CNV Deletion 23128226
esv22295 CNV Loss 19812545
esv2721665 CNV Deletion 23290073
esv24647 CNV Gain 19812545
esv2721666 CNV Deletion 23290073
nsv876016 CNV Gain 21882294
nsv876017 CNV Loss 21882294
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv2721668 CNV Deletion 23290073
esv2661542 CNV Deletion 23128226
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Relevant External Links for UGT1A8 Gene

HapMap Linkage Disequilibrium report
UGT1A8
Human Gene Mutation Database (HGMD)
UGT1A8

Disorders for UGT1A8 Gene

(1) MalaCards Diseases for UGT1A8 Gene

Search for UGT1A8 Gene in MalaCards »

(2) University of Copenhagen DISEASES for UGT1A8 Gene

Relevant External Links for UGT1A8

Genetic Association Database (GAD)
UGT1A8
Human Genome Epidemiology (HuGE) Navigator
UGT1A8
genes like me logo Genes that share disorders with UGT1A8: view

No data available for UniProtKB/Swiss-Prot for UGT1A8 Gene

Publications for UGT1A8 Gene

  1. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. (PMID: 9535849) Strassburg C.P. … Tukey R.H. (J. Biol. Chem. 1998) 3 4 23
  2. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PMID: 15057901) Ehmer U. … Strassburg C.P. (Hepatology 2004) 3 23 49
  3. Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (PMID: 15247627) Verlaan M. … Drenth J.P. (Pharmacogenetics 2004) 3 23 49
  4. Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. (PMID: 15319294) van der Logt E.M. … Peters W.H. (Carcinogenesis 2004) 3 23 49
  5. Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. (PMID: 16397224) Thibaudeau J. … Guillemette C. (Cancer Res. 2006) 3 23 49

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