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Aliases for ROBO4 Gene

Aliases for ROBO4 Gene

  • Roundabout Guidance Receptor 4 2 3 5
  • Magic Roundabout 2 4
  • Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) 2
  • Roundabout, Axon Guidance Receptor, Homolog 4 3
  • Roundabout Homolog 4, Magic Roundabout 3
  • Roundabout Homolog 4 (Drosophila) 2
  • Roundabout Homolog 4 3
  • ECSM4 3
  • MRB 3

External Ids for ROBO4 Gene

Previous GeneCards Identifiers for ROBO4 Gene

  • GC11M126754
  • GC11M126266
  • GC11M124787
  • GC11M124291
  • GC11M124258
  • GC11M120696
  • GC11M124753

Summaries for ROBO4 Gene

CIViC summary for ROBO4 Gene

GeneCards Summary for ROBO4 Gene

ROBO4 (Roundabout Guidance Receptor 4) is a Protein Coding gene. Diseases associated with ROBO4 include Gilles De La Tourette Syndrome. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is ROBO1.

UniProtKB/Swiss-Prot for ROBO4 Gene

  • Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Gene Wiki entry for ROBO4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROBO4 Gene

Genomics for ROBO4 Gene

Regulatory Elements for ROBO4 Gene

Enhancers for ROBO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G124757 1.5 FANTOM5 ENCODE dbSUPER 17.3 +137.4 137364 6.4 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 GATA2 ROBO4 ESAM VSIG2 NRGN SPA17 LOC101929340
GH11G125068 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -173.9 -173892 8.2 HDGF PKNOX1 FOXA2 CREB3L1 MLX ARNT WRNIP1 ZFP64 ARID4B FOS SLC37A2 CCDC15 TMEM218 KRT18P59 ENSG00000255475 ROBO4 HEPACAM TBRG1 PIR45309 GC11M125054
GH11G124894 1.4 Ensembl ENCODE dbSUPER 11.1 +0.8 763 8.2 ELF3 ATF1 FOXA2 ARID4B SIN3A ZNF2 RAD21 YY1 RARA EGR1 ROBO3 ROBO4 HEPACAM CCDC15 ENSG00000254943
GH11G124953 1.4 ENCODE dbSUPER 9.8 -55.6 -55619 2.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 YY1 CCDC15 ROBO4 ROBO3 LOC105369547
GH11G125370 1.2 Ensembl ENCODE dbSUPER 9.2 -472.9 -472938 1.9 CTCF MXI1 RFX1 CEBPB BMI1 RBBP5 ZNF623 ZIC2 RAD21 EP300 LOC105369549 RNU6-321P PKNOX2 PKNOX2-AS1 ROBO4 DDX25 GC11M125369 GC11M125370
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ROBO4 on UCSC Golden Path with GeneCards custom track

Promoters for ROBO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000266387 1100 401
ENSR00000046457 1899 800 GATAD2A FOXA2 RARA

Genomic Location for ROBO4 Gene

Chromosome:
11
Start:
124,883,691 bp from pter
End:
124,898,500 bp from pter
Size:
14,810 bases
Orientation:
Minus strand

Genomic View for ROBO4 Gene

Genes around ROBO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROBO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROBO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROBO4 Gene

Proteins for ROBO4 Gene

  • Protein details for ROBO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ75-ROBO4_HUMAN
    Recommended name:
    Roundabout homolog 4
    Protein Accession:
    Q8WZ75
    Secondary Accessions:
    • A8K154
    • Q14DU7
    • Q8TEG1
    • Q96JV6
    • Q9H718
    • Q9NWJ8

    Protein attributes for ROBO4 Gene

    Size:
    1007 amino acids
    Molecular mass:
    107457 Da
    Quaternary structure:
    • Interacts with SLIT2 and ENAH.
    SequenceCaution:
    • Sequence=AAH64643.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91382.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15082.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55411.1; Type=Frameshift; Positions=706; Evidence={ECO:0000305};

    Alternative splice isoforms for ROBO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROBO4 Gene

Post-translational modifications for ROBO4 Gene

  • Glycosylation at isoforms=2, 3246, Asn360, Asn389, isoforms=2, 3396, and isoforms=2, 3680
  • Modification sites at PhosphoSitePlus

Other Protein References for ROBO4 Gene

No data available for DME Specific Peptides for ROBO4 Gene

Domains & Families for ROBO4 Gene

Suggested Antigen Peptide Sequences for ROBO4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WZ75

UniProtKB/Swiss-Prot:

ROBO4_HUMAN :
  • Belongs to the immunoglobulin superfamily. ROBO family.
Family:
  • Belongs to the immunoglobulin superfamily. ROBO family.
genes like me logo Genes that share domains with ROBO4: view

Function for ROBO4 Gene

Molecular function for ROBO4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Gene Ontology (GO) - Molecular Function for ROBO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 14527427
genes like me logo Genes that share ontologies with ROBO4: view
genes like me logo Genes that share phenotypes with ROBO4: view

Animal Models for ROBO4 Gene

MGI Knock Outs for ROBO4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ROBO4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROBO4 Gene

Localization for ROBO4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROBO4 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ROBO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane TAS 14527427
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ROBO4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ROBO4 Gene

Pathways & Interactions for ROBO4 Gene

genes like me logo Genes that share pathways with ROBO4: view

Pathways by source for ROBO4 Gene

1 GeneGo (Thomson Reuters) pathway for ROBO4 Gene

SIGNOR curated interactions for ROBO4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ROBO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IGI 15849270
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0030334 regulation of cell migration NAS 15894287
genes like me logo Genes that share ontologies with ROBO4: view

Transcripts for ROBO4 Gene

Unigene Clusters for ROBO4 Gene

Roundabout, axon guidance receptor, homolog 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ROBO4 Gene

No ASD Table

Relevant External Links for ROBO4 Gene

GeneLoc Exon Structure for
ROBO4
ECgene alternative splicing isoforms for
ROBO4

Expression for ROBO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ROBO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROBO4 Gene

This gene is overexpressed in Spleen (x5.5) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for ROBO4 Gene

This gene is overexpressed in Urine (32.9), Bone marrow mesenchymal stem cell (16.1), Serum (10.7), and Plasma (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROBO4 Gene



Protein tissue co-expression partners for ROBO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ROBO4 Gene:

ROBO4

SOURCE GeneReport for Unigene cluster for ROBO4 Gene:

Hs.524121

mRNA Expression by UniProt/SwissProt for ROBO4 Gene:

Q8WZ75-ROBO4_HUMAN
Tissue specificity: Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.

Evidence on tissue expression from TISSUES for ROBO4 Gene

  • Nervous system(4.8)
  • Intestine(4.1)
  • Liver(4.1)
  • Bone marrow(4)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with ROBO4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ROBO4 Gene

Orthologs for ROBO4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROBO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROBO4 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia ROBO4 34 35
  • 86.16 (n)
cow
(Bos Taurus)
Mammalia ROBO4 34 35
  • 84.95 (n)
mouse
(Mus musculus)
Mammalia Robo4 34 16 35
  • 81.61 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911068 34
  • 81.06 (n)
oppossum
(Monodelphis domestica)
Mammalia ROBO4 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves ROBO4 35
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROBO4 35
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493397 34
  • 47.56 (n)
zebrafish
(Danio rerio)
Actinopterygii robo4 35
  • 28 (a)
OneToOne
Species where no ortholog for ROBO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ROBO4 Gene

ENSEMBL:
Gene Tree for ROBO4 (if available)
TreeFam:
Gene Tree for ROBO4 (if available)

Paralogs for ROBO4 Gene

Paralogs for ROBO4 Gene

(1) SIMAP similar genes for ROBO4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ROBO4: view

Variants for ROBO4 Gene

Sequence variations from dbSNP and Humsavar for ROBO4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000168368 -- 124,887,593(+) CTACC(C/T)GTCCA intron-variant
rs1000250530 -- 124,892,151(+) TTGCA(C/G)TTGGG intron-variant
rs1000516169 -- 124,889,911(+) TTGAC(C/T)TATCC intron-variant
rs1000641027 -- 124,886,083(+) CTACT(C/T)GGGAG intron-variant
rs1001075718 -- 124,883,762(+) CCTCC(A/G)CCTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ROBO4 Gene

Variant ID Type Subtype PubMed ID
nsv1054824 CNV gain 25217958
nsv520150 CNV loss 19592680
nsv531 CNV insertion 18451855
nsv952753 CNV deletion 24416366

Variation tolerance for ROBO4 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.73; 91.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ROBO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROBO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROBO4 Gene

Disorders for ROBO4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ROBO4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gilles de la tourette syndrome
  • tourette syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ROBO4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ROBO4

Genetic Association Database (GAD)
ROBO4
Human Genome Epidemiology (HuGE) Navigator
ROBO4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ROBO4
genes like me logo Genes that share disorders with ROBO4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ROBO4 Gene

Publications for ROBO4 Gene

  1. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. (PMID: 17671968) Miranda D.M. … Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  2. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. (PMID: 18270976) Anitha A. … Mori N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  3. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. (PMID: 16685377) GrAPne J. … Bhargava S. (Oncol. Rep. 2006) 3 22 64
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ROBO4 Gene

Sources for ROBO4 Gene

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