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Aliases for ROBO4 Gene

Aliases for ROBO4 Gene

  • Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) 2 3
  • Magic Roundabout 2 4
  • Roundabout Homolog 4, Magic Roundabout 3
  • Roundabout Homolog 4 (Drosophila) 2
  • Roundabout Homolog 4 3
  • ECSM4 3
  • MRB 3

External Ids for ROBO4 Gene

Summaries for ROBO4 Gene

GeneCards Summary for ROBO4 Gene

ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for ROBO4 Gene

  • Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Gene Wiki entry for ROBO4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROBO4 Gene

Genomics for ROBO4 Gene

Genomic Location for ROBO4 Gene

Start:
124,883,691 bp from pter
End:
124,898,500 bp from pter
Size:
14,810 bases
Orientation:
Minus strand

Genomic View for ROBO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ROBO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROBO4 Gene

Regulatory Elements for ROBO4 Gene

Proteins for ROBO4 Gene

  • Protein details for ROBO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ75-ROBO4_HUMAN
    Recommended name:
    Roundabout homolog 4
    Protein Accession:
    Q8WZ75
    Secondary Accessions:
    • A8K154
    • Q14DU7
    • Q8TEG1
    • Q96JV6
    • Q9H718
    • Q9NWJ8

    Protein attributes for ROBO4 Gene

    Size:
    1007 amino acids
    Molecular mass:
    107457 Da
    Quaternary structure:
    • Interacts with SLIT2 and ENAH.
    SequenceCaution:
    • Sequence=AAH64643.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91382.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15082.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55411.1; Type=Frameshift; Positions=706; Evidence={ECO:0000305};

    Alternative splice isoforms for ROBO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROBO4 Gene

Proteomics data for ROBO4 Gene at MOPED

Post-translational modifications for ROBO4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn246, Asn360, Asn389, Asn396, and Asn680

Other Protein References for ROBO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ROBO4 Gene

Domains for ROBO4 Gene

Gene Families for ROBO4 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing

Protein Domains for ROBO4 Gene

UniProtKB/Swiss-Prot:

ROBO4_HUMAN
Domain:
  • Contains 2 fibronectin type-III domains.:
    • Q8WZ75
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q8WZ75
Family:
  • Belongs to the immunoglobulin superfamily. ROBO family.:
    • Q8WZ75
genes like me logo Genes that share domains with ROBO4: view

Function for ROBO4 Gene

Molecular function for ROBO4 Gene

UniProtKB/Swiss-Prot Function: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Gene Ontology (GO) - Molecular Function for ROBO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 14527427
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ROBO4: view
genes like me logo Genes that share phenotypes with ROBO4: view

miRNA for ROBO4 Gene

miRTarBase miRNAs that target ROBO4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ROBO4 Gene

Localization for ROBO4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ROBO4 Gene COMPARTMENTS Subcellular localization image for ROBO4 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ROBO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane TAS 14527427
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ROBO4: view

Pathways for ROBO4 Gene

SuperPathways for ROBO4 Gene

genes like me logo Genes that share pathways with ROBO4: view

Pathways by source for ROBO4 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ROBO4 Gene

Gene Ontology (GO) - Biological Process for ROBO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IGI 15849270
GO:0030154 cell differentiation IEA --
GO:0030334 regulation of cell migration NAS 15894287
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with ROBO4: view

Transcripts for ROBO4 Gene

Unigene Clusters for ROBO4 Gene

Roundabout, axon guidance receptor, homolog 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ROBO4 Gene

No ASD Table

Relevant External Links for ROBO4 Gene

GeneLoc Exon Structure for
ROBO4
ECgene alternative splicing isoforms for
ROBO4

Expression for ROBO4 Gene

mRNA expression in normal human tissues for ROBO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROBO4 Gene

This gene is overexpressed in Spleen (5.5) and Adipose - Visceral (Omentum) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ROBO4 Gene

SOURCE GeneReport for Unigene cluster for ROBO4 Gene Hs.524121

mRNA Expression by UniProt/SwissProt for ROBO4 Gene

Q8WZ75-ROBO4_HUMAN
Tissue specificity: Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.
genes like me logo Genes that share expressions with ROBO4: view

Orthologs for ROBO4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROBO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROBO4 36
  • 99.26 (n)
  • 98.83 (a)
ROBO4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ROBO4 36
  • 84.95 (n)
  • 83.38 (a)
ROBO4 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ROBO4 36
  • 86.16 (n)
  • 85.51 (a)
ROBO4 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Robo4 36
  • 81.61 (n)
  • 78.05 (a)
Robo4 16
Robo4 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ROBO4 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 50 (a)
OneToMany
-- 37
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100911068 36
  • 81.06 (n)
  • 78.77 (a)
chicken
(Gallus gallus)
Aves ROBO4 37
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROBO4 37
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493397 36
  • 47.56 (n)
  • 37.02 (a)
zebrafish
(Danio rerio)
Actinopterygii robo4 37
  • 28 (a)
OneToOne
Species with no ortholog for ROBO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ROBO4 Gene

ENSEMBL:
Gene Tree for ROBO4 (if available)
TreeFam:
Gene Tree for ROBO4 (if available)

Paralogs for ROBO4 Gene

Selected SIMAP similar genes for ROBO4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ROBO4: view

No data available for Paralogs for ROBO4 Gene

Variants for ROBO4 Gene

Sequence variations from dbSNP and Humsavar for ROBO4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12823 -- 124,884,715(+) TGCTC(A/T)AATTT utr-variant-3-prime
rs1132958 -- 124,884,631(-) CCATC(A/C)ACTCC utr-variant-3-prime
rs4078313 -- 124,896,232(+) TCCCT(A/G)TGTCC synonymous-codon, reference
rs4078483 -- 124,896,695(-) GCTCC(C/G)TGTCA intron-variant
rs4245058 -- 124,889,446(+) TCCTA(C/T)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ROBO4 Gene

Variant ID Type Subtype PubMed ID
nsv531 CNV Insertion 18451855
nsv520150 CNV Loss 19592680

Relevant External Links for ROBO4 Gene

HapMap Linkage Disequilibrium report
ROBO4

Disorders for ROBO4 Gene

Relevant External Links for ROBO4

Genetic Association Database (GAD)
ROBO4
Human Genome Epidemiology (HuGE) Navigator
ROBO4
genes like me logo Genes that share disorders with ROBO4: view

No data available for UniProtKB/Swiss-Prot for ROBO4 Gene

Publications for ROBO4 Gene

  1. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. (PMID: 17671968) Miranda D.M. … Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 49
  2. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. (PMID: 18270976) Anitha A. … Mori N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 49
  3. In silico cloning of novel endothelial-specific genes. (PMID: 11076864) Huminiecki L. … Bicknell R. (Genome Res. 2000) 2 3
  4. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. (PMID: 11944987) Huminiecki L. … Bicknell R. (Genomics 2002) 3 4
  5. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. (PMID: 16685377) GrAPne J. … Bhargava S. (Oncol. Rep. 2006) 3 23

Products for ROBO4 Gene

Sources for ROBO4 Gene

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