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Aliases for POU2AF1 Gene

Aliases for POU2AF1 Gene

  • POU Class 2 Associating Factor 1 2 3
  • OBF1 3 4 6
  • B-Cell-Specific Coactivator OBF-1 3 4
  • OCT-Binding Factor 1 3 4
  • BOB-1 3 4
  • OCA-B 3 4
  • POU Domain, Class 2, Associating Factor 1 3
  • POU Domain Class 2, Associating Factor 1 2
  • POU Domain Class 2-Associating Factor 1 3
  • OBF-1 3
  • BOB1 3
  • OCAB 3

External Ids for POU2AF1 Gene

Previous GeneCards Identifiers for POU2AF1 Gene

  • GC11M113575
  • GC11M112735
  • GC11M111256
  • GC11M110760
  • GC11M110728
  • GC11M111222
  • GC11M107147

Summaries for POU2AF1 Gene

GeneCards Summary for POU2AF1 Gene

POU2AF1 (POU Class 2 Associating Factor 1) is a Protein Coding gene. Diseases associated with POU2AF1 include primary biliary cirrhosis and nodular lymphocyte predominant hodgkin lymphoma. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for POU2AF1 Gene

  • Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers

Gene Wiki entry for POU2AF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2AF1 Gene

Genomics for POU2AF1 Gene

Regulatory Elements for POU2AF1 Gene

Genomic Location for POU2AF1 Gene

Start:
111,352,251 bp from pter
End:
111,455,630 bp from pter
Size:
103,380 bases
Orientation:
Minus strand

Genomic View for POU2AF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU2AF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2AF1 Gene

Proteins for POU2AF1 Gene

  • Protein details for POU2AF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16633-OBF1_HUMAN
    Recommended name:
    POU domain class 2-associating factor 1
    Protein Accession:
    Q16633
    Secondary Accessions:
    • B2R8Z9
    • Q14983

    Protein attributes for POU2AF1 Gene

    Size:
    256 amino acids
    Molecular mass:
    27436 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for POU2AF1 Gene

neXtProt entry for POU2AF1 Gene

Proteomics data for POU2AF1 Gene at MOPED

Post-translational modifications for POU2AF1 Gene

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU2AF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for POU2AF1 Gene

Domains for POU2AF1 Gene

Protein Domains for POU2AF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POU2AF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16633

UniProtKB/Swiss-Prot:

OBF1_HUMAN :
  • Q16633
Family:
  • Belongs to the POU2AF1 family.
genes like me logo Genes that share domains with POU2AF1: view

No data available for Gene Families for POU2AF1 Gene

Function for POU2AF1 Gene

Molecular function for POU2AF1 Gene

GENATLAS Biochemistry: POU domain class 2,associating factor 1,B-cell specific coactivator,specifically associating with OCT1 (OTF1) and OCT2,fused with LAZ3/BCL6 in a B-cell leukemia cell line (Karpas 231)
UniProtKB/Swiss-Prot Function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers

Gene Ontology (GO) - Molecular Function for POU2AF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003712 transcription cofactor activity TAS 7859290
GO:0003713 transcription coactivator activity TAS 7859290
GO:0005515 protein binding IPI 11483518
genes like me logo Genes that share ontologies with POU2AF1: view
genes like me logo Genes that share phenotypes with POU2AF1: view

Animal Models for POU2AF1 Gene

MGI Knock Outs for POU2AF1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for POU2AF1 Gene

Localization for POU2AF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2AF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU2AF1 Gene COMPARTMENTS Subcellular localization image for POU2AF1 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for POU2AF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with POU2AF1: view

Pathways for POU2AF1 Gene

SuperPathways for POU2AF1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for POU2AF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 7859290
GO:0006959 humoral immune response TAS 7859290
genes like me logo Genes that share ontologies with POU2AF1: view

No data available for Pathways by source for POU2AF1 Gene

Compounds for POU2AF1 Gene

(1) Novoseek inferred chemical compound relationships for POU2AF1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 2
genes like me logo Genes that share compounds with POU2AF1: view

Transcripts for POU2AF1 Gene

Unigene Clusters for POU2AF1 Gene

POU class 2 associating factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU2AF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for POU2AF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU2AF1 Gene

No ASD Table

Relevant External Links for POU2AF1 Gene

GeneLoc Exon Structure for
POU2AF1
ECgene alternative splicing isoforms for
POU2AF1

Expression for POU2AF1 Gene

mRNA expression in normal human tissues for POU2AF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POU2AF1 Gene

This gene is overexpressed in Spleen (8.0) and Small Intestine - Terminal Ileum (4.0).

SOURCE GeneReport for Unigene cluster for POU2AF1 Gene Hs.654525

mRNA Expression by UniProt/SwissProt for POU2AF1 Gene

Q16633-OBF1_HUMAN
Tissue specificity: B-cell specific
genes like me logo Genes that share expressions with POU2AF1: view

In Situ Assay Products

No data available for Protein expression for POU2AF1 Gene

Orthologs for POU2AF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POU2AF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU2AF1 35
  • 99.74 (n)
  • 99.61 (a)
POU2AF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POU2AF1 35
  • 87.24 (n)
  • 92.19 (a)
POU2AF1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POU2AF1 35
  • 89.71 (n)
  • 93.75 (a)
POU2AF1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou2af1 35
  • 86.33 (n)
  • 89.45 (a)
Pou2af1 16
Pou2af1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POU2AF1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POU2AF1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou2af1 35
  • 85.55 (n)
  • 88.67 (a)
chicken
(Gallus gallus)
Aves CHOBF-1 36
  • 66 (a)
OneToOne
POU2AF1 35
  • 71.52 (n)
  • 66.54 (a)
lizard
(Anolis carolinensis)
Reptilia POU2AF1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2af1 35
  • 60.37 (n)
  • 54.33 (a)
Species with no ortholog for POU2AF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for POU2AF1 Gene

ENSEMBL:
Gene Tree for POU2AF1 (if available)
TreeFam:
Gene Tree for POU2AF1 (if available)

Paralogs for POU2AF1 Gene

No data available for Paralogs for POU2AF1 Gene

Variants for POU2AF1 Gene

Sequence variations from dbSNP and Humsavar for POU2AF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1042750 - 111,357,480(-) TGTTG(A/G)CCTAT reference, missense
rs1042751 - 111,354,451(-) GTACC(A/G)GCCTC reference, missense, downstream-variant-500B
rs1042752 -- 111,352,386(-) GTCAC(C/T)ATTAA utr-variant-3-prime
rs1126884 -- 111,352,708(-) tccgc(C/G)cgcct utr-variant-3-prime
rs1126886 -- 111,352,279(-) TGCCC(A/C)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for POU2AF1 Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV Loss 17160897
nsv490 CNV Loss 18451855
nsv39618 CNV Loss 16902084

Relevant External Links for POU2AF1 Gene

HapMap Linkage Disequilibrium report
POU2AF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2AF1 Gene

Disorders for POU2AF1 Gene

UniProtKB/Swiss-Prot

OBF1_HUMAN
  • Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.

(1) University of Copenhagen DISEASES for POU2AF1 Gene

(2) Novoseek inferred disease relationships for POU2AF1 Gene

Disease -log(P) Hits PubMed IDs
hodgkin disease 36 3
lymphoma 21.6 2

Relevant External Links for POU2AF1

Genetic Association Database (GAD)
POU2AF1
Human Genome Epidemiology (HuGE) Navigator
POU2AF1
genes like me logo Genes that share disorders with POU2AF1: view

Publications for POU2AF1 Gene

  1. Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. (PMID: 8617501) Junker S. … Tommerup N. (Genomics 1996) 2 3 23
  2. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PMID: 7623806) Luo Y. … Roeder R.G. (Mol. Cell. Biol. 1995) 3 4 23
  3. Coactivation by OCA-B: definition of critical regions and synergism with general cofactors. (PMID: 9632764) Luo Y. … Roeder R.G. (Mol. Cell. Biol. 1998) 3 23
  4. Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. (PMID: 11136971) Tomilin A. … SchAPler H.R. (Cell 2000) 3 23
  5. Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator. (PMID: 11380252) Lee L. … Luisi B. (Biochemistry 2001) 3 23

Products for POU2AF1 Gene

Sources for POU2AF1 Gene

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