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Aliases for POU2AF1 Gene

Aliases for POU2AF1 Gene

  • POU Class 2 Associating Factor 1 2 3 5
  • B-Cell-Specific Coactivator OBF-1 3 4
  • OCT-Binding Factor 1 3 4
  • BOB-1 3 4
  • OCA-B 3 4
  • OBF1 3 4
  • POU Domain, Class 2, Associating Factor 1 3
  • POU Domain Class 2, Associating Factor 1 2
  • OBF-1 3
  • BOB1 3
  • OCAB 3

External Ids for POU2AF1 Gene

Previous GeneCards Identifiers for POU2AF1 Gene

  • GC11M113575
  • GC11M112735
  • GC11M111256
  • GC11M110760
  • GC11M110728
  • GC11M111222
  • GC11M107147

Summaries for POU2AF1 Gene

GeneCards Summary for POU2AF1 Gene

POU2AF1 (POU Class 2 Associating Factor 1) is a Protein Coding gene. Diseases associated with POU2AF1 include primary biliary cirrhosis and hodgkin lymphoma. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for POU2AF1 Gene

  • Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Gene Wiki entry for POU2AF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2AF1 Gene

Genomics for POU2AF1 Gene

Regulatory Elements for POU2AF1 Gene

Genomic Location for POU2AF1 Gene

Chromosome:
11
Start:
111,352,251 bp from pter
End:
111,455,630 bp from pter
Size:
103,380 bases
Orientation:
Minus strand

Genomic View for POU2AF1 Gene

Genes around POU2AF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU2AF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU2AF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2AF1 Gene

Proteins for POU2AF1 Gene

  • Protein details for POU2AF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16633-OBF1_HUMAN
    Recommended name:
    POU domain class 2-associating factor 1
    Protein Accession:
    Q16633
    Secondary Accessions:
    • B2R8Z9
    • Q14983

    Protein attributes for POU2AF1 Gene

    Size:
    256 amino acids
    Molecular mass:
    27436 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for POU2AF1 Gene

neXtProt entry for POU2AF1 Gene

Proteomics data for POU2AF1 Gene at MOPED

Post-translational modifications for POU2AF1 Gene

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU2AF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU2AF1 Gene

Domains & Families for POU2AF1 Gene

Protein Domains for POU2AF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POU2AF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16633

UniProtKB/Swiss-Prot:

OBF1_HUMAN :
  • Belongs to the POU2AF1 family.
Family:
  • Belongs to the POU2AF1 family.
genes like me logo Genes that share domains with POU2AF1: view

No data available for Gene Families for POU2AF1 Gene

Function for POU2AF1 Gene

Molecular function for POU2AF1 Gene

GENATLAS Biochemistry:
POU domain class 2,associating factor 1,B-cell specific coactivator,specifically associating with OCT1 (OTF1) and OCT2,fused with LAZ3/BCL6 in a B-cell leukemia cell line (Karpas 231)
UniProtKB/Swiss-Prot Function:
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Gene Ontology (GO) - Molecular Function for POU2AF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with POU2AF1: view
genes like me logo Genes that share phenotypes with POU2AF1: view

Human Phenotype Ontology for POU2AF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for POU2AF1 Gene

MGI Knock Outs for POU2AF1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for POU2AF1 Gene

Localization for POU2AF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2AF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU2AF1 Gene COMPARTMENTS Subcellular localization image for POU2AF1 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for POU2AF1 Gene

Pathways & Interactions for POU2AF1 Gene

SuperPathways for POU2AF1 Gene

No Data Available

SIGNOR curated interactions for POU2AF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for POU2AF1 Gene

None

No data available for Pathways by source for POU2AF1 Gene

Drugs & Compounds for POU2AF1 Gene

(1) Drugs for POU2AF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with POU2AF1: view

Transcripts for POU2AF1 Gene

Unigene Clusters for POU2AF1 Gene

POU class 2 associating factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POU2AF1 Gene

No ASD Table

Relevant External Links for POU2AF1 Gene

GeneLoc Exon Structure for
POU2AF1
ECgene alternative splicing isoforms for
POU2AF1

Expression for POU2AF1 Gene

mRNA expression in normal human tissues for POU2AF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for POU2AF1 Gene

This gene is overexpressed in Spleen (x8.0) and Small Intestine - Terminal Ileum (x4.0).

SOURCE GeneReport for Unigene cluster for POU2AF1 Gene Hs.654525

mRNA Expression by UniProt/SwissProt for POU2AF1 Gene

Q16633-OBF1_HUMAN
Tissue specificity: B-cell specific.
genes like me logo Genes that share expression patterns with POU2AF1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for POU2AF1 Gene

Orthologs for POU2AF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POU2AF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU2AF1 35
  • 99.74 (n)
  • 99.61 (a)
POU2AF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POU2AF1 36
  • 92 (a)
OneToOne
POU2AF1 35
  • 87.24 (n)
  • 92.19 (a)
dog
(Canis familiaris)
Mammalia POU2AF1 35
  • 89.71 (n)
  • 93.75 (a)
POU2AF1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pou2af1 16
Pou2af1 36
  • 89 (a)
OneToOne
Pou2af1 35
  • 86.33 (n)
  • 89.45 (a)
oppossum
(Monodelphis domestica)
Mammalia POU2AF1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POU2AF1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou2af1 35
  • 85.55 (n)
  • 88.67 (a)
chicken
(Gallus gallus)
Aves POU2AF1 35
  • 71.52 (n)
  • 66.54 (a)
CHOBF-1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POU2AF1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2af1 35
  • 60.37 (n)
  • 54.33 (a)
Species with no ortholog for POU2AF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for POU2AF1 Gene

ENSEMBL:
Gene Tree for POU2AF1 (if available)
TreeFam:
Gene Tree for POU2AF1 (if available)

Paralogs for POU2AF1 Gene

No data available for Paralogs for POU2AF1 Gene

Variants for POU2AF1 Gene

Sequence variations from dbSNP and Humsavar for POU2AF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1042750 - 111,357,480(-) TGTTG(A/G)CCTAT reference, missense
rs1042751 - 111,354,451(-) GTACC(A/G)GCCTC reference, missense
rs1806434 -- 111,362,607(-) ctgga(C/G)gacgt intron-variant
rs2002367 -- 111,360,644(+) CAGGA(A/G)AGTCT intron-variant
rs1815945 -- 111,365,031(+) AAACA(G/T)AACTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POU2AF1 Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV Loss 17160897
nsv490 CNV Loss 18451855
nsv39618 CNV Loss 16902084

Variation tolerance for POU2AF1 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU2AF1 Gene

HapMap Linkage Disequilibrium report
POU2AF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2AF1 Gene

Disorders for POU2AF1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for POU2AF1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
primary biliary cirrhosis
  • biliary liver cirrhosis
hodgkin lymphoma
  • hodgkin's lymphoma
hodgkin's lymphoma, lymphocytic depletion
  • hodgkin lymphoma, lymphocyte depletion
primary mediastinal large b-cell lymphoma
  • large cell lymphoma of the mediastinum
hematologic cancer
  • blood cancer
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

OBF1_HUMAN
  • Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6. {ECO:0000269 PubMed:8574789}.

Relevant External Links for POU2AF1

Genetic Association Database (GAD)
POU2AF1
Human Genome Epidemiology (HuGE) Navigator
POU2AF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU2AF1
genes like me logo Genes that share disorders with POU2AF1: view

No data available for Genatlas for POU2AF1 Gene

Publications for POU2AF1 Gene

  1. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. (PMID: 7623806) Luo Y. … Roeder R.G. (Mol. Cell. Biol. 1995) 3 4 23 67
  2. Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. (PMID: 8617501) Junker S. … Tommerup N. (Genomics 1996) 2 3 23
  3. Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma. (PMID: 15796964) Cavazzini F. … Wlodarska I. (Cancer Genet. Cytogenet. 2005) 3 23
  4. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. (PMID: 15672409) Auer R.L. … Cotter F.E. (Genes Chromosomes Cancer 2005) 3 23
  5. Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells. (PMID: 14662861) Salas M. … Eckhardt L.A. (J. Immunol. 2003) 3 23

Products for POU2AF1 Gene

Sources for POU2AF1 Gene

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