Aliases for PON1 Gene
External Ids for PON1 Gene
Previous HGNC Symbols for PON1 Gene
Previous GeneCards Identifiers for PON1 Gene
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
GeneCards Summary for PON1 Gene
PON1 (Paraoxonase 1) is a Protein Coding gene. Diseases associated with PON1 include Microvascular Complications Of Diabetes 5 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Arachidonic acid metabolism and Phase I biotransformations, non P450. GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is PON2.
UniProtKB/Swiss-Prot for PON1 Gene
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.