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Aliases for SSH1 Gene

Aliases for SSH1 Gene

  • Slingshot Protein Phosphatase 1 2 3 5
  • SSH-Like Protein 1 3 4
  • HSSH-1L 3 4
  • SSH1L 3 4
  • Protein Phosphatase Slingshot Homolog 1 3
  • Slingshot Homolog 1 (Drosophila) 2
  • Slingshot Homolog 1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KIAA1298 4
  • SSH-1L 4

External Ids for SSH1 Gene

Previous GeneCards Identifiers for SSH1 Gene

  • GC12M108286
  • GC12M109057
  • GC12M109111
  • GC12M107681
  • GC12M107683
  • GC12M107705
  • GC12M109180
  • GC12M106241
  • GC12M108779
  • GC12M108780
  • GC12M108781
  • GC12M108782
  • GC12M108783
  • GC12M108784

Summaries for SSH1 Gene

Entrez Gene Summary for SSH1 Gene

  • The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SSH1 Gene

SSH1 (Slingshot Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with SSH1 include Porokeratosis and Polycystic Kidney Disease 3. Among its related pathways are Regulation of actin cytoskeleton and FGF signaling pathway. GO annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH2.

UniProtKB/Swiss-Prot for SSH1 Gene

  • Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Gene Wiki entry for SSH1 Gene

Additional gene information for SSH1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH1 Gene

Genomics for SSH1 Gene

Regulatory Elements for SSH1 Gene

Enhancers for SSH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H108820 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +25.9 25880 23.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 CBX5 ZNF143 SART3 UBE3B SSH1 CORO1C LINC01486 LOC644746 RNU4-32P SELPLG ALKBH2 ACACB
GH12H108663 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +191.6 191574 5.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 FOS CORO1C SELPLG SSH1 ISCU SART3 ENSG00000257221 MVK ACACB RNU7-169P GC12P108645
GH12H108797 1.4 Ensembl ENCODE dbSUPER 11.6 +54.7 54663 10 HDGF ARNT ARID4B BATF DNMT3B ZNF2 RAD21 ZNF143 RCOR1 FOS CORO1C SSH1 MIR619 SELPLG RNU7-169P TMEM119 ACACB ENSG00000257221 LOC101929204 ENSG00000274598
GH12H108726 1.4 ENCODE dbSUPER 10.7 +126.5 126485 9.3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 LOC101929162 RNU7-169P SSH1 SELPLG RNU4-32P CORO1C PRDM4 ENSG00000257221 ACACB FOXN4
GH12H108849 2.1 FANTOM5 Ensembl ENCODE dbSUPER 6.9 +3.2 3211 9.6 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B ZNF766 ZNF143 ZNF207 FOS SART3 ALKBH2 UBE3B CORO1C SSH1 ENSG00000257221 SELPLG MIR619
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSH1 on UCSC Golden Path with GeneCards custom track

Promoters for SSH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057118 290 2201 HDGF ARNT ARID4B SIN3A ZBTB7B ZNF766 ZNF143 FOS SP5 ZNF592

Genomic Locations for SSH1 Gene

Genomic Locations for SSH1 Gene
chr12:108,778,192-108,857,590
(GRCh38/hg38)
Size:
79,399 bases
Orientation:
Minus strand
chr12:109,176,466-109,251,366
(GRCh37/hg19)

Genomic View for SSH1 Gene

Genes around SSH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH1 Gene

Proteins for SSH1 Gene

  • Protein details for SSH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYL5-SSH1_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 1
    Protein Accession:
    Q8WYL5
    Secondary Accessions:
    • Q6P6C0
    • Q8N9A7
    • Q8WYL3
    • Q8WYL4
    • Q9P2P8

    Protein attributes for SSH1 Gene

    Size:
    1049 amino acids
    Molecular mass:
    115511 Da
    Quaternary structure:
    • Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date.
    SequenceCaution:
    • Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SSH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH1 Gene

Post-translational modifications for SSH1 Gene

  • Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH1 Gene

Domains & Families for SSH1 Gene

Gene Families for SSH1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SSH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYL5

UniProtKB/Swiss-Prot:

SSH1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH1: view

Function for SSH1 Gene

Molecular function for SSH1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Enzyme Numbers (IUBMB) for SSH1 Gene

Phenotypes From GWAS Catalog for SSH1 Gene

Gene Ontology (GO) - Molecular Function for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA,IEA 11832213
GO:0004721 phosphoprotein phosphatase activity IMP 19000834
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 15159416
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with SSH1: view
genes like me logo Genes that share phenotypes with SSH1: view

miRNA for SSH1 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSH1 Gene

Localization for SSH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH1 Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSH1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 14645219
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA 14645219
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SSH1: view

Pathways & Interactions for SSH1 Gene

genes like me logo Genes that share pathways with SSH1: view

Pathways by source for SSH1 Gene

1 Cell Signaling Technology pathway for SSH1 Gene
2 KEGG pathways for SSH1 Gene

SIGNOR curated interactions for SSH1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IMP 14645219
GO:0006470 protein dephosphorylation IMP 11832213
GO:0008064 regulation of actin polymerization or depolymerization IBA --
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with SSH1: view

Drugs & Compounds for SSH1 Gene

(2) Drugs for SSH1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for SSH1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with SSH1: view

Transcripts for SSH1 Gene

Unigene Clusters for SSH1 Gene

Slingshot protein phosphatase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for SSH1 Gene

GeneLoc Exon Structure for
SSH1
ECgene alternative splicing isoforms for
SSH1

Expression for SSH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSH1 Gene

This gene is overexpressed in Spinal cord (35.4), Peripheral blood mononuclear cells (10.1), and Heart (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSH1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SSH1 Gene:

SSH1

SOURCE GeneReport for Unigene cluster for SSH1 Gene:

Hs.199763

Evidence on tissue expression from TISSUES for SSH1 Gene

  • Nervous system(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with SSH1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSH1 Gene

Orthologs for SSH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSH1 33
  • 97.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SSH1 33 34
  • 86.13 (n)
cow
(Bos Taurus)
Mammalia SSH1 33 34
  • 83.99 (n)
mouse
(Mus musculus)
Mammalia Ssh1 33 16 34
  • 82.41 (n)
rat
(Rattus norvegicus)
Mammalia Ssh1 33
  • 81.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSH1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSH1 33 34
  • 71.86 (n)
lizard
(Anolis carolinensis)
Reptilia SSH1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssh1 33
  • 63.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia SSH 33
zebrafish
(Danio rerio)
Actinopterygii LOC101885659 33
  • 65.29 (n)
ssh1b 34
  • 53 (a)
OneToMany
ssh1a 34
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ssh 35 34
  • 51 (a)
Species where no ortholog for SSH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH1 Gene

ENSEMBL:
Gene Tree for SSH1 (if available)
TreeFam:
Gene Tree for SSH1 (if available)

Paralogs for SSH1 Gene

Paralogs for SSH1 Gene

(7) SIMAP similar genes for SSH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SSH1: view

Variants for SSH1 Gene

Sequence variations from dbSNP and Humsavar for SSH1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000031909 -- 108,814,119(+) CTCAG(A/G)AGACT intron-variant
rs1000047329 -- 108,811,840(+) GAGAC(C/T)GGCGC intron-variant, nc-transcript-variant
rs1000077143 -- 108,853,453(+) GAGGC(A/G)CCCAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000104847 -- 108,807,571(+) GGGCA(-/G)GTGGG intron-variant
rs1000107067 -- 108,813,611(+) AGGGG(C/G)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSH1 Gene

Variant ID Type Subtype PubMed ID
nsv976026 CNV duplication 23825009
nsv952473 CNV deletion 24416366
nsv952472 CNV deletion 24416366
nsv1145620 CNV deletion 24896259
nsv1119430 CNV insertion 24896259
nsv1071053 CNV deletion 25765185
nsv1070125 CNV deletion 25765185
esv3370337 CNV insertion 20981092
esv2763002 CNV gain 21179565
esv2422361 CNV duplication 17116639
esv24121 CNV loss 19812545
dgv865n106 CNV deletion 24896259
dgv864n106 CNV deletion 24896259

Variation tolerance for SSH1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSH1 Gene

Human Gene Mutation Database (HGMD)
SSH1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSH1 Gene

Disorders for SSH1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SSH1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
porokeratosis
  • disseminated superficial actinic porokeratosis
polycystic kidney disease 3
  • apkd3
- elite association - COSMIC cancer census association via MalaCards
Search SSH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSH1

Genetic Association Database (GAD)
SSH1
Human Genome Epidemiology (HuGE) Navigator
SSH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSH1
genes like me logo Genes that share disorders with SSH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSH1 Gene

Publications for SSH1 Gene

  1. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PMID: 15660133) Soosairajah J … Bernard O (The EMBO journal 2005) 3 4 22 60
  2. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PMID: 15671020) Wang Y … Mizuno K (The Journal of biological chemistry 2005) 3 4 22 60
  3. Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. (PMID: 16230460) Nishita M … Mizuno K (The Journal of cell biology 2005) 3 4 22 60
  4. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PMID: 15159416) Nagata-Ohashi K … Mizuno K (The Journal of cell biology 2004) 3 4 22 60
  5. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. (PMID: 12684437) Endo M … Mizuno K (The Journal of neuroscience : the official journal of the Society for Neuroscience 2003) 3 4 22 60

Products for SSH1 Gene

Sources for SSH1 Gene

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