Aliases for POLRMT Gene
External Ids for POLRMT Gene
Previous GeneCards Identifiers for POLRMT Gene
This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLRMT Gene
POLRMT (RNA Polymerase Mitochondrial) is a Protein Coding gene. Diseases associated with POLRMT include Autosomal Dominant Progressive External Ophthalmoplegia. Among its related pathways are Pyrimidine metabolism (KEGG) and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and DNA-directed 5-3 RNA polymerase activity.
UniProtKB/Swiss-Prot for POLRMT Gene
DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.