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Aliases for SLC38A2 Gene

Aliases for SLC38A2 Gene

  • Solute Carrier Family 38, Member 2 2 3
  • ATA2 3 4 6
  • System A Amino Acid Transporter 2 3 4
  • System N Amino Acid Transporter 2 3 4
  • Amino Acid Transporter A2 3 4
  • System A Transporter 1 3 4
  • Protein 40-9-1 3 4
  • KIAA1382 4 6
  • SNAT2 3 4
  • SAT2 3 4
  • Sodium-Coupled Neutral Amino Acid Transporter 2 3
  • Solute Carrier Family 38 Member 2 4
  • Amino Acid Transporter 2 3
  • PRO1068 3

External Ids for SLC38A2 Gene

Summaries for SLC38A2 Gene

GeneCards Summary for SLC38A2 Gene

SLC38A2 (Solute Carrier Family 38, Member 2) is a Protein Coding gene. Diseases associated with SLC38A2 include adult syndrome. Among its related pathways are Endochondral Ossification and Arginine and proline metabolism. GO annotations related to this gene include symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A1.

UniProtKB/Swiss-Prot for SLC38A2 Gene

  • Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.

Gene Wiki entry for SLC38A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A2 Gene

Genomics for SLC38A2 Gene

Genomic Location for SLC38A2 Gene

46,358,188 bp from pter
46,372,867 bp from pter
14,680 bases
Minus strand

Genomic View for SLC38A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC38A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A2 Gene

Regulatory Elements for SLC38A2 Gene

Proteins for SLC38A2 Gene

  • Protein details for SLC38A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Protein Accession:
    Secondary Accessions:
    • Q6IA88
    • Q6ZMG2
    • Q9HAV3
    • Q9NVA8
    • Q9P2G5

    Protein attributes for SLC38A2 Gene

    506 amino acids
    Molecular mass:
    56026 Da
    Quaternary structure:
    No Data Available
    • Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress
    • Sequence=BAD18765.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A2 Gene


neXtProt entry for SLC38A2 Gene

Proteomics data for SLC38A2 Gene at MOPED

Post-translational modifications for SLC38A2 Gene

  • Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33 and Lys38
  • Glycosylation at Asn258 and Asn274

Other Protein References for SLC38A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC38A2 Gene

Domains for SLC38A2 Gene

Gene Families for SLC38A2 Gene

  • SLC :Solute carriers

Protein Domains for SLC38A2 Gene


  • Belongs to the amino acid/polyamine transporter 2 family.:
    • Q96QD8
genes like me logo Genes that share domains with SLC38A2: view

Function for SLC38A2 Gene

Molecular function for SLC38A2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0);
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by N-methyl-D-glucamine and probably choline.
UniProtKB/Swiss-Prot Function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
UniProtKB/Swiss-Prot Induction: Up-regulated upon hypertonic conditions and amino acid deprivation.

Gene Ontology (GO) - Molecular Function for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC38A2: view

Phenotypes for SLC38A2 Gene

GenomeRNAi human phenotypes for SLC38A2:
genes like me logo Genes that share phenotypes with SLC38A2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC38A2 Gene

Localization for SLC38A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A2 Gene

Cell membrane; Multi-pass membrane protein. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SLC38A2 Gene COMPARTMENTS Subcellular localization image for SLC38A2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC38A2: view

Pathways for SLC38A2 Gene

genes like me logo Genes that share pathways with SLC38A2: view

Interacting Proteins for SLC38A2 Gene

Gene Ontology (GO) - Biological Process for SLC38A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport TAS --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with SLC38A2: view

Compounds for SLC38A2 Gene

(1) HMDB Compounds for SLC38A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium

(2) IUPHAR Ligand for SLC38A2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]alanine None None
[14C]alanine None None

(4) Novoseek inferred chemical compound relationships for SLC38A2 Gene

Compound -log(P) Hits PubMed IDs
meaib 91.4 1
glutamate 17.9 1
glutamine 15 1
glucose 6.51 4
genes like me logo Genes that share compounds with SLC38A2: view

Transcripts for SLC38A2 Gene

Unigene Clusters for SLC38A2 Gene

Solute carrier family 38, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - - - - -
SP4: - -
SP6: -

Relevant External Links for SLC38A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC38A2 Gene

mRNA expression in normal human tissues for SLC38A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC38A2 Gene

SOURCE GeneReport for Unigene cluster for SLC38A2 Gene Hs.221847

mRNA Expression by UniProt/SwissProt for SLC38A2 Gene

Tissue specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
genes like me logo Genes that share expressions with SLC38A2: view

Orthologs for SLC38A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC38A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC38A2 36
  • 99.87 (n)
  • 99.8 (a)
SLC38A2 37
  • 100 (a)
(Bos Taurus)
Mammalia SLC38A2 36
  • 91.3 (n)
  • 89.72 (a)
SLC38A2 37
  • 90 (a)
(Canis familiaris)
Mammalia SLC38A2 36
  • 91.55 (n)
  • 92.67 (a)
SLC38A2 37
  • 88 (a)
(Mus musculus)
Mammalia Slc38a2 36
  • 82.84 (n)
  • 89.26 (a)
Slc38a2 16
Slc38a2 37
  • 89 (a)
(Monodelphis domestica)
Mammalia SLC38A2 37
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
-- 37
  • 68 (a)
(Rattus norvegicus)
Mammalia Slc38a2 36
  • 83.4 (n)
  • 88.29 (a)
(Gallus gallus)
Aves SLC38A2 36
  • 78.13 (n)
  • 80.28 (a)
SLC38A2 37
  • 82 (a)
(Anolis carolinensis)
Reptilia SLC38A2 37
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a2 36
  • 71.84 (n)
  • 75.53 (a)
(Danio rerio)
Actinopterygii slc38a2 36
  • 67 (n)
  • 71.81 (a)
slc38a2 37
  • 70 (a)
Species with no ortholog for SLC38A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A2 Gene

Gene Tree for SLC38A2 (if available)
Gene Tree for SLC38A2 (if available)

Paralogs for SLC38A2 Gene

Paralogs for SLC38A2 Gene

Selected SIMAP similar genes for SLC38A2 Gene using alignment to 3 proteins: Pseudogenes for SLC38A2 Gene

genes like me logo Genes that share paralogs with SLC38A2: view

Variants for SLC38A2 Gene

Sequence variations from dbSNP and Humsavar for SLC38A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs956910 -- 46,366,005(+) TTCTA(A/G)AGCCA intron-variant
rs1046296 -- 46,358,308(-) TCCCC(A/C)CTGTA utr-variant-3-prime
rs1873793 -- 46,367,541(-) CCTGA(A/G)AAATG intron-variant
rs2307060 -- 46,364,846(-) GTATC(A/G)TAAGA intron-variant
rs2307061 -- 46,364,711(-) ACCCC(C/G/T)CCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A2 Gene

Variant ID Type Subtype PubMed ID
nsv832398 CNV Gain 17160897

Relevant External Links for SLC38A2 Gene

HapMap Linkage Disequilibrium report

Disorders for SLC38A2 Gene

(1) MalaCards Diseases for SLC38A2 Gene

Search for SLC38A2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC38A2 Gene

(1) Novoseek inferred disease relationships for SLC38A2 Gene

Disease -log(P) Hits PubMed IDs
intrauterine growth retardation 60.4 1
genes like me logo Genes that share disorders with SLC38A2: view

No data available for UniProtKB/Swiss-Prot for SLC38A2 Gene

Publications for SLC38A2 Gene

  1. SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. (PMID: 15922329) Bevilacqua E. … Franchi-Gazzola R. (FEBS Lett. 2005) 3 4 23
  2. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. (PMID: 14623874) Palii S.S. … Kilberg M.S. (J. Biol. Chem. 2004) 3 4 23
  3. IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. (PMID: 19741197) Jones H.N. … Powell T.L. (Am. J. Physiol., Cell Physiol. 2009) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. (PMID: 10747860) Sugawara M. … Ganapathy V. (J. Biol. Chem. 2000) 2 3

Products for SLC38A2 Gene

Sources for SLC38A2 Gene

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