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Aliases for POLR2K Gene

Aliases for POLR2K Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa 2 3
  • RNA Polymerases I, II, And III Subunit ABC4 3 4
  • DNA-Directed RNA Polymerase II Subunit K 3 4
  • RNA Polymerase II 7.0 KDa Subunit 3 4
  • ABC10-Alpha 3 4
  • RPB10alpha 3 4
  • RPB7.0 3 4
  • RPB12 3 6
  • DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide 3
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide K (7.0kD) 2
  • HsRPB10a 3
  • HRPB7.0 3
  • RPABC4 3

External Ids for POLR2K Gene

Summaries for POLR2K Gene

Entrez Gene Summary for POLR2K Gene

  • This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2K Gene

POLR2K (Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa) is a Protein Coding gene. Diseases associated with POLR2K include hiv-1. Among its related pathways are Disease and Epstein-Barr virus infection. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR2K Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively

Gene Wiki entry for POLR2K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2K Gene

Genomics for POLR2K Gene

Genomic Location for POLR2K Gene

Start:
100,150,584 bp from pter
End:
100,154,002 bp from pter
Size:
3,419 bases
Orientation:
Plus strand

Genomic View for POLR2K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2K Gene

Regulatory Elements for POLR2K Gene

Proteins for POLR2K Gene

  • Protein details for POLR2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53803-RPAB4_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Protein Accession:
    P53803
    Secondary Accessions:
    • Q6IBD4

    Protein attributes for POLR2K Gene

    Size:
    58 amino acids
    Molecular mass:
    7004 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

neXtProt entry for POLR2K Gene

Proteomics data for POLR2K Gene at MOPED

Post-translational modifications for POLR2K Gene

No Post-translational modifications

Other Protein References for POLR2K Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2K Gene

Domains for POLR2K Gene

Gene Families for POLR2K Gene

HGNC:
  • POLR :RNA polymerase subunits

Protein Domains for POLR2K Gene

UniProtKB/Swiss-Prot:

RPAB4_HUMAN
Family:
  • Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.:
    • P53803
genes like me logo Genes that share domains with POLR2K: view

Function for POLR2K Gene

Molecular function for POLR2K Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively

Gene Ontology (GO) - Molecular Function for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity --
genes like me logo Genes that share ontologies with POLR2K: view
genes like me logo Genes that share phenotypes with POLR2K: view

miRNA for POLR2K Gene

miRTarBase miRNAs that target POLR2K

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLR2K Gene

Localization for POLR2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2K Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2K Gene COMPARTMENTS Subcellular localization image for POLR2K gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with POLR2K: view

Pathways for POLR2K Gene

SuperPathways for POLR2K Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 RNA Polymerase III Transcription Initiation
3 DNA Repair
4 mRNA Splicing - Major Pathway
5 RNA Polymerase I Promoter Opening
genes like me logo Genes that share pathways with POLR2K: view

Gene Ontology (GO) - Biological Process for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated --
genes like me logo Genes that share ontologies with POLR2K: view

Transcripts for POLR2K Gene

mRNA/cDNA for POLR2K Gene

Unigene Clusters for POLR2K Gene

Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2K Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for POLR2K Gene

GeneLoc Exon Structure for
POLR2K
ECgene alternative splicing isoforms for
POLR2K

Expression for POLR2K Gene

mRNA expression in normal human tissues for POLR2K Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2K Gene

SOURCE GeneReport for Unigene cluster for POLR2K Gene Hs.351475

genes like me logo Genes that share expressions with POLR2K: view

Orthologs for POLR2K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR2K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2K 36
  • 100 (n)
  • 100 (a)
POLR2K 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR2K 36
  • 95.4 (n)
  • 100 (a)
POLR2K 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2K 36
  • 95.4 (n)
  • 100 (a)
POLR2K 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2k 36
  • 92.53 (n)
  • 98.28 (a)
Polr2k 16
Polr2k 37
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2K 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2K 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2k 36
  • 94.83 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves POLR2K 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2K 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2k 36
  • 85.63 (n)
  • 91.38 (a)
Str.6978 36
zebrafish
(Danio rerio)
Actinopterygii polr2k 36
  • 81.03 (n)
  • 94.83 (a)
polr2k 37
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rpb12 37
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpb-12 37
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC10 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13296 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2976 37
  • 56 (a)
OneToOne
Species with no ortholog for POLR2K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2K Gene

ENSEMBL:
Gene Tree for POLR2K (if available)
TreeFam:
Gene Tree for POLR2K (if available)

Paralogs for POLR2K Gene

Pseudogenes.org Pseudogenes for POLR2K Gene

genes like me logo Genes that share paralogs with POLR2K: view

No data available for Paralogs for POLR2K Gene

Variants for POLR2K Gene

Sequence variations from dbSNP and Humsavar for POLR2K Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7924 -- 100,153,906(+) CCACA(C/G)TTTTA utr-variant-3-prime
rs14960 -- 100,153,427(-) TCTCC(A/C)GAAGA utr-variant-3-prime
rs1056585 -- 100,153,872(+) AACAC(A/C)CAATA utr-variant-3-prime
rs2254883 -- 100,150,730(+) GGTTG(A/G)GGTTT intron-variant
rs2446923 -- 100,148,753(+) TCACT(A/G)ATTTC upstream-variant-2KB

Relevant External Links for POLR2K Gene

HapMap Linkage Disequilibrium report
POLR2K

No data available for Structural Variations from Database of Genomic Variants (DGV) for POLR2K Gene

Disorders for POLR2K Gene

(1) MalaCards Diseases for POLR2K Gene

Search for POLR2K Gene in MalaCards »

Relevant External Links for POLR2K

Genetic Association Database (GAD)
POLR2K
Human Genome Epidemiology (HuGE) Navigator
POLR2K
genes like me logo Genes that share disorders with POLR2K: view

No data available for UniProtKB/Swiss-Prot for POLR2K Gene

Publications for POLR2K Gene

  1. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. (PMID: 7651387) Shpakovski G.V. … Vigneron M. (Mol. Cell. Biol. 1995) 3 4
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 49
  5. Role of Tat protein in HIV neuropathogenesis. (PMID: 19526283) Li W. … Nath A. (Neurotox Res 2009) 3

Products for POLR2K Gene

Sources for POLR2K Gene

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