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Aliases for POLR2K Gene

Aliases for POLR2K Gene

  • Polymerase (RNA) II Subunit K 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa 2 3 5
  • RNA Polymerases I, II, And III Subunit ABC4 3 4
  • DNA-Directed RNA Polymerase II Subunit K 3 4
  • RNA Polymerase II 7.0 KDa Subunit 3 4
  • ABC10-Alpha 3 4
  • RPB10alpha 3 4
  • RPB7.0 3 4
  • DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide 3
  • HsRPB10a 3
  • HRPB7.0 3
  • RPABC4 3
  • RPB12 3

External Ids for POLR2K Gene

Previous GeneCards Identifiers for POLR2K Gene

  • GC08P100168
  • GC08P101232
  • GC08P100831
  • GC08P101119
  • GC08P096365
  • GC08P101162

Summaries for POLR2K Gene

Entrez Gene Summary for POLR2K Gene

  • This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2K Gene

POLR2K (Polymerase (RNA) II Subunit K) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and mRNA Splicing - Major Pathway. GO annotations related to this gene include DNA-directed RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot for POLR2K Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Wiki entry for POLR2K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2K Gene

Genomics for POLR2K Gene

Regulatory Elements for POLR2K Gene

Enhancers for POLR2K Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLR2K on UCSC Golden Path with GeneCards custom track

Promoters for POLR2K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR2K on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR2K Gene

Chromosome:
8
Start:
100,150,584 bp from pter
End:
100,154,002 bp from pter
Size:
3,419 bases
Orientation:
Plus strand

Genomic View for POLR2K Gene

Genes around POLR2K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2K Gene

Proteins for POLR2K Gene

  • Protein details for POLR2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53803-RPAB4_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Protein Accession:
    P53803
    Secondary Accessions:
    • Q6IBD4

    Protein attributes for POLR2K Gene

    Size:
    58 amino acids
    Molecular mass:
    7004 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

neXtProt entry for POLR2K Gene

Proteomics data for POLR2K Gene at MOPED

Post-translational modifications for POLR2K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR2K Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2K Gene

Domains & Families for POLR2K Gene

Gene Families for POLR2K Gene

Protein Domains for POLR2K Gene

Suggested Antigen Peptide Sequences for POLR2K Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53803

UniProtKB/Swiss-Prot:

RPAB4_HUMAN :
  • Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2K: view

Function for POLR2K Gene

Molecular function for POLR2K Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
genes like me logo Genes that share phenotypes with POLR2K: view

Animal Model Products

miRNA for POLR2K Gene

miRTarBase miRNAs that target POLR2K

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2K Gene

Localization for POLR2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2K Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2K Gene COMPARTMENTS Subcellular localization image for POLR2K gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR2K: view

Pathways & Interactions for POLR2K Gene

SuperPathways for POLR2K Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
4 RNA Polymerase III Transcription Initiation
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2K: view

Gene Ontology (GO) - Biological Process for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006356 regulation of transcription from RNA polymerase I promoter TAS 7651387
genes like me logo Genes that share ontologies with POLR2K: view

No data available for SIGNOR curated interactions for POLR2K Gene

Drugs & Compounds for POLR2K Gene

(5) Drugs for POLR2K Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR2K: view

Transcripts for POLR2K Gene

mRNA/cDNA for POLR2K Gene

Unigene Clusters for POLR2K Gene

Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2K Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for POLR2K Gene

GeneLoc Exon Structure for
POLR2K
ECgene alternative splicing isoforms for
POLR2K

Expression for POLR2K Gene

mRNA expression in normal human tissues for POLR2K Gene

Protein differential expression in normal tissues from HIPED for POLR2K Gene

This gene is overexpressed in Breast (16.7), Fetal Brain (8.5), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2K Gene



SOURCE GeneReport for Unigene cluster for POLR2K Gene Hs.351475

genes like me logo Genes that share expression patterns with POLR2K: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for POLR2K Gene

Orthologs for POLR2K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR2K Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2K 35
  • 95.4 (n)
  • 100 (a)
POLR2K 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2K 35
  • 95.4 (n)
  • 100 (a)
POLR2K 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2k 35
  • 92.53 (n)
  • 98.28 (a)
Polr2k 16
Polr2k 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2K 35
  • 100 (n)
  • 100 (a)
POLR2K 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2k 35
  • 94.83 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia POLR2K 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2K 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR2K 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2K 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2k 35
  • 85.63 (n)
  • 91.38 (a)
Str.6978 35
zebrafish
(Danio rerio)
Actinopterygii polr2k 35
  • 81.03 (n)
  • 94.83 (a)
polr2k 36
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rpb12 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpb-12 36
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC10 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13296 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2976 36
  • 56 (a)
OneToOne
Species with no ortholog for POLR2K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2K Gene

ENSEMBL:
Gene Tree for POLR2K (if available)
TreeFam:
Gene Tree for POLR2K (if available)

Paralogs for POLR2K Gene

Pseudogenes.org Pseudogenes for POLR2K Gene

genes like me logo Genes that share paralogs with POLR2K: view

No data available for Paralogs for POLR2K Gene

Variants for POLR2K Gene

Sequence variations from dbSNP and Humsavar for POLR2K Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2453642 -- 100,153,657(+) tactc(A/G)cctat utr-variant-3-prime
rs2453643 -- 100,154,227(+) AGGCT(A/G)TTAAG downstream-variant-500B
rs11555067 -- 100,153,439(+) ACATT(C/T)CAAGG utr-variant-3-prime
rs11555069 -- 100,153,553(+) GCAAG(A/G)GATTA utr-variant-3-prime
rs7924 -- 100,153,906(+) CCACA(C/G)TTTTA utr-variant-3-prime

Variation tolerance for POLR2K Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for POLR2K Gene

Disorders for POLR2K Gene

Relevant External Links for POLR2K

Genetic Association Database (GAD)
POLR2K
Human Genome Epidemiology (HuGE) Navigator
POLR2K
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2K

No disorders were found for POLR2K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2K Gene

Publications for POLR2K Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 48 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription. (PMID: 24217245) Zhao W. … He J.J. (J. Biol. Chem. 2014) 3

Products for POLR2K Gene

Sources for POLR2K Gene

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