Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WNT4 Gene

Aliases for WNT4 Gene

  • Wingless-Type MMTV Integration Site Family, Member 4 2 3
  • SERKAL 3 6
  • Protein Wnt-4 3
  • WNT-4 3

External Ids for WNT4 Gene

Summaries for WNT4 Gene

Entrez Gene Summary for WNT4 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT4 Gene

WNT4 (Wingless-Type MMTV Integration Site Family, Member 4) is a Protein Coding gene. Diseases associated with WNT4 include mullerian aplasia and hyperandrogenism and serkal syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include transcription corepressor activity and frizzled binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT4 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.

Gene Wiki entry for WNT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT4 Gene

Genomics for WNT4 Gene

Genomic Location for WNT4 Gene

Start:
22,117,305 bp from pter
End:
22,143,969 bp from pter
Size:
26,665 bases
Orientation:
Minus strand

Genomic View for WNT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT4 Gene

Regulatory Elements for WNT4 Gene

Proteins for WNT4 Gene

  • Protein details for WNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56705-WNT4_HUMAN
    Recommended name:
    Protein Wnt-4
    Protein Accession:
    P56705
    Secondary Accessions:
    • B4DJF9
    • Q5TZQ0
    • Q96T81
    • Q9BXF5
    • Q9H1J8
    • Q9UJM2

    Protein attributes for WNT4 Gene

    Size:
    351 amino acids
    Molecular mass:
    39052 Da
    Quaternary structure:
    • Interacts with PORCN.

    Alternative splice isoforms for WNT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT4 Gene

Proteomics data for WNT4 Gene at MOPED

Post-translational modifications for WNT4 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn88 and Asn297

Other Protein References for WNT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT4 Gene

Domains for WNT4 Gene

Gene Families for WNT4 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT4 Gene

Suggested Antigen Peptide Sequences for WNT4 Gene

Graphical View of Domain Structure for InterPro Entry

P56705

UniProtKB/Swiss-Prot:

WNT4_HUMAN
Family:
  • Belongs to the Wnt family.:
    • P56705
genes like me logo Genes that share domains with WNT4: view

Function for WNT4 Gene

Molecular function for WNT4 Gene

UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.

Gene Ontology (GO) - Molecular Function for WNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity ISS --
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
GO:0005515 protein binding --
GO:0048018 receptor agonist activity IC 16959810
genes like me logo Genes that share ontologies with WNT4: view
genes like me logo Genes that share phenotypes with WNT4: view

Animal Models for WNT4 Gene

MGI Knock Outs for WNT4:

miRNA for WNT4 Gene

miRTarBase miRNAs that target WNT4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT4 Gene

Localization for WNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT4 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT4 Gene COMPARTMENTS Subcellular localization image for WNT4 gene
Compartment Confidence
extracellular 5
golgi apparatus 3
plasma membrane 3
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 16959810
GO:0005737 cytoplasm IDA 16959810
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with WNT4: view

Pathways for WNT4 Gene

genes like me logo Genes that share pathways with WNT4: view

Gene Ontology (GO) - Biological Process for WNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001822 kidney development IEP 15312687
GO:0001823 mesonephros development --
GO:0001837 epithelial to mesenchymal transition IEP 12841867
genes like me logo Genes that share ontologies with WNT4: view

Compounds for WNT4 Gene

(2) Novoseek inferred chemical compound relationships for WNT4 Gene

Compound -log(P) Hits PubMed IDs
testosterone 13.4 2
progesterone 6.8 2
genes like me logo Genes that share compounds with WNT4: view

Transcripts for WNT4 Gene

Unigene Clusters for WNT4 Gene

Wingless-type MMTV integration site family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT4 Gene

No ASD Table

Relevant External Links for WNT4 Gene

GeneLoc Exon Structure for
WNT4
ECgene alternative splicing isoforms for
WNT4

Expression for WNT4 Gene

mRNA expression in normal human tissues for WNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (7.6), Ovary (6.3), and Skin - Sun Exposed (Lower leg) (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT4 Gene

SOURCE GeneReport for Unigene cluster for WNT4 Gene Hs.25766

genes like me logo Genes that share expressions with WNT4: view

No data available for mRNA Expression by UniProt/SwissProt for WNT4 Gene

Orthologs for WNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT4 35
  • 91.95 (n)
  • 90.23 (a)
WNT4 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT4 35
  • 92.72 (n)
  • 99.69 (a)
WNT4 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT4 35
  • 94.36 (n)
  • 100 (a)
WNT4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt4 35
  • 90.22 (n)
  • 98.86 (a)
Wnt4 16
Wnt4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT4 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT4 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt4 35
  • 90.5 (n)
  • 98.29 (a)
chicken
(Gallus gallus)
Aves WNT4 35
  • 81.2 (n)
  • 85.47 (a)
WNT4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT4 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xwnt-4 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17939 35
wnt4 35
  • 73.79 (n)
  • 85.96 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt4a 35
  • 75.88 (n)
  • 82.62 (a)
wnt4a 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 35
  • 52.97 (n)
  • 44.17 (a)
Wnt5 37
  • 45 (a)
Wnt6 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-1 35
  • 50.54 (n)
  • 47.18 (a)
lin-44 37
  • 29 (a)
egl-20 37
  • 35 (a)
mom-2 37
  • 36 (a)
cwn-2 37
  • 42 (a)
cwn-1 37
  • 46 (a)
Species with no ortholog for WNT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT4 Gene

ENSEMBL:
Gene Tree for WNT4 (if available)
TreeFam:
Gene Tree for WNT4 (if available)

Paralogs for WNT4 Gene

Paralogs for WNT4 Gene

Selected SIMAP similar genes for WNT4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WNT4: view

Variants for WNT4 Gene

Sequence variations from dbSNP and Humsavar for WNT4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs736835 -- 22,141,407(-) CTGGG(C/T)GTCCC intron-variant, upstream-variant-2KB
rs742358 -- 22,132,677(-) CCCTG(C/T)GACTG intron-variant
rs877628 -- 22,130,534(-) GACTC(A/G)GTGTG intron-variant
rs877629 -- 22,130,402(-) CCTCA(C/T)TGTCC intron-variant
rs909816 -- 22,130,477(-) GAAGC(A/G)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT4 Gene

Variant ID Type Subtype PubMed ID
nsv871778 CNV Gain 21882294
nsv6076 CNV Insertion 18451855
nsv460806 CNV Loss 19166990

Relevant External Links for WNT4 Gene

HapMap Linkage Disequilibrium report
WNT4
Human Gene Mutation Database (HGMD)
WNT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT4 Gene

Disorders for WNT4 Gene

(2) OMIM Diseases for WNT4 Gene (603490)

UniProtKB/Swiss-Prot

WNT4_HUMAN
  • 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]: A disease characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs. {ECO:0000269 PubMed:18179883}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Mullerian aplasia and hyperandrogenism (MULLAPL) [MIM:158330]: A disorder of sex development. Affected females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional ovaries, primary amenorrhea, hyperandrogenism and hirsutism. {ECO:0000269 PubMed:15317892, ECO:0000269 PubMed:16959810, ECO:0000269 PubMed:18182450}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) Novoseek inferred disease relationships for WNT4 Gene

Disease -log(P) Hits PubMed IDs
virilization 60.8 4
tumors 6.47 1
breast cancer 0 1

Relevant External Links for WNT4

GeneTests
WNT4
GeneReviews
WNT4
Genetic Association Database (GAD)
WNT4
Human Genome Epidemiology (HuGE) Navigator
WNT4
genes like me logo Genes that share disorders with WNT4: view

Publications for WNT4 Gene

  1. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PMID: 8168088) Huguet E.L. … Harris A.L. (Cancer Res. 1994) 2 3 4 23
  2. Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans. (PMID: 11283799) Jordan B.K. … Vilain E. (Am. J. Hum. Genet. 2001) 3 4 23
  3. WNT4 deficiency-a clinical phenotype distinct from the classic Mayer- Rokitansky-Kuster-Hauser syndrome: a case report. (PMID: 16959810) Biason-Lauber A. … Schoenle E.J. (Hum. Reprod. 2007) 3 4 23
  4. A WNT4 mutation associated with Muellerian-duct regression and virilization in a 46,XX woman. (PMID: 15317892) Biason-Lauber A. … Schoenle E.J. (N. Engl. J. Med. 2004) 3 4 23
  5. Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells. (PMID: 15389636) Nishioka K. … Caplan A.I. (J. Cell. Physiol. 2005) 3 23

Products for WNT4 Gene

  • Addgene plasmids for WNT4

Sources for WNT4 Gene

Back to Top

Content