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Aliases for DPM3 Gene

Aliases for DPM3 Gene

  • Dolichyl-Phosphate Mannosyltransferase Polypeptide 3 2 3
  • Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 3 3 4
  • Dolichol-Phosphate Mannose Synthase Subunit 3 3 4
  • Mannose-P-Dolichol Synthase Subunit 3 3 4
  • DPM Synthase Subunit 3 3 4
  • MPD Synthase Subunit 3 3 4
  • Prostin-1 3 4
  • CDG1O 3 6
  • Dolichol-Phosphate Mannosyltransferase Subunit 3 3
  • DPM Synthase Complex Subunit 3 3
  • DPM Synthase Complex Subunit 2
  • Prostin 1 3

External Ids for DPM3 Gene

Previous GeneCards Identifiers for DPM3 Gene

  • GC01M152991
  • GC01M150852
  • GC01M151887
  • GC01M152329
  • GC01M151925
  • GC01M153379
  • GC01M126474

Summaries for DPM3 Gene

Entrez Gene Summary for DPM3 Gene

  • Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPM3 Gene

DPM3 (Dolichyl-Phosphate Mannosyltransferase Polypeptide 3) is a Protein Coding gene. Diseases associated with DPM3 include congenital disorder of glycosylation, type io. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include dolichyl-phosphate beta-D-mannosyltransferase activity.

UniProtKB/Swiss-Prot for DPM3 Gene

  • Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.

Gene Wiki entry for DPM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPM3 Gene

Genomics for DPM3 Gene

Regulatory Elements for DPM3 Gene

Genomic Location for DPM3 Gene

Start:
155,139,891 bp from pter
End:
155,140,595 bp from pter
Size:
705 bases
Orientation:
Minus strand

Genomic View for DPM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPM3 Gene

Proteins for DPM3 Gene

  • Protein details for DPM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2X0-DPM3_HUMAN
    Recommended name:
    Dolichol-phosphate mannosyltransferase subunit 3
    Protein Accession:
    Q9P2X0
    Secondary Accessions:
    • Q5SR62
    • Q5SR63
    • Q9BXN4
    • Q9BXN5

    Protein attributes for DPM3 Gene

    Size:
    92 amino acids
    Molecular mass:
    10094 Da
    Quaternary structure:
    • Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion.

    Alternative splice isoforms for DPM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPM3 Gene

Proteomics data for DPM3 Gene at MOPED

Post-translational modifications for DPM3 Gene

  • Glycosylation at Thr63
  • Modification sites at PhosphoSitePlus

Other Protein References for DPM3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DPM3 Gene

Domains for DPM3 Gene

Protein Domains for DPM3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P2X0

UniProtKB/Swiss-Prot:

DPM3_HUMAN :
  • Q9P2X0
Family:
  • Belongs to the DPM3 family.
genes like me logo Genes that share domains with DPM3: view

No data available for Gene Families for DPM3 Gene

Function for DPM3 Gene

Molecular function for DPM3 Gene

UniProtKB/Swiss-Prot Function: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.

Gene Ontology (GO) - Molecular Function for DPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004582 contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity IDA 10835346
GO:0005515 protein binding IPI 10835346
genes like me logo Genes that share ontologies with DPM3: view

Phenotypes for DPM3 Gene

GenomeRNAi human phenotypes for DPM3:
genes like me logo Genes that share phenotypes with DPM3: view

miRNA for DPM3 Gene

miRTarBase miRNAs that target DPM3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPM3 Gene

Localization for DPM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPM3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPM3 Gene COMPARTMENTS Subcellular localization image for DPM3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 10835346
GO:0005789 endoplasmic reticulum membrane TAS 16280320
GO:0016020 membrane IDA 19946888
GO:0030176 integral component of endoplasmic reticulum membrane IDA 10835346
GO:0031501 mannosyltransferase complex TAS 16280320
genes like me logo Genes that share ontologies with DPM3: view

Pathways for DPM3 Gene

genes like me logo Genes that share pathways with DPM3: view

UniProtKB/Swiss-Prot Q9P2X0-DPM3_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for DPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 10835346
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process TAS 16280320
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with DPM3: view

Transcripts for DPM3 Gene

mRNA/cDNA for DPM3 Gene

Unigene Clusters for DPM3 Gene

Dolichyl-phosphate mannosyltransferase polypeptide 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPM3 Gene

No ASD Table

Relevant External Links for DPM3 Gene

GeneLoc Exon Structure for
DPM3
ECgene alternative splicing isoforms for
DPM3

Expression for DPM3 Gene

mRNA expression in normal human tissues for DPM3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DPM3 Gene

SOURCE GeneReport for Unigene cluster for DPM3 Gene Hs.110477

genes like me logo Genes that share expressions with DPM3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPM3 Gene

Orthologs for DPM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPM3 35
  • 99.64 (n)
  • 100 (a)
DPM3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPM3 35
  • 89.13 (n)
  • 92.39 (a)
DPM3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPM3 35
  • 90.94 (n)
  • 93.48 (a)
DPM3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpm3 35
  • 85.14 (n)
  • 90.22 (a)
Dpm3 16
Dpm3 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPM3 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPM3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPM3 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dpm3 35
  • 57.88 (n)
  • 56.04 (a)
dpm3 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33977 36
  • 39 (a)
OneToOne
Species with no ortholog for DPM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPM3 Gene

ENSEMBL:
Gene Tree for DPM3 (if available)
TreeFam:
Gene Tree for DPM3 (if available)

Paralogs for DPM3 Gene

Pseudogenes.org Pseudogenes for DPM3 Gene

genes like me logo Genes that share paralogs with DPM3: view

No data available for Paralogs for DPM3 Gene

Variants for DPM3 Gene

Sequence variations from dbSNP and Humsavar for DPM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4971073 untested 155,140,628(+) CCAGC(G/T)CCTCA upstream-variant-2KB
rs6413882 -- 155,142,298(+) atgaa(A/G)cagtg upstream-variant-2KB
rs12126509 -- 155,142,207(+) ttgcc(C/T)aggcg upstream-variant-2KB
rs12745576 untested 155,140,598(+) TTCAC(A/C)TGGCG upstream-variant-2KB
rs34148097 -- 155,141,531(+) AATTT(-/C)ATTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPM3 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850

Relevant External Links for DPM3 Gene

HapMap Linkage Disequilibrium report
DPM3
Human Gene Mutation Database (HGMD)
DPM3
Locus Specific Mutation Databases (LSDB)
DPM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPM3 Gene

Disorders for DPM3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DPM3 Gene including...

Search for DPM3 Gene in MalaCards »

(1) OMIM Diseases for DPM3 Gene (605951)

UniProtKB/Swiss-Prot

DPM3_HUMAN
  • Congenital disorder of glycosylation 1O (CDG1O) [MIM:612937]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1O patients have increased serum creatine kinase, dystrophic changes on muscle biopsy, and reduced O-mannosylation of alpha-dystroglycan. {ECO:0000269 PubMed:19576565}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for DPM3 Gene

Relevant External Links for DPM3

GeneTests
DPM3
GeneReviews
DPM3
Genetic Association Database (GAD)
DPM3
genes like me logo Genes that share disorders with DPM3: view

Publications for DPM3 Gene

  1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PMID: 10835346) Maeda Y. … Kinoshita T. (EMBO J. 2000) 2 3 4 23
  2. Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. (PMID: 11420690) Manos E.J. … Jones D.A. (Oncogene 2001) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 48
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for DPM3 Gene

Sources for DPM3 Gene

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