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Aliases for GNG2 Gene

Aliases for GNG2 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 2 2 3
  • G Gamma-I 4

External Ids for GNG2 Gene

Previous GeneCards Identifiers for GNG2 Gene

  • GC14P049702
  • GC14M046231
  • GC14M050426
  • GC14P050303
  • GC14P051383
  • GC14P052327
  • GC14P032487
  • GC14P052292

Summaries for GNG2 Gene

Entrez Gene Summary for GNG2 Gene

  • This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]

GeneCards Summary for GNG2 Gene

GNG2 (Guanine Nucleotide Binding Protein (G Protein), Gamma 2) is a Protein Coding gene. Diseases associated with GNG2 include familial hemiplegic migraine and hemiplegic migraine. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG2 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).

Tocris Summary for GNG2 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG2 Gene

Genomics for GNG2 Gene

Genomic Location for GNG2 Gene

Start:
51,826,195 bp from pter
End:
51,979,342 bp from pter
Size:
153,148 bases
Orientation:
Plus strand

Genomic View for GNG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG2 Gene

No data available for Regulatory Elements for GNG2 Gene

Proteins for GNG2 Gene

  • Protein details for GNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59768-GBG2_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Protein Accession:
    P59768
    Secondary Accessions:
    • Q5JPE2
    • Q6P9A9

    Protein attributes for GNG2 Gene

    Size:
    71 amino acids
    Molecular mass:
    7850 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for GNG2 Gene

neXtProt entry for GNG2 Gene

Proteomics data for GNG2 Gene at MOPED

Post-translational modifications for GNG2 Gene

  • Ubiquitination at Lys32
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GNG2 Gene

Domains for GNG2 Gene

Protein Domains for GNG2 Gene

Suggested Antigen Peptide Sequences for GNG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59768

UniProtKB/Swiss-Prot:

GBG2_HUMAN :
  • P59768
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG2: view

No data available for Gene Families for GNG2 Gene

Function for GNG2 Gene

Molecular function for GNG2 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).

Gene Ontology (GO) - Molecular Function for GNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0031681 G-protein beta-subunit binding IPI 12606627
genes like me logo Genes that share ontologies with GNG2: view

Phenotypes for GNG2 Gene

genes like me logo Genes that share phenotypes with GNG2: view

Animal Model Products

CRISPR Products

miRNA for GNG2 Gene

miRTarBase miRNAs that target GNG2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNG2 Gene

Localization for GNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG2 Gene COMPARTMENTS Subcellular localization image for GNG2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex ISS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane ISS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with GNG2: view

Pathways for GNG2 Gene

SuperPathways for GNG2 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 fMLP Pathway
5 GPCR Pathway
genes like me logo Genes that share pathways with GNG2: view

Gene Ontology (GO) - Biological Process for GNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway ISS --
GO:0007268 synaptic transmission TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with GNG2: view

Compounds for GNG2 Gene

(5) Tocris Compounds for GNG2 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNG2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for GNG2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Halothane
  • 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
151-67-7 target other/unknown
genes like me logo Genes that share compounds with GNG2: view

Transcripts for GNG2 Gene

Unigene Clusters for GNG2 Gene

Guanine nucleotide binding protein (G protein), gamma 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - -
SP9: -

Relevant External Links for GNG2 Gene

GeneLoc Exon Structure for
GNG2
ECgene alternative splicing isoforms for
GNG2

Expression for GNG2 Gene

mRNA expression in normal human tissues for GNG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG2 Gene

This gene is overexpressed in Whole Blood (10.0) and Testis (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG2 Gene

SOURCE GeneReport for Unigene cluster for GNG2 Gene Hs.187772

mRNA Expression by UniProt/SwissProt for GNG2 Gene

P59768-GBG2_HUMAN
Tissue specificity: Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.
genes like me logo Genes that share expressions with GNG2: view

In Situ Assay Products

Orthologs for GNG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG2 35
  • 100 (n)
  • 100 (a)
GNG2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG2 35
  • 95.31 (n)
  • 100 (a)
GNG2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG2 35
  • 92.02 (n)
  • 100 (a)
GNG2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng2 35
  • 92.49 (n)
  • 100 (a)
Gng2 16
Gng2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng2 35
  • 91.55 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves GNG2 35
  • 85.92 (n)
  • 98.59 (a)
GNG2 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNG2 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng2 35
  • 85.45 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii gng2 36
  • 94 (a)
OneToMany
gng2 36
  • 94 (a)
OneToMany
LOC100332296 35
  • 82.63 (n)
  • 94.37 (a)
Species with no ortholog for GNG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG2 Gene

ENSEMBL:
Gene Tree for GNG2 (if available)
TreeFam:
Gene Tree for GNG2 (if available)

Paralogs for GNG2 Gene

Paralogs for GNG2 Gene

Selected SIMAP similar genes for GNG2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GNG2: view

Variants for GNG2 Gene

Sequence variations from dbSNP and Humsavar for GNG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs950010 -- 51,970,017(-) GCCCC(C/T)ACCTT downstream-variant-500B
rs1032582 -- 51,966,385(+) cctgt(A/G)aggtc intron-variant
rs1032583 -- 51,966,397(+) gtgtc(A/G)tcaac intron-variant
rs1032584 -- 51,966,461(+) TCATG(A/G)AGCAA intron-variant
rs1057804 -- 51,967,337(-) GAACA(A/C)AGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNG2 Gene

Variant ID Type Subtype PubMed ID
nsv901947 CNV Gain 21882294
nsv456317 CNV Loss 19166990
nsv826952 CNV Loss 20364138
esv2748712 CNV Deletion 23290073
esv2670027 CNV Deletion 23128226
esv2672618 CNV Deletion 23128226
esv2514556 CNV Deletion 19546169
esv2748713 CNV Deletion 23290073
esv2000663 CNV Deletion 18987734
esv2675664 CNV Deletion 23128226
dgv35n6 CNV Loss 16902084
esv1005848 CNV Deletion 20482838
esv2748714 CNV Deletion 23290073
nsv7252 OTHER Inversion 18451855
esv2571786 CNV Deletion 19546169

Relevant External Links for GNG2 Gene

HapMap Linkage Disequilibrium report
GNG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG2 Gene

Disorders for GNG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for GNG2 Gene including...

Search for GNG2 Gene in MalaCards »

Relevant External Links for GNG2

Genetic Association Database (GAD)
GNG2
Human Genome Epidemiology (HuGE) Navigator
GNG2
genes like me logo Genes that share disorders with GNG2: view

No data available for UniProtKB/Swiss-Prot for GNG2 Gene

Publications for GNG2 Gene

  1. Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit. (PMID: 10833460) Modarressi M.H. … Wolfe J. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. GI^I^ subunits inhibit Epac-induced melanoma cell migration. (PMID: 21679469) Baljinnyam E. … Iwatsubo K. (BMC Cancer 2011) 3
  5. The WD40 repeat protein WDR26 binds GI^I^ and promotes GI^I^-dependent signal transduction and leukocyte migration. (PMID: 22065575) Sun Z. … Chen S. (J. Biol. Chem. 2011) 3

Products for GNG2 Gene

Sources for GNG2 Gene

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