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Aliases for GPR85 Gene

Aliases for GPR85 Gene

  • G Protein-Coupled Receptor 85 2 3
  • SREB2 3 4 6
  • Super Conserved Receptor Expressed In Brain 2 3 4
  • Probable G-Protein Coupled Receptor 85 3
  • Seven Transmembrane Helix Receptor 3
  • SREB 3

External Ids for GPR85 Gene

Previous GeneCards Identifiers for GPR85 Gene

  • GC07M111205
  • GC07M112267
  • GC07M112280
  • GC07M112314
  • GC07M112507
  • GC07M112720
  • GC07M107088

Summaries for GPR85 Gene

Entrez Gene Summary for GPR85 Gene

  • Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]

GeneCards Summary for GPR85 Gene

GPR85 (G Protein-Coupled Receptor 85) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR173.

UniProtKB/Swiss-Prot for GPR85 Gene

  • Orphan receptor

Gene Wiki entry for GPR85 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR85 Gene

Genomics for GPR85 Gene

Regulatory Elements for GPR85 Gene

Genomic Location for GPR85 Gene

113,078,331 bp from pter
113,087,778 bp from pter
9,448 bases
Minus strand

Genomic View for GPR85 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR85 Gene

Proteins for GPR85 Gene

  • Protein details for GPR85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 85
    Protein Accession:
    Secondary Accessions:
    • Q9JHI6
    • Q9NPD1

    Protein attributes for GPR85 Gene

    370 amino acids
    Molecular mass:
    41995 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR85 Gene

Proteomics data for GPR85 Gene at MOPED

Post-translational modifications for GPR85 Gene

  • Glycosylation at Asn3, Asn83, and Asn182
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR85

No data available for DME Specific Peptides for GPR85 Gene

Domains for GPR85 Gene

Gene Families for GPR85 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for GPR85 Gene


Graphical View of Domain Structure for InterPro Entry



  • P60893
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR85: view

Function for GPR85 Gene

Molecular function for GPR85 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10833454
genes like me logo Genes that share ontologies with GPR85: view

Phenotypes for GPR85 Gene

genes like me logo Genes that share phenotypes with GPR85: view

Animal Models for GPR85 Gene

MGI Knock Outs for GPR85:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR85

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GPR85 Gene

Localization for GPR85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR85 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR85 Gene COMPARTMENTS Subcellular localization image for GPR85 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR85: view

Pathways for GPR85 Gene

SuperPathways for GPR85 Gene

genes like me logo Genes that share pathways with GPR85: view

Pathways by source for GPR85 Gene

1 BioSystems pathway for GPR85 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR85 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000297146 for GPR85 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR85: view

Transcripts for GPR85 Gene

Unigene Clusters for GPR85 Gene

G protein-coupled receptor 85:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR85

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -

Relevant External Links for GPR85 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR85 Gene

mRNA expression in normal human tissues for GPR85 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR85 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (5.0), Brain - Caudate (basal ganglia) (4.8), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR85 Gene

SOURCE GeneReport for Unigene cluster for GPR85 Gene Hs.152009

mRNA Expression by UniProt/SwissProt for GPR85 Gene

Tissue specificity: Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.
genes like me logo Genes that share expressions with GPR85: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for GPR85 Gene

Orthologs for GPR85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR85 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR85 35
  • 97.48 (n)
  • 99.73 (a)
GPR85 36
  • 100 (a)
(Canis familiaris)
Mammalia GPR85 35
  • 97.21 (n)
  • 100 (a)
GPR85 36
  • 100 (a)
(Mus musculus)
Mammalia Gpr85 35
  • 94.95 (n)
  • 100 (a)
Gpr85 16
Gpr85 36
  • 100 (a)
(Pan troglodytes)
Mammalia GPR85 35
  • 99.64 (n)
  • 100 (a)
GPR85 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr85 35
  • 95.59 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia GPR85 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia GPR85 36
  • 94 (a)
(Gallus gallus)
Aves GPR85 35
  • 91.17 (n)
  • 99.73 (a)
GPR85 36
  • 100 (a)
(Anolis carolinensis)
Reptilia GPR85 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr85 35
  • 87.39 (n)
  • 98.92 (a)
(Danio rerio)
Actinopterygii gpr85 35
  • 77.66 (n)
  • 94.05 (a)
sreb2 35
gpr85 36
  • 92 (a)
Species with no ortholog for GPR85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR85 Gene

Gene Tree for GPR85 (if available)
Gene Tree for GPR85 (if available)

Paralogs for GPR85 Gene

Paralogs for GPR85 Gene

Selected SIMAP similar genes for GPR85 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR85: view

Variants for GPR85 Gene

Sequence variations from dbSNP and Humsavar for GPR85 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs870266 -- 113,083,466(-) TGCAA(A/T)AGTTC utr-variant-3-prime
rs1056588 -- 113,086,060(-) GAGGA(A/G)TATCA utr-variant-5-prime, intron-variant
rs1575012 -- 113,084,740(+) ATAAG(G/T)ATACA utr-variant-5-prime
rs1575013 -- 113,088,855(+) GCTTA(A/G)TTGGT upstream-variant-2KB
rs1581688 -- 113,083,038(+) CAATA(C/T)ACTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR85 Gene

Variant ID Type Subtype PubMed ID
nsv464689 CNV Gain 19166990
nsv7405 OTHER Inversion 18451855
dgv2130e1 CNV Complex 17122850
nsv435847 CNV Deletion 17901297
dgv7463n71 CNV Loss 21882294
nsv5907 CNV Insertion 18451855

Relevant External Links for GPR85 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR85 Gene

Disorders for GPR85 Gene

Relevant External Links for GPR85

Genetic Association Database (GAD)

No disorders were found for GPR85 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GPR85 Gene

Publications for GPR85 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. (PMID: 10978537) Hellebrand S. … Wittenberger T. (Biochim. Biophys. Acta 2000) 2 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48
  5. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M. … Kleinman J.E. (Brain Res. Mol. Brain Res. 2005) 3 23

Products for GPR85 Gene

Sources for GPR85 Gene

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