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Aliases for GPR173 Gene

Aliases for GPR173 Gene

  • G Protein-Coupled Receptor 173 2 3
  • SREB3 3 4 6
  • Super Conserved Receptor Expressed In Brain 3 3 4
  • Probable G-Protein Coupled Receptor 173 3
  • G-Protein Coupled Receptor 173 2
  • G Protein Coupled Receptor 173 2

External Ids for GPR173 Gene

Previous GeneCards Identifiers for GPR173 Gene

  • GC0XP052961
  • GC0XP053095
  • GC0XP050140

Summaries for GPR173 Gene

Entrez Gene Summary for GPR173 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]

GeneCards Summary for GPR173 Gene

GPR173 (G Protein-Coupled Receptor 173) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR85.

UniProtKB/Swiss-Prot for GPR173 Gene

  • Orphan receptor

Gene Wiki entry for GPR173 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR173 Gene

Genomics for GPR173 Gene

Regulatory Elements for GPR173 Gene

Genomic Location for GPR173 Gene

Start:
53,049,091 bp from pter
End:
53,080,615 bp from pter
Size:
31,525 bases
Orientation:
Plus strand

Genomic View for GPR173 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR173 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR173 Gene

Proteins for GPR173 Gene

  • Protein details for GPR173 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS66-GP173_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 173
    Protein Accession:
    Q9NS66
    Secondary Accessions:
    • B1B0A5

    Protein attributes for GPR173 Gene

    Size:
    373 amino acids
    Molecular mass:
    41481 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR173 Gene

Proteomics data for GPR173 Gene at MOPED

Post-translational modifications for GPR173 Gene

  • Glycosylation at Asn3 and Asn184
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR173 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR173 Gene

Domains for GPR173 Gene

Gene Families for GPR173 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR173 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR173 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS66

UniProtKB/Swiss-Prot:

GP173_HUMAN :
  • Q9NS66
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR173: view

Function for GPR173 Gene

Molecular function for GPR173 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor

Gene Ontology (GO) - Molecular Function for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10833454
GO:0004968 gonadotropin-releasing hormone receptor activity IEA --
genes like me logo Genes that share ontologies with GPR173: view

Phenotypes for GPR173 Gene

GenomeRNAi human phenotypes for GPR173:
genes like me logo Genes that share phenotypes with GPR173: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GPR173 Gene

Localization for GPR173 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR173 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR173 Gene COMPARTMENTS Subcellular localization image for GPR173 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR173: view

Pathways for GPR173 Gene

SuperPathways for GPR173 Gene

genes like me logo Genes that share pathways with GPR173: view

Pathways by source for GPR173 Gene

1 BioSystems pathway for GPR173 Gene

Interacting Proteins for GPR173 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331600%0d%0a9606.ENSP00000349238%0d%0a9606.ENSP00000386444%0d%0a
Selected Interacting proteins: ENSP00000331600 for GPR173 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0097211 cellular response to gonadotropin-releasing hormone IEA --
GO:2001223 negative regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with GPR173: view

Transcripts for GPR173 Gene

mRNA/cDNA for GPR173 Gene

(22) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR173 Gene

G protein-coupled receptor 173:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR173 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for GPR173 Gene

GeneLoc Exon Structure for
GPR173
ECgene alternative splicing isoforms for
GPR173

Expression for GPR173 Gene

mRNA expression in normal human tissues for GPR173 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for GPR173 Gene Hs.193011

mRNA Expression by UniProt/SwissProt for GPR173 Gene

Q9NS66-GP173_HUMAN
Tissue specificity: Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex
genes like me logo Genes that share expressions with GPR173: view

No data available for mRNA differential expression in normal tissues and Protein expression for GPR173 Gene

Orthologs for GPR173 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR173 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR173 35
  • 98.75 (n)
  • 97.84 (a)
GPR173 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR173 35
  • 95.08 (n)
  • 99.46 (a)
GPR173 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR173 35
  • 94.82 (n)
  • 99.73 (a)
GPR173 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr173 35
  • 94.64 (n)
  • 99.46 (a)
Gpr173 16
Gpr173 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR173 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr173 35
  • 94.64 (n)
  • 99.46 (a)
chicken
(Gallus gallus)
Aves GPR27 35
  • 73.94 (n)
  • 72.52 (a)
lizard
(Anolis carolinensis)
Reptilia GPR173 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr173 35
  • 74.12 (n)
  • 82.48 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr173 35
  • 74.41 (n)
  • 81.08 (a)
gpr173 36
  • 78 (a)
OneToOne
Species with no ortholog for GPR173:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR173 Gene

ENSEMBL:
Gene Tree for GPR173 (if available)
TreeFam:
Gene Tree for GPR173 (if available)

Paralogs for GPR173 Gene

Paralogs for GPR173 Gene

Selected SIMAP similar genes for GPR173 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR173: view

Variants for GPR173 Gene

Sequence variations from dbSNP and Humsavar for GPR173 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6650047 -- 53,064,350(+) gattg(C/T)ttgag intron-variant
rs6650052 -- 53,062,608(+) taagg(G/T)ctccc intron-variant
rs6650053 -- 53,062,727(+) ttgta(A/G)agatg intron-variant
rs6650054 -- 53,062,729(+) gtaga(A/G)atggg intron-variant
rs7049463 -- 53,067,622(+) agatc(A/G)agacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR173 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv508773 CNV Insertion 20534489
esv24544 CNV Gain 19812545
esv1009949 CNV Insertion 20482838

Relevant External Links for GPR173 Gene

HapMap Linkage Disequilibrium report
GPR173
Locus Specific Mutation Databases (LSDB)
GPR173

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR173 Gene

Disorders for GPR173 Gene

No disorders were found for GPR173 Gene.

No data available for UniProtKB/Swiss-Prot for GPR173 Gene

Publications for GPR173 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M. … Furuichi K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 3
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for GPR173 Gene

Sources for GPR173 Gene

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