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Aliases for POLR2C Gene

Aliases for POLR2C Gene

  • Polymerase (RNA) II Subunit C 2 3
  • RNA Polymerase II Subunit 3 2 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa 3 5
  • DNA-Directed RNA Polymerase II 33 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit C 3 4
  • RNA Polymerase II Subunit B3 3 4
  • RPB31 3 4
  • RPB33 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide C (33kD) 2
  • HRPB33 3
  • HsRPB3 3
  • RPB3 3

External Ids for POLR2C Gene

Previous GeneCards Identifiers for POLR2C Gene

  • GC16P047891
  • GC16P057556
  • GC16P057230
  • GC16P057271
  • GC16P056054
  • GC16P057496
  • GC16P043364

Summaries for POLR2C Gene

Entrez Gene Summary for POLR2C Gene

  • This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2C Gene

POLR2C (Polymerase (RNA) II Subunit C) is a Protein Coding gene. Diseases associated with POLR2C include Hiv-1. Among its related pathways are mRNA Splicing - Major Pathway and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include protein dimerization activity and RNA polymerase II activity.

UniProtKB/Swiss-Prot for POLR2C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).

Gene Wiki entry for POLR2C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2C Gene

Genomics for POLR2C Gene

Regulatory Elements for POLR2C Gene

Enhancers for POLR2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLR2C on UCSC Golden Path with GeneCards custom track

Promoters for POLR2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLR2C on UCSC Golden Path with GeneCards custom track

Genomic Location for POLR2C Gene

Chromosome:
16
Start:
57,462,287 bp from pter
End:
57,472,010 bp from pter
Size:
9,724 bases
Orientation:
Plus strand

Genomic View for POLR2C Gene

Genes around POLR2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2C Gene

Proteins for POLR2C Gene

  • Protein details for POLR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19387-RPB3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB3
    Protein Accession:
    P19387
    Secondary Accessions:
    • O15161

    Protein attributes for POLR2C Gene

    Size:
    275 amino acids
    Molecular mass:
    31441 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB11/POLR2J and RPB3/POLR2C subunits interact with each other.

neXtProt entry for POLR2C Gene

Proteomics data for POLR2C Gene at MOPED

Post-translational modifications for POLR2C Gene

  • Ubiquitination at Lys 20, Lys 81, Lys 175, Lys 225, and Lys 255
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2C Gene

Domains & Families for POLR2C Gene

Gene Families for POLR2C Gene

Graphical View of Domain Structure for InterPro Entry

P19387

UniProtKB/Swiss-Prot:

RPB3_HUMAN :
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2C: view

Function for POLR2C Gene

Molecular function for POLR2C Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide C (33kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).

Gene Ontology (GO) - Molecular Function for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2C: view
genes like me logo Genes that share phenotypes with POLR2C: view

Animal Model Products

miRNA for POLR2C Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2C Gene

Localization for POLR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2C Gene COMPARTMENTS Subcellular localization image for POLR2C gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for POLR2C Gene

Pathways & Interactions for POLR2C Gene

SuperPathways for POLR2C Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 Assembly of RNA Polymerase-II Initiation Complex
5 Signaling by FGFR2 in disease
genes like me logo Genes that share pathways with POLR2C: view

Gene Ontology (GO) - Biological Process for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with POLR2C: view

No data available for SIGNOR curated interactions for POLR2C Gene

Drugs & Compounds for POLR2C Gene

(5) Drugs for POLR2C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with POLR2C: view

Transcripts for POLR2C Gene

Unigene Clusters for POLR2C Gene

Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2C Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for POLR2C Gene

GeneLoc Exon Structure for
POLR2C
ECgene alternative splicing isoforms for
POLR2C

Expression for POLR2C Gene

mRNA expression in normal human tissues for POLR2C Gene

Protein differential expression in normal tissues from HIPED for POLR2C Gene

This gene is overexpressed in Pancreas (13.3) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR2C Gene



SOURCE GeneReport for Unigene cluster for POLR2C Gene Hs.79402

genes like me logo Genes that share expression patterns with POLR2C: view

Protein tissue co-expression partners for POLR2C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2C Gene

Orthologs for POLR2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2C 35
  • 92.24 (n)
  • 99.64 (a)
POLR2C 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2C 35
  • 92.85 (n)
  • 99.64 (a)
POLR2C 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2c 35
  • 91.03 (n)
  • 99.27 (a)
Polr2c 16
Polr2c 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2C 35
  • 99.03 (n)
  • 100 (a)
POLR2C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2c 35
  • 91.76 (n)
  • 99.27 (a)
oppossum
(Monodelphis domestica)
Mammalia POLR2C 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2C 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLR2C 35
  • 84 (n)
  • 96.36 (a)
POLR2C 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2C 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76329 35
polr2c 35
  • 79.64 (n)
  • 94.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16883 35
zebrafish
(Danio rerio)
Actinopterygii polr2c 35
  • 78.42 (n)
  • 89.82 (a)
wufk48d01 35
polr2c 36
  • 90 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5536 35
fruit fly
(Drosophila melanogaster)
Insecta RpII33 37
  • 69 (a)
RpII33 35
  • 68.73 (n)
  • 69.34 (a)
RpII33 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010321 35
  • 64.46 (n)
  • 70.59 (a)
worm
(Caenorhabditis elegans)
Secernentea C36B1.3 37
  • 56 (a)
rpb-3 35
  • 57.74 (n)
  • 57.99 (a)
rpb-3 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL120C 35
  • 55 (n)
  • 48.08 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16170g 35
  • 53.05 (n)
  • 49.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB3 35
  • 51.92 (n)
  • 47.31 (a)
RPB3 36
  • 38 (a)
OneToOne
RPB3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB3 35
  • 50.6 (n)
  • 49.4 (a)
soybean
(Glycine max)
eudicotyledons Gma.10273 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1797 35
barley
(Hordeum vulgare)
Liliopsida Hv.9186 35
rice
(Oryza sativa)
Liliopsida Os.5510 35
Os09g0110400 35
  • 56.7 (n)
  • 47.51 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.10459 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5647 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01515 35
  • 56.08 (n)
  • 49.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb3 35
  • 51.67 (n)
  • 47.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4193 36
  • 68 (a)
OneToOne
Species with no ortholog for POLR2C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2C Gene

ENSEMBL:
Gene Tree for POLR2C (if available)
TreeFam:
Gene Tree for POLR2C (if available)

Paralogs for POLR2C Gene

Pseudogenes.org Pseudogenes for POLR2C Gene

genes like me logo Genes that share paralogs with POLR2C: view

No data available for Paralogs for POLR2C Gene

Variants for POLR2C Gene

Sequence variations from dbSNP and Humsavar for POLR2C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4937 -- 57,465,990(+) TCAGT(C/T)CTTCA reference, synonymous-codon
rs170365 -- 57,469,448(+) GATTC(C/T)TCTTG intron-variant
rs178601 -- 57,462,582(+) TCGGC(A/G)GTTCT upstream-variant-2KB, utr-variant-5-prime
rs223837 -- 57,463,019(+) CTTTT(C/G)ATCTT intron-variant
rs223838 -- 57,464,973(+) GTCTT(C/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2C Gene

Variant ID Type Subtype PubMed ID
nsv906724 CNV Loss 21882294
nsv833245 CNV Loss 17160897
esv2676266 CNV Deletion 23128226
nsv906725 CNV Loss 21882294

Variation tolerance for POLR2C Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POLR2C Gene

Disorders for POLR2C Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR2C Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2C

Genetic Association Database (GAD)
POLR2C
Human Genome Epidemiology (HuGE) Navigator
POLR2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2C
genes like me logo Genes that share disorders with POLR2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2C Gene

Publications for POLR2C Gene

  1. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S. … Benhamou S. (Carcinogenesis 2009) 3 48 67
  2. RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. (PMID: 16141233) Corbi N. … Passananti C. (J. Cell. Sci. 2005) 3 23
  3. The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. (PMID: 12207009) Corbi N. … Passananti C. (FASEB J. 2002) 3 23
  4. Chromosomal localization of human RNA polymerase II subunit genes. (PMID: 8034326) Acker J. … Kedinger C. (Genomics 1994) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for POLR2C Gene

Sources for POLR2C Gene

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