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Aliases for POLR2A Gene

Aliases for POLR2A Gene

  • RNA Polymerase II Subunit A 2 3 5
  • RNA Polymerase II Subunit B1 2 3 4
  • DNA-Directed RNA Polymerase II Largest Subunit, RNA Polymerase II 220 Kd Subunit 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa 2 3
  • DNA-Directed RNA Polymerase III Largest Subunit 3 4
  • RNA-Directed RNA Polymerase II Subunit RPB1 3 4
  • DNA-Directed RNA Polymerase II Subunit A 3 4
  • EC 2.7.7.6 4 61
  • POLR2 3 4
  • DNA-Directed RNA Polymerase II Subunit RPB1 3
  • Polymerase (RNA) II Subunit A 3
  • EC 2.7.7.48 4
  • HRPB220 3
  • RpIILS 3
  • HsRPB1 3
  • POLRA 3
  • RPBh1 3
  • RPOL2 3
  • RPB1 3
  • RPO2 3

External Ids for POLR2A Gene

Previous HGNC Symbols for POLR2A Gene

  • POLR2

Previous GeneCards Identifiers for POLR2A Gene

  • GC17M007800
  • GC17P008117
  • GC17P007330
  • GC17P007588
  • GC17P007329
  • GC17P007387
  • GC17P007491
  • GC17P007493
  • GC17P007499
  • GC17P007515
  • GC17P007626

Summaries for POLR2A Gene

Entrez Gene Summary for POLR2A Gene

  • This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2A Gene

POLR2A (RNA Polymerase II Subunit A) is a Protein Coding gene. Diseases associated with POLR2A include La Crosse Encephalitis and Uv-Sensitive Syndrome. Among its related pathways are HIV Life Cycle and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and DNA-directed 5-3 RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR2A Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.

Gene Wiki entry for POLR2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2A Gene

Genomics for POLR2A Gene

Regulatory Elements for POLR2A Gene

Enhancers for POLR2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007833 1.9 FANTOM5 ENCODE dbSUPER 14.8 +355.4 355364 12.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 DVL2 PFAS CTC1 NLGN2 SNORD10 PER1 SNORA48 KDM6B RPL26 VAMP2
GH17G007474 1.8 FANTOM5 ENCODE dbSUPER 6.1 -3.8 -3777 12.5 CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 CHRNB1 SNORD10 PFAS SNORA48 KCTD11 NEURL4 CTC1 CD68 FGF11
GH17G007461 0.4 ENCODE 13.2 -22.9 -22920 0.2 ZNF341 PRDM10 POLR2A ZBTB4 FGF11 TMEM102 C17orf74 SPEM1 TNFSF12-TNFSF13 TNFSF12 NLGN2 TMEM256
GH17G007045 1.6 FANTOM5 Ensembl ENCODE 2.9 -437.7 -437746 2.5 HNRNPUL1 PKNOX1 ATF1 MLX ARID4B ZNF143 SP5 JUNB REST PPARG ACAP1 KIAA0753 POLR2A MED31 ZBTB4 SLC16A11 ENSG00000262067
GH17G007130 2 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -352.2 -352155 4.0 HDGF PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68 GABARAP SAT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around POLR2A on UCSC Golden Path with GeneCards custom track

Promoters for POLR2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090867 334 2601 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for POLR2A Gene

Chromosome:
17
Start:
7,484,366 bp from pter
End:
7,514,618 bp from pter
Size:
30,253 bases
Orientation:
Plus strand

Genomic View for POLR2A Gene

Genes around POLR2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2A Gene

Proteins for POLR2A Gene

  • Protein details for POLR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24928-RPB1_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB1
    Protein Accession:
    P24928
    Secondary Accessions:
    • A6NN93
    • B9EH88
    • Q6NX41

    Protein attributes for POLR2A Gene

    Size:
    1970 amino acids
    Molecular mass:
    217176 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active). Interacts (via the C-terminal domain (CTD)) with U2AF2; recruits PRPF19 and the Prp19 complex to the pre-mRNA and may couple transcription to pre-mRNA splicing. Interacts (via the C-terminal domain (CTD)) with SMN1/SMN2; recruits SMN1/SMN2 to RNA Pol II elongation complexes. Interacts via the phosphorylated C-terminal domain with WDR82 and with SETD1A and SETD1B only in the presence of WDR82. When phosphorylated at Ser-5, interacts with MEN1; the unphosphorylated form, or phosphorylated at Ser-2 does not interact. When phosphorylated at Ser-2, interacts with SUPT6H (via SH2 domain). Interacts with RECQL5 and TCEA1; binding of RECQL5 prevents TCEA1 binding. The phosphorylated C-terminal domain interacts with FNBP3 and SYNCRIP. Interacts with ATF7IP. Interacts with DDX5. Interacts with WWP2. Interacts with SETX. Interacts (phosphorylated) with PIH1D1. Interacts (via the C-terminal domain (CTD)) with TDRD3. Interacts with PRMT5. Interacts with XRN2. Interacts with SAFB/SAFB1. Interacts with CCNL1. Interacts with CCNL2, MYO1C, PAF1 and SFRS19. Interacts (via C-terminus) with CMTR1, CTDSP1 and SCAF8. Interacts (via the C-terminal domain (CTD)) with CCNT2 (PubMed:15563843).
    • (Microbial infection) Interacts with herpes simplex virus 1 protein ICP22; this interaction causes loss of CTD Ser-2 phosphorylation from pol II engaged in transcription (PubMed:23029222).
    Miscellaneous:
    • The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.

    Three dimensional structures from OCA and Proteopedia for POLR2A Gene

    Alternative splice isoforms for POLR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR2A Gene

Selected DME Specific Peptides for POLR2A Gene

P24928:
  • TFHYAGV
  • RGNLMGKRVD
  • GREGLIDTA
  • ETGYIQRRL
  • TQMTLNTFH
  • GKRVDFS
  • GYKVERH
  • EFFFHAM
  • CPGHFGH
  • SPSYSPSSP
  • LAKPVFH
  • FSARTVI
  • RLKGKEGR
  • GFVENSYL
  • CSFEETV
  • LQFHVAT
  • DFDGDEMN
  • KNVTLGVPRL
  • TSPKYSPTSP
  • NADFDGD
  • YSPTSPNY
  • GSYVNYRH
  • VGALAAQS

Post-translational modifications for POLR2A Gene

  • Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue Ser-7 being replaced by a lysine. Lys-7 in these non-consensus heptapeptide repeats can be alternatively acetylated, methylated and dimethylated. EP300 is one of the enzyme able to acetylate Lys-7. Acetylation at Lys-7 of non-consensus heptapeptide repeats is associated with Ser-2 phosphorylation and active transcription. It may regulate initiation or early elongation steps of transcription specially for inducible genes.
  • Methylated at Arg-1810 prior to transcription initiation when the CTD is hypophosphorylated, phosphorylation at Ser-1805 and Ser-1808 preventing this methylation. Symmetrically or asymmetrically dimethylated at Arg-1810 by PRMT5 and CARM1 respectively. Symmetric or asymmetric dimethylation modulates interactions with CTD-binding proteins like SMN1/SMN2 and TDRD3. SMN1/SMN2 interacts preferentially with the symmetrically dimethylated form while TDRD3 interacts with the asymmetric form. Through the recruitment of SMN1/SMN2, symmetric dimethylation is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. CTD dimethylation may also facilitate the expression of select RNAs. Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue Ser-7 being replaced by a lysine. Lys-7 in these non-consensus heptapeptide repeats can be alternatively acetylated, methylated and dimethylated. Methylation occurs in the earliest transcription stages and precedes or is concomitant to Ser-5 and Ser-7 phosphorylation.
  • The tandem heptapeptide repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues Ser-2 and Ser-5 of the heptapeptide repeat and is mediated, at least, by CDK7 and CDK9. CDK7 phosphorylation of POLR2A associated with DNA promotes transcription initiation by triggering dissociation from DNA. Phosphorylation also takes place at Ser-7 of the heptapeptide repeat, which is required for efficient transcription of snRNA genes and processing of the transcripts. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatases, and a CTD code that specifies the position of Pol II within the transcription cycle has been proposed. Dephosphorylated by the protein phosphatase CTDSP1.
  • Ubiquitinated by WWP2 leading to proteasomal degradation (By similarity). Following UV treatment, the elongating form of RNA polymerase II (RNA pol IIo) is ubiquitinated UV damage sites without leading to degradation: ubiquitination is facilitated by KIAA1530/UVSSA and promotes RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery.
  • Ubiquitination at posLast=4242, posLast=163163, posLast=213213, Lys279, Lys285, Lys619, Lys707, Lys710, posLast=758758, Lys767, posLast=796796, posLast=803803, Lys812, posLast=853853, posLast=866866, posLast=910910, Lys940, Lys976, Lys992, Lys1008, Lys1019, posLast=11251125, Lys1225, posLast=12681268, Lys1319, and Lys1350
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for POLR2A Gene

Gene Families for POLR2A Gene

Suggested Antigen Peptide Sequences for POLR2A Gene

Graphical View of Domain Structure for InterPro Entry

P24928

UniProtKB/Swiss-Prot:

RPB1_HUMAN :
  • The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
  • Belongs to the RNA polymerase beta chain family.
Domain:
  • The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR2A: view

Function for POLR2A Gene

Molecular function for POLR2A Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) large polypeptide A (220kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.

Enzyme Numbers (IUBMB) for POLR2A Gene

Gene Ontology (GO) - Molecular Function for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IEA --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding NAS,TAS 7622068
GO:0003723 RNA binding IDA 22658674
GO:0003899 DNA-directed 5-3 RNA polymerase activity TAS,NAS 7622068
genes like me logo Genes that share ontologies with POLR2A: view
genes like me logo Genes that share phenotypes with POLR2A: view

Animal Models for POLR2A Gene

MGI Knock Outs for POLR2A:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLR2A Gene

Localization for POLR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2A gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 colocalizes_with Prp19 complex IDA 21536736
GO:0005634 nucleus NAS 7622068
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005719 nuclear euchromatin IEA --
genes like me logo Genes that share ontologies with POLR2A: view

Pathways & Interactions for POLR2A Gene

SuperPathways for POLR2A Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Capping
4 HIV Life Cycle
.45
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2A: view

SIGNOR curated interactions for POLR2A Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001172 transcription, RNA-templated IEA --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA,TAS --
GO:0006353 DNA-templated transcription, termination IMP 26700805
genes like me logo Genes that share ontologies with POLR2A: view

Drugs & Compounds for POLR2A Gene

(10) Drugs for POLR2A Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma 1117
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for POLR2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2

(4) ApexBio Compounds for POLR2A Gene

Compound Action Cas Number
Actinomycin D RNA polymerase inhibitor 50-76-0
Cytarabine 147-94-4
PSI-6206 Inhibitor of HCV RNA polymerase,potent and selective 863329-66-2
PSI-7977 Antiviral agents for chronic HCV infection 1190307-88-0
genes like me logo Genes that share compounds with POLR2A: view

Drug Products

Transcripts for POLR2A Gene

Unigene Clusters for POLR2A Gene

Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2A Gene

No ASD Table

Relevant External Links for POLR2A Gene

GeneLoc Exon Structure for
POLR2A
ECgene alternative splicing isoforms for
POLR2A

Expression for POLR2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2A Gene

Protein differential expression in normal tissues from HIPED for POLR2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Lymph node (11.9), and Nasal epithelium (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2A Gene



Protein tissue co-expression partners for POLR2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2A Gene:

POLR2A

SOURCE GeneReport for Unigene cluster for POLR2A Gene:

Hs.270017

Evidence on tissue expression from TISSUES for POLR2A Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Pancreas(4.3)
  • Lung(3.8)
  • Intestine(3.6)
  • Skin(2.9)
  • Blood(2.7)
  • Eye(2.6)
  • Heart(2.5)
  • Kidney(2.5)
  • Spleen(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with POLR2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2A Gene

Orthologs for POLR2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2A Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2A 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2A 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2A 34 35
  • 97.22 (n)
cow
(Bos Taurus)
Mammalia POLR2A 34 35
  • 91.54 (n)
dog
(Canis familiaris)
Mammalia POLR2A 34 35
  • 90.58 (n)
mouse
(Mus musculus)
Mammalia Polr2a 34 16 35
  • 90.17 (n)
rat
(Rattus norvegicus)
Mammalia Polr2a 34
  • 89.61 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2A 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2a 34
  • 80.38 (n)
Str.17483 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7189 34
zebrafish
(Danio rerio)
Actinopterygii polr2a 34 35
  • 79.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007810 34
  • 68.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpII215 36 34 35
  • 68.29 (n)
worm
(Caenorhabditis elegans)
Secernentea ama-1 36 34 35
  • 63.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR086C 34
  • 55.8 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05071g 34
  • 54.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPO21 34
  • 53.25 (n)
RPO31 35
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB1 34
  • 58.53 (n)
rice
(Oryza sativa)
Liliopsida Os05g0151000 34
  • 58.67 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.5170 34
corn
(Zea mays)
Liliopsida Zm.4606 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02103 34
  • 56.65 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb1 34
  • 55.65 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2262 34
Species where no ortholog for POLR2A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2A Gene

ENSEMBL:
Gene Tree for POLR2A (if available)
TreeFam:
Gene Tree for POLR2A (if available)

Paralogs for POLR2A Gene

(2) SIMAP similar genes for POLR2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with POLR2A: view

No data available for Paralogs for POLR2A Gene

Variants for POLR2A Gene

Sequence variations from dbSNP and Humsavar for POLR2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000137218 -- 7,514,821(+) GTCCT(A/C)TATTA downstream-variant-500B
rs1000219256 -- 7,511,779(+) TCCTG(A/G)CCCTC intron-variant
rs1000332341 -- 7,507,453(+) GAGTT(G/T)GAGAC intron-variant
rs1000364604 -- 7,492,880(+) TCATG(A/T)TTCTC intron-variant
rs1000460840 -- 7,484,368(+) GCTGC(C/T)CAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for POLR2A Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2677329 CNV deletion 23128226
esv3639871 CNV loss 21293372
nsv1127534 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv523672 CNV loss 19592680
nsv574322 CNV loss 21841781

Variation tolerance for POLR2A Gene

Residual Variation Intolerance Score: 0.114% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2A Gene

Human Gene Mutation Database (HGMD)
POLR2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2A Gene

Disorders for POLR2A Gene

MalaCards: The human disease database

(5) MalaCards diseases for POLR2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
la crosse encephalitis
  • california encephalitis
uv-sensitive syndrome
  • uv sensitive syndrome
subcutaneous mycosis
  • subcutaneous fungal disease
herpes simplex
  • herpesvirus hominis disease
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POLR2A

Genetic Association Database (GAD)
POLR2A
Human Genome Epidemiology (HuGE) Navigator
POLR2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2A
genes like me logo Genes that share disorders with POLR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2A Gene

Publications for POLR2A Gene

  1. The human gene encoding the largest subunit of RNA polymerase II. (PMID: 7622068) Mita K. … Hayashi A. (Gene 1995) 3 4 22 64
  2. SMN and symmetric arginine dimethylation of RNA polymerase II C- terminal domain control termination. (PMID: 26700805) Yanling Zhao D. … Greenblatt J.F. (Nature 2015) 3 4 64
  3. Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5. (PMID: 23748380) Kassube S.A. … Nogales E. (Nat. Struct. Mol. Biol. 2013) 3 4 64
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 3 4 64
  5. The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. (PMID: 21536736) David C.J. … Manley J.L. (Genes Dev. 2011) 3 4 64

Products for POLR2A Gene

Sources for POLR2A Gene