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Aliases for POLR2A Gene

Aliases for POLR2A Gene

  • Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa 2 3
  • RNA Polymerase II Subunit B1 2 3 4
  • DNA-Directed RNA Polymerase III Largest Subunit 3 4
  • RNA-Directed RNA Polymerase II Subunit RPB1 3 4
  • DNA-Directed RNA Polymerase II Subunit A 3 4
  • EC 2.7.7.6 4 63
  • POLR2 3 4
  • DNA-Directed RNA Polymerase II Largest Subunit, RNA Polymerase II 220 Kd Subunit 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide A (220kD) 2
  • DNA-Directed RNA Polymerase II Largest Subunit 2
  • RNA Polymerase II 220 Kd Subunit 2
  • EC 2.7.7.48 4
  • HRPB220 3
  • RpIILS 3
  • HsRPB1 3
  • POLRA 3
  • RPBh1 3
  • RPOL2 3
  • RPB1 3
  • RPO2 3

External Ids for POLR2A Gene

Previous HGNC Symbols for POLR2A Gene

  • POLR2

Previous GeneCards Identifiers for POLR2A Gene

  • GC17M007800
  • GC17P008117
  • GC17P007330
  • GC17P007588
  • GC17P007329
  • GC17P007387
  • GC17P007491

Summaries for POLR2A Gene

Entrez Gene Summary for POLR2A Gene

  • This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2A Gene

POLR2A (Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa) is a Protein Coding gene. Diseases associated with POLR2A include la crosse encephalitis and subcutaneous mycosis. Among its related pathways are Developmental Biology and Infectious disease. GO annotations related to this gene include poly(A) RNA binding and DNA-directed RNA polymerase activity. An important paralog of this gene is POLR3A.

UniProtKB/Swiss-Prot for POLR2A Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.

Gene Wiki entry for POLR2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2A Gene

Genomics for POLR2A Gene

Regulatory Elements for POLR2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLR2A Gene

Chromosome:
17
Start:
7,484,366 bp from pter
End:
7,514,618 bp from pter
Size:
30,253 bases
Orientation:
Plus strand

Genomic View for POLR2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2A Gene

Proteins for POLR2A Gene

  • Protein details for POLR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24928-RPB1_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB1
    Protein Accession:
    P24928
    Secondary Accessions:
    • A6NN93
    • B9EH88
    • Q6NX41

    Protein attributes for POLR2A Gene

    Size:
    1970 amino acids
    Molecular mass:
    217176 Da
    Quaternary structure:
    • Interacts with SETX (PubMed:23149945). The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active). When phosphorylated at Ser-2, interacts with SUPT6H (via SH2 domain). Interacts with SCAF8. Interacts with MYO1C. Interacts with WWP2 (By similarity). Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. The phosphorylated C-terminal domain interacts with FNBP3 and SYNCRIP. Interacts with SAFB/SAFB1. Interacts with CCNL1. Interacts with CCNL2 and SFRS19. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with PAF1. Interacts (via C-terminus) with CMTR1 and CTDSP1. Interacts via the phosphorylated C-terminal domain with WDR82 and with SETD1A and SETD1B only in the presence of WDR82. Interacts with ATF7IP. When phosphorylated at Ser-5, interacts with MEN1; the unphosphorylated form, or phosphorylated at Ser-2 does not interact. Interacts with DDX5. Interacts with RECQL5 and TCEA1; binding of RECQL5 prevents TCEA1 binding. Interacts (via the C-terminal domain (CTD)) with U2AF2; recruits PRPF19 and the Prp19 complex to the pre-mRNA and may couple transcription to pre-mRNA splicing. Interacts with herpes simplex virus 1 protein ICP22; this interaction causes loss of CTD Ser-2 phosphorylation from pol II engaged in transcription (PubMed:23029222). Interacts (phosphorylated) with PIH1D1 (PubMed:24656813).
    Miscellaneous:
    • The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion

    Three dimensional structures from OCA and Proteopedia for POLR2A Gene

    Alternative splice isoforms for POLR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR2A Gene

Proteomics data for POLR2A Gene at MOPED

Post-translational modifications for POLR2A Gene

  • Methylated at Arg-1810 by CARM1. Methylation occurs only when the CTD is hypophosphorylated, and phosphorylation at Ser-1805 and Ser-1808 prevent methylation (in vitro). It is assumed that methylation occurs prior to phosphorylation and transcription initiation. CTD methylation may facilitate the expression of select RNAs.
  • The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues Ser-2 and Ser-5 of the heptapeptide repeat and is mediated, at least, by CDK7 and CDK9. CDK7 phosphorylation of POLR2A associated with DNA promotes transcription initiation by triggering dissociation from DNA. Phosphorylation also takes place at Ser-7 of the heptapeptide repeat, which is required for efficient transcription of snRNA genes and processing of the transcripts. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatases, and a CTD code that specifies the position of Pol II within the transcription cycle has been proposed. Dephosphorylated by the protein phosphatase CTDSP1
  • Ubiquitinated by WWP2 leading to proteasomal degradation (By similarity). Following UV treatment, the elongating form of RNA polymerase II (RNA pol IIo) is ubiquitinated UV damage sites without leading to degradation: ubiquitination is facilitated by KIAA1530/UVSSA and promotes RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery.
  • Ubiquitination at Lys 42, Lys 163, Lys 213, Lys 279, Lys 285, Lys 619, Lys 707, Lys 710, Lys 758, Lys 767, Lys 796, Lys 803, Lys 812, Lys 853, Lys 866, Lys 910, Lys 940, Lys 976, Lys 992, Lys 1008, Lys 1019, Lys 1125, Lys 1225, Lys 1268, Lys 1319, and Lys 1350
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for POLR2A (RNA Polymerase II/POLR2A)
  • Cell Signaling Technology (CST) Antibodies for POLR2A (POLR2A)

Domains & Families for POLR2A Gene

Gene Families for POLR2A Gene

Suggested Antigen Peptide Sequences for POLR2A Gene

Graphical View of Domain Structure for InterPro Entry

P24928

UniProtKB/Swiss-Prot:

RPB1_HUMAN :
  • The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
  • Belongs to the RNA polymerase beta chain family.
Domain:
  • The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR2A: view

Function for POLR2A Gene

Molecular function for POLR2A Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) large polypeptide A (220kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.

Enzyme Numbers (IUBMB) for POLR2A Gene

Gene Ontology (GO) - Molecular Function for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding --
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding NAS 7622068
GO:0003899 DNA-directed RNA polymerase activity NAS 7622068
GO:0003968 RNA-directed RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2A: view
genes like me logo Genes that share phenotypes with POLR2A: view

Animal Models for POLR2A Gene

MGI Knock Outs for POLR2A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2A

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for POLR2A Gene

Localization for POLR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR2A Gene COMPARTMENTS Subcellular localization image for POLR2A gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 colocalizes_with Prp19 complex IDA 21536736
GO:0005634 nucleus NAS 7622068
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005719 nuclear euchromatin --
genes like me logo Genes that share ontologies with POLR2A: view

Pathways & Interactions for POLR2A Gene

SuperPathways for POLR2A Gene

Superpath Contained pathways
1 Formation of the HIV-1 Early Elongation Complex
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Splicing - Major Pathway
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
genes like me logo Genes that share pathways with POLR2A: view

SIGNOR curated interactions for POLR2A Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001172 transcription, RNA-templated IEA --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with POLR2A: view

Drugs & Compounds for POLR2A Gene

(9) Drugs for POLR2A Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma 995
Adenosine triphosphate Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for POLR2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with POLR2A: view

Transcripts for POLR2A Gene

mRNA/cDNA for POLR2A Gene

Unigene Clusters for POLR2A Gene

Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2A Gene

No ASD Table

Relevant External Links for POLR2A Gene

GeneLoc Exon Structure for
POLR2A
ECgene alternative splicing isoforms for
POLR2A

Expression for POLR2A Gene

mRNA expression in normal human tissues for POLR2A Gene

Protein differential expression in normal tissues from HIPED for POLR2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Lymph node (11.9), and Nasal epithelium (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for POLR2A Gene



SOURCE GeneReport for Unigene cluster for POLR2A Gene Hs.270017

genes like me logo Genes that share expression patterns with POLR2A: view

Protein tissue co-expression partners for POLR2A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR2A Gene

Orthologs for POLR2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLR2A 35
  • 91.54 (n)
  • 99.95 (a)
POLR2A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2A 35
  • 90.58 (n)
  • 99.7 (a)
POLR2A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2a 35
  • 90.17 (n)
  • 99.94 (a)
Polr2a 16
Polr2a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2A 35
  • 97.22 (n)
  • 98.5 (a)
POLR2A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2a 35
  • 89.61 (n)
  • 99.9 (a)
oppossum
(Monodelphis domestica)
Mammalia POLR2A 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2A 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2A 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2a 35
  • 80.38 (n)
  • 95.52 (a)
Str.17483 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7189 35
zebrafish
(Danio rerio)
Actinopterygii polr2a 35
  • 79.96 (n)
  • 94.77 (a)
polr2a 36
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpII215 37
  • 76 (a)
RpII215 35
  • 68.29 (n)
  • 74.96 (a)
RpII215 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007810 35
  • 68.97 (n)
  • 76.22 (a)
worm
(Caenorhabditis elegans)
Secernentea ama-1 37
  • 69 (a)
ama-1 35
  • 63.27 (n)
  • 71.35 (a)
ama-1 36
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR086C 35
  • 55.8 (n)
  • 53.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05071g 35
  • 54.33 (n)
  • 53.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPO21 35
  • 53.25 (n)
  • 55.61 (a)
RPO31 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB1 35
  • 58.53 (n)
  • 60.73 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5170 35
rice
(Oryza sativa)
Liliopsida Os05g0151000 35
  • 58.67 (n)
  • 60.15 (a)
corn
(Zea mays)
Liliopsida Zm.4606 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2262 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02103 35
  • 56.65 (n)
  • 52.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb1 35
  • 55.65 (n)
  • 56.18 (a)
Species with no ortholog for POLR2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2A Gene

ENSEMBL:
Gene Tree for POLR2A (if available)
TreeFam:
Gene Tree for POLR2A (if available)

Paralogs for POLR2A Gene

Paralogs for POLR2A Gene

(2) SIMAP similar genes for POLR2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with POLR2A: view

Variants for POLR2A Gene

Sequence variations from dbSNP and Humsavar for POLR2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6761 -- 7,514,346(+) GCAGA(C/T)TCTTG utr-variant-3-prime
rs8753 -- 7,514,323(+) AACTT(C/T)TGGAT utr-variant-3-prime
rs9533 -- 7,514,234(+) GCTGC(C/T)GTGCA utr-variant-3-prime
rs25603 -- 7,498,017(+) CAGGG(-/CTCTGGGGTG)AGGGT intron-variant
rs1058385 -- 7,513,244(+) CCCAC(C/G/T)TCTCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for POLR2A Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv523672 CNV Loss 19592680
dgv3054n71 CNV Loss 21882294
esv2677329 CNV Deletion 23128226

Variation tolerance for POLR2A Gene

Residual Variation Intolerance Score: .11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLR2A Gene

HapMap Linkage Disequilibrium report
POLR2A
Human Gene Mutation Database (HGMD)
POLR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2A Gene

Disorders for POLR2A Gene

MalaCards: The human disease database

(4) MalaCards diseases for POLR2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
la crosse encephalitis
  • california encephalitis
subcutaneous mycosis
uv-sensitive syndrome
  • uv sensitive syndrome
hiv-1
  • aids, slow progression to
- elite association

Relevant External Links for POLR2A

Genetic Association Database (GAD)
POLR2A
Human Genome Epidemiology (HuGE) Navigator
POLR2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLR2A
genes like me logo Genes that share disorders with POLR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2A Gene

Publications for POLR2A Gene

  1. Species recognition and clinical relevance of the zygomycetous genus Lichtheimia (syn. Absidia pro parte, Mycocladus). (PMID: 20357218) Alastruey-Izquierdo A. … Walther G. (J. Clin. Microbiol. 2010) 23 67
  2. Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA. (PMID: 19808979) VispAc S. … Bailly C. (Mol. Cancer Ther. 2009) 23 67
  3. CpG-island promoters drive transcription of human telomeres. (PMID: 19850908) Nergadze S.G. … Azzalin C.M. (RNA 2009) 23 67
  4. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. (PMID: 18157120) Schoeftner S. … Blasco M.A. (Nat. Cell Biol. 2008) 23 67
  5. A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3' end RNA polyadenylation. (PMID: 18487515) Lian Z. … Weissman S.M. (Genome Res. 2008) 23 67

Products for POLR2A Gene

Sources for POLR2A Gene

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