Aliases for POLD1 Gene
Aliases for POLD1 Gene
External Ids for POLD1 Gene
- HGNC: 9175
- Entrez Gene: 5424
- Ensembl: ENSG00000062822
- OMIM: 174761
- UniProtKB: P28340
Previous HGNC Symbols for POLD1 Gene
- POLD
Previous GeneCards Identifiers for POLD1 Gene
- GC19P051516
- GC19P051248
- GC19P055563
- GC19P055580
- GC19P055581
- GC19P055582
- GC19P050889
- GC19P047225
Summaries for POLD1 Gene
-
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
GeneCards Summary for POLD1 Gene
POLD1 (Polymerase (DNA) Delta 1, Catalytic Subunit) is a Protein Coding gene. Diseases associated with POLD1 include Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome and Colorectal Cancer 10. Among its related pathways are HTLV-I infection and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include nucleic acid binding and chromatin binding.
UniProtKB/Swiss-Prot for POLD1 Gene
-
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3- to 5-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLD1 Gene
Genomics for POLD1 Gene
Regulatory Elements for POLD1 Gene
Enhancers for POLD1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around POLD1 on UCSC Golden Path with GeneCards custom track
Promoters for POLD1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around POLD1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the POLD1 gene promoter:
Regulatory Element Products
Genomic Location for POLD1 Gene
- Chromosome:
- 19
- Start:
- 50,384,204 bp from pter
- End:
- 50,418,018 bp from pter
- Size:
- 33,815 bases
- Orientation:
- Plus strand
Genomic View for POLD1 Gene
Genes around POLD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Ensembl
- 19q13.3 by Entrez Gene
- 19q13.3 by HGNC
POLD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POLD1 Gene
Proteins for POLD1 Gene
-
Protein details for POLD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28340-DPOD1_HUMAN
- Recommended name:
- DNA polymerase delta catalytic subunit
- Protein Accession:
- P28340
- Q8NER3
- Q96H98
Protein attributes for POLD1 Gene
- Size:
- 1107 amino acids
- Molecular mass:
- 123631 Da
- Cofactor:
- Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
- Quaternary structure:
-
- Interacts with PCNA (PubMed:16510448, PubMed:24939902). Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3-5 exonuclease activity. Interacts with WRNIP1 (PubMed:15670210). Interacts with POLD4 (PubMed:16510448).
- Miscellaneous:
-
- In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Protein Expression for POLD1 Gene
Selected DME Specific Peptides for POLD1 Gene
- P28340:
-
- LDFSSLYPS
- PLIFQQLE
- SIITDLQNG
- VGKLPCL
- LPLRLLERLMVLVN
- FPSPIRL
- RRRLAVYC
- YGDTDSVM
- GYYDVPIATLDF
- ELCSRESMFGYHGHGPSPFLRIT
- VLLRGDHTRCKTVLT
- TPTGDEFVK
- RLWTQCQ
- KKRYAGL
- SNIRDSSFQS
- KVGGLLAF
- FQQLEID
- KQAHVELA
- EMARVTG
- LISKKRY
- GLGTPSFAPYEANVDFEIRFMVD
- YCLKDAYLP
- LSFDIEC
- DIVGCNWLELPAGKY
- SMVGRVQMDMLQVLLRE
- ELAERMRKRD
- RDPGSAP
- VLDGRQLALK
- EDPLFVLE
- SLYPSIM
- DVICTSRDCPIFYMR
- YFPYLLI
- SVRKGLLPQILENLLSARKRAKAELA
- IDTQYYL
- NSVYGFTG
- LPCLEIS
- DLLCNRIDIS
- ISDLLCN
Post-translational modifications for POLD1 Gene
Other Protein References for POLD1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for POLD1
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- Invitrogen Antibodies for POLD1
- antibodies-online Antibodies for POLD1: See all 49
- GeneTex POLD1 antibody for POLD1
-
Santa Cruz Biotechnology (SCBT) Antibodies for POLD1
Protein Products
-
OriGene Purified Proteins for POLD1
- Search Origene for MassSpec and Protein Over-expression Lysates for POLD1
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- Search GeneTex for Proteins for POLD1
Domains & Families for POLD1 Gene
Gene Families for POLD1 Gene
Protein Domains for POLD1 Gene
Suggested Antigen Peptide Sequences for POLD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P28340UniProtKB/Swiss-Prot:
DPOD1_HUMAN :- The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
- Belongs to the DNA polymerase type-B family.
- Contains 1 CysA-type zinc finger.
- Domain:
-
- The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
- Family:
-
- Belongs to the DNA polymerase type-B family.
- Similarity:
-
- Contains 1 CysA-type zinc finger.
Function for POLD1 Gene
Molecular function for POLD1 Gene
- GENATLAS Biochemistry:
- polymerase (DNA directed),delta 1,catalytic subunit 125kDa,involved in DNA replication of nuclear genome,also possessing an intrinsic proofreading function that reduces the levels of errors during replication,deleted in sporadic colorectal cancers
- UniProtKB/Swiss-Prot CatalyticActivity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- UniProtKB/Swiss-Prot Function:
- Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3- to 5-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
Enzyme Numbers (IUBMB) for POLD1 Gene
- EC 2.7.7.7 63 4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA | 16762037 |
| GO:0005515 | protein binding | IPI | 12403614 |
| GO:0008408 | 3-5 exonuclease activity | IEA | -- |
Phenotypes for POLD1 Gene
- MGI mutant phenotypes for POLD1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for POLD1:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for POLD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POLD1 gene
- Search ViGene Biosciences for POLD1
CRISPR Products
-
OriGene CRISPR knockouts for POLD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLD1
- GenScript: Design CRISPR guide RNA sequences for POLD1
miRNA for POLD1 Gene
- miRTarBase miRNAs that target POLD1
miRNA Products
- Search ViGene Biosciences for POLD1
Clone Products
- OriGene clones in human for POLD1
- OriGene ORF clones in human,mouse,rat for POLD1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for POLD1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for POLD1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for POLD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POLD1 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for POLD1 Gene
Localization for POLD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POLD1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for POLD1 Gene
More details on SuperPathways for POLD1Pathways by source for POLD1 Gene
4 BioSystems pathways for POLD1 Gene
43 Reactome pathways for POLD1 Gene
9 KEGG pathways for POLD1 Gene
1 GeneGo (Thomson Reuters) pathway for POLD1 Gene
4 Qiagen pathways for POLD1 Gene
Interacting Proteins for POLD1 Gene
Selected Interacting proteins:
P28340-DPOD1_HUMAN
ENSP00000406046
for POLD1 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS | -- |
| GO:0000722 | telomere maintenance via recombination | TAS | -- |
| GO:0006260 | DNA replication | IEA,IMP | 16762037 |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | -- |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
No data available for SIGNOR curated interactions for POLD1 Gene
Drugs & Compounds for POLD1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| phosphoric acid |
|
7664-38-2 |
|
|||
| Thymidine 5'-triphosphate |
|
365-08-2 |
|
Transcripts for POLD1 Gene
mRNA/cDNA for POLD1 Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (214) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POLD1 Gene
- Polymerase (DNA directed), delta 1, catalytic subunit:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for POLD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLD1
- GenScript: Design CRISPR guide RNA sequences for POLD1
miRNA Products
- Search ViGene Biosciences for POLD1
Clone Products
- OriGene clones in human for POLD1
- OriGene ORF clones in human,mouse,rat for POLD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for POLD1
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | · | 24c | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | - |
Expression for POLD1 Gene
This gene is overexpressed in Fetal gut (9.7), Lymph node (9.1), Peripheral blood mononuclear cells (7.6), Stomach (6.5), and Frontal cortex (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLD1 Gene
SOURCE GeneReport for Unigene cluster for POLD1 Gene Hs.279413
mRNA Expression by UniProt/SwissProt for POLD1 Gene
P28340-DPOD1_HUMAN
Tissue specificity:
Expressed across a panel of tissues, with high levels of expression in heart and lung.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for POLD1
-
OriGene qPCR primer pairs and template standards for POLD1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for POLD1 Gene
Orthologs for POLD1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | POLD1 35 |
|
||
| POLD1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | POLD1 35 |
|
||
| POLD1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pold1 35 |
|
||
| Pold1 16 |
|
||||
| Pold1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | POLD1 35 |
|
||
| POLD1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pold1 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | POLD1 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | POLD1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pold1 35 |
|
||
| Str.1564 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | iktdsubc_1d11 35 |
|
||
| pold1 35 |
|
||||
| pold1 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10161 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | DNApol-dgr 37 |
|
|
|
| DNApol-delta 35 |
|
||||
| DNApol-delta 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | F10C2.4 37 |
|
|
|
| F10C2.4 35 |
|
||||
| F10C2.4 36 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL189W 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E01607g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | POL3 35 |
|
||
| POL3 36 |
|
OneToOne | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | EMB2780 35 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.158 35 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.1187 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.3738 35 |
|
||
| Os11g0186400 35 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5611 35 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01192 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cdc6 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for POLD1:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for POLD1 Gene
(1) SIMAP similar genes for POLD1 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for POLD1 Gene
No data available for Paralogs for POLD1 Gene
Variants for POLD1 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs3218772 | - | 50,398,939(+) | CACCT(C/T)GGCCA | nc-transcript-variant, reference, missense | |
| rs3218773 | - | 50,398,907(+) | GGCCC(A/G)TGGGG | nc-transcript-variant, reference, missense | |
| rs1726801 | - | 50,401,817(+) | ATCCC(A/G)CGGCT | nc-transcript-variant, reference, missense | |
| rs1726803 | - | 50,402,053(+) | CATCA(A/G)CCGGG | nc-transcript-variant, reference, missense | |
| rs3218750 | - | 50,402,065(+) | CAGTC(A/G)CGGGG | nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3976n71 | CNV | Loss | 21882294 |
| nsv912281 | CNV | Loss | 21882294 |
| nsv912282 | CNV | Loss | 21882294 |
| esv2718732 | CNV | Deletion | 23290073 |
| esv2667096 | CNV | Deletion | 23128226 |
Residual Variation Intolerance Score:
23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.78;
66.72% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for POLD1 Gene
- Human Gene Mutation Database (HGMD)
- POLD1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLD1 Gene
Disorders for POLD1 Gene
(8) MalaCards diseases for POLD1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome |
|
|
| colorectal cancer 10 |
|
|
| mandibular hypoplasia-deafness-progeroid syndrome |
|
|
| polymerase proofreading-associated adenomatous polyposis |
|
|
| colorectal cancer susceptibility 10 |
|
|
Search POLD1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DPOD1_HUMAN- Colorectal cancer 10 (CRCS10) [MIM:612591]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:23263490, ECO:0000269 PubMed:24501277}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL) [MIM:615381]: An autosomal dominant systemic disorder characterized by prominent loss of subcutaneous fat, metabolic abnormalities including insulin resistance and diabetes mellitus, sclerodermatous skin, and a facial appearance characterized by mandibular hypoplasia. Sensorineural deafness occurs late in the first or second decades of life. {ECO:0000269 PubMed:23770608}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for POLD1
No data available for Genatlas for POLD1 Gene
Publications for POLD1 Gene
- Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene. (PMID: 1722322) Chung D.W. … Downey K.M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 67
- Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1). (PMID: 7490075) Chang L.S. … Lee M.Y. (Genomics 1995) 3 23
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
- Human POLD1 modulates cell cycle progression and DNA damage repair. (PMID: 26087769) Song J. … Wang P. (BMC Biochem. 2015) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
Products for POLD1 Gene
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- antibodies-online Antibodies for POLD1: See all 49
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- Search antibodies-online for peptides
- GeneTex POLD1 antibody for POLD1
- Search GeneTex for Proteins for POLD1
- ViGene Biosciences adenoviral particle packaged cDNA for POLD1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for POLD1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for POLD1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for POLD1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for POLD1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for POLD1 gene
- Search ViGene Biosciences for POLD1
- Search ViGene Biosciences for POLD1
- Santa Cruz Biotechnology (SCBT) Antibodies for POLD1
- Search Santa Cruz Biotechnology (SCBT) for POLD1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POLD1
Sources for POLD1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (13) InterPro
- (14) ProtoNet
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- (16) MGI
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- (18) KEGG
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- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (123) ProteomicsDB
- (124) SCBT
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- (143) Gene Damage Index
- (144) ViGene Biosciences
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- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon