Aliases for POLA1 Gene
Aliases for POLA1 Gene
External Ids for POLA1 Gene
- HGNC: 9173
- Entrez Gene: 5422
- Ensembl: ENSG00000101868
- OMIM: 312040
- UniProtKB: P09884
Previous HGNC Symbols for POLA1 Gene
- POLA
- NSX
Previous GeneCards Identifiers for POLA1 Gene
- GC0XP024622
- GC0XP022457
Summaries for POLA1 Gene
-
This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]
GeneCards Summary for POLA1 Gene
POLA1 (DNA Polymerase Alpha 1, Catalytic Subunit) is a Protein Coding gene. Diseases associated with POLA1 include Pigmentary Disorder, Reticulate, With Systemic Manifestations, X-Linked and Netherton Syndrome. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot for POLA1 Gene
-
Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3 exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227).
Additional gene information for POLA1 Gene
- Monarch Initiative
- Search for POLA1 at DataMed
- Search for POLA1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLA1 Gene
Genomics for POLA1 Gene
GeneHancer (GH) Regulatory Elements for POLA1 Gene
Regulatory Element Products
Genomic Locations for POLA1 Gene
- chrX:24,693,874-24,996,986
- (GRCh38/hg38)
- Size:
- 303,113 bases
- Orientation:
- Plus strand
- chrX:24,712,036-25,015,103
- (GRCh37/hg19)
Genomic View for POLA1 Gene
- Cytogenetic band:
-
- Xp22.11 by Ensembl
- Xp22.11-p21.3 by Entrez Gene
- Xp22.11-p21.3 by HGNC


RefSeq DNA sequence for POLA1 Gene
Proteins for POLA1 Gene
-
Protein details for POLA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09884-DPOLA_HUMAN
- Recommended name:
- DNA polymerase alpha catalytic subunit
- Protein Accession:
- P09884
- Q86UQ7
Protein attributes for POLA1 Gene
- Size:
- 1462 amino acids
- Molecular mass:
- 165913 Da
- Cofactor:
- Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
- Quaternary structure:
-
- The DNA polymerase alpha complex is composed of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Interacts with PARP1; this interaction functions as part of the control of replication fork progression. Interacts with MCM10 and WDHD1; these interactions recruit the polymerase alpha complex to the pre-replicative complex bound to DNA. Interacts with RPA1; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp. Interacts with SV40 Large T antigen; this interaction allows viral DNA replication. Interacts with herpes simplex virus 1 (HHV-1) replication origin-binding protein UL9.
- Miscellaneous:
-
- In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Protein Expression for POLA1 Gene
Selected DME Specific Peptides for POLA1 Gene
- P09884:
-
- ALKLTANSMYGCLGF
- LLLKKKKYAA
- GYVEDGREIFDDDLED
- YAFEIPDVP
- NICFTTV
- LYTQLCFYR
- SRFYAKPLA
- MSRTLMGGRSERNE
- VIYGDTDS
- SYVICQDGSNL
- KYKIMKFKSK
- HPVVARICEPIDGID
- WSKIGRL
- NLEEVFKLGN
- FSHVFGTNT
- PLALQITNI
- DEENDALLGGP
- LEVLLQRIN
- IDTQYYL
- SLYPSII
- RQDDDWIVDDDG
Post-translational modifications for POLA1 Gene
- A 165 kDa form is probably produced by proteolytic cleavage at Lys-124.
- Ubiquitination at isoforms=970, isoforms=1200, isoforms=1316, and Lys1376
Other Protein References for POLA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
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Abcam proteins for POLA1
Assay Products
Domains & Families for POLA1 Gene
Gene Families for POLA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for POLA1 Gene
Suggested Antigen Peptide Sequences for POLA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09884UniProtKB/Swiss-Prot:
DPOLA_HUMAN :- The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
- Belongs to the DNA polymerase type-B family.
- Domain:
-
- The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
- Family:
-
- Belongs to the DNA polymerase type-B family.
Function for POLA1 Gene
Molecular function for POLA1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- UniProtKB/Swiss-Prot Function:
- Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3 exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227).
Enzyme Numbers (IUBMB) for POLA1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IDA,IEA | 3139084 |
GO:0001882 | nucleoside binding | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA,NAS | 3359994 |
GO:0003682 | chromatin binding | IDA | 16762037 |
Phenotypes for POLA1 Gene
- MGI mutant phenotypes for POLA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for POLA1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased homologous recombination repair frequency
- Increased cell number in S
- Decreased viability of wild-type and TP53 knockout cells
- Increased telomere dysfunction-induced foci (TIF) formation
Animal Model Products
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-
-
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-
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- Search ViGene Biosciences for POLA1
CRISPR Products
-
OriGene CRISPR knockouts for POLA1
- genomics-online: gRNA clones - Search results for available DNApol-alpha50 gene related products
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-
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-
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miRNA for POLA1 Gene
- miRTarBase miRNAs that target POLA1
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DNApol-alpha50 gene related products
- orf clones - Search results for available DNApol-alpha50 gene related products
- Applied Biological Materials Clones for POLA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for POLA1 gene
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No data available for Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for POLA1 Gene
Localization for POLA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POLA1 Gene
- Nucleus. Cytoplasm, cytosol. Note=In the cytosol, colocalizes with RNA:DNA hybrids with a speckled pattern. {ECO:0000269 PubMed:27019227}.
- Nucleoplasm (3)
- Cytosol (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | colocalizes_with chromatin | IDA | 9815285 |
GO:0005634 | nucleus | IDA,IEA | 4084590 |
GO:0005635 | nuclear envelope | IDA | 9518481 |
GO:0005654 | nucleoplasm | TAS,IDA | -- |
GO:0005658 | alpha DNA polymerase:primase complex | TAS | 2243771 |
Pathways & Interactions for POLA1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
|
2 | E2F mediated regulation of DNA replication |
.64
|
|
3 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
|
4 | Pyrimidine metabolism (KEGG) | ||
5 | Cell Cycle, Mitotic |
.83
|
Pathways by source for POLA1 Gene
4 BioSystems pathways for POLA1 Gene
26 Reactome pathways for POLA1 Gene
4 KEGG pathways for POLA1 Gene
3 GeneGo (Thomson Reuters) pathways for POLA1 Gene
1 R&D Systems pathway for POLA1 Gene
3 Qiagen pathways for POLA1 Gene
Interacting Proteins for POLA1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000731 | NOT DNA synthesis involved in DNA repair | IMP | 1508673 |
GO:0006260 | DNA replication | IMP,IEA | 3917431 |
GO:0006269 | DNA replication, synthesis of RNA primer | IDA | 2175912 |
No data available for SIGNOR curated interactions for POLA1 Gene
Drugs & Compounds for POLA1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Clofarabine | Approved, Investigational | Pharma | Target, inhibitor, binder | Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase | 161 | |
Fludarabine | Approved | Pharma | Target, inhibitor | DNA synthsis inhibitor | 1231,1231 | |
Nelarabine | Approved, Investigational | Pharma | Target, inhibitor, binder | Prodrug of ara-G for T-LBL/T-ALL | 0 | |
Cladribine | Approved, Investigational | Pharma | Target, inhibitor | Apoptosis inducer in CLL cells | 81 | |
Cytarabine | Approved, Investigational | Pharma | 1166 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
|||
Thymidine 5'-triphosphate |
|
365-08-2 |
|
(4) ApexBio Compounds for POLA1 Gene
Compound | Action | Cas Number |
---|---|---|
Clofarabine | Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase | 123318-82-1 |
Cytarabine | 147-94-4 | |
Fludarabine Phosphate (Fludara) | Inhibits STAT1 activation and DNA synthesis | 75607-67-9 |
Vitamin D2 (Ergocalciferol) | DNA Polymerase inhibitor | 50-14-6 |
Transcripts for POLA1 Gene
mRNA/cDNA for POLA1 Gene
- (9) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (62) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POLA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for POLA1
- genomics-online: gRNA clones - Search results for available DNApol-alpha50 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLA1
- GenScript: Design CRISPR guide RNA sequences for POLA1
miRNA Products
- Search ViGene Biosciences for POLA1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POLA1
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-
ViGene Biosciences ready-to-package AAV shRNAs for POLA1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for POLA1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DNApol-alpha50 gene related products
- orf clones - Search results for available DNApol-alpha50 gene related products
- Applied Biological Materials Clones for POLA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for POLA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of POLA1 Gene:
POLA1SOURCE GeneReport for Unigene cluster for POLA1 Gene:
Hs.567319Phenotype-based relationships between genes and organs from Gene ORGANizer for POLA1 Gene
- ectoderm
- endoderm
- mesoderm
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- skeletal muscle
- urinary
- brain
- cranial nerve
- ear
- eye
- head
- penis
- testicle
- urethra
- blood
- bone marrow
- peripheral nervous system
- skin
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for POLA1
- genomics-online: primer clones - Search results for available DNApol-alpha50 gene related products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for POLA1 Gene
Orthologs for POLA1 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | POLA1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | POLA1 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | POLA1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Pola1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Pola1 16 34 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | POLA1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | POLA1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | POLA1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pola1 33 |
|
||
Str.19655 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398200 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | pola1 33 34 |
|
||
mpzf637-2-001461 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | DNApol-alpha180 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001929 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | Y47D3A.29 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | POL1 33 34 36 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER381C 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C13255g 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | ICU2 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os01g0868300 33 |
|
||
Os.47313 33 |
|
||||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7288 34 |
|
OneToOne | |
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pol1 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU07870 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10716 33 |
|
- Species where no ortholog for POLA1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for POLA1 Gene
No data available for Paralogs for POLA1 Gene
Variants for POLA1 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs869312979 | pathogenic, Pigmentary disorder, reticulate, with systemic manifestations, X-linked | 24,726,579(+) | A/G | intron_variant | |
rs1000011455 | -- | 24,820,446(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
rs1000021655 | -- | 24,759,534(+) | T/A | genic_downstream_transcript_variant, intron_variant | |
rs1000040035 | -- | 24,765,825(+) | G/C | genic_downstream_transcript_variant, intron_variant | |
rs1000081341 | -- | 24,707,308(+) | C/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2146318 | CNV | deletion | 18987734 |
esv2672026 | CNV | deletion | 23128226 |
esv2675627 | CNV | deletion | 23128226 |
esv2740014 | CNV | deletion | 23290073 |
esv3558714 | CNV | deletion | 23714750 |
nsv517960 | CNV | gain | 19592680 |
Additional Variant Information for POLA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLA1 Gene
Disorders for POLA1 Gene

(9) MalaCards diseases for POLA1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
pigmentary disorder, reticulate, with systemic manifestations, x-linked |
|
|
netherton syndrome |
|
|
thoracic outlet syndrome |
|
|
latent syphilis |
|
|
congenital syphilis |
|
|
UniProtKB/Swiss-Prot
DPOLA_HUMAN- Pigmentary disorder, reticulate, with systemic manifestations, X-linked (PDR) [MIM:301220]: A X-linked recessive disorder characterized by recurrent infections and sterile inflammation in various organs. Diffuse skin hyperpigmentation with a distinctive reticulate pattern is universally evident by early childhood. This is later followed in many patients by hypohidrosis, corneal inflammation and scarring, enterocolitis that resembles inflammatory bowel disease, and recurrent urethral strictures. Melanin and amyloid deposition is present in the dermis. Affected males also have a characteristic facies with frontally upswept hair and flared eyebrows. Female carriers have only restricted pigmentary changes along Blaschkos lines. {ECO:0000269 PubMed:27019227}. Note=The disease is caused by mutations affecting the gene represented in this entry. XLPDR is caused by a recurrent intronic mutation that results in missplicing and reduced POLA1 expression. This leads to a decrease in cytosolic RNA:DNA hybrids and constitutive activation of type I interferon responses, but has no effect on cell replication. {ECO:0000269 PubMed:27019227}.
Additional Disease Information for POLA1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for POLA1 Gene
Publications for POLA1 Gene
- DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. (PMID: 27019227) Starokadomskyy P … Burstein E (Nature immunology 2016) 3 4 58
- Physical interactions between Mcm10, DNA, and DNA polymerase alpha. (PMID: 19608746) Warren EM … Eichman BF (The Journal of biological chemistry 2009) 3 4 58
- Nuclear magnetic resonance structures of the zinc finger domain of human DNA polymerase-alpha. (PMID: 14499601) Evanics F … Bose RN (Biochimica et biophysica acta 2003) 3 4 58
- Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. (PMID: 9518481) Dantzer F … Ménissier-de Murcia J (Nucleic acids research 1998) 3 4 58
- Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha. (PMID: 7644508) Lee SS … Lehman IR (Proceedings of the National Academy of Sciences of the United States of America 1995) 3 4 58
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for POLA1
- Novus Biologicals proteins for POLA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for POLA1
- Abcam proteins for POLA1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for POLA1
- Cloud-Clone Corp. Proteins for POLA1
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for POLA1
- ApexBio compounds for POLA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for POLA1
- VectorBuilder custom plasmid, inducible vectors for POLA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POLA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available DNApol-alpha50 related products ranked by validation data
- antibodies-online: Search results for available DNApol-alpha50 related products ranked by validation data
- antibodies-online: Search results for available DNApol-alpha50 related products ranked by validation data
- Search GeneTex for Antibodies for POLA1
- Search GeneTex for Proteins for POLA1
- ViGene Biosciences adenoviral particle packaged cDNA for POLA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for POLA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for POLA1 gene
- Search ViGene Biosciences for POLA1
- Santa Cruz Biotechnology (SCBT) Antibodies for POLA1
- Search Santa Cruz Biotechnology (SCBT) for POLA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POLA1
- genomics-online: cdna clones - Search results for available DNApol-alpha50 gene related products
- orf clones - Search results for available DNApol-alpha50 gene related products
- genomics-online: gRNA clones - Search results for available DNApol-alpha50 gene related products
- genomics-online: primer clones - Search results for available DNApol-alpha50 gene related products
- genomics-online: shRNA clones - Search results for available DNApol-alpha50 gene related products
Sources for POLA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew