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Aliases for SNTG1 Gene

Aliases for SNTG1 Gene

  • Syntrophin, Gamma 1 2 3
  • SYN4 3 4 6
  • Syntrophin-4 3 4
  • G1SYN 3 4
  • Gamma-1-Syntrophin 3
  • Gamma1-Syntrophin 3
  • Syntrophin 4 3

External Ids for SNTG1 Gene

Previous GeneCards Identifiers for SNTG1 Gene

  • GC08P049844
  • GC08P050829
  • GC08P050547
  • GC08P050874
  • GC08P050986
  • GC08P046289
  • GC08P050823

Summaries for SNTG1 Gene

Entrez Gene Summary for SNTG1 Gene

  • The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for SNTG1 Gene

SNTG1 (Syntrophin, Gamma 1) is a Protein Coding gene. Diseases associated with SNTG1 include scrub typhus. GO annotations related to this gene include phospholipid binding and protein C-terminus binding. An important paralog of this gene is SNTB1.

UniProtKB/Swiss-Prot for SNTG1 Gene

  • Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.

Gene Wiki entry for SNTG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNTG1 Gene

Genomics for SNTG1 Gene

Regulatory Elements for SNTG1 Gene

Genomic Location for SNTG1 Gene

49,909,789 bp from pter
50,794,118 bp from pter
884,330 bases
Plus strand

Genomic View for SNTG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNTG1 Gene

Proteins for SNTG1 Gene

  • Protein details for SNTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q2M3Q0
    • Q9NY98

    Protein attributes for SNTG1 Gene

    517 amino acids
    Molecular mass:
    57969 Da
    Quaternary structure:
    • Isoform 1, but not isoform 2, interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ.

    Alternative splice isoforms for SNTG1 Gene


neXtProt entry for SNTG1 Gene

Proteomics data for SNTG1 Gene at MOPED

Post-translational modifications for SNTG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNTG1 Gene

Domains for SNTG1 Gene

Protein Domains for SNTG1 Gene

Suggested Antigen Peptide Sequences for SNTG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NSN8
  • The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
  • Belongs to the syntrophin family.
genes like me logo Genes that share domains with SNTG1: view

No data available for Gene Families for SNTG1 Gene

Function for SNTG1 Gene

Molecular function for SNTG1 Gene

UniProtKB/Swiss-Prot Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.

Gene Ontology (GO) - Molecular Function for SNTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0008022 protein C-terminus binding IPI 15485858
genes like me logo Genes that share ontologies with SNTG1: view

Phenotypes for SNTG1 Gene

GenomeRNAi human phenotypes for SNTG1:
genes like me logo Genes that share phenotypes with SNTG1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNTG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNTG1 Gene

Localization for SNTG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNTG1 Gene

Cytoplasm, cytoskeleton. Nucleus. Note=Mainly cytoplasmic and weakly nuclear.

Subcellular locations from

Jensen Localization Image for SNTG1 Gene COMPARTMENTS Subcellular localization image for SNTG1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 15485858
GO:0005856 cytoskeleton IDA --
GO:0016013 syntrophin complex TAS 10747910
GO:0032587 ruffle membrane IDA 15485858
genes like me logo Genes that share ontologies with SNTG1: view

Pathways for SNTG1 Gene

SuperPathways for SNTG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007154 cell communication TAS 10747910
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with SNTG1: view

No data available for Pathways by source for SNTG1 Gene

Compounds for SNTG1 Gene

(843) HMDB Compounds for SNTG1 Gene

Compound Synonyms Cas Number PubMed IDs
  • DAG(14:0/14:0)
Not Available
  • DAG(14:0/14:1)
Not Available
  • Diacylglycerol(29:0)
Not Available
  • DAG(30:0)
Not Available
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with SNTG1: view

Transcripts for SNTG1 Gene

Unigene Clusters for SNTG1 Gene

Syntrophin, gamma 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNTG1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNTG1 Gene

No ASD Table

Relevant External Links for SNTG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNTG1 Gene

mRNA expression in normal human tissues for SNTG1 Gene

mRNA differential expression in normal tissues according to GTEx for SNTG1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.3), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Cortex (5.3), Brain - Nucleus accumbens (basal ganglia) (5.1), Brain - Putamen (basal ganglia) (5.0), Brain - Caudate (basal ganglia) (4.9), and Brain - Hippocampus (4.2).

SOURCE GeneReport for Unigene cluster for SNTG1 Gene Hs.584914

mRNA Expression by UniProt/SwissProt for SNTG1 Gene

Tissue specificity: Brain specific. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. No expression in muscle cells.
genes like me logo Genes that share expressions with SNTG1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for SNTG1 Gene

Orthologs for SNTG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNTG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNTG1 35
  • 99.48 (n)
  • 99.23 (a)
SNTG1 36
  • 99 (a)
(Bos Taurus)
Mammalia SNTG1 35
  • 86.08 (n)
  • 94.78 (a)
SNTG1 36
  • 91 (a)
(Canis familiaris)
Mammalia SNTG1 35
  • 91.62 (n)
  • 97.68 (a)
SNTG1 36
  • 98 (a)
(Mus musculus)
Mammalia Sntg1 35
  • 88.22 (n)
  • 94.98 (a)
Sntg1 16
Sntg1 36
  • 93 (a)
(Monodelphis domestica)
Mammalia SNTG1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia SNTG1 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Sntg1 35
  • 84.4 (n)
  • 90.56 (a)
(Gallus gallus)
Aves SNTG1 35
  • 83.43 (n)
  • 93.42 (a)
SNTG1 36
  • 92 (a)
(Anolis carolinensis)
Reptilia SNTG1 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sntg1 35
  • 78.65 (n)
  • 88.35 (a)
(Danio rerio)
Actinopterygii sntg1 35
  • 75.84 (n)
  • 83.13 (a)
SNTG1 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006633 35
  • 48.67 (n)
  • 41.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syn2 35
  • 48.1 (n)
  • 40.99 (a)
Syn2 36
  • 37 (a)
Syn2 37
  • 34 (a)
(Caenorhabditis elegans)
Secernentea stn-2 35
  • 45.69 (n)
  • 34.96 (a)
stn-2 36
  • 30 (a)
F27D9.8 37
  • 32 (a)
Species with no ortholog for SNTG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNTG1 Gene

Gene Tree for SNTG1 (if available)
Gene Tree for SNTG1 (if available)

Paralogs for SNTG1 Gene

Paralogs for SNTG1 Gene

Selected SIMAP similar genes for SNTG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNTG1: view

Variants for SNTG1 Gene

Sequence variations from dbSNP and Humsavar for SNTG1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs56725 -- 50,098,752(-) ATATG(A/G)CTTAT intron-variant
rs148692 -- 49,991,480(+) acaca(A/C/G)aaacg intron-variant
rs149936 -- 50,114,369(-) tcaca(A/G)atagc intron-variant
rs149991 -- 50,092,175(-) AACGG(A/G)GAGCT intron-variant
rs149992 -- 50,113,288(-) actac(A/G)gacca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNTG1 Gene

Variant ID Type Subtype PubMed ID
esv34788 CNV Loss 17911159
essv8403 CNV CNV 17122850
esv2674624 CNV Deletion 23128226
nsv818624 CNV Loss 17921354
essv14613 CNV CNV 17122850
essv376 CNV CNV 17122850
nsv890871 CNV Gain 21882294
nsv890872 CNV Loss 21882294
nsv6184 CNV Loss 18451855
nsv508509 CNV Loss 20534489
nsv26 CNV Loss 15895083
nsv437619 CNV Loss 16327808
esv1008187 CNV Deletion 20482838
esv2475988 CNV Deletion 19546169
nsv8339 CNV Loss 18304495
esv2246196 CNV Deletion 18987734
esv2503933 CNV Loss 19546169
nsv824624 CNV Loss 20364138
esv3328 CNV Deletion 18987735
esv2736985 CNV Deletion 23290073
esv6927 CNV Loss 19470904
nsv499111 CNV Loss 21111241
dgv1285e199 CNV Deletion 23128226
esv22898 CNV Loss 19812545
nsv515086 CNV Loss 21397061
nsv433494 CNV Loss 18776910
nsv442516 CNV CNV 18776908
nsv438053 CNV Loss 16468122
nsv8340 CNV Gain 18304495
nsv8341 CNV Loss 18304495
nsv524203 CNV Gain 19592680
esv2736986 CNV Deletion 23290073
nsv470212 CNV Gain 18288195
esv24787 CNV Gain 19812545
nsv522665 CNV Gain 19592680
nsv507463 CNV Insertion 20534489
nsv6185 CNV Loss 18451855
esv2662128 CNV Deletion 23128226
dgv1286e199 CNV Deletion 23128226
esv2437712 CNV Deletion 19546169
esv2077062 CNV Deletion 18987734
esv2593415 CNV Loss 19546169
dgv1182n67 CNV Loss 20364138
esv4199 CNV Deletion 18987735
nsv515087 CNV Loss 21397061
esv2736987 CNV Deletion 23290073
nsv499696 CNV Loss 21111241
esv5640 CNV Loss 19470904
esv22552 CNV Loss 19812545
nsv517030 CNV Loss 19592680
nsv831312 CNV Gain 17160897
dgv457n21 CNV Loss 19592680
nsv525765 CNV Loss 19592680
esv2521416 CNV Deletion 19546169
nsv520800 CNV Loss 19592680
esv2736988 CNV Deletion 23290073
esv2661172 CNV Deletion 23128226
esv270406 CNV Insertion 20981092
esv2666246 CNV Deletion 23128226
esv271575 CNV Insertion 20981092
nsv890873 CNV Gain 21882294
esv1715309 CNV Insertion 17803354
nsv522428 CNV Gain 19592680
esv25991 CNV Loss 19812545
esv2122954 CNV Deletion 18987734
esv2736989 CNV Deletion 23290073
esv2736990 CNV Deletion 23290073
esv2122452 CNV Deletion 18987734
esv2736991 CNV Deletion 23290073
dgv7789n71 CNV Loss 21882294

Relevant External Links for SNTG1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNTG1 Gene

Disorders for SNTG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SNTG1 Gene including...

Search for SNTG1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SNTG1 Gene

Relevant External Links for SNTG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SNTG1: view

No data available for UniProtKB/Swiss-Prot for SNTG1 Gene

Publications for SNTG1 Gene

  1. Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. (PMID: 10747910) Piluso G. … Nigro V. (J. Biol. Chem. 2000) 2 3 4
  2. Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. (PMID: 11352924) Hogan A. … Gee S.H. (J. Biol. Chem. 2001) 3 4 23
  3. SNTG1, the gene encoding gamma1-syntrophin: a candidate gene for idiopathic scoliosis. (PMID: 15088139) Bashiardes S. … Lovett M. (Hum. Genet. 2004) 3 23 48
  4. The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization. (PMID: 15485858) Hogan A. … Gee S.H. (J. Biol. Chem. 2004) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SNTG1 Gene

Sources for SNTG1 Gene

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