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Aliases for TREM2 Gene

Aliases for TREM2 Gene

  • Triggering Receptor Expressed On Myeloid Cells 2 2 3
  • Triggering Receptor Expressed On Myeloid Cells 2a 2 3
  • Triggering Receptor Expressed On Monocytes 2 3 4
  • TREM-2 3 4
  • Trem2a 3
  • Trem2b 3
  • Trem2c 3

External Ids for TREM2 Gene

Summaries for TREM2 Gene

Entrez Gene Summary for TREM2 Gene

  • This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

GeneCards Summary for TREM2 Gene

TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) is a Protein Coding gene. Diseases associated with TREM2 include trem2-related polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy and nasu-hakola disease. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include receptor activity and lipopolysaccharide binding.

UniProtKB/Swiss-Prot for TREM2 Gene

  • May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

Gene Wiki entry for TREM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREM2 Gene

Genomics for TREM2 Gene

Genomic Location for TREM2 Gene

Start:
41,158,506 bp from pter
End:
41,163,186 bp from pter
Size:
4,681 bases
Orientation:
Minus strand

Genomic View for TREM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TREM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREM2 Gene

Regulatory Elements for TREM2 Gene

Proteins for TREM2 Gene

  • Protein details for TREM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZC2-TREM2_HUMAN
    Recommended name:
    Triggering receptor expressed on myeloid cells 2
    Protein Accession:
    Q9NZC2
    Secondary Accessions:
    • Q8N5H8
    • Q8WYN6

    Protein attributes for TREM2 Gene

    Size:
    230 amino acids
    Molecular mass:
    25447 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12.
    SequenceCaution:
    • Sequence=BAB78736.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TREM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREM2 Gene

Proteomics data for TREM2 Gene at MOPED

Post-translational modifications for TREM2 Gene

Other Protein References for TREM2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TREM2 Gene

Domains for TREM2 Gene

Gene Families for TREM2 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for TREM2 Gene

UniProtKB/Swiss-Prot:

TREM2_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9NZC2
genes like me logo Genes that share domains with TREM2: view

Function for TREM2 Gene

Molecular function for TREM2 Gene

UniProtKB/Swiss-Prot Function: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

Gene Ontology (GO) - Molecular Function for TREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0004872 receptor activity TAS 10799849
GO:0005515 protein binding --
GO:0042834 peptidoglycan binding IEA --
GO:0070891 lipoteichoic acid binding IEA --
genes like me logo Genes that share ontologies with TREM2: view

Phenotypes for TREM2 Gene

MGI mutant phenotypes for TREM2:
inferred from 1 alleles
GenomeRNAi human phenotypes for TREM2:
genes like me logo Genes that share phenotypes with TREM2: view

Animal Models for TREM2 Gene

MGI Knock Outs for TREM2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TREM2 Gene

Localization for TREM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREM2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREM2 Gene COMPARTMENTS Subcellular localization image for TREM2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for TREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 11602640
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TREM2: view

Pathways for TREM2 Gene

genes like me logo Genes that share pathways with TREM2: view

Pathways by source for TREM2 Gene

Gene Ontology (GO) - Biological Process for TREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II IDA 11602640
GO:0006959 humoral immune response TAS 10799849
GO:0007411 axon guidance TAS --
GO:0032497 detection of lipopolysaccharide IEA --
GO:0032499 detection of peptidoglycan IEA --
genes like me logo Genes that share ontologies with TREM2: view

Transcripts for TREM2 Gene

Unigene Clusters for TREM2 Gene

Triggering receptor expressed on myeloid cells 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for TREM2 Gene

GeneLoc Exon Structure for
TREM2
ECgene alternative splicing isoforms for
TREM2

Expression for TREM2 Gene

mRNA expression in normal human tissues for TREM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.9) and Brain - Substantia nigra (6.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TREM2 Gene

SOURCE GeneReport for Unigene cluster for TREM2 Gene Hs.435295

mRNA Expression by UniProt/SwissProt for TREM2 Gene

Q9NZC2-TREM2_HUMAN
Tissue specificity: Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.
genes like me logo Genes that share expressions with TREM2: view

Orthologs for TREM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TREM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREM2 36
  • 99.42 (n)
  • 98.7 (a)
TREM2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TREM2 36
  • 85.94 (n)
  • 80 (a)
TREM2 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TREM2 36
  • 84.28 (n)
  • 82.1 (a)
TREM2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trem2 36
  • 77.28 (n)
  • 69.96 (a)
Trem2 16
Trem2 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TREM2 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TREM2 37
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TREM-A1 37
  • 30 (a)
OneToOne
TREM2 36
  • 59.09 (n)
  • 43.18 (a)
lizard
(Anolis carolinensis)
Reptilia TREM2 37
  • 26 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trem2 36
  • 49.9 (n)
  • 37.13 (a)
Species with no ortholog for TREM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREM2 Gene

ENSEMBL:
Gene Tree for TREM2 (if available)
TreeFam:
Gene Tree for TREM2 (if available)

Paralogs for TREM2 Gene

No data available for Paralogs for TREM2 Gene

Variants for TREM2 Gene

Sequence variations from dbSNP and Humsavar for TREM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2234247 -- 41,163,990(-) TCCTG(C/T)AGGAT upstream-variant-2KB
rs2234248 -- 41,163,980(-) TAGGA(C/T)GATCA upstream-variant-2KB
rs2234249 -- 41,163,273(-) TGGCC(A/G)ACTCC upstream-variant-2KB
rs2234250 -- 41,162,955(-) TGAAT(C/T)ATGAA intron-variant
rs2234251 -- 41,161,656(-) CAAAG(C/T)GTATT intron-variant

Relevant External Links for TREM2 Gene

HapMap Linkage Disequilibrium report
TREM2
Human Gene Mutation Database (HGMD)
TREM2

No data available for Structural Variations from Database of Genomic Variants (DGV) for TREM2 Gene

Disorders for TREM2 Gene

(1) OMIM Diseases for TREM2 Gene (605086)

UniProtKB/Swiss-Prot

TREM2_HUMAN
  • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. {ECO:0000269 PubMed:12080485}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) Novoseek inferred disease relationships for TREM2 Gene

Disease -log(P) Hits PubMed IDs
nasu-hakola disease 98.8 9
lipomembranous polycystic osteodysplasia 97.7 1
bone cysts 85.8 1
dementia 42.8 2

Relevant External Links for TREM2

GeneTests
TREM2
GeneReviews
TREM2
Genetic Association Database (GAD)
TREM2
Human Genome Epidemiology (HuGE) Navigator
TREM2
genes like me logo Genes that share disorders with TREM2: view

Publications for TREM2 Gene

  1. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PMID: 10799849) Bouchon A. … Colonna M. (J. Immunol. 2000) 2 3 4
  2. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. (PMID: 12080485) Paloneva J. … Peltonen L. (Am. J. Hum. Genet. 2002) 2 3 4
  3. Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response. (PMID: 17530208) Kiialainen A. … Peltonen L. (J. Mol. Med. 2007) 3 23
  4. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. (PMID: 19457124) Stefano L. … Meldolesi J. (J. Neurochem. 2009) 3 23
  5. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. (PMID: 12925681) Paloneva J. … Peltonen L. (J. Exp. Med. 2003) 3 23

Products for TREM2 Gene

Sources for TREM2 Gene

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