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Aliases for PODXL Gene

Aliases for PODXL Gene

  • Podocalyxin-Like 2 3
  • PCLP 3 4 6
  • Podocalyxin-Like Protein 1 3 4
  • GCTM-2 Antigen 3 4
  • PCLP-1 3 4
  • Gp200 3 4
  • PC 3 4
  • Podocalyxin 3
  • PCLP1 4

External Ids for PODXL Gene

Summaries for PODXL Gene

Entrez Gene Summary for PODXL Gene

  • This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

GeneCards Summary for PODXL Gene

PODXL (Podocalyxin-Like) is a Protein Coding gene. Diseases associated with PODXL include sick sinus syndrome. Among its related pathways are Disease and Metabolism.

UniProtKB/Swiss-Prot for PODXL Gene

  • Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Gene Wiki entry for PODXL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PODXL Gene

Genomics for PODXL Gene

Genomic Location for PODXL Gene

Start:
131,500,262 bp from pter
End:
131,558,217 bp from pter
Size:
57,956 bases
Orientation:
Minus strand

Genomic View for PODXL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PODXL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PODXL Gene

Regulatory Elements for PODXL Gene

Proteins for PODXL Gene

  • Protein details for PODXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00592-PODXL_HUMAN
    Recommended name:
    Podocalyxin
    Protein Accession:
    O00592
    Secondary Accessions:
    • A6NHX8
    • Q52LZ7
    • Q53ER6

    Protein attributes for PODXL Gene

    Size:
    558 amino acids
    Molecular mass:
    58635 Da
    Quaternary structure:
    • Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); the interaction is not detected in glomerular epithelium cells, take place early in the secretory pathway and is necessary for its apical membrane sorting. Found in a complex with EZR, PODXL and SLC9A3R2. Associates with the actin cytoskeleton through complex formation with EZR and SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells (By similarity). Interacts with EZR.

    Alternative splice isoforms for PODXL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PODXL Gene

Proteomics data for PODXL Gene at MOPED

Post-translational modifications for PODXL Gene

  • N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys526

Other Protein References for PODXL Gene

No data available for DME Specific Peptides for PODXL Gene

Domains for PODXL Gene

Protein Domains for PODXL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PODXL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00592

UniProtKB/Swiss-Prot:

PODXL_HUMAN
Domain:
  • Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes.:
    • O00592
Family:
  • Belongs to the podocalyxin family.:
    • O00592
genes like me logo Genes that share domains with PODXL: view

No data available for Gene Families for PODXL Gene

Function for PODXL Gene

Molecular function for PODXL Gene

GENATLAS Biochemistry: podocalyxin-like protein,integral component of the glomerular epithelial cell glycocalyx
UniProtKB/Swiss-Prot Function: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Gene Ontology (GO) - Molecular Function for PODXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22662192
genes like me logo Genes that share ontologies with PODXL: view
genes like me logo Genes that share phenotypes with PODXL: view

Animal Models for PODXL Gene

MGI Knock Outs for PODXL:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PODXL Gene

Localization for PODXL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PODXL Gene

Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Membrane raft. Membrane; Single-pass type I membrane protein. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PODXL Gene COMPARTMENTS Subcellular localization image for PODXL gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytoskeleton 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PODXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 18456258
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IDA 18456258
GO:0005886 plasma membrane IDA 18456258
GO:0005887 integral component of plasma membrane TAS 9188463
genes like me logo Genes that share ontologies with PODXL: view

Pathways for PODXL Gene

SuperPathways for PODXL Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Glycolysis and gluconeogenesis (short map)
3 Metabolism
4 Carbon metabolism
5 Glucose metabolism
genes like me logo Genes that share pathways with PODXL: view

Gene Ontology (GO) - Biological Process for PODXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion ISS --
GO:0016477 cell migration ISS --
GO:0022408 negative regulation of cell-cell adhesion ISS --
GO:0030335 positive regulation of cell migration IDA 18456258
genes like me logo Genes that share ontologies with PODXL: view

Transcripts for PODXL Gene

Unigene Clusters for PODXL Gene

Podocalyxin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PODXL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for PODXL Gene

GeneLoc Exon Structure for
PODXL
ECgene alternative splicing isoforms for
PODXL

Expression for PODXL Gene

mRNA expression in normal human tissues for PODXL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PODXL Gene

This gene is overexpressed in Kidney - Cortex (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PODXL Gene

SOURCE GeneReport for Unigene cluster for PODXL Gene Hs.744213

mRNA Expression by UniProt/SwissProt for PODXL Gene

O00592-PODXL_HUMAN
Tissue specificity: Glomerular epithelium cell (podocyte)
genes like me logo Genes that share expressions with PODXL: view

Orthologs for PODXL Gene

This gene was present in the common ancestor of chordates.

Orthologs for PODXL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PODXL 35
  • 98.99 (n)
  • 97.98 (a)
PODXL 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PODXL 36
  • 38 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PODXL 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Podxl 16
Podxl 36
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PODXL 36
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves PODXL 36
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PODXL 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18470 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9085 35
zebrafish
(Danio rerio)
Actinopterygii podxl 36
  • 22 (a)
OneToOne
Species with no ortholog for PODXL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PODXL Gene

ENSEMBL:
Gene Tree for PODXL (if available)
TreeFam:
Gene Tree for PODXL (if available)

Paralogs for PODXL Gene

Selected SIMAP similar genes for PODXL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PODXL: view

No data available for Paralogs for PODXL Gene

Variants for PODXL Gene

Sequence variations from dbSNP and Humsavar for PODXL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs8232 -- 131,500,635(-) TTTAT(A/G)TATGG utr-variant-3-prime
rs15894 -- 131,500,672(+) CAGAA(A/G)GAAAG utr-variant-3-prime
rs412140 -- 131,511,586(+) TTCGG(G/T)GGTTC intron-variant
rs424546 -- 131,501,255(-) TGGCC(A/C)AGTTT utr-variant-3-prime
rs430597 -- 131,511,751(-) ATgcc(A/C)ggcgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PODXL Gene

Variant ID Type Subtype PubMed ID
nsv831134 CNV Gain 17160897
esv7269 CNV Gain 19470904
esv2735154 CNV Deletion 23290073
esv2735155 CNV Deletion 23290073
esv2735156 CNV Deletion 23290073

Relevant External Links for PODXL Gene

HapMap Linkage Disequilibrium report
PODXL
Human Gene Mutation Database (HGMD)
PODXL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PODXL Gene

Disorders for PODXL Gene

(1) MalaCards Diseases for PODXL Gene

Search for PODXL Gene in MalaCards »

(2) University of Copenhagen DISEASES for PODXL Gene

(4) Novoseek inferred disease relationships for PODXL Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 58.5 3
hepatocellular carcinoma 21.5 1
proteinuria 19.1 1
tumors 14.3 8

Relevant External Links for PODXL

Genetic Association Database (GAD)
PODXL
Human Genome Epidemiology (HuGE) Navigator
PODXL
genes like me logo Genes that share disorders with PODXL: view

No data available for UniProtKB/Swiss-Prot for PODXL Gene

Publications for PODXL Gene

  1. Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin. (PMID: 9188463) Kershaw D.B. … Wiggins R.C. (J. Biol. Chem. 1997) 3 4 23
  2. Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin. (PMID: 12504081) Schopperle W.M. … DeWolf W.C. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  3. Podocalyxin variants and risk of prostate cancer and tumor aggressiveness. (PMID: 16434482) Casey G. … Witte J.S. (Hum. Mol. Genet. 2006) 3 23 48
  4. Expression of podocalyxin enhances the adherence, migration, and intercellular communication of cells. (PMID: 18456258) Larrucea S. … Parrilla R. (Exp. Cell Res. 2008) 3 4 23
  5. Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1. (PMID: 18356574) Choo A.B. … Yap M. (Stem Cells 2008) 3 23

Products for PODXL Gene

Sources for PODXL Gene

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