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Aliases for TLR9 Gene

Aliases for TLR9 Gene

  • Toll-Like Receptor 9 2 3
  • CD289 Antigen 4
  • CD289 3

External Ids for TLR9 Gene

Previous GeneCards Identifiers for TLR9 Gene

  • GC03M051347
  • GC03M051507
  • GC03M052111
  • GC03M052213
  • GC03M052230
  • GC03M052255

Summaries for TLR9 Gene

Entrez Gene Summary for TLR9 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR9 Gene

TLR9 (Toll-Like Receptor 9) is a Protein Coding gene. Diseases associated with TLR9 include meningococcal meningitis and myositis fibrosa. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include transmembrane signaling receptor activity and siRNA binding. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR9 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

Gene Wiki entry for TLR9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR9 Gene

Genomics for TLR9 Gene

Regulatory Elements for TLR9 Gene

Genomic Location for TLR9 Gene

Chromosome:
3
Start:
52,221,080 bp from pter
End:
52,226,163 bp from pter
Size:
5,084 bases
Orientation:
Minus strand

Genomic View for TLR9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR9 Gene

Proteins for TLR9 Gene

  • Protein details for TLR9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR96-TLR9_HUMAN
    Recommended name:
    Toll-like receptor 9
    Protein Accession:
    Q9NR96
    Secondary Accessions:
    • B3Y661
    • D1CS56
    • Q6UVZ2
    • Q9HD68
    • Q9HD69
    • Q9HD70
    • Q9NYC2
    • Q9NYC3

    Protein attributes for TLR9 Gene

    Size:
    1032 amino acids
    Molecular mass:
    115860 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.

    Alternative splice isoforms for TLR9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR9 Gene

Proteomics data for TLR9 Gene at MOPED

Post-translational modifications for TLR9 Gene

  • Glycosylation at Asn 64, Asn 129, Asn 200, Asn 210, Asn 242, Asn 300, Asn 340, Asn 469, Asn 474, Asn 513, Asn 567, Asn 694, and Asn 731
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLR9 (TLR9)

No data available for DME Specific Peptides for TLR9 Gene

Domains & Families for TLR9 Gene

Gene Families for TLR9 Gene

Protein Domains for TLR9 Gene

Suggested Antigen Peptide Sequences for TLR9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR96

UniProtKB/Swiss-Prot:

TLR9_HUMAN :
  • Contains 1 TIR domain.
  • Belongs to the Toll-like receptor family.
  • Contains 26 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 26 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR9: view

Function for TLR9 Gene

Molecular function for TLR9 Gene

UniProtKB/Swiss-Prot Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

Gene Ontology (GO) - Molecular Function for TLR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005149 interleukin-1 receptor binding IPI 12925853
GO:0005515 protein binding --
GO:0035197 siRNA binding IMP 15723075
genes like me logo Genes that share ontologies with TLR9: view
genes like me logo Genes that share phenotypes with TLR9: view

Animal Models for TLR9 Gene

MGI Knock Outs for TLR9:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TLR9 Gene

Localization for TLR9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR9 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR9 Gene COMPARTMENTS Subcellular localization image for TLR9 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
lysosome 4
plasma membrane 4
vacuole 4
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TLR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region NAS 11130078
GO:0005737 cytoplasm IDA 19740627
GO:0005764 lysosome ISS --
GO:0005768 endosome ISS --
genes like me logo Genes that share ontologies with TLR9: view

Pathways & Interactions for TLR9 Gene

genes like me logo Genes that share pathways with TLR9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TLR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin TAS 15356140
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with TLR9: view

No data available for SIGNOR curated interactions for TLR9 Gene

Drugs & Compounds for TLR9 Gene

(27) Drugs for TLR9 Gene - From: NovoSeek, DGIdb, ClinicalTrials, DrugBank, PharmGKB, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxychloroquine Approved Pharma inhibitor, antagonist, Target Autophagy inhibitor 128
chloroquine Approved Pharma Agonist, Target 137
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 696
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1937

(17) Additional Compounds for TLR9 Gene - From: NovoSeek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CpG
Agonist
Bafilomycin A
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
  • 4-Amino-2-hydroxypyrimidine
  • 4-Amino-2-oxo-1,2-dihydropyrimidine
  • 4-Aminouracil
  • Cytosine
71-30-7
deoxyguanosine
  • 2'-Deoxy-Guanosine
  • 2'-Deoxyguanosine
  • 2-Deoxyguanosine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-Guanine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine
961-07-9
DOTAP
genes like me logo Genes that share compounds with TLR9: view

Transcripts for TLR9 Gene

mRNA/cDNA for TLR9 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(543) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLR9 Gene

Toll-like receptor 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLR9 Gene

No ASD Table

Relevant External Links for TLR9 Gene

GeneLoc Exon Structure for
TLR9
ECgene alternative splicing isoforms for
TLR9

Expression for TLR9 Gene

mRNA expression in normal human tissues for TLR9 Gene

mRNA expression in normal human tissues for TLR9 Gene

Protein differential expression in normal tissues from HIPED for TLR9 Gene

This gene is overexpressed in Heart (26.8), Adrenal (20.5), Blymphocyte (13.4), and Adipocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR9 Gene



SOURCE GeneReport for Unigene cluster for TLR9 Gene Hs.87968

mRNA Expression by UniProt/SwissProt for TLR9 Gene

Q9NR96-TLR9_HUMAN
Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver
genes like me logo Genes that share expression patterns with TLR9: view

Protein tissue co-expression partners for TLR9 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TLR9 Gene

Orthologs for TLR9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLR9 35
  • 83.69 (n)
  • 80.14 (a)
TLR9 36
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TLR9 35
  • 85.23 (n)
  • 81.83 (a)
TLR9 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tlr9 35
  • 77.72 (n)
  • 75.56 (a)
Tlr9 16
Tlr9 36
  • 75 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TLR9 35
  • 99.29 (n)
  • 99.32 (a)
TLR9 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tlr9 35
  • 77.65 (n)
  • 74.15 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves TLR21 36
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494387 35
  • 45.66 (n)
  • 37.37 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr9 35
  • 48.88 (n)
  • 40.73 (a)
tlr9 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7896 37
  • 28 (a)
Species with no ortholog for TLR9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR9 Gene

ENSEMBL:
Gene Tree for TLR9 (if available)
TreeFam:
Gene Tree for TLR9 (if available)

Paralogs for TLR9 Gene

Paralogs for TLR9 Gene

(2) SIMAP similar genes for TLR9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TLR9: view

Variants for TLR9 Gene

Sequence variations from dbSNP and Humsavar for TLR9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs187084 -- 52,227,015(-) gccct(C/T)aagaa upstream-variant-2KB
rs352139 -- 52,224,356(-) GAGGT(A/G)GAGCT intron-variant
rs352140 -- 52,222,681(+) AGTCG(A/C/T)GGTAG synonymous-codon, reference
rs352144 -- 52,227,452(-) GGCTC(A/C)GGGCA upstream-variant-2KB
rs445676 -- 52,221,376(-) CGCTA(C/T)GTGCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TLR9 Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv460537 CNV Loss 19166990
nsv508218 CNV Loss 20534489
nsv508926 CNV Insertion 20534489
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv482084 CNV Gain 20164927

Variation tolerance for TLR9 Gene

Residual Variation Intolerance Score: 3.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLR9 Gene

HapMap Linkage Disequilibrium report
TLR9
Human Gene Mutation Database (HGMD)
TLR9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR9 Gene

Disorders for TLR9 Gene

MalaCards: The human disease database

(19) MalaCards diseases for TLR9 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
meningococcal meningitis
  • meningitis meningococcal
myositis fibrosa
  • interstitial myositis
ocular toxoplasmosis
  • toxoplasmosis ocular
juvenile nasopharyngeal angiofibroma
  • jna
tonsillitis
  • tonsillitis, nos
- elite association
Search TLR9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLR9

Genetic Association Database (GAD)
TLR9
Human Genome Epidemiology (HuGE) Navigator
TLR9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLR9
genes like me logo Genes that share disorders with TLR9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR9 Gene

Publications for TLR9 Gene

  1. Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity. (PMID: 16849519) Merrell M.A. … Selander K.S. (Mol. Cancer Res. 2006) 23 25 26 67
  2. Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases? (PMID: 15762869) Lenert P. (Clin. Exp. Immunol. 2005) 23 25 26 67
  3. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. (PMID: 15307186) Rutz M. … Bauer S. (Eur. J. Immunol. 2004) 23 25 26 67
  4. TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. (PMID: 18220957) Sun S. … Karlsson L. (Inflamm Allergy Drug Targets 2007) 25 26 67
  5. Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation. (PMID: 19685493) RozkovA! D. … SpA-sek R. (Int. J. Cancer 2010) 23 67

Products for TLR9 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TLR9
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR9
  • Block miRNA regulation of TLR9 using miScript Target Protectors
  • Addgene plasmids for TLR9

Sources for TLR9 Gene

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