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Aliases for PNLIP Gene

Aliases for PNLIP Gene

  • Pancreatic Lipase 2 3 4
  • EC 3.1.1.3 4 64
  • PNLIPD 3 6
  • PTL 3 4
  • PL 3 4
  • Pancreatic Triacylglycerol Lipase 3
  • Triacylglycerol Acylhydrolase 3

External Ids for PNLIP Gene

Summaries for PNLIP Gene

Entrez Gene Summary for PNLIP Gene

  • This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for PNLIP Gene

PNLIP (Pancreatic Lipase) is a Protein Coding gene. Diseases associated with PNLIP include pancreatic lipase deficiency and pancreatic colipase deficiency. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include triglyceride lipase activity. An important paralog of this gene is LPL.

Gene Wiki entry for PNLIP Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIP Gene

Genomics for PNLIP Gene

Genomic Location for PNLIP Gene

Start:
116,545,916 bp from pter
End:
116,567,855 bp from pter
Size:
21,940 bases
Orientation:
Plus strand

Genomic View for PNLIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIP Gene

Regulatory Elements for PNLIP Gene

Proteins for PNLIP Gene

  • Protein details for PNLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16233-LIPP_HUMAN
    Recommended name:
    Pancreatic triacylglycerol lipase
    Protein Accession:
    P16233
    Secondary Accessions:
    • Q5VSQ2

    Protein attributes for PNLIP Gene

    Size:
    465 amino acids
    Molecular mass:
    51157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIP Gene

neXtProt entry for PNLIP Gene

Proteomics data for PNLIP Gene at MOPED

Post-translational modifications for PNLIP Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn183

Other Protein References for PNLIP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PNLIP Gene

UniProtKB/Swiss-Prot:

LIPP_HUMAN
Domain:
  • Contains 1 PLAT domain.:
    • P16233
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.:
    • P16233
genes like me logo Genes that share domains with PNLIP: view

No data available for Gene Families for PNLIP Gene

Function for PNLIP Gene

Molecular function for PNLIP Gene

GENATLAS Biochemistry: lipase,pancreatic (56kDa)
UniProtKB/Swiss-Prot CatalyticActivity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Induction: By colipase/CLPS in the presence of bile salts

Enzyme Numbers (IUBMB) for PNLIP Gene

Gene Ontology (GO) - Molecular Function for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0052689 carboxylic ester hydrolase activity --
genes like me logo Genes that share ontologies with PNLIP: view
genes like me logo Genes that share phenotypes with PNLIP: view

Animal Models for PNLIP Gene

MGI Knock Outs for PNLIP:

miRNA for PNLIP Gene

miRTarBase miRNAs that target PNLIP

No data available for Transcription Factor Targeting and HOMER Transcription for PNLIP Gene

Localization for PNLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNLIP Gene COMPARTMENTS Subcellular localization image for PNLIP gene
Compartment Confidence
extracellular 5
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PNLIP: view

Pathways for PNLIP Gene

genes like me logo Genes that share pathways with PNLIP: view

Gene Ontology (GO) - Biological Process for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process --
GO:0007603 phototransduction, visible light TAS --
GO:0016042 lipid catabolic process IEA --
GO:0030299 intestinal cholesterol absorption IEA --
genes like me logo Genes that share ontologies with PNLIP: view

Compounds for PNLIP Gene

(4) Tocris Compounds for PNLIP Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor [685506-42-7]
JZL 184 Monoacylglycerol lipase (MAGL) inhibitor [1101854-58-3]
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity [96829-58-2]
Pristimerin Potent, reversible MAGL inhibitor [1258-84-0]

(1142) HMDB Compounds for PNLIP Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available

(4) Drugbank Compounds for PNLIP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(Hydroxyethyloxy)Tri(Ethyloxy)Octane
target
Glycerol Phenylbutyrate
  • Glyceryl Tri-4-Phenylbutyrate
611168-24-2 enzyme substrate
METHOXYUNDECYLPHOSPHINIC ACID
target
Orlistat
  • (-)-Tetrahydrolipstatin
96829-58-2 target inhibitor

(51) Novoseek inferred chemical compound relationships for PNLIP Gene

Compound -log(P) Hits PubMed IDs
orlistat 88.9 41
ar-25 83.7 6
5-(dodecyldithio)-2-nitrobenzoic acid 83.7 3
vinyl propionate 83.7 1
lipstatin 82.3 1
genes like me logo Genes that share compounds with PNLIP: view

Transcripts for PNLIP Gene

mRNA/cDNA for PNLIP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(725) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNLIP Gene

Pancreatic lipase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIP Gene

No ASD Table

Relevant External Links for PNLIP Gene

GeneLoc Exon Structure for
PNLIP
ECgene alternative splicing isoforms for
PNLIP

Expression for PNLIP Gene

mRNA expression in normal human tissues for PNLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIP Gene

This gene is overexpressed in Pancreas (52.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PNLIP Gene

SOURCE GeneReport for Unigene cluster for PNLIP Gene Hs.501135

genes like me logo Genes that share expressions with PNLIP: view

Orthologs for PNLIP Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNLIP 36
  • 99.07 (n)
  • 98.92 (a)
PNLIP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PNLIP 36
  • 85.98 (n)
  • 83.7 (a)
PNLIP 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNLIP 36
  • 87.22 (n)
  • 86.78 (a)
PNLIP 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnlip 36
  • 79.66 (n)
  • 78.85 (a)
Pnlip 16
Pnlip 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNLIP 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIP 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnlip 36
  • 79.88 (n)
  • 78.41 (a)
chicken
(Gallus gallus)
Aves PNLIP 37
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000211 36
  • 45.48 (n)
  • 36.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5966 36
  • 48.69 (n)
  • 38.78 (a)
CG5966 37
  • 27 (a)
OneToMany
CG6271 38
  • 34 (a)
CG7367 38
  • 33 (a)
CG6283 38
  • 31 (a)
CG17191 38
  • 33 (a)
CG6472 38
  • 34 (a)
CG5966 38
  • 36 (a)
CG6847 38
  • 29 (a)
CG6277 38
  • 32 (a)
CG17192 38
  • 31 (a)
CG6295 38
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 37
  • 43 (a)
OneToMany
Species with no ortholog for PNLIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIP Gene

ENSEMBL:
Gene Tree for PNLIP (if available)
TreeFam:
Gene Tree for PNLIP (if available)

Paralogs for PNLIP Gene

Paralogs for PNLIP Gene

Selected SIMAP similar genes for PNLIP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PNLIP Gene

genes like me logo Genes that share paralogs with PNLIP: view

Variants for PNLIP Gene

Sequence variations from dbSNP and Humsavar for PNLIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2070772 -- 116,560,751(+) TTTTG(C/T)ATTTT intron-variant
rs2234972 -- 116,556,077(+) ATGGC(C/T)TTGCT missense, reference
rs2915749 -- 116,553,604(-) aaagt(A/G)tattt intron-variant
rs2915769 -- 116,565,481(-) tccat(C/T)tcaaa intron-variant
rs2915770 -- 116,564,999(-) ACAGG(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIP Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv832001 CNV Loss 17160897

Relevant External Links for PNLIP Gene

HapMap Linkage Disequilibrium report
PNLIP
Human Gene Mutation Database (HGMD)
PNLIP

Disorders for PNLIP Gene

(1) OMIM Diseases for PNLIP Gene (246600)

(25) Novoseek inferred disease relationships for PNLIP Gene

Disease -log(P) Hits PubMed IDs
pancreatic insufficiency 70.8 3
exocrine pancreatic insufficiency 68.7 3
steatorrhea 59.8 4
pancreas exocrine 59.8 3
pancreatic diseases 57.8 5

Relevant External Links for PNLIP

Genetic Association Database (GAD)
PNLIP
Human Genome Epidemiology (HuGE) Navigator
PNLIP
genes like me logo Genes that share disorders with PNLIP: view

No data available for UniProtKB/Swiss-Prot for PNLIP Gene

Publications for PNLIP Gene

  1. Structure-function relationships in naturally occurring mutants of pancreatic lipase. (PMID: 8029213) Carriere F. … Thim L. (Protein Eng. 1994) 3 4 23
  2. Structure of the pancreatic lipase-procolipase complex. (PMID: 1522902) van Tilbeurgh H. … Cambillau C. (Nature 1992) 3 4 23
  3. Assignment of human pancreatic lipase gene (PNLIP) to chromosome 10q24-q26. (PMID: 1783385) Davis R.C. … Lusis A.J. (Genomics 1991) 2 3 23
  4. Structure of human pancreatic lipase. (PMID: 2106079) Winkler F.K. … Hunziker W. (Nature 1990) 3 4 23
  5. Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits. (PMID: 11393534) Hegele R.A. … Cao H. (J. Hum. Genet. 2001) 3 23 49

Products for PNLIP Gene

Sources for PNLIP Gene

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