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Aliases for PNLIP Gene

Aliases for PNLIP Gene

  • Pancreatic Lipase 2 3 4
  • EC 3.1.1.3 4 63
  • PNLIPD 3 6
  • PTL 3 4
  • PL 3 4
  • Pancreatic Triacylglycerol Lipase 3
  • Triacylglycerol Acylhydrolase 3

External Ids for PNLIP Gene

Previous GeneCards Identifiers for PNLIP Gene

  • GC10P117224
  • GC10P117549
  • GC10P118436
  • GC10P117970
  • GC10P118295
  • GC10P111932
  • GC10P118305

Summaries for PNLIP Gene

Entrez Gene Summary for PNLIP Gene

  • This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for PNLIP Gene

PNLIP (Pancreatic Lipase) is a Protein Coding gene. Diseases associated with PNLIP include pancreatic lipase deficiency and pancreatic colipase deficiency. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include triglyceride lipase activity. An important paralog of this gene is LPL.

Tocris Summary for PNLIP Gene

Gene Wiki entry for PNLIP Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIP Gene

Genomics for PNLIP Gene

Regulatory Elements for PNLIP Gene

Genomic Location for PNLIP Gene

Start:
116,545,916 bp from pter
End:
116,567,855 bp from pter
Size:
21,940 bases
Orientation:
Plus strand

Genomic View for PNLIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PNLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIP Gene

Proteins for PNLIP Gene

  • Protein details for PNLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16233-LIPP_HUMAN
    Recommended name:
    Pancreatic triacylglycerol lipase
    Protein Accession:
    P16233
    Secondary Accessions:
    • Q5VSQ2

    Protein attributes for PNLIP Gene

    Size:
    465 amino acids
    Molecular mass:
    51157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIP Gene

neXtProt entry for PNLIP Gene

Proteomics data for PNLIP Gene at MOPED

Post-translational modifications for PNLIP Gene

  • Glycosylation at Asn183
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for PNLIP Gene

Gene Families for PNLIP Gene

HGNC:

Suggested Antigen Peptide Sequences for PNLIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16233

UniProtKB/Swiss-Prot:

LIPP_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIP: view

Function for PNLIP Gene

Molecular function for PNLIP Gene

GENATLAS Biochemistry:
lipase,pancreatic (56kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Induction:
By colipase/CLPS in the presence of bile salts

Enzyme Numbers (IUBMB) for PNLIP Gene

Gene Ontology (GO) - Molecular Function for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0052689 carboxylic ester hydrolase activity --
genes like me logo Genes that share ontologies with PNLIP: view
genes like me logo Genes that share phenotypes with PNLIP: view

Animal Models for PNLIP Gene

MGI Knock Outs for PNLIP:

Animal Model Products

miRNA for PNLIP Gene

miRTarBase miRNAs that target PNLIP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIP

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PNLIP Gene

Localization for PNLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PNLIP Gene COMPARTMENTS Subcellular localization image for PNLIP gene
Compartment Confidence
extracellular 5
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PNLIP: view

Pathways for PNLIP Gene

genes like me logo Genes that share pathways with PNLIP: view

Gene Ontology (GO) - Biological Process for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process --
GO:0007603 phototransduction, visible light TAS --
GO:0016042 lipid catabolic process IEA --
GO:0030299 intestinal cholesterol absorption IEA --
genes like me logo Genes that share ontologies with PNLIP: view

Drugs for PNLIP Gene

(4) Drugbank Compounds for PNLIP Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Orlistat
  • (-)-Tetrahydrolipstatin
96829-58-2 3034010 Target inhibitor approved, investigational
Glycerol Phenylbutyrate
  • Glyceryl Tri-4-Phenylbutyrate
611168-24-2 Enzyme substrate approved
(Hydroxyethyloxy)Tri(Ethyloxy)Octane
5414 Target experimental
METHOXYUNDECYLPHOSPHINIC ACID
446977 Target experimental

(2) Tocris Compounds for PNLIP Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor [685506-42-7]
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity [96829-58-2]

(15209) HMDB Compounds for PNLIP Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • (all-Z)-5,8,11,14-Eicosatetraenoate
506-32-1
DG(14:0/0:0/14:0)
  • 1-Myristoyl-3-myristoyl-sn-glycerol
DG(14:0/0:0/14:1n5)
  • 1-Myristoyl-3-myristoleoyl-sn-glycerol
DG(14:0/0:0/15:0)
  • 1-Myristoyl-3-pentadecanoyl-sn-glycerol

(51) Novoseek inferred chemical compound relationships for PNLIP Gene

Compound -log(P) Hits PubMed IDs
orlistat 88.9 41
ar-25 83.7 6
5-(dodecyldithio)-2-nitrobenzoic acid 83.7 3
vinyl propionate 83.7 1
lipstatin 82.3 1
genes like me logo Genes that share compounds with PNLIP: view

Transcripts for PNLIP Gene

mRNA/cDNA for PNLIP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(725) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PNLIP Gene

Pancreatic lipase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PNLIP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIP Gene

No ASD Table

Relevant External Links for PNLIP Gene

GeneLoc Exon Structure for
PNLIP
ECgene alternative splicing isoforms for
PNLIP

Expression for PNLIP Gene

mRNA expression in normal human tissues for PNLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIP Gene

This gene is overexpressed in Pancreas (52.9).

Protein differential expression in normal tissues for PNLIP Gene

This gene is overexpressed in Pancreatic juice (65.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PNLIP Gene

SOURCE GeneReport for Unigene cluster for PNLIP Gene Hs.501135

genes like me logo Genes that share expressions with PNLIP: view

Expression partners for PNLIP Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PNLIP Gene

Orthologs for PNLIP Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PNLIP 35
  • 85.98 (n)
  • 83.7 (a)
PNLIP 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PNLIP 35
  • 87.22 (n)
  • 86.78 (a)
PNLIP 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pnlip 35
  • 79.66 (n)
  • 78.85 (a)
Pnlip 16
Pnlip 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PNLIP 35
  • 99.07 (n)
  • 98.92 (a)
PNLIP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pnlip 35
  • 79.88 (n)
  • 78.41 (a)
oppossum
(Monodelphis domestica)
Mammalia PNLIP 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIP 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNLIP 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17191 37
  • 33 (a)
CG17192 37
  • 31 (a)
CG5966 37
  • 36 (a)
CG6271 37
  • 34 (a)
CG6277 37
  • 32 (a)
CG6283 37
  • 31 (a)
CG6295 37
  • 37 (a)
CG6472 37
  • 34 (a)
CG6847 37
  • 29 (a)
CG7367 37
  • 33 (a)
CG5966 35
  • 48.69 (n)
  • 38.78 (a)
CG5966 36
  • 27 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000211 35
  • 45.48 (n)
  • 36.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 36
  • 43 (a)
OneToMany
Species with no ortholog for PNLIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIP Gene

ENSEMBL:
Gene Tree for PNLIP (if available)
TreeFam:
Gene Tree for PNLIP (if available)

Paralogs for PNLIP Gene

Paralogs for PNLIP Gene

(7) SIMAP similar genes for PNLIP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PNLIP Gene

genes like me logo Genes that share paralogs with PNLIP: view

Variants for PNLIP Gene

Sequence variations from dbSNP and Humsavar for PNLIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs148864963 -- 116,553,737(+) GTTCG(A/G)TTACT missense, reference
rs149017824 -- 116,545,872(+) ATTTT(C/T)CCACG upstream-variant-2KB
rs149330969 -- 116,546,718(+) ATCTA(A/G)ATTTA intron-variant
rs149567242 -- 116,561,514(+) TTTGA(C/G)TCAGA reference, missense
rs149884015 other 116,555,226(+) AGTCC(A/G)ATTGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PNLIP Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv832001 CNV Loss 17160897

Relevant External Links for PNLIP Gene

HapMap Linkage Disequilibrium report
PNLIP
Human Gene Mutation Database (HGMD)
PNLIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIP Gene

Disorders for PNLIP Gene

(1) OMIM Diseases for PNLIP Gene (246600)

(25) Novoseek inferred disease relationships for PNLIP Gene

Disease -log(P) Hits PubMed IDs
pancreatic insufficiency 70.8 3
exocrine pancreatic insufficiency 68.7 3
steatorrhea 59.8 4
pancreas exocrine 59.8 3
pancreatic diseases 57.8 5

Relevant External Links for PNLIP

Genetic Association Database (GAD)
PNLIP
Human Genome Epidemiology (HuGE) Navigator
PNLIP
genes like me logo Genes that share disorders with PNLIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIP Gene

Publications for PNLIP Gene

  1. Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits. (PMID: 11393534) Hegele R.A. … Cao H. (J. Hum. Genet. 2001) 3 23 48
  2. Structure of human pancreatic lipase. (PMID: 2106079) Winkler F.K. … Hunziker W. (Nature 1990) 3 4 23
  3. Structure-function relationships in naturally occurring mutants of pancreatic lipase. (PMID: 8029213) Carriere F. … Thim L. (Protein Eng. 1994) 3 4 23
  4. Assignment of human pancreatic lipase gene (PNLIP) to chromosome 10q24-q26. (PMID: 1783385) Davis R.C. … Lusis A.J. (Genomics 1991) 2 3 23
  5. Structure of the pancreatic lipase-procolipase complex. (PMID: 1522902) van Tilbeurgh H. … Cambillau C. (Nature 1992) 3 4 23

Products for PNLIP Gene

Sources for PNLIP Gene

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