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Aliases for PNLIP Gene

Aliases for PNLIP Gene

  • Pancreatic Lipase 2 3 4 5
  • EC 3.1.1.3 4 61
  • PTL 3 4
  • PL 3 4
  • Pancreatic Triacylglycerol Lipase 3
  • Triacylglycerol Acylhydrolase 3
  • PNLIPD 3

External Ids for PNLIP Gene

Previous GeneCards Identifiers for PNLIP Gene

  • GC10P117224
  • GC10P117549
  • GC10P118436
  • GC10P117970
  • GC10P118295
  • GC10P111932
  • GC10P118305

Summaries for PNLIP Gene

Entrez Gene Summary for PNLIP Gene

  • This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016]

GeneCards Summary for PNLIP Gene

PNLIP (Pancreatic Lipase) is a Protein Coding gene. Diseases associated with PNLIP include Pancreatic Lipase Deficiency and Steatorrhea. Among its related pathways are Metabolism of fat-soluble vitamins and the visual cycle I (vertebrates). GO annotations related to this gene include carboxylic ester hydrolase activity and triglyceride lipase activity. An important paralog of this gene is PNLIPRP1.

Tocris Summary for PNLIP Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

Gene Wiki entry for PNLIP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIP Gene

Genomics for PNLIP Gene

Regulatory Elements for PNLIP Gene

Enhancers for PNLIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G116614 0.6 FANTOM5 147.1 +68.4 68364 0.4 PKNOX1 FEZF1 ZNF384 ZIC2 JUND PRDM10 FOS ZNF548 PNLIP PNLIPRP2 PNLIPRP1
GH10G116589 0.9 ENCODE dbSUPER 10.9 +44.6 44604 2.3 SCRT1 NFIA NFIB FEZF1 ZNF843 HHEX FOXA1 GATA3 HNF4A ZNF18 PNLIPRP2 PNLIP RNU6-1090P PNLIPRP1
GH10G116470 0.7 ENCODE 10.3 -75.7 -75677 0.3 PKNOX1 ZNF680 ATF1 ATF2 ARID1B JUND GATA3 ATF3 GATA2 CREB1 RNU6-1090P PNLIP HMGB3P8 GC10P116539
GH10G116417 0.5 ENCODE dbSUPER 10.5 -127.3 -127252 3.0 PNLIP SLC18A2 PNLIPRP3 SNRPGP6
GH10G116487 0.5 ENCODE 10.3 -58.1 -58132 1.6 ZNF680 HLF ZNF24 ZIC2 EZH2 PNLIP RNU6-1090P HMGB3P8 GC10P116539
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PNLIP on UCSC Golden Path with GeneCards custom track

Genomic Location for PNLIP Gene

Chromosome:
10
Start:
116,545,916 bp from pter
End:
116,567,855 bp from pter
Size:
21,940 bases
Orientation:
Plus strand

Genomic View for PNLIP Gene

Genes around PNLIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIP Gene

Proteins for PNLIP Gene

  • Protein details for PNLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16233-LIPP_HUMAN
    Recommended name:
    Pancreatic triacylglycerol lipase
    Protein Accession:
    P16233
    Secondary Accessions:
    • Q5VSQ2

    Protein attributes for PNLIP Gene

    Size:
    465 amino acids
    Molecular mass:
    51157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIP Gene

neXtProt entry for PNLIP Gene

Selected DME Specific Peptides for PNLIP Gene

P16233:
  • HLRSYKYY
  • YSPSNVH
  • RLDPSDA
  • HAAGEAGRRTNG
  • CPQMGHYAD
  • DFFPNGG
  • WRYKVSVTLSG
  • EVCYERLGCF
  • VNCICVDW
  • GRITGLD
  • NFARWRY
  • FLLYTNENPNN
  • DSDVDVGD
  • FVDVIHTD
  • NNVINPTLP

Post-translational modifications for PNLIP Gene

  • Glycosylation at posLast=183183
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PNLIP Gene

Gene Families for PNLIP Gene

Suggested Antigen Peptide Sequences for PNLIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16233

UniProtKB/Swiss-Prot:

LIPP_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIP: view

Function for PNLIP Gene

Molecular function for PNLIP Gene

GENATLAS Biochemistry:
lipase,pancreatic (56kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Induction:
By colipase/CLPS in the presence of bile salts.

Enzyme Numbers (IUBMB) for PNLIP Gene

Gene Ontology (GO) - Molecular Function for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity ISS,TAS --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PNLIP: view
genes like me logo Genes that share phenotypes with PNLIP: view

Human Phenotype Ontology for PNLIP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PNLIP Gene

MGI Knock Outs for PNLIP:

Animal Model Products

  • Taconic Biosciences Mouse Models for PNLIP

miRNA for PNLIP Gene

miRTarBase miRNAs that target PNLIP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PNLIP Gene

Localization for PNLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNLIP gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PNLIP: view

Pathways & Interactions for PNLIP Gene

genes like me logo Genes that share pathways with PNLIP: view

Gene Ontology (GO) - Biological Process for PNLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0030299 intestinal cholesterol absorption IEA --
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with PNLIP: view

No data available for SIGNOR curated interactions for PNLIP Gene

Drugs & Compounds for PNLIP Gene

(33) Drugs for PNLIP Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Glycerol Phenylbutyrate Approved Pharma Enzyme, substrate 0
Water Approved Pharma 0
Stearic acid Experimental Pharma 0
(Hydroxyethyloxy)Tri(Ethyloxy)Octane Experimental Pharma Target 0

(43) Additional Compounds for PNLIP Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(3) Tocris Compounds for PNLIP Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4

(1) ApexBio Compounds for PNLIP Gene

Compound Action Cas Number
Dihydroberberine Pancreatic lipase inhibitor 483-15-8
genes like me logo Genes that share compounds with PNLIP: view

Transcripts for PNLIP Gene

mRNA/cDNA for PNLIP Gene

Unigene Clusters for PNLIP Gene

Pancreatic lipase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIP Gene

No ASD Table

Relevant External Links for PNLIP Gene

GeneLoc Exon Structure for
PNLIP
ECgene alternative splicing isoforms for
PNLIP

Expression for PNLIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIP Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for PNLIP Gene

This gene is overexpressed in Pancreatic juice (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PNLIP Gene



Protein tissue co-expression partners for PNLIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PNLIP Gene:

PNLIP

SOURCE GeneReport for Unigene cluster for PNLIP Gene:

Hs.501135

Evidence on tissue expression from TISSUES for PNLIP Gene

  • Pancreas(5)
  • Lung(4.1)
  • Liver(4)
  • Stomach(2.7)
  • Intestine(2.6)
  • Muscle(2.3)
  • Blood(2.2)
  • Heart(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PNLIP Gene

Germ Layers:
  • endoderm
Systems:
  • digestive
Organs:
Abdomen:
  • intestine
  • large intestine
  • pancreas
  • small intestine
genes like me logo Genes that share expression patterns with PNLIP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PNLIP Gene

Orthologs for PNLIP Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNLIP 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia PNLIP 34 35
  • 87.22 (n)
cow
(Bos Taurus)
Mammalia PNLIP 34 35
  • 85.98 (n)
rat
(Rattus norvegicus)
Mammalia Pnlip 34
  • 79.88 (n)
mouse
(Mus musculus)
Mammalia Pnlip 34 16 35
  • 79.66 (n)
oppossum
(Monodelphis domestica)
Mammalia PNLIP 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNLIP 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNLIP 35
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5966 36 34 35
  • 48.69 (n)
CG6295 36
  • 37 (a)
CG6271 36
  • 34 (a)
CG6472 36
  • 34 (a)
CG17191 36
  • 33 (a)
CG7367 36
  • 33 (a)
CG6277 36
  • 32 (a)
CG17192 36
  • 31 (a)
CG6283 36
  • 31 (a)
CG6847 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000211 34
  • 45.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4080 35
  • 43 (a)
OneToMany
Species where no ortholog for PNLIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIP Gene

ENSEMBL:
Gene Tree for PNLIP (if available)
TreeFam:
Gene Tree for PNLIP (if available)

Paralogs for PNLIP Gene

Paralogs for PNLIP Gene

(7) SIMAP similar genes for PNLIP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PNLIP Gene

genes like me logo Genes that share paralogs with PNLIP: view

Variants for PNLIP Gene

Sequence variations from dbSNP and Humsavar for PNLIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000103563 -- 116,549,259(+) GATCA(C/T)GAGGT intron-variant
rs1000494610 -- 116,550,884(+) ATCCA(A/C/G)TTCCC intron-variant
rs1000555658 -- 116,545,743(+) CTTTA(C/T)ATAAT upstream-variant-2KB
rs1000602256 -- 116,545,403(+) AGCTT(A/G)TTTAT upstream-variant-2KB
rs1000752235 -- 116,552,130(+) GTCTA(C/T)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIP Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER inversion 18451855
nsv832001 CNV loss 17160897

Variation tolerance for PNLIP Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PNLIP Gene

Human Gene Mutation Database (HGMD)
PNLIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNLIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIP Gene

Disorders for PNLIP Gene

MalaCards: The human disease database

(23) MalaCards diseases for PNLIP Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic lipase deficiency
  • pnlipd
steatorrhea
  • fatty stool
multicentric papillary thyroid carcinoma
  • multicentric thyroid gland papillary carcinoma
lipoprotein lipase deficiency
  • hyperlipoproteinemia, type i
exocrine pancreatic insufficiency
- elite association - COSMIC cancer census association via MalaCards
Search PNLIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for PNLIP

Genetic Association Database (GAD)
PNLIP
Human Genome Epidemiology (HuGE) Navigator
PNLIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PNLIP
genes like me logo Genes that share disorders with PNLIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIP Gene

Publications for PNLIP Gene

  1. Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits. (PMID: 11393534) Hegele R.A. … Cao H. (J. Hum. Genet. 2001) 3 22 46 64
  2. Structure-function relationships in naturally occurring mutants of pancreatic lipase. (PMID: 8029213) Carriere F. … Thim L. (Protein Eng. 1994) 3 4 22 64
  3. Structure of the pancreatic lipase-procolipase complex. (PMID: 1522902) van Tilbeurgh H. … Cambillau C. (Nature 1992) 3 4 22 64
  4. Assignment of human pancreatic lipase gene (PNLIP) to chromosome 10q24-q26. (PMID: 1783385) Davis R.C. … Lusis A.J. (Genomics 1991) 2 3 22 64
  5. Structure of human pancreatic lipase. (PMID: 2106079) Winkler F.K. … Hunziker W. (Nature 1990) 3 4 22 64

Products for PNLIP Gene

Sources for PNLIP Gene