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Aliases for DUOX1 Gene

Aliases for DUOX1 Gene

  • Dual Oxidase 1 2 3 5
  • NADPH Thyroid Oxidase 1 2 3 4
  • Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 3
  • Flavoprotein NADPH Oxidase 2 3
  • Thyroid Oxidase 1 3 4
  • Large NOX 1 3 4
  • Long NOX 1 3 4
  • LNOX1 3 4
  • THOX1 3 4
  • EC 1.11.1.- 4
  • EC 1.6.3.1 4
  • NOXEF1 3
  • DUOX 4

External Ids for DUOX1 Gene

Previous GeneCards Identifiers for DUOX1 Gene

  • GC15P040980
  • GC15P038469
  • GC15P043001
  • GC15P043138
  • GC15P043209
  • GC15P045422
  • GC15P022246

Summaries for DUOX1 Gene

Entrez Gene Summary for DUOX1 Gene

  • The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for DUOX1 Gene

DUOX1 (Dual Oxidase 1) is a Protein Coding gene. Diseases associated with DUOX1 include adrenal rest tumor. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is NOX5.

UniProtKB/Swiss-Prot for DUOX1 Gene

  • Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

Gene Wiki entry for DUOX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUOX1 Gene

Genomics for DUOX1 Gene

Regulatory Elements for DUOX1 Gene

Promoters for DUOX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUOX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUOX1 Gene

Chromosome:
15
Start:
45,129,933 bp from pter
End:
45,165,578 bp from pter
Size:
35,646 bases
Orientation:
Plus strand

Genomic View for DUOX1 Gene

Genes around DUOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUOX1 Gene

Proteins for DUOX1 Gene

  • Protein details for DUOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD9-DUOX1_HUMAN
    Recommended name:
    Dual oxidase 1
    Protein Accession:
    Q9NRD9
    Secondary Accessions:
    • A6NH28
    • Q14C94
    • Q6ZMB3
    • Q6ZR09
    • Q9NZC1

    Protein attributes for DUOX1 Gene

    Size:
    1551 amino acids
    Molecular mass:
    177235 Da
    Quaternary structure:
    • Interacts with TXNDC11, TPO and CYBA.
    SequenceCaution:
    • Sequence=AK128591; Type=Erroneous termination; Positions=967; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAD18816.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DUOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUOX1 Gene

Proteomics data for DUOX1 Gene at MOPED

Post-translational modifications for DUOX1 Gene

Other Protein References for DUOX1 Gene

No data available for DME Specific Peptides for DUOX1 Gene

Domains & Families for DUOX1 Gene

Gene Families for DUOX1 Gene

Suggested Antigen Peptide Sequences for DUOX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRD9

UniProtKB/Swiss-Prot:

DUOX1_HUMAN :
  • Contains 3 EF-hand domains.
  • In the N-terminal section; belongs to the peroxidase family.
Domain:
  • Contains 3 EF-hand domains.
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 ferric oxidoreductase domain.
Family:
  • In the N-terminal section; belongs to the peroxidase family.
genes like me logo Genes that share domains with DUOX1: view

Function for DUOX1 Gene

Molecular function for DUOX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.
UniProtKB/Swiss-Prot Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
UniProtKB/Swiss-Prot Induction:
By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.

Enzyme Numbers (IUBMB) for DUOX1 Gene

Gene Ontology (GO) - Molecular Function for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0005515 protein binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DUOX1: view

Phenotypes for DUOX1 Gene

GenomeRNAi human phenotypes for DUOX1:
genes like me logo Genes that share phenotypes with DUOX1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUOX1 Gene

Localization for DUOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUOX1 Gene

Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUOX1 Gene COMPARTMENTS Subcellular localization image for DUOX1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for DUOX1 Gene

Pathways & Interactions for DUOX1 Gene

genes like me logo Genes that share pathways with DUOX1: view

Pathways by source for DUOX1 Gene

UniProtKB/Swiss-Prot Q9NRD9-DUOX1_HUMAN

  • Pathway: Hormone biosynthesis; thyroid hormone biosynthesis.

Gene Ontology (GO) - Biological Process for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation TAS --
GO:0019221 cytokine-mediated signaling pathway IDA 16111680
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0042446 hormone biosynthetic process IEA --
GO:0042554 superoxide anion generation NAS 10806195
genes like me logo Genes that share ontologies with DUOX1: view

No data available for SIGNOR curated interactions for DUOX1 Gene

Drugs & Compounds for DUOX1 Gene

(4) Drugs for DUOX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Hydrogen peroxide Pharma 46
NAD Pharma Full agonist, Agonist 0
calcium Nutra 0

(6) Additional Compounds for DUOX1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with DUOX1: view

Transcripts for DUOX1 Gene

Unigene Clusters for DUOX1 Gene

Dual oxidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUOX1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DUOX1 Gene

GeneLoc Exon Structure for
DUOX1
ECgene alternative splicing isoforms for
DUOX1

Expression for DUOX1 Gene

mRNA expression in normal human tissues for DUOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUOX1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.8), Lung (x7.4), Thyroid (x6.3), Skin - Not Sun Exposed (Suprapubic) (x4.7), Stomach (x4.6), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for DUOX1 Gene

This gene is overexpressed in Nasal epithelium (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUOX1 Gene



SOURCE GeneReport for Unigene cluster for DUOX1 Gene Hs.272813

mRNA Expression by UniProt/SwissProt for DUOX1 Gene

Q9NRD9-DUOX1_HUMAN
Tissue specificity: Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
genes like me logo Genes that share expression patterns with DUOX1: view

Protein tissue co-expression partners for DUOX1 Gene

Primer Products

In Situ Assay Products

Orthologs for DUOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUOX1 36
  • 99 (a)
OneToOne
DUOX1 35
  • 99.42 (n)
  • 99.42 (a)
cow
(Bos Taurus)
Mammalia DUOX1 35
  • 89.64 (n)
  • 90.14 (a)
DUOX1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUOX1 36
  • 91 (a)
OneToOne
DUOX1 35
  • 89.58 (n)
  • 91.23 (a)
mouse
(Mus musculus)
Mammalia Duox1 16
Duox1 35
  • 87.28 (n)
  • 91.04 (a)
Duox1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUOX1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Duox1 35
  • 86.76 (n)
  • 90.2 (a)
chicken
(Gallus gallus)
Aves DUOX2 35
  • 70.46 (n)
  • 66.84 (a)
-- 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia duox1 35
  • 62.36 (n)
  • 64.28 (a)
zebrafish
(Danio rerio)
Actinopterygii duox 36
  • 57 (a)
OneToMany
duox 35
  • 60.61 (n)
  • 56.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3131 37
  • 39 (a)
Duox 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53G12.3 37
  • 33 (a)
F56C11.1 37
  • 34 (a)
bli-3 36
  • 35 (a)
ManyToMany
duox-2 36
  • 34 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RBOHA 35
  • 45.96 (n)
  • 36.57 (a)
rice
(Oryza sativa)
Liliopsida Os01g0360200 35
  • 45.13 (n)
  • 32.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for DUOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUOX1 Gene

ENSEMBL:
Gene Tree for DUOX1 (if available)
TreeFam:
Gene Tree for DUOX1 (if available)

Paralogs for DUOX1 Gene

Paralogs for DUOX1 Gene

(6) SIMAP similar genes for DUOX1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DUOX1 Gene

genes like me logo Genes that share paralogs with DUOX1: view

Variants for DUOX1 Gene

Sequence variations from dbSNP and Humsavar for DUOX1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs16939752 - 45,151,935(+) GCAGC(C/T)GTCTC reference, missense
rs2458236 - 45,153,958(+) CTGAG(A/C/T)TCCCC reference, missense
rs16939743 - 45,150,698(+) TATGA(C/T)CTGGT reference, missense
rs938131 -- 45,132,720(+) GAGCT(A/G)CTCAC intron-variant
rs1617207 -- 45,155,064(+) AGTAC(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUOX1 Gene

Variant ID Type Subtype PubMed ID
dgv744e1 CNV Complex 17122850
dgv2378n71 CNV Loss 21882294
esv1002924 CNV Deletion 20482838
nsv457125 CNV Loss 19166990
nsv518213 CNV Gain 19592680
nsv520580 CNV Loss 19592680
nsv904187 CNV Loss 21882294

Variation tolerance for DUOX1 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUOX1 Gene

HapMap Linkage Disequilibrium report
DUOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUOX1 Gene

Disorders for DUOX1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUOX1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adrenal rest tumor
  • adrenal rest neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search DUOX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUOX1

Genetic Association Database (GAD)
DUOX1
Human Genome Epidemiology (HuGE) Navigator
DUOX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUOX1
genes like me logo Genes that share disorders with DUOX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUOX1 Gene

Publications for DUOX1 Gene

  1. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. (PMID: 10806195) De Deken X. … Miot F. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Association of duoxes with thyroid peroxidase and its regulation in thyrocytes. (PMID: 19952225) Song Y. … De Deken X. (J. Clin. Endocrinol. Metab. 2010) 3 23
  3. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. (PMID: 19339556) Luxen S. … Knaus U.G. (J. Cell. Sci. 2009) 3 23
  4. Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity. (PMID: 19460756) Meitzler J.L. … Ortiz de Montellano P.R. (J. Biol. Chem. 2009) 3 23
  5. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. (PMID: 18281478) Luxen S. … Knaus U.G. (Cancer Res. 2008) 3 23

Products for DUOX1 Gene

Sources for DUOX1 Gene

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