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Aliases for DUOX1 Gene

Aliases for DUOX1 Gene

  • Dual Oxidase 1 2 3
  • NADPH Thyroid Oxidase 1 2 3 4
  • THOX1 3 4 6
  • Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 3
  • Flavoprotein NADPH Oxidase 2 3
  • Thyroid Oxidase 1 3 4
  • Large NOX 1 3 4
  • Long NOX 1 3 4
  • LNOX1 3 4
  • EC 1.11.1.- 4
  • EC 1.6.3.1 4
  • NOXEF1 3
  • DUOX 4

External Ids for DUOX1 Gene

Previous GeneCards Identifiers for DUOX1 Gene

  • GC15P040980
  • GC15P038469
  • GC15P043001
  • GC15P043138
  • GC15P043209
  • GC15P045422
  • GC15P022246

Summaries for DUOX1 Gene

Entrez Gene Summary for DUOX1 Gene

  • The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for DUOX1 Gene

DUOX1 (Dual Oxidase 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and NADP binding. An important paralog of this gene is NOX5.

UniProtKB/Swiss-Prot for DUOX1 Gene

  • Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

Gene Wiki entry for DUOX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUOX1 Gene

Genomics for DUOX1 Gene

Regulatory Elements for DUOX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUOX1 Gene

Start:
45,129,933 bp from pter
End:
45,165,578 bp from pter
Size:
35,646 bases
Orientation:
Plus strand

Genomic View for DUOX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUOX1 Gene

Proteins for DUOX1 Gene

  • Protein details for DUOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD9-DUOX1_HUMAN
    Recommended name:
    Dual oxidase 1
    Protein Accession:
    Q9NRD9
    Secondary Accessions:
    • A6NH28
    • Q14C94
    • Q6ZMB3
    • Q6ZR09
    • Q9NZC1

    Protein attributes for DUOX1 Gene

    Size:
    1551 amino acids
    Molecular mass:
    177235 Da
    Quaternary structure:
    • Interacts with TXNDC11, TPO and CYBA.
    SequenceCaution:
    • Sequence=AK128591; Type=Erroneous termination; Positions=967; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAD18816.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DUOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUOX1 Gene

Proteomics data for DUOX1 Gene at MOPED

Post-translational modifications for DUOX1 Gene

Other Protein References for DUOX1 Gene

No data available for DME Specific Peptides for DUOX1 Gene

Domains for DUOX1 Gene

Gene Families for DUOX1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for DUOX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRD9

UniProtKB/Swiss-Prot:

DUOX1_HUMAN :
  • Q9NRD9
Domain:
  • Contains 3 EF-hand domains.
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 ferric oxidoreductase domain.
Family:
  • In the N-terminal section; belongs to the peroxidase family.
genes like me logo Genes that share domains with DUOX1: view

Function for DUOX1 Gene

Molecular function for DUOX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
UniProtKB/Swiss-Prot EnzymeRegulation: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.
UniProtKB/Swiss-Prot Function: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
UniProtKB/Swiss-Prot Induction: By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.

Enzyme Numbers (IUBMB) for DUOX1 Gene

Gene Ontology (GO) - Molecular Function for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0016174 NAD(P)H oxidase activity NAS 10806195
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with DUOX1: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUOX1 Gene

Localization for DUOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUOX1 Gene

Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUOX1 Gene COMPARTMENTS Subcellular localization image for DUOX1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane NAS 10806195
genes like me logo Genes that share ontologies with DUOX1: view

Pathways for DUOX1 Gene

SuperPathways for DUOX1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9NRD9-DUOX1_HUMAN

  • Pathway: Hormone biosynthesis; thyroid hormone biosynthesis

Gene Ontology (GO) - Biological Process for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation IEA --
GO:0006979 response to oxidative stress IEA --
GO:0019221 cytokine-mediated signaling pathway IDA 16111680
GO:0042335 cuticle development IMP 11514595
GO:0042446 hormone biosynthetic process IEA --
genes like me logo Genes that share ontologies with DUOX1: view

No data available for Pathways by source for DUOX1 Gene

Compounds for DUOX1 Gene

(5) HMDB Compounds for DUOX1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Hydrogen peroxide
  • Hydrogen peroxide
7722-84-1
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6

(6) Novoseek inferred chemical compound relationships for DUOX1 Gene

Compound -log(P) Hits PubMed IDs
nadph 78 18
iodide 72 3
h2o2 63.9 13
diphenyleneiodonium 52.3 1
superoxide 44.7 2
genes like me logo Genes that share compounds with DUOX1: view

Transcripts for DUOX1 Gene

Unigene Clusters for DUOX1 Gene

Dual oxidase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUOX1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DUOX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUOX1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DUOX1 Gene

GeneLoc Exon Structure for
DUOX1
ECgene alternative splicing isoforms for
DUOX1

Expression for DUOX1 Gene

mRNA expression in normal human tissues for DUOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUOX1 Gene

This gene is overexpressed in Esophagus - Mucosa (8.8), Lung (7.4), Thyroid (6.3), Skin - Not Sun Exposed (Suprapubic) (4.7), Stomach (4.6), and Skin - Sun Exposed (Lower leg) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUOX1 Gene

SOURCE GeneReport for Unigene cluster for DUOX1 Gene Hs.272813

mRNA Expression by UniProt/SwissProt for DUOX1 Gene

Q9NRD9-DUOX1_HUMAN
Tissue specificity: Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
genes like me logo Genes that share expressions with DUOX1: view

In Situ Assay Products

Orthologs for DUOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUOX1 35
  • 99.42 (n)
  • 99.42 (a)
DUOX1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUOX1 35
  • 89.64 (n)
  • 90.14 (a)
DUOX1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUOX1 35
  • 89.58 (n)
  • 91.23 (a)
DUOX1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Duox1 35
  • 87.28 (n)
  • 91.04 (a)
Duox1 16
Duox1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUOX1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Duox1 35
  • 86.76 (n)
  • 90.2 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 66 (a)
OneToMany
DUOX2 35
  • 70.46 (n)
  • 66.84 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia duox1 35
  • 62.36 (n)
  • 64.28 (a)
zebrafish
(Danio rerio)
Actinopterygii duox 35
  • 60.61 (n)
  • 56.76 (a)
duox 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Duox 36
  • 39 (a)
OneToMany
CG3131 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea bli-3 36
  • 35 (a)
ManyToMany
duox-2 36
  • 34 (a)
ManyToMany
F56C11.1 37
  • 34 (a)
F53G12.3 37
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RBOHA 35
  • 45.96 (n)
  • 36.57 (a)
rice
(Oryza sativa)
Liliopsida Os01g0360200 35
  • 45.13 (n)
  • 32.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for DUOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUOX1 Gene

ENSEMBL:
Gene Tree for DUOX1 (if available)
TreeFam:
Gene Tree for DUOX1 (if available)

Paralogs for DUOX1 Gene

Paralogs for DUOX1 Gene

Selected SIMAP similar genes for DUOX1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DUOX1 Gene

genes like me logo Genes that share paralogs with DUOX1: view

Variants for DUOX1 Gene

Sequence variations from dbSNP and Humsavar for DUOX1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs938129 -- 45,147,712(+) TGGAG(A/G)TGGGG intron-variant
rs938130 -- 45,163,058(+) GCCCC(A/G)CTTTC intron-variant
rs938131 -- 45,132,720(+) GAGCT(A/G)CTCAC intron-variant
rs938132 -- 45,132,857(+) GCCAC(A/G)GGTTC intron-variant
rs1617207 -- 45,155,064(+) AGTAC(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUOX1 Gene

Variant ID Type Subtype PubMed ID
dgv744e1 CNV Complex 17122850
dgv2378n71 CNV Loss 21882294
esv1002924 CNV Deletion 20482838
nsv457125 CNV Loss 19166990
nsv518213 CNV Gain 19592680
nsv520580 CNV Loss 19592680
nsv904187 CNV Loss 21882294

Relevant External Links for DUOX1 Gene

HapMap Linkage Disequilibrium report
DUOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUOX1 Gene

Disorders for DUOX1 Gene

(2) University of Copenhagen DISEASES for DUOX1 Gene

(6) Novoseek inferred disease relationships for DUOX1 Gene

Disease -log(P) Hits PubMed IDs
congenital hypothyroidism 71.9 2
carcinoma papillary 46.5 1
thyroid carcinoma 31 1
adenoma 29.9 1
carcinoma 13 2

Relevant External Links for DUOX1

Genetic Association Database (GAD)
DUOX1
Human Genome Epidemiology (HuGE) Navigator
DUOX1
genes like me logo Genes that share disorders with DUOX1: view

No data available for UniProtKB/Swiss-Prot for DUOX1 Gene

Publications for DUOX1 Gene

  1. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. (PMID: 10806195) De Deken X. … Miot F. (J. Biol. Chem. 2000) 2 3 4 23
  2. Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. (PMID: 11822874) De Deken X. … Miot F. (Exp. Cell Res. 2002) 3 4 23
  3. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. (PMID: 12824283) Geiszt M. … Leto T.L. (FASEB J. 2003) 3 4 23
  4. Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. (PMID: 15972824) Ameziane-El-Hassani R. … Dupuy C. (J. Biol. Chem. 2005) 3 4 23
  5. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. (PMID: 16111680) Harper R.W. … Wu R. (FEBS Lett. 2005) 3 4 23

Products for DUOX1 Gene

Sources for DUOX1 Gene

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