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Aliases for PMP2 Gene

Aliases for PMP2 Gene

  • Peripheral Myelin Protein 2 2 3 4
  • M-FABP 3
  • FABP8 3
  • MP2 3
  • P2 3

External Ids for PMP2 Gene

Previous GeneCards Identifiers for PMP2 Gene

  • GC08M081231
  • GC08M082402
  • GC08M082075
  • GC08M082515
  • GC08M082352
  • GC08M077842

Summaries for PMP2 Gene

GeneCards Summary for PMP2 Gene

PMP2 (Peripheral Myelin Protein 2) is a Protein Coding gene. Diseases associated with PMP2 include neuritis and encephalitozoonosis. GO annotations related to this gene include transporter activity and cholesterol binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for PMP2 Gene

  • May play a role in lipid transport protein in Schwann cells. May bind cholesterol.

Gene Wiki entry for PMP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMP2 Gene

Genomics for PMP2 Gene

Regulatory Elements for PMP2 Gene

Genomic Location for PMP2 Gene

Chromosome:
8
Start:
81,440,326 bp from pter
End:
81,447,523 bp from pter
Size:
7,198 bases
Orientation:
Minus strand

Genomic View for PMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PMP2 Gene

Proteins for PMP2 Gene

  • Protein details for PMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02689-MYP2_HUMAN
    Recommended name:
    Myelin P2 protein
    Protein Accession:
    P02689
    Secondary Accessions:
    • Q6FHL4

    Protein attributes for PMP2 Gene

    Size:
    132 amino acids
    Molecular mass:
    14909 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein

    Three dimensional structures from OCA and Proteopedia for PMP2 Gene

neXtProt entry for PMP2 Gene

Proteomics data for PMP2 Gene at MOPED

Post-translational modifications for PMP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PMP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PMP2 Gene

Domains & Families for PMP2 Gene

Gene Families for PMP2 Gene

Suggested Antigen Peptide Sequences for PMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02689

UniProtKB/Swiss-Prot:

MYP2_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with PMP2: view

Function for PMP2 Gene

Molecular function for PMP2 Gene

GENATLAS Biochemistry:
peripheral myelin protein 2,potentially involved in the transport of fatty acids or metabolism of myelin lipids
UniProtKB/Swiss-Prot Function:
May play a role in lipid transport protein in Schwann cells. May bind cholesterol.

Gene Ontology (GO) - Molecular Function for PMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005504 fatty acid binding IDA 20421974
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding --
GO:0015485 cholesterol binding IDA 20421974
genes like me logo Genes that share ontologies with PMP2: view

Phenotypes for PMP2 Gene

GenomeRNAi human phenotypes for PMP2:
genes like me logo Genes that share phenotypes with PMP2: view

miRNA for PMP2 Gene

miRTarBase miRNAs that target PMP2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PMP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PMP2 Gene

Localization for PMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PMP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PMP2 Gene COMPARTMENTS Subcellular localization image for PMP2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0043209 myelin sheath IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PMP2: view

Pathways & Interactions for PMP2 Gene

SuperPathways for PMP2 Gene

No Data Available

Interacting Proteins for PMP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256103%0d%0a9606.ENSP00000300213%0d%0a
Selected Interacting proteins: P02689-MYP2_HUMAN ENSP00000256103 for PMP2 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for PMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0061024 membrane organization IEA --
genes like me logo Genes that share ontologies with PMP2: view

No data available for Pathways by source and SIGNOR curated interactions for PMP2 Gene

Drugs & Compounds for PMP2 Gene

(4) Drugs for PMP2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lauryl Dimethylamine-N-Oxide Experimental Pharma Target 0
oleic acid Experimental Pharma Activation, Activator, Target 0
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 20
S-Hydroxycysteine Experimental Pharma Target 0

(2) Additional Compounds for PMP2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fatty acid
LIPID
genes like me logo Genes that share compounds with PMP2: view

Transcripts for PMP2 Gene

mRNA/cDNA for PMP2 Gene

Unigene Clusters for PMP2 Gene

Peripheral myelin protein 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PMP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PMP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: -

Relevant External Links for PMP2 Gene

GeneLoc Exon Structure for
PMP2
ECgene alternative splicing isoforms for
PMP2

Expression for PMP2 Gene

mRNA expression in normal human tissues for PMP2 Gene

mRNA differential expression in normal tissues according to GTEx for PMP2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.7), Brain - Substantia nigra (x5.9), Brain - Amygdala (x5.2), Nerve - Tibial (x4.2), Brain - Putamen (basal ganglia) (x4.1), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for PMP2 Gene

This gene is overexpressed in Spinal cord (61.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PMP2 Gene



SOURCE GeneReport for Unigene cluster for PMP2 Gene Hs.571512

genes like me logo Genes that share expression patterns with PMP2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PMP2 Gene

Orthologs for PMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PMP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PMP2 35
  • 90.66 (n)
  • 92.42 (a)
PMP2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PMP2 35
  • 90.66 (n)
  • 93.94 (a)
mouse
(Mus musculus)
Mammalia Pmp2 35
  • 86.36 (n)
  • 87.12 (a)
Pmp2 16
Pmp2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PMP2 35
  • 99.49 (n)
  • 100 (a)
PMP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pmp2 35
  • 86.11 (n)
  • 90.15 (a)
oppossum
(Monodelphis domestica)
Mammalia PMP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PMP2 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PMP2 35
  • 75.25 (n)
  • 80.3 (a)
PMP2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PMP2 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100536788 35
  • 62.85 (n)
  • 53.44 (a)
worm
(Caenorhabditis elegans)
Secernentea lbp-9 35
  • 52.34 (n)
  • 42.19 (a)
Species with no ortholog for PMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PMP2 Gene

ENSEMBL:
Gene Tree for PMP2 (if available)
TreeFam:
Gene Tree for PMP2 (if available)

Paralogs for PMP2 Gene

(15) SIMAP similar genes for PMP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PMP2: view

Variants for PMP2 Gene

Sequence variations from dbSNP and Humsavar for PMP2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1042807 -- 81,441,732(-) gagcc(A/T)atctg utr-variant-3-prime
rs1042808 -- 81,441,729(-) ccaat(C/G)tgaga utr-variant-3-prime
rs1042810 -- 81,441,726(-) atctg(A/T)gagca utr-variant-3-prime
rs1042811 -- 81,441,719(-) agcaa(A/T)ataaT utr-variant-3-prime
rs1126912 -- 81,441,741(-) gccaa(A/G)cttga utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PMP2 Gene

Variant ID Type Subtype PubMed ID
nsv891065 CNV Loss 21882294
nsv465721 CNV Gain 19166990

Variation tolerance for PMP2 Gene

Residual Variation Intolerance Score: 79.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PMP2 Gene

HapMap Linkage Disequilibrium report
PMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PMP2 Gene

Disorders for PMP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PMP2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
neuritis
  • peripheral neuritis
encephalitozoonosis
  • infection by encephalitozoon
neuropathy, congenital hypomyelinating
  • dejerine-sottas disease
- elite association
Search PMP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PMP2

Genetic Association Database (GAD)
PMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PMP2
genes like me logo Genes that share disorders with PMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PMP2 Gene

Publications for PMP2 Gene

  1. Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2). (PMID: 8288226) Hayasaka K. … Shimizu N. (Genomics 1993) 2 23 67
  2. Structural and functional characterization of human peripheral nervous system myelin protein P2. (PMID: 20421974) Majava V. … Kursula P. (PLoS ONE 2010) 23 67
  3. Myelin sheaths are formed with proteins that originated in vertebrate lineages. (PMID: 19737434) Gould R.M. … Gow A. (Neuron Glia Biol. 2008) 23 67
  4. The pH-dependent unfolding mechanism of P2 myelin protein: an experimental and computational study. (PMID: 16427315) Polverini E. … Cavatorta P. (J. Struct. Biol. 2006) 23 67
  5. Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2). (PMID: 11241848) BesanAson R. … Vandenberghe A. (Hum. Mutat. 2001) 23 67

Products for PMP2 Gene

Sources for PMP2 Gene

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