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Aliases for PLXNB1 Gene

Aliases for PLXNB1 Gene

  • Plexin B1 2 3
  • Semaphorin Receptor SEP 3 4
  • PLXN5 3 4
  • SEP 3 4
  • PLEXIN-B1 3
  • Plexin 5 3
  • KIAA0407 4

External Ids for PLXNB1 Gene

Previous HGNC Symbols for PLXNB1 Gene

  • PLXN5

Previous GeneCards Identifiers for PLXNB1 Gene

  • GC03M048246
  • GC03M047727
  • GC03M048405

Summaries for PLXNB1 Gene

GeneCards Summary for PLXNB1 Gene

PLXNB1 (Plexin B1) is a Protein Coding gene. Diseases associated with PLXNB1 include male reproductive organ cancer. Among its related pathways are Signaling by GPCR and Developmental Biology. GO annotations related to this gene include receptor activity and GTPase activating protein binding. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNB1 Gene

  • Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

Gene Wiki entry for PLXNB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNB1 Gene

Genomics for PLXNB1 Gene

Regulatory Elements for PLXNB1 Gene

Transcription factor binding sites by QIAGEN in the PLXNB1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLXNB1 Gene

Chromosome:
3
Start:
48,403,854 bp from pter
End:
48,430,324 bp from pter
Size:
26,471 bases
Orientation:
Minus strand

Genomic View for PLXNB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLXNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNB1 Gene

Proteins for PLXNB1 Gene

  • Protein details for PLXNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43157-PLXB1_HUMAN
    Recommended name:
    Plexin-B1
    Protein Accession:
    O43157
    Secondary Accessions:
    • A6H8Y2
    • Q6NY20
    • Q9UIV7
    • Q9UJ92
    • Q9UJ93

    Protein attributes for PLXNB1 Gene

    Size:
    2135 amino acids
    Molecular mass:
    232298 Da
    Quaternary structure:
    • Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2.
    SequenceCaution:
    • Sequence=BAA23703.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLXNB1 Gene

    Alternative splice isoforms for PLXNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXNB1 Gene

Proteomics data for PLXNB1 Gene at MOPED

Post-translational modifications for PLXNB1 Gene

  • Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.
  • Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.
  • Glycosylation at Asn 31, Asn 334, Asn 543, Ser 691, Ser 693, Thr 696, Asn 1183, Asn 1253, and Asn 1330
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNB1 Gene

Antibody Products

No data available for DME Specific Peptides for PLXNB1 Gene

Domains & Families for PLXNB1 Gene

Gene Families for PLXNB1 Gene

Suggested Antigen Peptide Sequences for PLXNB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43157

UniProtKB/Swiss-Prot:

PLXB1_HUMAN :
  • Contains 3 IPT/TIG domains.
  • Belongs to the plexin family.
Domain:
  • Contains 3 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNB1: view

Function for PLXNB1 Gene

Molecular function for PLXNB1 Gene

GENATLAS Biochemistry:
plexin B1,calcium-dependent cell adhesion molecule at the neuronal cell surface,also expressed in hematopoietic and endothelial cells,receptor for the semaphorin,homologous to the hepatocyte growth factor receptor family
UniProtKB/Swiss-Prot Function:
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

Gene Ontology (GO) - Molecular Function for PLXNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8570614
GO:0004888 transmembrane signaling receptor activity NAS 10520995
GO:0005515 protein binding IPI 12730235
GO:0017154 semaphorin receptor activity TAS 10520995
GO:0030215 semaphorin receptor binding TAS 10520995
genes like me logo Genes that share ontologies with PLXNB1: view
genes like me logo Genes that share phenotypes with PLXNB1: view

Animal Models for PLXNB1 Gene

MGI Knock Outs for PLXNB1:

Animal Model Products

miRNA for PLXNB1 Gene

miRTarBase miRNAs that target PLXNB1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXNB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLXNB1 Gene

Localization for PLXNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNB1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNB1 Gene COMPARTMENTS Subcellular localization image for PLXNB1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PLXNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005576 extracellular region IEA --
GO:0005622 intracellular NAS 10520995
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10520995
genes like me logo Genes that share ontologies with PLXNB1: view

Pathways & Interactions for PLXNB1 Gene

genes like me logo Genes that share pathways with PLXNB1: view

Pathways by source for PLXNB1 Gene

1 KEGG pathway for PLXNB1 Gene
1 GeneGo (Thomson Reuters) pathway for PLXNB1 Gene

SIGNOR curated interactions for PLXNB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLXNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IDA 15218527
GO:0007165 signal transduction TAS 8570614
GO:0007411 axon guidance TAS --
GO:0008360 regulation of cell shape IDA 19843518
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS --
genes like me logo Genes that share ontologies with PLXNB1: view

Drugs & Compounds for PLXNB1 Gene

(4) Drugs for PLXNB1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Guanosine Experimental Pharma 0
arginine Nutra 346
tyrosine Nutra 547

(1) Additional Compounds for PLXNB1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol
genes like me logo Genes that share compounds with PLXNB1: view

Transcripts for PLXNB1 Gene

Unigene Clusters for PLXNB1 Gene

Plexin B1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLXNB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNB1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - -
SP13: -
SP14:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b ^
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PLXNB1 Gene

GeneLoc Exon Structure for
PLXNB1
ECgene alternative splicing isoforms for
PLXNB1

Expression for PLXNB1 Gene

mRNA expression in normal human tissues for PLXNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLXNB1 Gene

This gene is overexpressed in Spinal cord (14.6), Serum (7.5), and Frontal cortex (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXNB1 Gene



SOURCE GeneReport for Unigene cluster for PLXNB1 Gene Hs.476209

mRNA Expression by UniProt/SwissProt for PLXNB1 Gene

O43157-PLXB1_HUMAN
Tissue specificity: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.
genes like me logo Genes that share expression patterns with PLXNB1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PLXNB1 Gene

Orthologs for PLXNB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLXNB1 35
  • 87.41 (n)
  • 89.93 (a)
PLXNB1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNB1 35
  • 88.93 (n)
  • 90.73 (a)
PLXNB1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxnb1 35
  • 85.94 (n)
  • 87.35 (a)
Plxnb1 16
Plxnb1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLXNB1 35
  • 99.63 (n)
  • 99.53 (a)
PLXNB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plxnb1 35
  • 85.54 (n)
  • 87.03 (a)
oppossum
(Monodelphis domestica)
Mammalia PLXNB1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNB1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLXNB1 35
  • 68.57 (n)
  • 69.7 (a)
PLXNB1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNB1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxnb1 35
  • 61.53 (n)
  • 60.85 (a)
Str.10773 35
zebrafish
(Danio rerio)
Actinopterygii plxnb1b 35
  • 60.03 (n)
  • 59.5 (a)
wufb83a09 35
plxnb1a 36
  • 76 (a)
OneToMany
plxnb1b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta plexB 37
  • 40 (a)
plexB 35
  • 45.09 (n)
  • 37.51 (a)
plexB 36
  • 31 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011139 35
  • 49.08 (n)
  • 37.11 (a)
worm
(Caenorhabditis elegans)
Secernentea plx-2 37
  • 28 (a)
plx-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for PLXNB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXNB1 Gene

ENSEMBL:
Gene Tree for PLXNB1 (if available)
TreeFam:
Gene Tree for PLXNB1 (if available)

Paralogs for PLXNB1 Gene

Paralogs for PLXNB1 Gene

(7) SIMAP similar genes for PLXNB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLXNB1: view

Variants for PLXNB1 Gene

Sequence variations from dbSNP and Humsavar for PLXNB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1002069 -- 48,404,744(+) AGGGC(C/G)TCGCT intron-variant
rs1061488 -- 48,404,099(-) CCTGT(C/T)TGCCT utr-variant-3-prime, nc-transcript-variant
rs1531317 -- 48,404,973(-) TTGAT(C/T)AGTGT intron-variant
rs2305966 -- 48,419,207(-) AGCCT(C/T)CTTAG intron-variant
rs2362450 -- 48,419,904(+) TCTGA(C/G/T)GGTGA synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNB1 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897
nsv834684 CNV Gain 17160897
nsv508917 CNV Insertion 20534489
nsv876761 CNV Loss 21882294

Variation tolerance for PLXNB1 Gene

Residual Variation Intolerance Score: 20.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLXNB1 Gene

HapMap Linkage Disequilibrium report
PLXNB1
Human Gene Mutation Database (HGMD)
PLXNB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNB1 Gene

Disorders for PLXNB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXNB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
male reproductive organ cancer
  • malignant neoplasm of male genital organ, unspecified
- elite association

Relevant External Links for PLXNB1

Genetic Association Database (GAD)
PLXNB1
Human Genome Epidemiology (HuGE) Navigator
PLXNB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLXNB1
genes like me logo Genes that share disorders with PLXNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNB1 Gene

Publications for PLXNB1 Gene

  1. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. (PMID: 11035813) Vikis H.G. … Guan K.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 23 67
  2. Mical links semaphorins to F-actin disassembly. (PMID: 20148037) Hung R.J. … Terman J.R. (Nature 2010) 23 67
  3. Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met. (PMID: 20164843) Stevens L. … Scott G. (J. Invest. Dermatol. 2010) 23 67
  4. Thermodynamic characterization of two homologous protein complexes: associations of the semaphorin receptor plexin-B1 RhoGTPase binding domain with Rnd1 and active Rac1. (PMID: 19388051) Hota P.K. … Buck M. (Protein Sci. 2009) 23 67
  5. Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology. (PMID: 19444311) Saito Y. … Negishi M. (EMBO Rep. 2009) 23 67

Products for PLXNB1 Gene

Sources for PLXNB1 Gene

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