Aliases for PLXNA1 Gene
External Ids for PLXNA1 Gene
Previous HGNC Symbols for PLXNA1 Gene
Previous GeneCards Identifiers for PLXNA1 Gene
GeneCards Summary for PLXNA1 Gene
PLXNA1 (Plexin A1) is a Protein Coding gene. Diseases associated with PLXNA1 include Hereditary Congenital Facial Paresis and Dubowitz Syndrome. Among its related pathways are Development Slit-Robo signaling and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNA3.
UniProtKB/Swiss-Prot for PLXNA1 Gene
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).