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Aliases for PLXNA1 Gene

Aliases for PLXNA1 Gene

  • Plexin A1 2 3
  • PLXN1 3 4 6
  • NOV 3 4 6
  • Semaphorin Receptor NOV 3 4
  • NOVP 3 6
  • PLEXIN-A1 3
  • Plexin 1 3

External Ids for PLXNA1 Gene

Previous HGNC Symbols for PLXNA1 Gene

  • PLXN1

Previous GeneCards Identifiers for PLXNA1 Gene

  • GC03P123491
  • GC03P126738
  • GC03P127989
  • GC03P128028
  • GC03P128190
  • GC03P124086

Summaries for PLXNA1 Gene

GeneCards Summary for PLXNA1 Gene

PLXNA1 (Plexin A1) is a Protein Coding gene. Diseases associated with PLXNA1 include hereditary congenital facial paresis. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor activity and semaphorin receptor activity. An important paralog of this gene is PLXNB2.

UniProtKB/Swiss-Prot for PLXNA1 Gene

  • Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Gene Wiki entry for PLXNA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA1 Gene

Genomics for PLXNA1 Gene

Regulatory Elements for PLXNA1 Gene

Genomic Location for PLXNA1 Gene

Start:
126,988,521 bp from pter
End:
127,037,392 bp from pter
Size:
48,872 bases
Orientation:
Plus strand

Genomic View for PLXNA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLXNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA1 Gene

Proteins for PLXNA1 Gene

  • Protein details for PLXNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIW2-PLXA1_HUMAN
    Recommended name:
    Plexin-A1
    Protein Accession:
    Q9UIW2
    Secondary Accessions:

    Protein attributes for PLXNA1 Gene

    Size:
    1896 amino acids
    Molecular mass:
    211067 Da
    Quaternary structure:
    • Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).

neXtProt entry for PLXNA1 Gene

Proteomics data for PLXNA1 Gene at MOPED

Post-translational modifications for PLXNA1 Gene

  • Ubiquitination at Lys1418
  • Glycosylation at Asn77, Asn660, Asn672, Asn701, Thr726, Asn1043, Asn1187, and Asn1212
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PLXNA1 Gene

Domains for PLXNA1 Gene

Gene Families for PLXNA1 Gene

HGNC:

Suggested Antigen Peptide Sequences for PLXNA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIW2

UniProtKB/Swiss-Prot:

PLXA1_HUMAN :
  • Q9UIW2
Domain:
  • Contains 4 IPT/TIG domains.
  • Contains 1 Sema domain.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA1: view

Function for PLXNA1 Gene

Molecular function for PLXNA1 Gene

GENATLAS Biochemistry: plexin A1,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family,expressed in fetal brain,putatively involved in signal transduction
UniProtKB/Swiss-Prot Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Gene Ontology (GO) - Molecular Function for PLXNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8570614
GO:0005515 protein binding --
GO:0017154 semaphorin receptor activity TAS 10520995
genes like me logo Genes that share ontologies with PLXNA1: view
genes like me logo Genes that share phenotypes with PLXNA1: view

Animal Models for PLXNA1 Gene

MGI Knock Outs for PLXNA1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLXNA1 Gene

Localization for PLXNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLXNA1 Gene COMPARTMENTS Subcellular localization image for PLXNA1 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLXNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PLXNA1: view

Pathways for PLXNA1 Gene

genes like me logo Genes that share pathways with PLXNA1: view

Pathways by source for PLXNA1 Gene

1 Qiagen pathway for PLXNA1 Gene
2 Cell Signaling Technology pathways for PLXNA1 Gene
1 BioSystems pathway for PLXNA1 Gene
1 KEGG pathway for PLXNA1 Gene
1 GeneGo (Thomson Reuters) pathway for PLXNA1 Gene
1 R&D Systems pathway for PLXNA1 Gene

Gene Ontology (GO) - Biological Process for PLXNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007275 multicellular organismal development TAS 8570614
GO:0007411 axon guidance TAS --
GO:0014910 regulation of smooth muscle cell migration IEA --
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching IEA --
genes like me logo Genes that share ontologies with PLXNA1: view

Compounds for PLXNA1 Gene

(1) Novoseek inferred chemical compound relationships for PLXNA1 Gene

Compound -log(P) Hits PubMed IDs
vegf 51.3 5
genes like me logo Genes that share compounds with PLXNA1: view

Transcripts for PLXNA1 Gene

Unigene Clusters for PLXNA1 Gene

Plexin A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA1 Gene

No ASD Table

Relevant External Links for PLXNA1 Gene

GeneLoc Exon Structure for
PLXNA1
ECgene alternative splicing isoforms for
PLXNA1

Expression for PLXNA1 Gene

mRNA expression in normal human tissues for PLXNA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLXNA1 Gene

SOURCE GeneReport for Unigene cluster for PLXNA1 Gene Hs.432329

mRNA Expression by UniProt/SwissProt for PLXNA1 Gene

Q9UIW2-PLXA1_HUMAN
Tissue specificity: Detected in fetal brain, lung, liver and kidney.
genes like me logo Genes that share expressions with PLXNA1: view

No data available for mRNA differential expression in normal tissues for PLXNA1 Gene

Orthologs for PLXNA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNA1 35
  • 98.35 (n)
  • 98.26 (a)
PLXNA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLXNA1 35
  • 89.49 (n)
  • 94.88 (a)
PLXNA1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNA1 35
  • 90.23 (n)
  • 97.1 (a)
PLXNA1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxna1 35
  • 87.84 (n)
  • 96.15 (a)
Plxna1 16
Plxna1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLXNA1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Plxna1 35
  • 87.73 (n)
  • 96.25 (a)
chicken
(Gallus gallus)
Aves PLXNA1 35
  • 80.81 (n)
  • 88.3 (a)
PLXNA1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNA1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxna1 35
  • 75.51 (n)
  • 85.8 (a)
zebrafish
(Danio rerio)
Actinopterygii PLXNA1 (1 of 3) 36
  • 79 (a)
OneToMany
PLXNA1 (2 of 3) 36
  • 83 (a)
OneToMany
PLXNA1 (3 of 3) 36
  • 77 (a)
OneToMany
plxna1b 35
  • 74.08 (n)
  • 80.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta plexA 37
  • 41 (a)
plexB 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea plx-1 37
  • 34 (a)
plx-2 37
  • 25 (a)
Species with no ortholog for PLXNA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXNA1 Gene

ENSEMBL:
Gene Tree for PLXNA1 (if available)
TreeFam:
Gene Tree for PLXNA1 (if available)

Paralogs for PLXNA1 Gene

Paralogs for PLXNA1 Gene

Selected SIMAP similar genes for PLXNA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLXNA1: view

Variants for PLXNA1 Gene

Sequence variations from dbSNP and Humsavar for PLXNA1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs732737 -- 126,993,915(+) CTCAA(C/T)GTCAT intron-variant
rs747966 -- 127,001,963(-) ACGGA(C/T)GCTTA intron-variant
rs747967 -- 127,001,721(-) ACCTG(A/C)GCAGC intron-variant
rs891762 -- 127,020,169(-) GCATG(A/C)CCTGG intron-variant
rs891763 -- 127,015,833(-) AGCCC(A/G)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNA1 Gene

Variant ID Type Subtype PubMed ID
nsv829719 CNV Gain 17160897
nsv877445 CNV Loss 21882294
nsv460846 CNV Loss 19166990
dgv5248n71 CNV Loss 21882294
nsv3987 CNV Insertion 18451855
esv2725882 CNV Deletion 23290073
nsv521490 CNV Loss 19592680

Relevant External Links for PLXNA1 Gene

HapMap Linkage Disequilibrium report
PLXNA1
Human Gene Mutation Database (HGMD)
PLXNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA1 Gene

Disorders for PLXNA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PLXNA1 Gene including...

Search for PLXNA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PLXNA1 Gene

(2) Novoseek inferred disease relationships for PLXNA1 Gene

Disease -log(P) Hits PubMed IDs
tumors 8.9 3
cancer 2.02 1

Relevant External Links for PLXNA1

Genetic Association Database (GAD)
PLXNA1
Human Genome Epidemiology (HuGE) Navigator
PLXNA1
genes like me logo Genes that share disorders with PLXNA1: view

No data available for UniProtKB/Swiss-Prot for PLXNA1 Gene

Publications for PLXNA1 Gene

  1. A family of transmembrane proteins with homology to the MET- hepatocyte growth factor receptor. (PMID: 8570614) Maestrini E. … Comoglio P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  4. Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. (PMID: 14500350) Bachelder R.E. … Mercurio A.M. (Cancer Res. 2003) 3 23
  5. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. (PMID: 14977921) Toyofuku T. … Kikutani H. (Genes Dev. 2004) 3 23

Products for PLXNA1 Gene

  • antibodies-online proteins for PLXNA1
  • antibodies-online antibodies for PLXNA1
  • antibodies-online kits for PLXNA1

Sources for PLXNA1 Gene

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