Aliases for PLSCR1 Gene
External Ids for PLSCR1 Gene
Previous GeneCards Identifiers for PLSCR1 Gene
GeneCards Summary for PLSCR1 Gene
PLSCR1 (Phospholipid Scramblase 1) is a Protein Coding gene. Diseases associated with PLSCR1 include Scott Syndrome. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include calcium ion binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is PLSCR4.
UniProtKB/Swiss-Prot for PLSCR1 Gene
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.