Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLP2 Gene

Aliases for PLP2 Gene

  • Proteolipid Protein 2 (Colonic Epithelium-Enriched) 2 3
  • A4 Differentiation-Dependent Protein 2 3
  • Differentiation-Dependent Protein A4 3 4
  • Intestinal Membrane A4 Protein 3 4
  • A4 3 4
  • A4LSB 3

External Ids for PLP2 Gene

Previous GeneCards Identifiers for PLP2 Gene

  • GC0XP047811
  • GC0XP047269
  • GC0XP048054
  • GC0XP048784
  • GC0XP048915
  • GC0XP049037
  • GC0XP046685

Summaries for PLP2 Gene

Entrez Gene Summary for PLP2 Gene

  • This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

GeneCards Summary for PLP2 Gene

PLP2 (Proteolipid Protein 2 (Colonic Epithelium-Enriched)) is a Protein Coding gene. GO annotations related to this gene include ion transmembrane transporter activity and chemokine binding. An important paralog of this gene is CMTM3.

UniProtKB/Swiss-Prot for PLP2 Gene

  • May play a role in cell differentiation in the intestinal epithelium

Gene Wiki entry for PLP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLP2 Gene

Genomics for PLP2 Gene

Regulatory Elements for PLP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLP2 Gene

49,171,837 bp from pter
49,175,239 bp from pter
3,403 bases
Plus strand

Genomic View for PLP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLP2 Gene

Proteins for PLP2 Gene

  • Protein details for PLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteolipid protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NDT7
    • Q32MM8

    Protein attributes for PLP2 Gene

    152 amino acids
    Molecular mass:
    16691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLP2 Gene


neXtProt entry for PLP2 Gene

Proteomics data for PLP2 Gene at MOPED

Post-translational modifications for PLP2 Gene

  • Glycosylation at Asn 18, Asn 108, Thr 141, and Thr 145
  • Modification sites at PhosphoSitePlus

Other Protein References for PLP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLP2 Gene

Domains & Families for PLP2 Gene

Protein Domains for PLP2 Gene


Suggested Antigen Peptide Sequences for PLP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Contains 1 MARVEL domain.
genes like me logo Genes that share domains with PLP2: view

No data available for Gene Families for PLP2 Gene

Function for PLP2 Gene

Molecular function for PLP2 Gene

GENATLAS Biochemistry:
proteolipid protein 2,50kDa,differentially expressed in colonic epithelial cell lines
UniProtKB/Swiss-Prot Function:
May play a role in cell differentiation in the intestinal epithelium

Gene Ontology (GO) - Molecular Function for PLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15474493
GO:0015075 ion transmembrane transporter activity TAS 9124532
GO:0019956 chemokine binding IPI 15474493
genes like me logo Genes that share ontologies with PLP2: view

Phenotypes for PLP2 Gene

GenomeRNAi human phenotypes for PLP2:
genes like me logo Genes that share phenotypes with PLP2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PLP2 Gene

Localization for PLP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PLP2 Gene COMPARTMENTS Subcellular localization image for PLP2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for PLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9124532
GO:0005789 endoplasmic reticulum membrane TAS 9124532
GO:0005886 plasma membrane IDA 15474493
GO:0016020 membrane TAS 9124532
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLP2: view

Pathways & Interactions for PLP2 Gene

SuperPathways for PLP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS 9124532
GO:0006935 chemotaxis NAS 15474493
GO:0019221 cytokine-mediated signaling pathway NAS 15474493
GO:0034220 ion transmembrane transport TAS 9124532
genes like me logo Genes that share ontologies with PLP2: view

No data available for Pathways by source and SIGNOR curated interactions for PLP2 Gene

Drugs & Compounds for PLP2 Gene

(1) Drugs for PLP2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with PLP2: view

Transcripts for PLP2 Gene

mRNA/cDNA for PLP2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(474) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLP2 Gene

Proteolipid protein 2 (colonic epithelium-enriched):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1: - -

Relevant External Links for PLP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLP2 Gene

mRNA expression in normal human tissues for PLP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLP2 Gene

This gene is overexpressed in Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for PLP2 Gene

This gene is overexpressed in Nasal epithelium (24.7) and Bone (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLP2 Gene

SOURCE GeneReport for Unigene cluster for PLP2 Gene Hs.77422

mRNA Expression by UniProt/SwissProt for PLP2 Gene

Tissue specificity: Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt
genes like me logo Genes that share expression patterns with PLP2: view

Protein tissue co-expression partners for PLP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PLP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLP2 35
  • 87.5 (n)
  • 87.5 (a)
MGC133647 36
  • 70 (a)
PLP2 36
  • 88 (a)
(Canis familiaris)
Mammalia PLP2 35
  • 91.39 (n)
  • 91.67 (a)
-- 36
  • 66 (a)
-- 36
  • 81 (a)
(Mus musculus)
Mammalia Plp2 35
  • 84.33 (n)
  • 80.13 (a)
Plp2 16
Gm6169 36
  • 80 (a)
Plp2 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Plp2 35
  • 85.43 (n)
  • 84.11 (a)
(Ornithorhynchus anatinus)
Mammalia PLP2 36
  • 54 (a)
(Pan troglodytes)
Mammalia PLP2 36
  • 99 (a)
(Anolis carolinensis)
Reptilia PLP2 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plp2 35
  • 53.11 (n)
  • 42.67 (a)
(Danio rerio)
Actinopterygii plp2 35
  • 55.78 (n)
  • 46.26 (a)
plp2 36
  • 43 (a)
Species with no ortholog for PLP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLP2 Gene

Gene Tree for PLP2 (if available)
Gene Tree for PLP2 (if available)

Paralogs for PLP2 Gene

Paralogs for PLP2 Gene Pseudogenes for PLP2 Gene

genes like me logo Genes that share paralogs with PLP2: view

Variants for PLP2 Gene

Sequence variations from dbSNP and Humsavar for PLP2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2071314 -- 49,172,131(+) AAAGC(C/G)GGATG intron-variant
rs5902432 -- 49,171,455(+) GCCCT(-/TT)TTTTT upstream-variant-2KB
rs41298450 -- 49,171,812(+) GCTTC(A/C)GGGGC upstream-variant-2KB
rs55794588 -- 49,174,294(+) CCTGA(C/T)CAGCT intron-variant
rs56121332 -- 49,172,016(+) CTGAG(C/T)GCCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLP2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv7442 OTHER Inversion 18451855
nsv205 OTHER Inversion 15895083

Variation tolerance for PLP2 Gene

Residual Variation Intolerance Score: 78.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLP2 Gene

Disorders for PLP2 Gene

Relevant External Links for PLP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLP2 Gene

Publications for PLP2 Gene

  1. PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. (PMID: 15474493) Lee S.M. … Kim J. (Biochem. Biophys. Res. Commun. 2004) 23 67
  2. Searching for a locus for schizophrenia within chromosome Xp11. (PMID: 10686543) Wei J. … Hemmings G.P. (Am. J. Med. Genet. 2000) 23 67
  3. Protein expression strategies for identification of novel target proteins. (PMID: 10803608) Schuster M. … Werner G. (J Biomol Screen 2000) 23 67
  4. Keratinocytes exposed to ultraviolet radiation reveal three down-regulated genes with potential function in differentiation and cell cycle control. (PMID: 10931686) PAPtter T. … KAPhnlein W. (Radiat. Res. 2000) 23 67
  5. Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics. (PMID: 9124532) Breitwieser G.E. … Yang V.W. (Am. J. Physiol. 1997) 23 67

Products for PLP2 Gene

Sources for PLP2 Gene

Back to Top