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Aliases for PLP2 Gene

Aliases for PLP2 Gene

  • Proteolipid Protein 2 (Colonic Epithelium-Enriched) 2 3 5
  • A4 Differentiation-Dependent Protein 2 3
  • Differentiation-Dependent Protein A4 3 4
  • Intestinal Membrane A4 Protein 3 4
  • A4 3 4
  • A4LSB 3

External Ids for PLP2 Gene

Previous GeneCards Identifiers for PLP2 Gene

  • GC0XP047811
  • GC0XP047269
  • GC0XP048054
  • GC0XP048784
  • GC0XP048915
  • GC0XP049037
  • GC0XP046685

Summaries for PLP2 Gene

Entrez Gene Summary for PLP2 Gene

  • This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

GeneCards Summary for PLP2 Gene

PLP2 (Proteolipid Protein 2 (Colonic Epithelium-Enriched)) is a Protein Coding gene. GO annotations related to this gene include ion transmembrane transporter activity and chemokine binding. An important paralog of this gene is CMTM5.

UniProtKB/Swiss-Prot for PLP2 Gene

  • May play a role in cell differentiation in the intestinal epithelium.

Gene Wiki entry for PLP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLP2 Gene

Genomics for PLP2 Gene

Regulatory Elements for PLP2 Gene

Enhancers for PLP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLP2 on UCSC Golden Path with GeneCards custom track

Promoters for PLP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLP2 Gene

Chromosome:
X
Start:
49,171,837 bp from pter
End:
49,175,239 bp from pter
Size:
3,403 bases
Orientation:
Plus strand

Genomic View for PLP2 Gene

Genes around PLP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLP2 Gene

Proteins for PLP2 Gene

  • Protein details for PLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04941-PLP2_HUMAN
    Recommended name:
    Proteolipid protein 2
    Protein Accession:
    Q04941
    Secondary Accessions:
    • A6NDT7
    • Q32MM8

    Protein attributes for PLP2 Gene

    Size:
    152 amino acids
    Molecular mass:
    16691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLP2 Gene

Proteomics data for PLP2 Gene at MOPED

Post-translational modifications for PLP2 Gene

  • Glycosylation at Asn 18, Asn 108, Thr 141, and Thr 145
  • Modification sites at PhosphoSitePlus

Other Protein References for PLP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLP2 Gene

Domains & Families for PLP2 Gene

Protein Domains for PLP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04941

UniProtKB/Swiss-Prot:

PLP2_HUMAN :
  • Contains 1 MARVEL domain.
Domain:
  • Contains 1 MARVEL domain.
genes like me logo Genes that share domains with PLP2: view

No data available for Gene Families for PLP2 Gene

Function for PLP2 Gene

Molecular function for PLP2 Gene

GENATLAS Biochemistry:
proteolipid protein 2,50kDa,differentially expressed in colonic epithelial cell lines
UniProtKB/Swiss-Prot Function:
May play a role in cell differentiation in the intestinal epithelium.

Phenotypes for PLP2 Gene

genes like me logo Genes that share phenotypes with PLP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLP2 Gene

Localization for PLP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLP2 Gene COMPARTMENTS Subcellular localization image for PLP2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS 9124532
genes like me logo Genes that share ontologies with PLP2: view

Pathways & Interactions for PLP2 Gene

SuperPathways for PLP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLP2 Gene

Drugs & Compounds for PLP2 Gene

(1) Drugs for PLP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PLP2: view

Transcripts for PLP2 Gene

mRNA/cDNA for PLP2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(474) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLP2 Gene

Proteolipid protein 2 (colonic epithelium-enriched):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for PLP2 Gene

GeneLoc Exon Structure for
PLP2
ECgene alternative splicing isoforms for
PLP2

Expression for PLP2 Gene

mRNA expression in normal human tissues for PLP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLP2 Gene

This gene is overexpressed in Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for PLP2 Gene

This gene is overexpressed in Nasal epithelium (24.7) and Bone (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLP2 Gene



SOURCE GeneReport for Unigene cluster for PLP2 Gene Hs.77422

mRNA Expression by UniProt/SwissProt for PLP2 Gene

Q04941-PLP2_HUMAN
Tissue specificity: Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.
genes like me logo Genes that share expression patterns with PLP2: view

Protein tissue co-expression partners for PLP2 Gene

- Elite partner

Primer Products

Orthologs for PLP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLP2 35
  • 87.5 (n)
  • 87.5 (a)
MGC133647 36
  • 70 (a)
OneToMany
PLP2 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PLP2 35
  • 91.39 (n)
  • 91.67 (a)
-- 36
  • 66 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Plp2 35
  • 84.33 (n)
  • 80.13 (a)
Plp2 16
Gm6169 36
  • 80 (a)
OneToMany
Plp2 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Plp2 35
  • 85.43 (n)
  • 84.11 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PLP2 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLP2 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLP2 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plp2 35
  • 53.11 (n)
  • 42.67 (a)
zebrafish
(Danio rerio)
Actinopterygii plp2 35
  • 55.78 (n)
  • 46.26 (a)
plp2 36
  • 43 (a)
OneToOne
Species with no ortholog for PLP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLP2 Gene

ENSEMBL:
Gene Tree for PLP2 (if available)
TreeFam:
Gene Tree for PLP2 (if available)

Paralogs for PLP2 Gene

Paralogs for PLP2 Gene

Pseudogenes.org Pseudogenes for PLP2 Gene

genes like me logo Genes that share paralogs with PLP2: view

Variants for PLP2 Gene

Sequence variations from dbSNP and Humsavar for PLP2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1802969 - 49,173,409(+) TCATA(G/T)CGGCA reference, missense
rs2071314 -- 49,172,131(+) AAAGC(C/G)GGATG intron-variant
rs3060517 -- 49,171,451(-) AAAAA(-/A/AA/AAA)Gggcc upstream-variant-2KB
rs5902432 -- 49,171,455(+) GCCCT(-/TT)TTTTT upstream-variant-2KB
rs11421660 -- 49,171,822(+) GGCAG(-/C)CACCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLP2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv7442 OTHER Inversion 18451855
nsv205 OTHER Inversion 15895083

Variation tolerance for PLP2 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLP2 Gene

Human Gene Mutation Database (HGMD)
PLP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLP2 Gene

Disorders for PLP2 Gene

Relevant External Links for PLP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLP2

No disorders were found for PLP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLP2 Gene

Publications for PLP2 Gene

  1. Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18. (PMID: 8470895) Oliva M.M. … Yang V.W. (Arch. Biochem. Biophys. 1993) 2 3 4 67
  2. PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. (PMID: 15474493) Lee S.M. … Kim J. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics. (PMID: 9124532) Breitwieser G.E. … Yang V.W. (Am. J. Physiol. 1997) 3 23
  4. Promoter regulation of a differentially expressed gene in the human colonic epithelial cell lines HT29-18 and HT29-18-C1. (PMID: 7622043) Oliva M.M. … Yang V.W. (Gene 1995) 2 3
  5. miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia. (PMID: 25735976) Zhu H. … Shao X.J. (Biochem. Biophys. Res. Commun. 2015) 3

Products for PLP2 Gene

Sources for PLP2 Gene

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