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Aliases for PLP2 Gene

Aliases for PLP2 Gene

  • Proteolipid Protein 2 (Colonic Epithelium-Enriched) 2 3
  • A4 Differentiation-Dependent Protein 2 3
  • Differentiation-Dependent Protein A4 3 4
  • Intestinal Membrane A4 Protein 3 4
  • A4 3 4
  • Proteolipid Protein 2 3
  • A4LSB 3

External Ids for PLP2 Gene

Previous GeneCards Identifiers for PLP2 Gene

  • GC0XP047811
  • GC0XP047269
  • GC0XP048054
  • GC0XP048784
  • GC0XP048915
  • GC0XP049037
  • GC0XP046685

Summaries for PLP2 Gene

Entrez Gene Summary for PLP2 Gene

  • This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

GeneCards Summary for PLP2 Gene

PLP2 (Proteolipid Protein 2 (Colonic Epithelium-Enriched)) is a Protein Coding gene. GO annotations related to this gene include ion transmembrane transporter activity and chemokine binding. An important paralog of this gene is CMTM3.

UniProtKB/Swiss-Prot for PLP2 Gene

  • May play a role in cell differentiation in the intestinal epithelium

Gene Wiki entry for PLP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLP2 Gene

Genomics for PLP2 Gene

Regulatory Elements for PLP2 Gene

Genomic Location for PLP2 Gene

Start:
49,171,837 bp from pter
End:
49,175,239 bp from pter
Size:
3,403 bases
Orientation:
Plus strand

Genomic View for PLP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLP2 Gene

Proteins for PLP2 Gene

  • Protein details for PLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04941-PLP2_HUMAN
    Recommended name:
    Proteolipid protein 2
    Protein Accession:
    Q04941
    Secondary Accessions:
    • A6NDT7
    • Q32MM8

    Protein attributes for PLP2 Gene

    Size:
    152 amino acids
    Molecular mass:
    16691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLP2 Gene

Proteomics data for PLP2 Gene at MOPED

Post-translational modifications for PLP2 Gene

  • Glycosylation at Asn18, Asn108, Thr141, and Thr145
  • Modification sites at PhosphoSitePlus

Other Protein References for PLP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLP2 Gene

Domains for PLP2 Gene

Protein Domains for PLP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04941

UniProtKB/Swiss-Prot:

PLP2_HUMAN :
  • Q04941
Domain:
  • Contains 1 MARVEL domain.
genes like me logo Genes that share domains with PLP2: view

No data available for Gene Families for PLP2 Gene

Function for PLP2 Gene

Molecular function for PLP2 Gene

GENATLAS Biochemistry: proteolipid protein 2,50kDa,differentially expressed in colonic epithelial cell lines
UniProtKB/Swiss-Prot Function: May play a role in cell differentiation in the intestinal epithelium

Gene Ontology (GO) - Molecular Function for PLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15474493
GO:0015075 ion transmembrane transporter activity TAS 9124532
GO:0019956 chemokine binding IPI 15474493
genes like me logo Genes that share ontologies with PLP2: view

Phenotypes for PLP2 Gene

GenomeRNAi human phenotypes for PLP2:
genes like me logo Genes that share phenotypes with PLP2: view

miRNA for PLP2 Gene

miRTarBase miRNAs that target PLP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLP2 Gene

Localization for PLP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLP2 Gene COMPARTMENTS Subcellular localization image for PLP2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
nucleus 1

Gene Ontology (GO) - Cellular Components for PLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9124532
GO:0005789 endoplasmic reticulum membrane TAS 9124532
GO:0005886 plasma membrane IDA 15474493
GO:0016020 membrane TAS 9124532
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLP2: view

Pathways for PLP2 Gene

SuperPathways for PLP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS 9124532
GO:0006935 chemotaxis NAS 15474493
GO:0019221 cytokine-mediated signaling pathway NAS 15474493
GO:0034220 ion transmembrane transport TAS 9124532
genes like me logo Genes that share ontologies with PLP2: view

No data available for Pathways by source for PLP2 Gene

Compounds for PLP2 Gene

(1) Novoseek inferred chemical compound relationships for PLP2 Gene

Compound -log(P) Hits PubMed IDs
calcium 8.92 2
genes like me logo Genes that share compounds with PLP2: view

Transcripts for PLP2 Gene

mRNA/cDNA for PLP2 Gene

(474) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLP2 Gene

Proteolipid protein 2 (colonic epithelium-enriched):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for PLP2 Gene

GeneLoc Exon Structure for
PLP2
ECgene alternative splicing isoforms for
PLP2

Expression for PLP2 Gene

mRNA expression in normal human tissues for PLP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLP2 Gene

This gene is overexpressed in Whole Blood (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLP2 Gene

SOURCE GeneReport for Unigene cluster for PLP2 Gene Hs.77422

mRNA Expression by UniProt/SwissProt for PLP2 Gene

Q04941-PLP2_HUMAN
Tissue specificity: Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt
genes like me logo Genes that share expressions with PLP2: view

Orthologs for PLP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC133647 36
  • 70 (a)
OneToMany
PLP2 35
  • 87.5 (n)
  • 87.5 (a)
PLP2 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
PLP2 35
  • 91.39 (n)
  • 91.67 (a)
mouse
(Mus musculus)
Mammalia Gm6169 36
  • 80 (a)
OneToMany
Plp2 35
  • 84.33 (n)
  • 80.13 (a)
Plp2 16
Plp2 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PLP2 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plp2 35
  • 85.43 (n)
  • 84.11 (a)
lizard
(Anolis carolinensis)
Reptilia PLP2 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plp2 35
  • 53.11 (n)
  • 42.67 (a)
zebrafish
(Danio rerio)
Actinopterygii plp2 35
  • 55.78 (n)
  • 46.26 (a)
plp2 36
  • 43 (a)
OneToOne
Species with no ortholog for PLP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLP2 Gene

ENSEMBL:
Gene Tree for PLP2 (if available)
TreeFam:
Gene Tree for PLP2 (if available)

Paralogs for PLP2 Gene

Paralogs for PLP2 Gene

Pseudogenes.org Pseudogenes for PLP2 Gene

genes like me logo Genes that share paralogs with PLP2: view

Variants for PLP2 Gene

Sequence variations from dbSNP and Humsavar for PLP2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_011924 -

Structural Variations from Database of Genomic Variants (DGV) for PLP2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv7442 OTHER Inversion 18451855
nsv205 OTHER Inversion 15895083

Relevant External Links for PLP2 Gene

HapMap Linkage Disequilibrium report
PLP2
Human Gene Mutation Database (HGMD)
PLP2
Locus Specific Mutation Databases (LSDB)
PLP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLP2 Gene

Disorders for PLP2 Gene

(1) University of Copenhagen DISEASES for PLP2 Gene

genes like me logo Genes that share disorders with PLP2: view

No data available for UniProtKB/Swiss-Prot for PLP2 Gene

Publications for PLP2 Gene

  1. Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18. (PMID: 8470895) Oliva M.M. … Yang V.W. (Arch. Biochem. Biophys. 1993) 2 3 4
  2. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. (PMID: 9344658) Fisher S.E. … Craig I.W. (Genomics 1997) 3 4
  3. Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics. (PMID: 9124532) Breitwieser G.E. … Yang V.W. (Am. J. Physiol. 1997) 3 23
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 4
  5. PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. (PMID: 15474493) Lee S.M. … Kim J. (Biochem. Biophys. Res. Commun. 2004) 3 23

Products for PLP2 Gene

Sources for PLP2 Gene

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