Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLK1 Gene

Aliases for PLK1 Gene

  • Polo Like Kinase 1 2 3
  • Polo-Like Kinase 1 2 3 4 5
  • Serine/Threonine-Protein Kinase 13 3 4
  • EC 2.7.11.21 4 63
  • STPK13 3 4
  • PLK-1 3 4
  • PLK 3 4
  • Cell Cycle Regulated Protein Kinase 3
  • Polo-Like Kinase (Drosophila) 2
  • Polo (Drosophia)-Like Kinase 3
  • Polo Like Kinase 3
  • EC 2.7.11 63

External Ids for PLK1 Gene

Previous HGNC Symbols for PLK1 Gene

  • PLK

Previous GeneCards Identifiers for PLK1 Gene

  • GC16P023657
  • GC16P023658
  • GC16P023597
  • GC16P023690
  • GC16P021779
  • GC16P023691
  • GC16P023698
  • GC16P023706
  • GC16P023712
  • GC16P023719
  • GC16P023726

Summaries for PLK1 Gene

Entrez Gene Summary for PLK1 Gene

  • The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

GeneCards Summary for PLK1 Gene

PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include tetraploidy and spinocerebellar ataxia 10. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PLK4.

UniProtKB/Swiss-Prot for PLK1 Gene

  • Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGOL1: required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564).

Tocris Summary for PLK1 Gene

  • Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues.

Gene Wiki entry for PLK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK1 Gene

Genomics for PLK1 Gene

Regulatory Elements for PLK1 Gene

Promoters for PLK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLK1 Gene

Chromosome:
16
Start:
23,677,656 bp from pter
End:
23,690,367 bp from pter
Size:
12,712 bases
Orientation:
Plus strand

Genomic View for PLK1 Gene

Genes around PLK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLK1 Gene

Proteins for PLK1 Gene

  • Protein details for PLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53350-PLK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PLK1
    Protein Accession:
    P53350
    Secondary Accessions:
    • Q15153
    • Q99746

    Protein attributes for PLK1 Gene

    Size:
    603 amino acids
    Molecular mass:
    68255 Da
    Quaternary structure:
    • Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, CENPU and CDC25C. Interacts with isoform 3 of SGOL1. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD. Interacts with ECT2; the interaction is stimulated upon phosphorylation of ECT2 on Thr-444. Interacts with PRC1. Interacts with KIF20A/MKLP2 (when phosphorylated), leading to the recruitment at the central spindle. Interacts (via POLO box domains) with PPP1R12A/MYPT1 (when previously phosphorylated by CDK1). Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with BIRC6/bruce. Interacts with CDK1-phosphorylated FRY; this interaction occurs in mitotic cells, but not in interphase cells. FRY interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with CDK1-phosphorylated DCTN6 during mitotic prometaphase; the interaction facilitates recruitment to kinetochores. Interacts with CEP68; the interaction phosphorylates CEP68 (PubMed:25503564).

    Three dimensional structures from OCA and Proteopedia for PLK1 Gene

neXtProt entry for PLK1 Gene

Proteomics data for PLK1 Gene at MOPED

Post-translational modifications for PLK1 Gene

  • Catalytic activity is enhanced by phosphorylation of Thr-210. Phosphorylation at Thr-210 is first detected on centrosomes in the G2 phase of the cell cycle, peaks in prometaphase and gradually disappears from centrosomes during anaphase. Dephosphorylation at Thr-210 at centrosomes is probably mediated by protein phosphatase 1C (PP1C), via interaction with PPP1R12A/MYPT1. Autophosphorylation and phosphorylation of Ser-137 may not be significant for the activation of PLK1 during mitosis, but may enhance catalytic activity during recovery after DNA damage checkpoint. Phosphorylated in vitro by STK10.
  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) in anaphase and following DNA damage, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Ubiquitination and subsequent degradation prevents entry into mitosis and is essential to maintain an efficient G2 DNA damage checkpoint. Monoubiquitination at Lys-492 by the BCR(KLHL22) ubiquitin ligase complex does not lead to degradation: it promotes PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.
  • Ubiquitination at Lys 19, Lys 272, Lys 480, and Lys 492
  • Modification sites at PhosphoSitePlus

Other Protein References for PLK1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLK1 (PLK1)

Domains & Families for PLK1 Gene

Gene Families for PLK1 Gene

Graphical View of Domain Structure for InterPro Entry

P53350

UniProtKB/Swiss-Prot:

PLK1_HUMAN :
  • The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK1 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them. PLK1 can also create its own docking sites by mediating phosphorylation of serine-[phosphothreonine/phosphoserine]-(proline/X) motifs subsequently recognized by the POLO box domains.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Domain:
  • The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK1 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them. PLK1 can also create its own docking sites by mediating phosphorylation of serine-[phosphothreonine/phosphoserine]-(proline/X) motifs subsequently recognized by the POLO box domains.
  • Contains 2 POLO box domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
genes like me logo Genes that share domains with PLK1: view

Function for PLK1 Gene

Molecular function for PLK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation of Thr-210 by AURKA; phosphorylation by AURKA is enhanced by BORA. Once activated, activity is stimulated by binding target proteins. Binding of target proteins has no effect on the non-activated kinase. Several inhibitors targeting PLKs are currently in development and are under investigation in a growing number of clinical trials, such as BI 2536, an ATP-competitive PLK1 inhibitor or BI 6727, a dihydropteridinone that specifically inhibits the catalytic activity of PLK1.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGOL1: required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564).
UniProtKB/Swiss-Prot Induction:
By growth-stimulating agents.

Enzyme Numbers (IUBMB) for PLK1 Gene

Phenotypes for PLK1 Gene

MGI mutant phenotypes for PLK1:
inferred from 2 alleles
GenomeRNAi human phenotypes for PLK1:
genes like me logo Genes that share phenotypes with PLK1: view

Animal Models for PLK1 Gene

MGI Knock Outs for PLK1:
  • Plk1 tm1b(EUCOMM)Hmgu

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLK1 Gene

Localization for PLK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK1 Gene

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLK1 Gene COMPARTMENTS Subcellular localization image for PLK1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
endosome 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 18615013
GO:0005876 colocalizes_with spindle microtubule IDA 21041660
genes like me logo Genes that share ontologies with PLK1: view

Pathways & Interactions for PLK1 Gene

genes like me logo Genes that share pathways with PLK1: view

Gene Ontology (GO) - Biological Process for PLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 23455478
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000281 mitotic cytokinesis IDA 19468302
GO:0000910 cytokinesis IMP 12939256
GO:0006468 protein phosphorylation IEA,IDA 19468300
genes like me logo Genes that share ontologies with PLK1: view

Drugs & Compounds for PLK1 Gene

(39) Drugs for PLK1 Gene - From: Novoseek, HMDB, DGIdb, ApexBio, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE Experimental Pharma Target 0
1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea Experimental Pharma Target 0
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide Experimental Pharma Target 0
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol Experimental Pharma Target 0

(18) Additional Compounds for PLK1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Cyclapolin 9
40533-25-3
GW 843682X
660868-91-7
SBE 13 hydrochloride
1052532-15-6
TC-S 7005
1082739-92-1

(5) Tocris Compounds for PLK1 Gene

Compound Action Cas Number
Cyclapolin 9 Selective, ATP-competitive PLK1 inhibitor 40533-25-3
GW 843682X Selective inhibitor of PLK1 and PLK3 660868-91-7
SBE 13 hydrochloride Potent and selective PLK1 inhibitor 1052532-15-6
TC-S 7005 Potent and selective PLK2 inhibitor 1082739-92-1
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7

(9) ApexBio Compounds for PLK1 Gene

Compound Action Cas Number
Bendamustine HCl Cytostatic agent for non-Hodgkin lymphomas 3543-75-7
BI 2536 Plk1 inhibitor,potent and ATP-competitive 755038-02-9
BI6727 (Volasertib) Plk inhibitor,highly potent 755038-65-4
GSK461364 Plk1 inhibitor 929095-18-1
HMN-214 Plk inhibitor,broad-spectrum anti-tumor agent 173529-46-9
MLN0905 Potent PLK1 inhibitor 1228960-69-7
NMS-1286937 1034616-18-6
Rigosertib (ON-01910,Estybon) Plk1 inhibitor 1225497-78-8
Ro3280 PLK1 inhibitor,potent and highly selective 1062243-51-9
genes like me logo Genes that share compounds with PLK1: view

Drug Products

Transcripts for PLK1 Gene

Unigene Clusters for PLK1 Gene

Polo-like kinase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: - -
SP7: -
SP8: -

Relevant External Links for PLK1 Gene

GeneLoc Exon Structure for
PLK1
ECgene alternative splicing isoforms for
PLK1

Expression for PLK1 Gene

mRNA expression in normal human tissues for PLK1 Gene

mRNA differential expression in normal tissues according to GTEx for PLK1 Gene

This gene is overexpressed in Testis (x6.2).

Protein differential expression in normal tissues from HIPED for PLK1 Gene

This gene is overexpressed in Breast (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLK1 Gene



SOURCE GeneReport for Unigene cluster for PLK1 Gene Hs.592049

mRNA Expression by UniProt/SwissProt for PLK1 Gene

P53350-PLK1_HUMAN
Tissue specificity: Placenta and colon.
genes like me logo Genes that share expression patterns with PLK1: view

Protein tissue co-expression partners for PLK1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLK1 Gene

Orthologs for PLK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLK1 35
  • 90.9 (n)
  • 95.84 (a)
PLK1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLK1 35
  • 90.27 (n)
  • 96.02 (a)
PLK1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plk1 35
  • 88.5 (n)
  • 95.02 (a)
Plk1 16
Plk1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLK1 35
  • 99.45 (n)
  • 99.83 (a)
PLK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plk1 35
  • 87.4 (n)
  • 94.2 (a)
oppossum
(Monodelphis domestica)
Mammalia PLK1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLK1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLK1 35
  • 76.44 (n)
  • 82.69 (a)
PLK1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLK1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plk1 35
  • 74.26 (n)
  • 81.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia plk-prov 35
zebrafish
(Danio rerio)
Actinopterygii plk1 35
  • 69.7 (n)
  • 77.36 (a)
plk1 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004239 35
  • 57.24 (n)
  • 53.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta polo 35
  • 58.74 (n)
  • 54.84 (a)
polo 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea plk-1 35
  • 56.93 (n)
  • 55.9 (a)
plk-1 36
  • 48 (a)
OneToMany
plk-2 36
  • 48 (a)
OneToMany
plk-3 36
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL006W 35
  • 50.87 (n)
  • 42.89 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06138g 35
  • 46.79 (n)
  • 41.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC5 35
  • 48.2 (n)
  • 43.19 (a)
CDC5 36
  • 28 (a)
OneToMany
CDC5 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2496 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5715 36
  • 63 (a)
OneToOne
Species with no ortholog for PLK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLK1 Gene

ENSEMBL:
Gene Tree for PLK1 (if available)
TreeFam:
Gene Tree for PLK1 (if available)

Paralogs for PLK1 Gene

Paralogs for PLK1 Gene

(7) SIMAP similar genes for PLK1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PLK1 Gene

genes like me logo Genes that share paralogs with PLK1: view

Variants for PLK1 Gene

Sequence variations from dbSNP and Humsavar for PLK1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_041018 A lung squamous cell carcinoma sample
rs35056440 - 23,682,122(+) CCTAC(C/T)TCCGG reference, missense
rs45489499 - 23,684,047(+) GCAGC(C/G)TGGAC reference, missense
rs45569335 - 23,689,355(+) CTACC(A/T)CACCG reference, missense
rs56027600 - 23,689,621(+) CACCC(A/G)CAGCG reference, missense

Variation tolerance for PLK1 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLK1 Gene

HapMap Linkage Disequilibrium report
PLK1
Human Gene Mutation Database (HGMD)
PLK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLK1 Gene

Disorders for PLK1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PLK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tetraploidy
  • tetraploidy syndrome
spinocerebellar ataxia 10
  • spinocerebellar ataxia type 10
adrenal rest tumor
  • adrenal rest neoplasm
pancreatic cancer
  • pancreatic carcinoma, somatic
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search PLK1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PLK1_HUMAN
  • Note=Defects in PLK1 are associated with some cancers, such as gastric, thyroid or B-cell lymphomas. Expression is cancer increased in tumor tissues with a poor prognosis, suggesting a role in malignant transformations and carcinogenesis.

Relevant External Links for PLK1

Genetic Association Database (GAD)
PLK1
Human Genome Epidemiology (HuGE) Navigator
PLK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLK1
genes like me logo Genes that share disorders with PLK1: view

No data available for Genatlas for PLK1 Gene

Publications for PLK1 Gene

  1. Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors. (PMID: 8127874) Holtrich U. … Strebhardt K. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer. (PMID: 19739117) Shi W. … Liu F.F. (Int. J. Cancer 2010) 3 23
  3. Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass. (PMID: 20089605) Chun G. … Ceryak S. (Carcinogenesis 2010) 3 23
  4. Polo-like kinase 1 (Plk1) as a novel drug target in chronic myeloid leukemia: overriding imatinib resistance with the Plk1 inhibitor BI 2536. (PMID: 20145140) Gleixner K.V. … Valent P. (Cancer Res. 2010) 3 23
  5. The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. (PMID: 20198330) Kim S.A. … Ahn S.G. (Int. J. Oncol. 2010) 3 23

Products for PLK1 Gene

Sources for PLK1 Gene

Back to Top

Content