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Aliases for PLD2 Gene

Aliases for PLD2 Gene

  • Phospholipase D2 2 3
  • Choline Phosphatase 2 2 3 4
  • Phosphatidylcholine-Hydrolyzing Phospholipase D2 3 4
  • EC 3.1.4.4 4 64
  • PLD1C 3 4
  • HPLD2 3 4
  • PLD 2 4

External Ids for PLD2 Gene

Summaries for PLD2 Gene

Entrez Gene Summary for PLD2 Gene

  • The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PLD2 Gene

PLD2 (Phospholipase D2) is a Protein Coding gene. Diseases associated with PLD2 include colorectal cancer. Among its related pathways are Ras signaling pathway and Development FGFR signaling pathway. GO annotations related to this gene include phosphatidylinositol binding and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD1.

UniProtKB/Swiss-Prot for PLD2 Gene

  • May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

Tocris Summary for PLD2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLD2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD2 Gene

Genomics for PLD2 Gene

Genomic Location for PLD2 Gene

Start:
4,807,096 bp from pter
End:
4,823,434 bp from pter
Size:
16,339 bases
Orientation:
Plus strand

Genomic View for PLD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD2 Gene

Regulatory Elements for PLD2 Gene

Proteins for PLD2 Gene

  • Protein details for PLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14939-PLD2_HUMAN
    Recommended name:
    Phospholipase D2
    Protein Accession:
    O14939
    Secondary Accessions:
    • I3L2C9
    • O43540
    • O43579
    • O43580
    • Q6PGR0
    • Q96BY3

    Protein attributes for PLD2 Gene

    Size:
    933 amino acids
    Molecular mass:
    105987 Da
    Quaternary structure:
    • Interacts with EGFR (By similarity). Interacts with PIP5K1B.

    Alternative splice isoforms for PLD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLD2 Gene

Proteomics data for PLD2 Gene at MOPED

Post-translational modifications for PLD2 Gene

Other Protein References for PLD2 Gene

Domains for PLD2 Gene

Gene Families for PLD2 Gene

UniProtKB/Swiss-Prot:

PLD2_HUMAN
Domain:
  • Contains 1 PH domain.:
    • O14939
  • Contains 2 PLD phosphodiesterase domains.:
    • O14939
  • Contains 1 PX (phox homology) domain.:
    • O14939
Family:
  • Belongs to the phospholipase D family.:
    • O14939
genes like me logo Genes that share domains with PLD2: view

Function for PLD2 Gene

Molecular function for PLD2 Gene

GENATLAS Biochemistry: phospholipase D2,106kDa,phosphatidylcholine specific,widely expressed,involved in metabolic regulation,cardiac and brain function,senescence regulated secretion,mitogenesis and cytoskeletal changes
UniProtKB/Swiss-Prot CatalyticActivity: A phosphatidylcholine + H(2)O = choline + a phosphatidate
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1)
UniProtKB/Swiss-Prot Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

Enzyme Numbers (IUBMB) for PLD2 Gene

Gene Ontology (GO) - Molecular Function for PLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004630 phospholipase D activity IEA --
GO:0005515 protein binding IPI 16407827
GO:0035091 phosphatidylinositol binding IEA --
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA --
genes like me logo Genes that share ontologies with PLD2: view
genes like me logo Genes that share phenotypes with PLD2: view

Animal Models for PLD2 Gene

MGI Knock Outs for PLD2:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PLD2 Gene

Localization for PLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD2 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLD2 Gene COMPARTMENTS Subcellular localization image for PLD2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4
cytosol 3
nucleus 3
endosome 2
golgi apparatus 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0031526 brush border membrane IEA --
genes like me logo Genes that share ontologies with PLD2: view

Pathways for PLD2 Gene

genes like me logo Genes that share pathways with PLD2: view

Gene Ontology (GO) - Biological Process for PLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006655 phosphatidylglycerol biosynthetic process TAS --
GO:0006898 receptor-mediated endocytosis --
genes like me logo Genes that share ontologies with PLD2: view

Compounds for PLD2 Gene

(5) Tocris Compounds for PLD2 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(2232) HMDB Compounds for PLD2 Gene

Compound Synonyms Cas Number PubMed IDs
Choline
  • (2-Hydroxyethyl)trimethyl ammonium
62-49-7
Ethanolamine
  • 1-Amino-2-hydroxyethane
141-43-5
LPA(0:0/16:0)
  • Lysophosphatidic acid(16:0)
Not Available
LPA(0:0/18:0)
  • 2-octadecanoyl-phosphatidic acid
Not Available
LPA(0:0/18:1(9Z))
  • LPA(18:1)
Not Available

(1) Drugbank Compounds for PLD2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Choline
  • Bilineurine
62-49-7 target product of

(4) IUPHAR Ligand for PLD2 Gene

Ligand Type Action Affinity Pubmed IDs
VU0364739 Inhibitor Inhibition 7.7
PIP2 Activator Agonist 5.3
ADP-ribosylation factor 1 Activator Activation
oleic acid Activator Activation

(32) Novoseek inferred chemical compound relationships for PLD2 Gene

Compound -log(P) Hits PubMed IDs
butanol 79.3 7
phosphatidylcholine 67.6 3
rottlerin 66.3 2
tert-butyl alcohol 64.7 1
choline 50.6 1
genes like me logo Genes that share compounds with PLD2: view

Transcripts for PLD2 Gene

Unigene Clusters for PLD2 Gene

Phospholipase D2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PLD2 Gene

GeneLoc Exon Structure for
PLD2
ECgene alternative splicing isoforms for
PLD2

Expression for PLD2 Gene

mRNA expression in normal human tissues for PLD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLD2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLD2 Gene

SOURCE GeneReport for Unigene cluster for PLD2 Gene Hs.104519

mRNA Expression by UniProt/SwissProt for PLD2 Gene

O14939-PLD2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PLD2: view

Orthologs for PLD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLD2 36
  • 98.71 (n)
  • 98.78 (a)
PLD2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLD2 36
  • 90.35 (n)
  • 92.28 (a)
PLD2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLD2 36
  • 84.82 (n)
  • 87.49 (a)
PLD2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pld2 36
  • 87.17 (n)
  • 90.03 (a)
Pld2 16
Pld2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLD2 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLD2 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pld2 36
  • 87.5 (n)
  • 90.46 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pld2 36
  • 64 (n)
  • 63.35 (a)
zebrafish
(Danio rerio)
Actinopterygii pld2 36
  • 61.35 (n)
  • 62.39 (a)
pld2 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pld 37
  • 31 (a)
OneToMany
Pld 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea pld-1 37
  • 28 (a)
OneToMany
pld-1 38
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPO14 37
  • 18 (a)
OneToMany
SPO14 39
barley
(Hordeum vulgare)
Liliopsida Hv.2078 36
corn
(Zea mays)
Liliopsida Zm.50 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for PLD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLD2 Gene

ENSEMBL:
Gene Tree for PLD2 (if available)
TreeFam:
Gene Tree for PLD2 (if available)

Paralogs for PLD2 Gene

Paralogs for PLD2 Gene

Selected SIMAP similar genes for PLD2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PLD2: view

Variants for PLD2 Gene

Sequence variations from dbSNP and Humsavar for PLD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1052742 -- 4,807,177(+) CCGTC(C/T)GCTCT utr-variant-5-prime, upstream-variant-2KB
rs1052746 -- 4,810,871(+) CTGGC(A/G)CAGGG reference, synonymous-codon, utr-variant-5-prime
rs1052748 - 4,817,174(+) TCCCA(C/T)ATACC reference, missense
rs1052751 -- 4,819,490(+) GTGCT(A/G)ATCGA synonymous-codon, reference
rs1052755 -- 4,823,008(+) TACAG(A/C)GGACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLD2 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv833347 CNV Loss 17160897
nsv820043 CNV Loss 19587683

Relevant External Links for PLD2 Gene

HapMap Linkage Disequilibrium report
PLD2
Human Gene Mutation Database (HGMD)
PLD2

Disorders for PLD2 Gene

(1) MalaCards Diseases for PLD2 Gene

Search for PLD2 Gene in MalaCards »

(10) Novoseek inferred disease relationships for PLD2 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 15.6 1
ewings sarcoma 13.2 4
ischemia 0 2
hypertrophy 0 2
breast cancer 0 5

Relevant External Links for PLD2

Genetic Association Database (GAD)
PLD2
Human Genome Epidemiology (HuGE) Navigator
PLD2
genes like me logo Genes that share disorders with PLD2: view

No data available for UniProtKB/Swiss-Prot for PLD2 Gene

Publications for PLD2 Gene

  1. Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. (PMID: 9582313) Lopez I. … Lambeth J.D. (J. Biol. Chem. 1998) 2 3 4 23
  2. Characterization of human PLD2 and the analysis of PLD isoform splice variants. (PMID: 9761774) Steed P.M. … Lasala D.J. (FASEB J. 1998) 3 4 23
  3. Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. (PMID: 11032811) Divecha N. … D'Santos C. (EMBO J. 2000) 3 4 23
  4. Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade. (PMID: 11042115) Slaaby R. … Seedorf K. (Biochem. J. 2000) 3 23
  5. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. (PMID: 9395408) Colley W.C. … Frohman M.A. (Curr. Biol. 1997) 3 23

Products for PLD2 Gene

Sources for PLD2 Gene

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