Aliases for PLAG1 Gene
External Ids for PLAG1 Gene
Previous GeneCards Identifiers for PLAG1 Gene
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLAG1 Gene
PLAG1 (Pleiomorphic Adenoma Gene 1) is a Protein Coding gene. Diseases associated with PLAG1 include adenomas, salivary gland pleomorphic and vulvar leiomyoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is PLAGL1.
UniProtKB/Swiss-Prot for PLAG1 Gene
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.