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Aliases for PLA2G5 Gene

Aliases for PLA2G5 Gene

  • Phospholipase A2, Group V 2 3
  • Phosphatidylcholine 2-Acylhydrolase 5 3 4
  • PLA2-10 3 4
  • FRFB 3 6
  • Calcium-Dependent Phospholipase A2 3
  • Ca2+-Dependent Phospholipase A2 3
  • Group V Phospholipase A2 4
  • EC 3.1.1.4 4
  • HVPLA(2) 3
  • GV-PLA2 3

External Ids for PLA2G5 Gene

Summaries for PLA2G5 Gene

Entrez Gene Summary for PLA2G5 Gene

  • This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G5 Gene

PLA2G5 (Phospholipase A2, Group V) is a Protein Coding gene. Diseases associated with PLA2G5 include fleck retina, familial benign and familial benign flecked retina. Among its related pathways are Ras signaling pathway and PAK Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G5 Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle

Tocris Summary for PLA2G5 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G5 Gene

Genomics for PLA2G5 Gene

Genomic Location for PLA2G5 Gene

Start:
20,028,179 bp from pter
End:
20,091,901 bp from pter
Size:
63,723 bases
Orientation:
Plus strand

Genomic View for PLA2G5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G5 Gene

Regulatory Elements for PLA2G5 Gene

Proteins for PLA2G5 Gene

  • Protein details for PLA2G5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39877-PA2G5_HUMAN
    Recommended name:
    Calcium-dependent phospholipase A2
    Protein Accession:
    P39877
    Secondary Accessions:
    • Q8N435

    Protein attributes for PLA2G5 Gene

    Size:
    138 amino acids
    Molecular mass:
    15674 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G5 Gene

neXtProt entry for PLA2G5 Gene

Proteomics data for PLA2G5 Gene at MOPED

Post-translational modifications for PLA2G5 Gene

  • This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins

Other Protein References for PLA2G5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G5 Gene

Domains for PLA2G5 Gene

Gene Families for PLA2G5 Gene

Protein Domains for PLA2G5 Gene

UniProtKB/Swiss-Prot:

PA2G5_HUMAN
Family:
  • Belongs to the phospholipase A2 family.:
    • P39877
genes like me logo Genes that share domains with PLA2G5: view

Function for PLA2G5 Gene

Molecular function for PLA2G5 Gene

GENATLAS Biochemistry: phospholipase A2,group V,Ca2+ dependent,cytosolic,strongly expressed in heart
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0.;
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle

Enzyme Numbers (IUBMB) for PLA2G5 Gene

Gene Ontology (GO) - Molecular Function for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008201 heparin binding IEA --
GO:0047498 calcium-dependent phospholipase A2 activity IEA --
genes like me logo Genes that share ontologies with PLA2G5: view
genes like me logo Genes that share phenotypes with PLA2G5: view

Animal Models for PLA2G5 Gene

MGI Knock Outs for PLA2G5:

miRNA for PLA2G5 Gene

miRTarBase miRNAs that target PLA2G5

No data available for Transcription Factor Targeting and HOMER Transcription for PLA2G5 Gene

Localization for PLA2G5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G5 Gene COMPARTMENTS Subcellular localization image for PLA2G5 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PLA2G5: view

Pathways for PLA2G5 Gene

genes like me logo Genes that share pathways with PLA2G5: view

Gene Ontology (GO) - Biological Process for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006663 platelet activating factor biosynthetic process IEA --
GO:0010518 positive regulation of phospholipase activity IDA 22837859
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G5: view

Compounds for PLA2G5 Gene

(5) Tocris Compounds for PLA2G5 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(2140) HMDB Compounds for PLA2G5 Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-Linolenic acid
  • (9,12,15)-linolenate
463-40-1
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Calcium
  • Ca
7440-70-2
Heptadecanoic acid
  • Heptadecanoate
506-12-7

(2) Novoseek inferred chemical compound relationships for PLA2G5 Gene

Compound -log(P) Hits PubMed IDs
leukotriene b4 59.8 1
phosphatidylcholine 58.6 1
genes like me logo Genes that share compounds with PLA2G5: view

Transcripts for PLA2G5 Gene

Unigene Clusters for PLA2G5 Gene

Phospholipase A2, group V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - - - -

Relevant External Links for PLA2G5 Gene

GeneLoc Exon Structure for
PLA2G5
ECgene alternative splicing isoforms for
PLA2G5

Expression for PLA2G5 Gene

mRNA expression in normal human tissues for PLA2G5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G5 Gene

This gene is overexpressed in Heart - Atrial Appendage (12.2), Ovary (7.0), Heart - Left Ventricle (7.0), and Artery - Coronary (6.5).

SOURCE GeneReport for Unigene cluster for PLA2G5 Gene Hs.319438

mRNA Expression by UniProt/SwissProt for PLA2G5 Gene

P39877-PA2G5_HUMAN
Tissue specificity: Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level).
genes like me logo Genes that share expressions with PLA2G5: view

Orthologs for PLA2G5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G5 36
  • 99.76 (n)
  • 99.28 (a)
PLA2G5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2G5 36
  • 79.23 (n)
  • 73.91 (a)
PLA2G5 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G5 36
  • 86.96 (n)
  • 86.23 (a)
PLA2G5 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g5 36
  • 79.08 (n)
  • 78.1 (a)
Pla2g5 16
Pla2g5 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 42 (a)
OneToMany
-- 37
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G5 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g5 36
  • 79.32 (n)
  • 78.1 (a)
chicken
(Gallus gallus)
Aves PLA2G5 36
  • 55.96 (n)
  • 45.99 (a)
PLA2G5 37
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 42 (a)
OneToMany
Species with no ortholog for PLA2G5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G5 Gene

ENSEMBL:
Gene Tree for PLA2G5 (if available)
TreeFam:
Gene Tree for PLA2G5 (if available)

Paralogs for PLA2G5 Gene

Paralogs for PLA2G5 Gene

Selected SIMAP similar genes for PLA2G5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G5: view

Variants for PLA2G5 Gene

Sequence variations from dbSNP and Humsavar for PLA2G5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13055 -- 20,090,860(+) TCCCA(G/T)GAGAG utr-variant-3-prime
rs475753 -- 20,076,184(-) ACAGA(A/C)ATCCA intron-variant
rs496648 -- 20,079,041(-) cacct(C/T)ctggg intron-variant, upstream-variant-2KB
rs504583 -- 20,059,573(-) AGTTA(A/G)TAATC upstream-variant-2KB
rs513246 -- 20,071,550(-) TGCTC(C/T)CTCTC intron-variant, utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLA2G5 Gene

Variant ID Type Subtype PubMed ID
nsv5520 CNV Loss 18451855
esv2435763 CNV Deletion 19546169
esv2164449 CNV Deletion 18987734
esv2665474 CNV Deletion 23128226
esv25446 CNV Loss 19812545
nsv519515 CNV Loss 19592680

Relevant External Links for PLA2G5 Gene

HapMap Linkage Disequilibrium report
PLA2G5
Human Gene Mutation Database (HGMD)
PLA2G5

Disorders for PLA2G5 Gene

(1) OMIM Diseases for PLA2G5 Gene (601192)

UniProtKB/Swiss-Prot

PA2G5_HUMAN
  • Fleck retina, familial benign (FRFB) [MIM:228980]: An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. {ECO:0000269 PubMed:22137173}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PLA2G5 Gene

Relevant External Links for PLA2G5

Genetic Association Database (GAD)
PLA2G5
Human Genome Epidemiology (HuGE) Navigator
PLA2G5
genes like me logo Genes that share disorders with PLA2G5: view

Publications for PLA2G5 Gene

  1. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PMID: 17545304) Wootton P.T. … Talmud P.J. (Hum. Mol. Genet. 2007) 3 23 49
  2. Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. (PMID: 8300559) Chen J. … Tischfield J.A. (J. Biol. Chem. 1994) 2 3 4
  3. Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PMID: 8838795) Tischfield J.A. … Lusis A.J. (Genomics 1996) 2 3
  4. Expression and characterization of human group V phospholipase A2. (PMID: 9767110) Chen Y. … Dennis E.A. (Biochim. Biophys. Acta 1998) 3 23
  5. The molecular basis of phosphatidylcholine preference of human group-V phospholipase A2. (PMID: 10839997) Kim K.P. … Cho W. (Biochem. J. 2000) 3 23

Products for PLA2G5 Gene

Sources for PLA2G5 Gene

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