Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLA2G4A Gene

Aliases for PLA2G4A Gene

  • Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) 2 3
  • Phospholipase A2 Group IVA 3 4
  • PLA2G4 3 4
  • CPLA2 3 4
  • Calcium-Dependent Phospholipid-Binding Protein 3
  • Phosphatidylcholine 2-Acylhydrolase 3
  • Lysophospholipase 3
  • CPLA2-Alpha 3

External Ids for PLA2G4A Gene

Previous HGNC Symbols for PLA2G4A Gene

  • PLA2G4

Previous GeneCards Identifiers for PLA2G4A Gene

  • GC01P184323
  • GC01P182226
  • GC01P183317
  • GC01P184037
  • GC01P184013
  • GC01P183529
  • GC01P185064
  • GC01P158032

Summaries for PLA2G4A Gene

Entrez Gene Summary for PLA2G4A Gene

  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for PLA2G4A Gene

PLA2G4A (Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)) is a Protein Coding gene. Diseases associated with PLA2G4A include phospholipase a2, group iv a, deficiency of and intestinal tuberculosis. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot for PLA2G4A Gene

  • Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

Tocris Summary for PLA2G4A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G4A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4A Gene

Genomics for PLA2G4A Gene

Regulatory Elements for PLA2G4A Gene

Genomic Location for PLA2G4A Gene

Chromosome:
1
Start:
186,828,900 bp from pter
End:
186,988,981 bp from pter
Size:
160,082 bases
Orientation:
Plus strand

Genomic View for PLA2G4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4A Gene

Proteins for PLA2G4A Gene

  • Protein details for PLA2G4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47712-PA24A_HUMAN
    Recommended name:
    Cytosolic phospholipase A2
    Protein Accession:
    P47712
    Secondary Accessions:
    • B1AKG4
    • Q29R80

    Protein attributes for PLA2G4A Gene

    Size:
    749 amino acids
    Molecular mass:
    85239 Da
    Quaternary structure:
    • Interacts with KAT5.

    Three dimensional structures from OCA and Proteopedia for PLA2G4A Gene

neXtProt entry for PLA2G4A Gene

Proteomics data for PLA2G4A Gene at MOPED

Post-translational modifications for PLA2G4A Gene

Other Protein References for PLA2G4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLA2G4A (cPLA2)

No data available for DME Specific Peptides for PLA2G4A Gene

Domains & Families for PLA2G4A Gene

Gene Families for PLA2G4A Gene

Suggested Antigen Peptide Sequences for PLA2G4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47712

UniProtKB/Swiss-Prot:

PA24A_HUMAN :
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • Contains 1 C2 domain.
  • Contains 1 PLA2c domain.
genes like me logo Genes that share domains with PLA2G4A: view

Function for PLA2G4A Gene

Molecular function for PLA2G4A Gene

GENATLAS Biochemistry:
phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction {ECO:0000269 PubMed:8083230}; Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction {ECO:0000269 PubMed:8083230};
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
UniProtKB/Swiss-Prot CatalyticActivity:
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+)
UniProtKB/Swiss-Prot Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

Gene Ontology (GO) - Molecular Function for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity --
GO:0004622 lysophospholipase activity IEA --
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IDA 9430701
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PLA2G4A: view
genes like me logo Genes that share phenotypes with PLA2G4A: view

Animal Models for PLA2G4A Gene

MGI Knock Outs for PLA2G4A:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G4A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLA2G4A Gene

Localization for PLA2G4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4A Gene

Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G4A Gene COMPARTMENTS Subcellular localization image for PLA2G4A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
mitochondrion 4
extracellular 2
golgi apparatus 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with PLA2G4A: view

Pathways & Interactions for PLA2G4A Gene

genes like me logo Genes that share pathways with PLA2G4A: view

PCR Array Products

SIGNOR curated interactions for PLA2G4A Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006663 platelet activating factor biosynthetic process NAS 9430701
GO:0006690 icosanoid metabolic process NAS 9430701
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PLA2G4A: view

Drugs & Compounds for PLA2G4A Gene

(75) Drugs for PLA2G4A Gene - From: NovoSeek, DrugBank, PharmGKB, HMDB, ApexBio, Tocris, FDA Approved Drugs, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluticasone propionate Approved Pharma antagonist, Target, inhibitor Selective high affinity glucocorticoid receptor agonist 0
Fluocinolone Acetonide Approved, Investigational Pharma binder, Enzyme, inhibitor 37
Quinacrine Approved Pharma Target, inhibitor 6
Carbachol Approved Pharma Full agonist, Agonist, Enzyme, inducer 3
Carbenicillin Approved Pharma Enzyme, inhibitor 1

(117) Additional Compounds for PLA2G4A Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerophosphocholine
  • 2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
  • a-Glycerophosphorylcholine
  • a-Glycerylphosphorylcholine
  • alpha-Glycerophosphorylcholine
  • alpha-Glycerylphosphorylcholine
28319-77-9
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
genes like me logo Genes that share compounds with PLA2G4A: view

Drug Products

Transcripts for PLA2G4A Gene

Unigene Clusters for PLA2G4A Gene

Phospholipase A2, group IVA (cytosolic, calcium-dependent):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4A Gene

No ASD Table

Relevant External Links for PLA2G4A Gene

GeneLoc Exon Structure for
PLA2G4A
ECgene alternative splicing isoforms for
PLA2G4A

Expression for PLA2G4A Gene

mRNA expression in normal human tissues for PLA2G4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4A Gene

This gene is overexpressed in Bladder (x4.0).

Protein differential expression in normal tissues from HIPED for PLA2G4A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3) and Uterus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G4A Gene



SOURCE GeneReport for Unigene cluster for PLA2G4A Gene Hs.497200

mRNA Expression by UniProt/SwissProt for PLA2G4A Gene

P47712-PA24A_HUMAN
Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium
genes like me logo Genes that share expression patterns with PLA2G4A: view

Protein tissue co-expression partners for PLA2G4A Gene

Primer Products

In Situ Assay Products

Orthologs for PLA2G4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G4A 35
  • 90.61 (n)
  • 93.32 (a)
PLA2G4A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G4A 35
  • 91.32 (n)
  • 93.72 (a)
PLA2G4A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g4a 35
  • 88.16 (n)
  • 94.91 (a)
Pla2g4a 16
Pla2g4a 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4A 35
  • 99.69 (n)
  • 100 (a)
PLA2G4A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g4a 35
  • 89.1 (n)
  • 94.79 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G4A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G4A 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G4A 35
  • 77.09 (n)
  • 83.89 (a)
PLA2G4A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G4A 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g4a 35
  • 74.5 (n)
  • 81.21 (a)
Str.20412 35
African clawed frog
(Xenopus laevis)
Amphibia pla2g4a-prov 35
zebrafish
(Danio rerio)
Actinopterygii cpla2 35
  • 67.99 (n)
  • 73.66 (a)
cpla2 36
  • 72 (a)
OneToMany
pla2g4a 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2704 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2601 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6135 36
  • 47 (a)
OneToOne
Species with no ortholog for PLA2G4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G4A Gene

ENSEMBL:
Gene Tree for PLA2G4A (if available)
TreeFam:
Gene Tree for PLA2G4A (if available)

Paralogs for PLA2G4A Gene

Paralogs for PLA2G4A Gene

(3) SIMAP similar genes for PLA2G4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLA2G4A: view

Variants for PLA2G4A Gene

Sequence variations from dbSNP and Humsavar for PLA2G4A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs725892 -- 186,931,994(+) TGAAG(G/T)CAAGG intron-variant
rs726706 -- 186,903,322(+) AGTAC(A/G)TAAGG intron-variant
rs763419 -- 186,854,826(-) TAGAA(C/G)AATTT intron-variant
rs932476 -- 186,964,423(+) ATCTC(A/G)TCTGT intron-variant
rs969357 -- 186,950,861(+) TTTCT(A/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4A Gene

Variant ID Type Subtype PubMed ID
nsv872590 CNV Gain 21882294
nsv466272 CNV Loss 19166990
esv2720350 CNV Deletion 23290073
esv1010484 CNV Insertion 20482838
esv1093925 CNV Insertion 17803354
nsv3877 CNV Insertion 18451855

Variation tolerance for PLA2G4A Gene

Residual Variation Intolerance Score: 51.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G4A Gene

HapMap Linkage Disequilibrium report
PLA2G4A
Human Gene Mutation Database (HGMD)
PLA2G4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4A Gene

Disorders for PLA2G4A Gene

MalaCards: The human disease database

(5) MalaCards diseases for PLA2G4A Gene - From: GeneTests, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
phospholipase a2, group iv a, deficiency of
intestinal tuberculosis
  • tuberculosis of intestine
krabbe disease
  • galactosylceramide beta-galactosidase deficiency
mood disorder
  • episodic mood disorder
schizophrenia
  • schizophrenia 12
- elite association

UniProtKB/Swiss-Prot

PA24A_HUMAN
  • Note=PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). {ECO:0000269 PubMed:18451993}.

Relevant External Links for PLA2G4A

Genetic Association Database (GAD)
PLA2G4A
Human Genome Epidemiology (HuGE) Navigator
PLA2G4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G4A
genes like me logo Genes that share disorders with PLA2G4A: view

No data available for Genatlas for PLA2G4A Gene

Publications for PLA2G4A Gene

  1. Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate. (PMID: 15083746) Myo S. … Leff A.R. (Eur. Respir. J. 2004) 23 25 26 67
  2. Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. (PMID: 10351938) Sano A. … Leff A.R. (Am. J. Respir. Crit. Care Med. 1999) 23 25 26 67
  3. Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway. (PMID: 9480923) Kim B.C. … Kim J.H. (Biochem. J. 1998) 23 25 26 67
  4. Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. (PMID: 20203101) Guo C. … Sun K. (Mol. Endocrinol. 2010) 23 67
  5. Cytosolic phospholipase A2 activation correlates with HER2 overexpression and mediates estrogen-dependent breast cancer cell growth. (PMID: 20211985) Caiazza F. … Thomas W. (Mol. Endocrinol. 2010) 23 67

Products for PLA2G4A Gene

Sources for PLA2G4A Gene

Back to Top

Content