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Aliases for PLA2G4A Gene

Aliases for PLA2G4A Gene

  • Phospholipase A2 Group IVA 2 3 4 5
  • Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) 2 3
  • PLA2G4 3 4
  • CPLA2 3 4
  • Calcium-Dependent Phospholipid-Binding Protein 3
  • Phosphatidylcholine 2-Acylhydrolase 3
  • Lysophospholipase 3
  • CPLA2-Alpha 3

External Ids for PLA2G4A Gene

Previous HGNC Symbols for PLA2G4A Gene

  • PLA2G4

Previous GeneCards Identifiers for PLA2G4A Gene

  • GC01P184323
  • GC01P182226
  • GC01P183317
  • GC01P184037
  • GC01P184013
  • GC01P183529
  • GC01P185064
  • GC01P158032

Summaries for PLA2G4A Gene

Entrez Gene Summary for PLA2G4A Gene

  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for PLA2G4A Gene

PLA2G4A (Phospholipase A2 Group IVA) is a Protein Coding gene. Diseases associated with PLA2G4A include Phospholipase A2, Group Iv A, Deficiency Of and Splenic Infarction. Among its related pathways are Platelet activation and Golgi-to-ER retrograde transport. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot for PLA2G4A Gene

  • Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Tocris Summary for PLA2G4A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G4A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4A Gene

Genomics for PLA2G4A Gene

Regulatory Elements for PLA2G4A Gene

Enhancers for PLA2G4A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G4A on UCSC Golden Path with GeneCards custom track

Promoters for PLA2G4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLA2G4A on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G4A Gene

Chromosome:
1
Start:
186,828,900 bp from pter
End:
186,988,981 bp from pter
Size:
160,082 bases
Orientation:
Plus strand

Genomic View for PLA2G4A Gene

Genes around PLA2G4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4A Gene

Proteins for PLA2G4A Gene

  • Protein details for PLA2G4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47712-PA24A_HUMAN
    Recommended name:
    Cytosolic phospholipase A2
    Protein Accession:
    P47712
    Secondary Accessions:
    • B1AKG4
    • Q29R80

    Protein attributes for PLA2G4A Gene

    Size:
    749 amino acids
    Molecular mass:
    85239 Da
    Quaternary structure:
    • Interacts with KAT5.

    Three dimensional structures from OCA and Proteopedia for PLA2G4A Gene

neXtProt entry for PLA2G4A Gene

Proteomics data for PLA2G4A Gene at MOPED

Post-translational modifications for PLA2G4A Gene

Other Protein References for PLA2G4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLA2G4A (cPLA2)

No data available for DME Specific Peptides for PLA2G4A Gene

Domains & Families for PLA2G4A Gene

Suggested Antigen Peptide Sequences for PLA2G4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47712

UniProtKB/Swiss-Prot:

PA24A_HUMAN :
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • Contains 1 C2 domain.
  • Contains 1 PLA2c domain.
genes like me logo Genes that share domains with PLA2G4A: view

Function for PLA2G4A Gene

Molecular function for PLA2G4A Gene

GENATLAS Biochemistry:
phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction {ECO:0000269 PubMed:8083230}; Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction {ECO:0000269 PubMed:8083230};
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
UniProtKB/Swiss-Prot Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Gene Ontology (GO) - Molecular Function for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IEA --
genes like me logo Genes that share ontologies with PLA2G4A: view
genes like me logo Genes that share phenotypes with PLA2G4A: view

Human Phenotype Ontology for PLA2G4A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLA2G4A Gene

MGI Knock Outs for PLA2G4A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLA2G4A Gene

Localization for PLA2G4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4A Gene

Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G4A Gene COMPARTMENTS Subcellular localization image for PLA2G4A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
mitochondrion 5
nucleus 4
golgi apparatus 3
extracellular 2
plasma membrane 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PLA2G4A Gene

Pathways & Interactions for PLA2G4A Gene

genes like me logo Genes that share pathways with PLA2G4A: view

SIGNOR curated interactions for PLA2G4A Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001554 luteolysis IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006663 platelet activating factor biosynthetic process NAS 9430701
GO:0006690 icosanoid metabolic process NAS 9430701
genes like me logo Genes that share ontologies with PLA2G4A: view

Drugs & Compounds for PLA2G4A Gene

(75) Drugs for PLA2G4A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluticasone propionate Approved Pharma antagonist, Target, inhibitor Selective high affinity glucocorticoid receptor agonist 0
Fluocinolone Acetonide Approved, Investigational Pharma binder, Enzyme, inhibitor 39
Quinacrine Approved Pharma Target, inhibitor 6
Carbachol Approved Pharma Full agonist, Agonist, Enzyme, inducer 3
Carbenicillin Approved Pharma Enzyme, inhibitor 1

(117) Additional Compounds for PLA2G4A Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerophosphocholine
  • 2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
  • a-Glycerophosphorylcholine
  • a-Glycerylphosphorylcholine
  • alpha-Glycerophosphorylcholine
  • alpha-Glycerylphosphorylcholine
28319-77-9
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6

(5) Tocris Compounds for PLA2G4A Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7

(3) ApexBio Compounds for PLA2G4A Gene

Compound Action Cas Number
Clofazimine Tuberculosis drug 2030-63-9
CP-91149 Selective inhibitor of glycogen phosphorylase 186392-40-5
Varespladib (LY315920) HnsPLA inhibitor,potent and selective 172732-68-2
genes like me logo Genes that share compounds with PLA2G4A: view

Drug Products

Transcripts for PLA2G4A Gene

Unigene Clusters for PLA2G4A Gene

Phospholipase A2, group IVA (cytosolic, calcium-dependent):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4A Gene

No ASD Table

Relevant External Links for PLA2G4A Gene

GeneLoc Exon Structure for
PLA2G4A
ECgene alternative splicing isoforms for
PLA2G4A

Expression for PLA2G4A Gene

mRNA expression in normal human tissues for PLA2G4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4A Gene

This gene is overexpressed in Bladder (x4.0).

Protein differential expression in normal tissues from HIPED for PLA2G4A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3) and Uterus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G4A Gene



SOURCE GeneReport for Unigene cluster for PLA2G4A Gene Hs.497200

mRNA Expression by UniProt/SwissProt for PLA2G4A Gene

P47712-PA24A_HUMAN
Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
genes like me logo Genes that share expression patterns with PLA2G4A: view

Protein tissue co-expression partners for PLA2G4A Gene

Primer Products

Orthologs for PLA2G4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G4A 35
  • 90.61 (n)
  • 93.32 (a)
PLA2G4A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G4A 35
  • 91.32 (n)
  • 93.72 (a)
PLA2G4A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g4a 35
  • 88.16 (n)
  • 94.91 (a)
Pla2g4a 16
Pla2g4a 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4A 35
  • 99.69 (n)
  • 100 (a)
PLA2G4A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g4a 35
  • 89.1 (n)
  • 94.79 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G4A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G4A 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G4A 35
  • 77.09 (n)
  • 83.89 (a)
PLA2G4A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G4A 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g4a 35
  • 74.5 (n)
  • 81.21 (a)
Str.20412 35
African clawed frog
(Xenopus laevis)
Amphibia pla2g4a-prov 35
zebrafish
(Danio rerio)
Actinopterygii cpla2 35
  • 67.99 (n)
  • 73.66 (a)
cpla2 36
  • 72 (a)
OneToMany
pla2g4a 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2704 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2601 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6135 36
  • 47 (a)
OneToOne
Species with no ortholog for PLA2G4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G4A Gene

ENSEMBL:
Gene Tree for PLA2G4A (if available)
TreeFam:
Gene Tree for PLA2G4A (if available)

Paralogs for PLA2G4A Gene

Paralogs for PLA2G4A Gene

(3) SIMAP similar genes for PLA2G4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLA2G4A: view

Variants for PLA2G4A Gene

Sequence variations from dbSNP and Humsavar for PLA2G4A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2307198 - 186,977,780(+) GTACA(A/G)GGCTC nc-transcript-variant, reference, missense
rs12720588 - 186,932,874(+) CCTAC(A/G)TTGCT nc-transcript-variant, reference, missense
rs28395828 - 186,894,140(+) CTCTA(A/G)GGACA nc-transcript-variant, reference, missense
VAR_035826 A breast cancer sample
rs28395831 - 186,977,737(+) CAACC(A/G)TCATC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4A Gene

Variant ID Type Subtype PubMed ID
nsv872590 CNV Gain 21882294
nsv466272 CNV Loss 19166990
esv2720350 CNV Deletion 23290073
esv1010484 CNV Insertion 20482838
esv1093925 CNV Insertion 17803354
nsv3877 CNV Insertion 18451855

Variation tolerance for PLA2G4A Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G4A Gene

Human Gene Mutation Database (HGMD)
PLA2G4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4A Gene

Disorders for PLA2G4A Gene

MalaCards: The human disease database

(6) MalaCards diseases for PLA2G4A Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
phospholipase a2, group iv a, deficiency of
splenic infarction
  • splenic infarct
anterior uveitis
  • iridocyclitis
krabbe disease
  • beta galactocerebrosidase deficiency
mood disorder
  • episodic mood disorder
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PA24A_HUMAN
  • Note=PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). {ECO:0000269 PubMed:18451993}.

Relevant External Links for PLA2G4A

Genetic Association Database (GAD)
PLA2G4A
Human Genome Epidemiology (HuGE) Navigator
PLA2G4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G4A
genes like me logo Genes that share disorders with PLA2G4A: view

No data available for Genatlas for PLA2G4A Gene

Publications for PLA2G4A Gene

  1. Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PMID: 8083230) Sharp J.D. … Kramer R.M. (J. Biol. Chem. 1994) 3 4 23 67
  2. Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate. (PMID: 15083746) Myo S. … Leff A.R. (Eur. Respir. J. 2004) 23 25 26
  3. Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. (PMID: 10351938) Sano A. … Leff A.R. (Am. J. Respir. Crit. Care Med. 1999) 23 25 26
  4. Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway. (PMID: 9480923) Kim B.C. … Kim J.H. (Biochem. J. 1998) 23 25 26
  5. Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. (PMID: 20203101) Guo C. … Sun K. (Mol. Endocrinol. 2010) 3 23

Products for PLA2G4A Gene

Sources for PLA2G4A Gene

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