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Aliases for PLA2G1B Gene

Aliases for PLA2G1B Gene

  • Phospholipase A2, Group IB (Pancreas) 2 3
  • PLA2A 3 4 6
  • PPLA2 3 4 6
  • PLA2 3 4 6
  • Phosphatidylcholine 2-Acylhydrolase 1B 3 4
  • EC 3.1.1.4 4 64
  • Group IB Phospholipase A2 4
  • Phospholipase A2 3

External Ids for PLA2G1B Gene

Previous Symbols for PLA2G1B Gene

  • PLA2
  • PPLA2
  • PLA2A

Summaries for PLA2G1B Gene

Entrez Gene Summary for PLA2G1B Gene

  • This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLA2G1B Gene

PLA2G1B (Phospholipase A2, Group IB (Pancreas)) is a Protein Coding gene. Diseases associated with PLA2G1B include distal hereditary motor neuropathy, type ii and acinar cell carcinoma. Among its related pathways are Ras signaling pathway and PAK Pathway. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G1B Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

Tocris Summary for PLA2G1B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G1B Gene

Genomics for PLA2G1B Gene

Genomic Location for PLA2G1B Gene

Start:
120,322,111 bp from pter
End:
120,327,789 bp from pter
Size:
5,679 bases
Orientation:
Minus strand

Genomic View for PLA2G1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G1B Gene

Regulatory Elements for PLA2G1B Gene

Proteins for PLA2G1B Gene

  • Protein details for PLA2G1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04054-PA21B_HUMAN
    Recommended name:
    Phospholipase A2
    Protein Accession:
    P04054
    Secondary Accessions:
    • B2R4H5
    • Q3KPI1

    Protein attributes for PLA2G1B Gene

    Size:
    148 amino acids
    Molecular mass:
    16360 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    • Monomer or homodimer (By similarity). The inactive pro-form is a homotrimer.

    Three dimensional structures from OCA and Proteopedia for PLA2G1B Gene

neXtProt entry for PLA2G1B Gene

Proteomics data for PLA2G1B Gene at MOPED

Selected DME Specific Peptides for PLA2G1B Gene

Post-translational modifications for PLA2G1B Gene

  • Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PLA2G1B Gene

Gene Families for PLA2G1B Gene

Protein Domains for PLA2G1B Gene

UniProtKB/Swiss-Prot:

PA21B_HUMAN
Family:
  • Belongs to the phospholipase A2 family.:
    • P04054
genes like me logo Genes that share domains with PLA2G1B: view

Function for PLA2G1B Gene

Molecular function for PLA2G1B Gene

GENATLAS Biochemistry: phospholipase A2,Ca2+ dependent,group 1B,pancreatic,secreted,cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis,inducing cell proliferation,smooth muscle contraction and lipid mediator release
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

Enzyme Numbers (IUBMB) for PLA2G1B Gene

Gene Ontology (GO) - Molecular Function for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IDA 1918029
GO:0005102 receptor binding IPI 7721806
GO:0005509 calcium ion binding IDA 7060561
GO:0032052 bile acid binding ISS 7060561
GO:0047498 calcium-dependent phospholipase A2 activity IDA 7060561
genes like me logo Genes that share ontologies with PLA2G1B: view
genes like me logo Genes that share phenotypes with PLA2G1B: view

Animal Models for PLA2G1B Gene

MGI Knock Outs for PLA2G1B:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PLA2G1B Gene

Localization for PLA2G1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G1B Gene

Secreted. Note=secreted from pancreatic acinar cells in its inactive form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G1B Gene COMPARTMENTS Subcellular localization image for PLA2G1B gene
Compartment Confidence
extracellular 5
mitochondrion 3
plasma membrane 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
vacuole 2
endosome 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 12860195
GO:0009986 cell surface IDA 1918029
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with PLA2G1B: view

Pathways for PLA2G1B Gene

genes like me logo Genes that share pathways with PLA2G1B: view

Gene Ontology (GO) - Biological Process for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity ISS 15528384
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0002446 neutrophil mediated immunity ISS 16005851
GO:0006633 fatty acid biosynthetic process IDA 1918029
GO:0006644 phospholipid metabolic process TAS --
genes like me logo Genes that share ontologies with PLA2G1B: view

Compounds for PLA2G1B Gene

(5) Tocris Compounds for PLA2G1B Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(2140) HMDB Compounds for PLA2G1B Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-Linolenic acid
  • (9,12,15)-linolenate
463-40-1
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Calcium
  • Ca
7440-70-2
Heptadecanoic acid
  • Heptadecanoate
506-12-7

(12) Drugbank Compounds for PLA2G1B Gene

(50) Novoseek inferred chemical compound relationships for PLA2G1B Gene

Compound -log(P) Hits PubMed IDs
scalaradial 84.1 3
aacocf3 81.7 4
leukotriene b4 81.3 27
manoalide 79.9 5
arachidonic acid 79.4 34
genes like me logo Genes that share compounds with PLA2G1B: view

Transcripts for PLA2G1B Gene

mRNA/cDNA for PLA2G1B Gene

Unigene Clusters for PLA2G1B Gene

Phospholipase A2, group IB (pancreas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for PLA2G1B Gene

GeneLoc Exon Structure for
PLA2G1B
ECgene alternative splicing isoforms for
PLA2G1B

Expression for PLA2G1B Gene

mRNA expression in normal human tissues for PLA2G1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G1B Gene

This gene is overexpressed in Pancreas (52.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLA2G1B Gene

SOURCE GeneReport for Unigene cluster for PLA2G1B Gene Hs.992

genes like me logo Genes that share expressions with PLA2G1B: view

Orthologs for PLA2G1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G1B 36
  • 98.87 (n)
  • 97.97 (a)
PLA2G1B 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2G1B 36
  • 78.79 (n)
  • 76.22 (a)
PLA2G1B 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G1B 36
  • 84.47 (n)
  • 85.62 (a)
PLA2G1B 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g1b 36
  • 80.21 (n)
  • 81.25 (a)
Pla2g1b 16
Pla2g1b 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G1B 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G1B 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g1b 36
  • 81.25 (n)
  • 80.47 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 63 (a)
OneToMany
PLA2G1B 36
  • 68.21 (n)
  • 67.69 (a)
PLA2G1B 37
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PLA2G1B 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g1b 36
  • 65.36 (n)
  • 64.06 (a)
Str.9482 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9086 36
zebrafish
(Danio rerio)
Actinopterygii pla2g1b 36
  • 60.93 (n)
  • 57.38 (a)
pla2g1b 37
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C07E3.9 37
  • 32 (a)
OneToMany
Species with no ortholog for PLA2G1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G1B Gene

ENSEMBL:
Gene Tree for PLA2G1B (if available)
TreeFam:
Gene Tree for PLA2G1B (if available)

Paralogs for PLA2G1B Gene

Paralogs for PLA2G1B Gene

Selected SIMAP similar genes for PLA2G1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2G1B: view

Variants for PLA2G1B Gene

Sequence variations from dbSNP and Humsavar for PLA2G1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs5631 -- 120,327,601(-) CTCAA(A/T)TCGAG intron-variant
rs5632 - 120,326,008(-) CGCCG(A/C)CAGCG reference, missense
rs5633 -- 120,325,932(-) CCCTT(C/T)TTGGA reference, synonymous-codon
rs5634 -- 120,325,034(-) TGCTA(C/T)GACCA synonymous-codon, reference
rs5635 - 120,324,990(-) GGACA(A/C)CCCGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLA2G1B Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv899556 CNV Gain 21882294

Relevant External Links for PLA2G1B Gene

HapMap Linkage Disequilibrium report
PLA2G1B

Disorders for PLA2G1B Gene

(11) Novoseek inferred disease relationships for PLA2G1B Gene

Disease -log(P) Hits PubMed IDs
shock septic 14.4 4
necrosis 3.47 2
acute pancreatitis 0.47 2
ischemia 0 1
schizophrenia 0 2

Relevant External Links for PLA2G1B

Genetic Association Database (GAD)
PLA2G1B
Human Genome Epidemiology (HuGE) Navigator
PLA2G1B
genes like me logo Genes that share disorders with PLA2G1B: view

No data available for UniProtKB/Swiss-Prot for PLA2G1B Gene

Publications for PLA2G1B Gene

  1. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. (PMID: 12759552) Rybakowski J.K. … Hauser J. (Neuropsychobiology 2003) 3 23 49
  2. Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. (PMID: 3028739) Seilhamer J.J. … Johnson L.K. (DNA 1986) 3 4
  3. The complete primary structure of phospholipase A2 from human pancreas. (PMID: 6349696) Verheij H.M. … de Haas G.H. (Biochim. Biophys. Acta 1983) 3 4
  4. Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region. (PMID: 7060561) Grataroli R. … Figarella C. (Eur. J. Biochem. 1982) 3 4
  5. Diversity of group types, regulation, and function of phospholipase A2. (PMID: 8175726) Dennis E.A. (J. Biol. Chem. 1994) 2 3

Products for PLA2G1B Gene

Sources for PLA2G1B Gene

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