Aliases for PIK3R2 Gene
- Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta) 2 3
- Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Beta 3 4
- PtdIns-3-Kinase Regulatory Subunit P85-Beta 3 4
- PI3K Regulatory Subunit Beta 3 4
- PI3-Kinase Subunit P85-Beta 3 4
- Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 2 (P85 Beta) 3
- PtdIns-3-Kinase Regulatory Subunit Beta 4
External Ids for PIK3R2 Gene
Previous GeneCards Identifiers for PIK3R2 Gene
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]
GeneCards Summary for PIK3R2 Gene
PIK3R2 (Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta)) is a Protein Coding gene. Diseases associated with PIK3R2 include megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 and megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include protein heterodimerization activity and receptor tyrosine kinase binding. An important paralog of this gene is PIK3R3.
UniProtKB/Swiss-Prot for PIK3R2 Gene
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.