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Aliases for PIK3CG Gene

Aliases for PIK3CG Gene

  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma 2 3 5
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Gamma 2 3
  • Serine/Threonine Protein Kinase PIK3CG 3 4
  • PtdIns-3-Kinase Subunit P110-Gamma 3 4
  • PtdIns-3-Kinase Subunit Gamma 3 4
  • PI3-Kinase Subunit Gamma 3 4
  • EC 2.7.1.153 4 63
  • PI3Kgamma 3 4
  • P110gamma 3 4
  • P120-PI3K 3 4
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Gamma 3
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform 3
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Gamma 4
  • Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide 2
  • Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide 4
  • Phosphatidylinositol 3-Kinase Catalytic 110-KD Gamma 3
  • Phosphoinositide-3-Kinase Gamma Catalytic Subunit 3
  • Phosphatidylinositol 3 Kinase Gamma, P110 Gamma 3
  • 1-Phosphatidylinositol 3-Kinase 3
  • EC 2.7.11.1 4
  • PI3K-Gamma 4
  • EC 2.7.1 63
  • PI3CG 3
  • PI3K 3
  • PIK3 3

External Ids for PIK3CG Gene

Previous GeneCards Identifiers for PIK3CG Gene

  • GC07P104989
  • GC07P106052
  • GC07P106066
  • GC07P106099
  • GC07P106292
  • GC07P106505
  • GC07P100864

Summaries for PIK3CG Gene

Entrez Gene Summary for PIK3CG Gene

  • Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

GeneCards Summary for PIK3CG Gene

PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PIK3CG include chorioangioma and hemangioma of intra-abdominal structure. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding. An important paralog of this gene is PIK3CB.

UniProtKB/Swiss-Prot for PIK3CG Gene

  • Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Tocris Summary for PIK3CG Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3CG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3CG Gene

Genomics for PIK3CG Gene

Regulatory Elements for PIK3CG Gene

Promoters for PIK3CG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIK3CG on UCSC Golden Path with GeneCards custom track

Genomic Location for PIK3CG Gene

Chromosome:
7
Start:
106,865,278 bp from pter
End:
106,908,978 bp from pter
Size:
43,701 bases
Orientation:
Plus strand

Genomic View for PIK3CG Gene

Genes around PIK3CG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3CG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3CG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3CG Gene

Proteins for PIK3CG Gene

  • Protein details for PIK3CG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48736-PK3CG_HUMAN
    Recommended name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Protein Accession:
    P48736
    Secondary Accessions:
    • A4D0Q6
    • Q8IV23
    • Q9BZC8

    Protein attributes for PIK3CG Gene

    Size:
    1102 amino acids
    Molecular mass:
    126454 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with ADRBK1 through the PIK helical domain. Interaction with ADRBK1 is required for targeting to agonist-occupied receptor. Interacts with PDE3B (By similarity). Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity).
    Miscellaneous:
    • Candidate target in therapy for inflammatory diseases. Selective inhibitors and protein ablation are anti-inflammatory in multiple disease models such as asthma, rheumatoid arthritis, allergy, systemic lupus erythematosus, airway inflammation, lung injury and pancreatitis (PubMed:18278175).

    Three dimensional structures from OCA and Proteopedia for PIK3CG Gene

neXtProt entry for PIK3CG Gene

Proteomics data for PIK3CG Gene at MOPED

Selected DME Specific Peptides for PIK3CG Gene

Post-translational modifications for PIK3CG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIK3CG Gene

Antibody Products

  • R&D Systems Antibodies for PIK3CG (PI 3-Kinase p110 gamma)
  • Cell Signaling Technology (CST) Antibodies for PIK3CG (PIK3CG)

Domains & Families for PIK3CG Gene

Suggested Antigen Peptide Sequences for PIK3CG Gene

Graphical View of Domain Structure for InterPro Entry

P48736

UniProtKB/Swiss-Prot:

PK3CG_HUMAN :
  • Contains 1 C2 PI3K-type domain.
  • Belongs to the PI3/PI4-kinase family.
Domain:
  • Contains 1 C2 PI3K-type domain.
  • Contains 1 PI3K-ABD domain.
  • Contains 1 PI3K-RBD domain.
  • Contains 1 PI3K/PI4K domain.
  • Contains 1 PIK helical domain.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3CG: view

Function for PIK3CG Gene

Molecular function for PIK3CG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6) leading to the translocation from the cytosol to the plasma membrane and to kinase activation. Inhibited by AS-604850 and AS-605240.
UniProtKB/Swiss-Prot Function:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Enzyme Numbers (IUBMB) for PIK3CG Gene

Phenotypes for PIK3CG Gene

genes like me logo Genes that share phenotypes with PIK3CG: view

Animal Models for PIK3CG Gene

MGI Knock Outs for PIK3CG:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3CG Gene

Localization for PIK3CG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3CG Gene

Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3CG Gene COMPARTMENTS Subcellular localization image for PIK3CG gene
Compartment Confidence
cytosol 5
lysosome 4
plasma membrane 4
vacuole 4
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PIK3CG Gene

Pathways & Interactions for PIK3CG Gene

genes like me logo Genes that share pathways with PIK3CG: view

Pathways by source for PIK3CG Gene

UniProtKB/Swiss-Prot P48736-PK3CG_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

SIGNOR curated interactions for PIK3CG Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PIK3CG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production TAS 19075988
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002250 adaptive immune response TAS 17290298
GO:0002407 dendritic cell chemotaxis TAS 18278175
GO:0002679 respiratory burst involved in defense response TAS 19075988
genes like me logo Genes that share ontologies with PIK3CG: view

Drugs & Compounds for PIK3CG Gene

(123) Drugs for PIK3CG Gene - From: Novoseek, ApexBio, DGIdb, HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Quercetin Experimental Nutra Target Antitumor agent, Non-selective PI 3-kinase inhibitor 36
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE Experimental Pharma Target 0
(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine Experimental Pharma Target 0

(447) Additional Compounds for PIK3CG Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY 303511
154447-38-8
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)

(5) Tocris Compounds for PIK3CG Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator 1236188-16-1
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
LY 303511 Negative control of LY 294002 (Cat. No. 1130) 154447-38-8
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7

(28) ApexBio Compounds for PIK3CG Gene

Compound Action Cas Number
740 Y-P PI 3-kinase activator,cell permeable 1236188-16-1
AS-252424 PI3Kγ inhibitor,novel and potent 900515-16-4
AS-604850 PI3Kγ inhibitor,selective and ATP-competitve 648449-76-7
AZD6482 PI3Kβ inhibitor,potent and selective 1173900-33-8
BAY 80-6946 (Copanlisib) PI3K inhibitor 1032568-63-0
BEZ235 (NVP-BEZ235) PI3K/mTOR inhibitor,ATP-competitve 915019-65-7
BKM120 Inhibitor of pan-Class I PI3K 944396-07-0
CAY10505 Potent PI3Kγ inhibitor 1218777-13-9
CH5132799 Class I PI3K inhibitor 1007207-67-1
CZC24832 Selective PI3K-γ inhibitor 1159824-67-5
GDC-0941 PI3K inhibitor,potent and selective 957054-30-7
GSK1059615 PI3K and mTOR inhibitor,potent and reversible 958852-01-2
GSK2126458 PI3K/mTOR inhibitor 1086062-66-9
INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective 1224844-38-5
NVP-BGT226 PI3K/mTOR inhibitor,selective and novel 1245537-68-1
PF-04691502 PI3K/mTOR (FRAP) inhibitor 1013101-36-4
PI-103 Class I PI3K, mTOR and DNA-PK inhibitor 371935-74-9
PIK-293 900185-01-5
PIK-294 900185-02-6
PIK-75 Inhibitor of PI3K isoform p110α 372196-77-5
PIK-90 PI3K inhibitor,potent selective 677338-12-4
PIK-93 PI3Kγ/PI4KIIIβ/PI3Kα inhibitor 593960-11-3
PKI-402 PI3K inhibitor,selective, reversible and ATP-competitive 1173204-81-3
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
Quercetin Antitumor agent 117-39-5
TGX-221 PI3Kβ inhibitor,potent,selective and ATP competitive 663619-89-4
VS-5584 (SB2343) MTOR/P13K inhibitor,potent and selective 1246560-33-7
ZSTK474 Potent PI3K inhibitor 475110-96-4
genes like me logo Genes that share compounds with PIK3CG: view

Drug Products

Transcripts for PIK3CG Gene

Unigene Clusters for PIK3CG Gene

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: -
SP2: - -
SP3:

Relevant External Links for PIK3CG Gene

GeneLoc Exon Structure for
PIK3CG
ECgene alternative splicing isoforms for
PIK3CG

Expression for PIK3CG Gene

mRNA expression in normal human tissues for PIK3CG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIK3CG Gene

This gene is overexpressed in Whole Blood (x20.2).

Protein differential expression in normal tissues from HIPED for PIK3CG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIK3CG Gene



SOURCE GeneReport for Unigene cluster for PIK3CG Gene Hs.32942

mRNA Expression by UniProt/SwissProt for PIK3CG Gene

P48736-PK3CG_HUMAN
Tissue specificity: Pancreas, skeletal muscle, liver and heart.
genes like me logo Genes that share expression patterns with PIK3CG: view

Protein tissue co-expression partners for PIK3CG Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PIK3CG Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3CG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIK3CG 35
  • 89.97 (n)
  • 94.98 (a)
PIK3CG 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3CG 35
  • 88.32 (n)
  • 92.29 (a)
PIK3CG 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3cg 35
  • 86.99 (n)
  • 94.1 (a)
Pik3cg 16
Pik3cg 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIK3CG 35
  • 99.55 (n)
  • 99.82 (a)
PIK3CG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3cg 35
  • 86.6 (n)
  • 93.65 (a)
oppossum
(Monodelphis domestica)
Mammalia PIK3CG 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3CG 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIK3CG 35
  • 75.59 (n)
  • 84.75 (a)
PIK3CG 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIK3CG 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3cg 35
  • 71.72 (n)
  • 79.76 (a)
Str.8580 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34757 35
zebrafish
(Danio rerio)
Actinopterygii pik3cg 35
  • 54.55 (n)
  • 47.84 (a)
wufb15d07 35
pik3cg 36
  • 72 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea age-1 36
  • 24 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5268 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for PIK3CG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIK3CG Gene

ENSEMBL:
Gene Tree for PIK3CG (if available)
TreeFam:
Gene Tree for PIK3CG (if available)

Paralogs for PIK3CG Gene

Paralogs for PIK3CG Gene

(7) SIMAP similar genes for PIK3CG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PIK3CG: view

Variants for PIK3CG Gene

Sequence variations from dbSNP and Humsavar for PIK3CG Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs718207 -- 106,870,903(+) TAGAA(A/T)AATTA intron-variant
rs849367 -- 106,875,709(+) tatgg(A/C)tatac intron-variant
rs849368 -- 106,876,040(+) ctccc(A/G)agtag intron-variant
rs849369 -- 106,876,270(+) tcact(A/G)ttgtt intron-variant
rs849370 -- 106,879,498(-) CACAT(A/G)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3CG Gene

Variant ID Type Subtype PubMed ID
nsv507407 CNV Insertion 20534489

Variation tolerance for PIK3CG Gene

Residual Variation Intolerance Score: 8.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.97; 84.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3CG Gene

HapMap Linkage Disequilibrium report
PIK3CG
Human Gene Mutation Database (HGMD)
PIK3CG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3CG Gene

Disorders for PIK3CG Gene

MalaCards: The human disease database

(10) MalaCards diseases for PIK3CG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chorioangioma
  • placental hemangioma
hemangioma of intra-abdominal structure
  • hemangioma of intra-abdominal structures
endometrial cancer
  • endometrial cancer, familial
prostate cancer
  • prostate cancer, hereditary, 5
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PIK3CG

Genetic Association Database (GAD)
PIK3CG
Human Genome Epidemiology (HuGE) Navigator
PIK3CG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIK3CG
genes like me logo Genes that share disorders with PIK3CG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3CG Gene

Publications for PIK3CG Gene

  1. Cardiac regulation by phosphoinositide 3-kinases and PTEN. (PMID: 19147653) Oudit G.Y. … Penninger J.M. (Cardiovasc. Res. 2009) 3 4 67
  2. Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. (PMID: 19609946) Ghayad S.E. … Cohen P.A. (Int. J. Cancer 2010) 3 23
  3. Pro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cells. (PMID: 20157617) Liu B. … Nussenblatt R.B. (Mol. Vis. 2010) 3 23
  4. PI3Kgamma controls oxidative bursts in neutrophils via interactions with PKCalpha and p47phox. (PMID: 18983267) Lehmann K. … Wetzker R. (Biochem. J. 2009) 3 23
  5. Stathmin, a microtubule regulatory protein, is associated with hypoxia-inducible factor-1alpha levels in human endometrial and endothelial cells. (PMID: 19179443) Yoshie M. … Tamura K. (Endocrinology 2009) 3 23

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