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Aliases for PIM1 Gene

Aliases for PIM1 Gene

  • Pim-1 Proto-Oncogene, Serine/Threonine Kinase 2 3
  • EC 2.7.11.1 4 63
  • Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 3
  • Pim-1 Oncogene (Proviral Integration Site 1) 3
  • Serine/Threonine-Protein Kinase Pim-1 3
  • Pim-1 Kinase 44 KDa Isoform 3
  • Pim-1 Oncogene 2
  • Oncogene PIM1 3
  • PIM 3

External Ids for PIM1 Gene

Previous HGNC Symbols for PIM1 Gene

  • PIM

Previous GeneCards Identifiers for PIM1 Gene

  • GC06P037140
  • GC06P037184
  • GC06P037245
  • GC06P036856
  • GC06P037137

Summaries for PIM1 Gene

Entrez Gene Summary for PIM1 Gene

  • The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

GeneCards Summary for PIM1 Gene

PIM1 (Pim-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM1 include nodal marginal zone b-cell lymphoma and diffuse large b-cell lymphoma. Among its related pathways are MicroRNAs in cancer and PEDF Induced Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and manganese ion binding. An important paralog of this gene is PIM2.

UniProtKB/Swiss-Prot for PIM1 Gene

  • Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

Tocris Summary for PIM1 Gene

  • Pim kinases are constitutively active serine/threonine kinases that promote growth factor-independent proliferation by phosphorylating, and thus inhibiting, a range of cellular proteins. Both Pim-1 and Pim-2 kinase are serine/threonine kinases that are involved in the control of cell growth, differentiation and apoptosis

Gene Wiki entry for PIM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIM1 Gene

Genomics for PIM1 Gene

Regulatory Elements for PIM1 Gene

Genomic Location for PIM1 Gene

Start:
37,170,146 bp from pter
End:
37,175,428 bp from pter
Size:
5,283 bases
Orientation:
Plus strand

Genomic View for PIM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIM1 Gene

Proteins for PIM1 Gene

  • Protein details for PIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11309-PIM1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase pim-1
    Protein Accession:
    P11309
    Secondary Accessions:
    • Q38RT9
    • Q5T7H7
    • Q96RG3

    Protein attributes for PIM1 Gene

    Size:
    404 amino acids
    Molecular mass:
    45412 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins (By similarity). Binds to RP9 (By similarity). Isoform 1, but not isoform 2, binds BMX. Isoform 2 interacts with CDKN1B and FOXO3. Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation (By similarity). Interacts with HSP90, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation. Interacts with CDKN1A. Interacts with CDC25C. Interacts (via N-terminal 96 residues) with CDC25A (By similarity). Interacts with MAP3K5. Interacts with MYC (By similarity).

    Three dimensional structures from OCA and Proteopedia for PIM1 Gene

    Alternative splice isoforms for PIM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIM1 Gene

Proteomics data for PIM1 Gene at MOPED

Post-translational modifications for PIM1 Gene

  • Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.
  • Ubiquitinated, leading to proteasomal degradation.
  • Ubiquitination at Lys96 and Lys285
  • Modification sites at PhosphoSitePlus

Other Protein References for PIM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PIM1 Gene

Gene Families for PIM1 Gene

Suggested Antigen Peptide Sequences for PIM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11309

UniProtKB/Swiss-Prot:

PIM1_HUMAN :
  • P11309
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
genes like me logo Genes that share domains with PIM1: view

Function for PIM1 Gene

Molecular function for PIM1 Gene

GENATLAS Biochemistry: pim-1 oncogene
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
UniProtKB/Swiss-Prot Induction: Strongly induced in leukocytes by the JAK/STAT pathway in response to cytokines. Induced by different cellular stresses, heat shock and cytotoxic agents.

Enzyme Numbers (IUBMB) for PIM1 Gene

Gene Ontology (GO) - Molecular Function for PIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 1825810
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16186805
GO:0005524 ATP binding IDA 1825810
genes like me logo Genes that share ontologies with PIM1: view
genes like me logo Genes that share phenotypes with PIM1: view

Animal Models for PIM1 Gene

MGI Knock Outs for PIM1:

No data available for Transcription Factor Targeting and HOMER Transcription for PIM1 Gene

Localization for PIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIM1 Gene

Isoform 2: Cytoplasm. Nucleus.
Isoform 1: Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIM1 Gene COMPARTMENTS Subcellular localization image for PIM1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 1825810
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PIM1: view

Pathways for PIM1 Gene

genes like me logo Genes that share pathways with PIM1: view

Gene Ontology (GO) - Biological Process for PIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 16266891
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organismal development TAS 2682662
GO:0007346 regulation of mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with PIM1: view

Compounds for PIM1 Gene

(8) ApexBio Compounds for PIM1 Gene

Compound Action Cas Number
AZD1208 novel, orally bioavailable, highly selective PIM kinase inhibitor. [1204144-28-4]
CX-6258 potent, orally efficacious pan-Pim kinases Inhibitor.
LKB1 (AAK1 dual inhibitor) Pim-1 kinase inhibitor. [1093222-27-5]
PIM-1 Inhibitor 2 Potent Pim-1 kinase inhibitor [477845-12-8]
R8-T198wt Cell-permeable peptide inhibitor of Pim-1 kinase
SGI-1776 free base potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase [1025065-69-3]
SMI-4a potent inhibitor of Pim1 [438190-29-5]
TCS PIM-1 1 ATP-competitive Pim-1 kinase inhibitor. [491871-58-0]

(4) Tocris Compounds for PIM1 Gene

Compound Action Cas Number
PIM-1 Inhibitor 2 Pim-1 kinase inhibitor [477845-12-8]
R8-T198wt Pim-1 kinase inhibitor
TCS PIM-1 1 Selective, ATP-competitive Pim-1 kinase inhibitor [491871-58-0]
TCS PIM-1 4a Selective, ATP-competitive Pim kinase inhibitor [438190-29-5]

(3) HMDB Compounds for PIM1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Manganese
  • manganese
7439-96-5

(13) Novoseek inferred chemical compound relationships for PIM1 Gene

Compound -log(P) Hits PubMed IDs
threonine 78 41
serine 67.6 42
tyrosine 46.4 14
amp-pnp 46 3
gp 130 38.1 3
genes like me logo Genes that share compounds with PIM1: view

Transcripts for PIM1 Gene

mRNA/cDNA for PIM1 Gene

Unigene Clusters for PIM1 Gene

Pim-1 oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: - -

Relevant External Links for PIM1 Gene

GeneLoc Exon Structure for
PIM1
ECgene alternative splicing isoforms for
PIM1

Expression for PIM1 Gene

mRNA expression in normal human tissues for PIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIM1 Gene

This gene is overexpressed in Whole Blood (6.3) and Esophagus - Mucosa (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIM1 Gene

SOURCE GeneReport for Unigene cluster for PIM1 Gene Hs.81170

mRNA Expression by UniProt/SwissProt for PIM1 Gene

P11309-PIM1_HUMAN
Tissue specificity: Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
genes like me logo Genes that share expressions with PIM1: view

Orthologs for PIM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIM1 35
  • 99.67 (n)
  • 99.5 (a)
PIM1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIM1 35
  • 94.78 (n)
  • 98.72 (a)
PIM1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIM1 35
  • 95.53 (n)
  • 99.04 (a)
PIM1 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pim1 35
  • 89.88 (n)
  • 94.25 (a)
Pim1 16
Pim1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIM1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pim1 35
  • 89.99 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves PIM1 35
  • 78.61 (n)
  • 83.39 (a)
PIM1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIM1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia pim1-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pim1 35
  • 68.79 (n)
  • 74.16 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2507 35
zebrafish
(Danio rerio)
Actinopterygii pim1 35
pim1 36
  • 70 (a)
OneToOne
zgc:153997 35
  • 69.4 (n)
  • 73.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3105 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea prk-2 35
  • 52.31 (n)
  • 45.77 (a)
prk-1 37
  • 36 (a)
prk-2 37
  • 45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5685 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for PIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIM1 Gene

ENSEMBL:
Gene Tree for PIM1 (if available)
TreeFam:
Gene Tree for PIM1 (if available)

Paralogs for PIM1 Gene

Paralogs for PIM1 Gene

Selected SIMAP similar genes for PIM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PIM1: view

Variants for PIM1 Gene

Sequence variations from dbSNP and Humsavar for PIM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10507 -- 37,174,646(+) CTGTC(C/T)TCCCT utr-variant-3-prime
rs15444 -- 37,175,143(+) TCAGG(C/T)GGGAC utr-variant-3-prime
rs15445 -- 37,175,236(+) CATTG(C/T)TGACT utr-variant-3-prime
rs262926 -- 37,173,570(+) TGGTG(G/T)TCGTG intron-variant
rs262928 -- 37,175,881(+) TGAGC(A/G)TGTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PIM1 Gene

Variant ID Type Subtype PubMed ID
nsv5264 CNV Insertion 18451855

Relevant External Links for PIM1 Gene

HapMap Linkage Disequilibrium report
PIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIM1 Gene

Disorders for PIM1 Gene

(17) Novoseek inferred disease relationships for PIM1 Gene

Disease -log(P) Hits PubMed IDs
leukemogenesis 65.1 3
prostate cancer 44.2 30
leukemia 40.8 7
lymphoma 38.5 8
primary central nervous system lymphoma 32.7 1

Relevant External Links for PIM1

Genetic Association Database (GAD)
PIM1
Human Genome Epidemiology (HuGE) Navigator
PIM1
Tumor Gene Database (TGDB):
PIM1
genes like me logo Genes that share disorders with PIM1: view

No data available for UniProtKB/Swiss-Prot for PIM1 Gene

Publications for PIM1 Gene

  1. Primary structure of the putative human oncogene, pim-1. (PMID: 2205533) Reeves R. … Power M. (Gene 1990) 3 4 23
  2. The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. (PMID: 1825810) Saris C.J. … Berns A. (EMBO J. 1991) 3 4 23
  3. Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1. (PMID: 10664448) Koike N. … Iguchi-Ariga S.M.M. (FEBS Lett. 2000) 3 4 23
  4. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. (PMID: 12431783) Wang Z. … Magnuson N.S. (Biochim. Biophys. Acta 2002) 3 4 23
  5. Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects. (PMID: 12680209) Ionov Y. … Kraft A.S. (Anticancer Res. 2003) 3 4 23

Products for PIM1 Gene

  • Addgene plasmids for PIM1

Sources for PIM1 Gene

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