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Aliases for PIK3CB Gene

Aliases for PIK3CB Gene

  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta 2 3 5
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Beta 3 4
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Beta 2 3
  • Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide 2 3
  • PtdIns-3-Kinase Subunit P110-Beta 3 4
  • PtdIns-3-Kinase Subunit Beta 3 4
  • PI3-Kinase Subunit Beta 3 4
  • EC 2.7.1.153 4 63
  • PI3K-Beta 3 4
  • P110BETA 3 4
  • PI3KBETA 3 4
  • PIK3C1 3 4
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Beta 3
  • PI3-Kinase P110 Subunit Beta 3
  • PtdIns-3-Kinase P110 3
  • EC 2.7.1 63
  • PI3K 3

External Ids for PIK3CB Gene

Previous HGNC Symbols for PIK3CB Gene

  • PIK3C1

Previous GeneCards Identifiers for PIK3CB Gene

  • GC03M135330
  • GC03M139174
  • GC03M139654
  • GC03M139693
  • GC03M139855
  • GC03M138372
  • GC03M135748

Summaries for PIK3CB Gene

Entrez Gene Summary for PIK3CB Gene

  • This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

GeneCards Summary for PIK3CB Gene

PIK3CB (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PIK3CB include Laryngeal Benign Neoplasm. Among its related pathways are Glioma and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C3.

UniProtKB/Swiss-Prot for PIK3CB Gene

  • Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

Tocris Summary for PIK3CB Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3CB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3CB Gene

Genomics for PIK3CB Gene

Regulatory Elements for PIK3CB Gene

Enhancers for PIK3CB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIK3CB on UCSC Golden Path with GeneCards custom track

Promoters for PIK3CB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIK3CB on UCSC Golden Path with GeneCards custom track

Genomic Location for PIK3CB Gene

Chromosome:
3
Start:
138,652,698 bp from pter
End:
138,834,938 bp from pter
Size:
182,241 bases
Orientation:
Minus strand

Genomic View for PIK3CB Gene

Genes around PIK3CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3CB Gene

Proteins for PIK3CB Gene

  • Protein details for PIK3CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42338-PK3CB_HUMAN
    Recommended name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Protein Accession:
    P42338
    Secondary Accessions:
    • D3DNF0
    • Q24JU2

    Protein attributes for PIK3CB Gene

    Size:
    1070 amino acids
    Molecular mass:
    122762 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity).

neXtProt entry for PIK3CB Gene

Proteomics data for PIK3CB Gene at MOPED

Post-translational modifications for PIK3CB Gene

  • Phosphorylation at Ser-1070 down-regulates lipid kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for PIK3CB (PI 3-Kinase p110 beta)
  • Cell Signaling Technology (CST) Antibodies for PIK3CB (PIK3CB)

Domains & Families for PIK3CB Gene

Suggested Antigen Peptide Sequences for PIK3CB Gene

Graphical View of Domain Structure for InterPro Entry

P42338

UniProtKB/Swiss-Prot:

PK3CB_HUMAN :
  • The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.
  • Belongs to the PI3/PI4-kinase family.
Domain:
  • The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.
  • Contains 1 C2 PI3K-type domain.
  • Contains 1 PI3K-ABD domain.
  • Contains 1 PI3K-RBD domain.
  • Contains 1 PI3K/PI4K domain.
  • Contains 1 PIK helical domain.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3CB: view

Function for PIK3CB Gene

Molecular function for PIK3CB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
UniProtKB/Swiss-Prot Function:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

Enzyme Numbers (IUBMB) for PIK3CB Gene

Gene Ontology (GO) - Molecular Function for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA,TAS --
genes like me logo Genes that share ontologies with PIK3CB: view
genes like me logo Genes that share phenotypes with PIK3CB: view

Animal Models for PIK3CB Gene

MGI Knock Outs for PIK3CB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIK3CB

miRNA for PIK3CB Gene

miRTarBase miRNAs that target PIK3CB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3CB Gene

Localization for PIK3CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3CB Gene

Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3CB Gene COMPARTMENTS Subcellular localization image for PIK3CB gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 4
plasma membrane 4
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PIK3CB Gene

Pathways & Interactions for PIK3CB Gene

SuperPathways for PIK3CB Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 Translation Insulin regulation of translation
4 IL-7 Signaling Pathways
5 Development HGF signaling pathway
genes like me logo Genes that share pathways with PIK3CB: view

Pathways by source for PIK3CB Gene

UniProtKB/Swiss-Prot P42338-PK3CB_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

SIGNOR curated interactions for PIK3CB Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10570282
GO:0001935 endothelial cell proliferation IEA --
GO:0001952 regulation of cell-matrix adhesion IEA,IMP 25139353
GO:0002250 adaptive immune response IBA --
GO:0006644 phospholipid metabolic process TAS --
genes like me logo Genes that share ontologies with PIK3CB: view

Drugs & Compounds for PIK3CB Gene

(71) Drugs for PIK3CB Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Nutra Antagonist, Target 349
Adenosine triphosphate Approved Nutra 0
Quercetin Experimental Nutra Antitumor agent, Non-selective PI 3-kinase inhibitor 36
XL765 Investigational Pharma Target PI3K/mTOR Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0
SF1126 Investigational Pharma inhibitor Kinase Inhibitors 0

(402) Additional Compounds for PIK3CB Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)

(5) Tocris Compounds for PIK3CB Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator 1236188-16-1
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
LY 303511 Negative control of LY 294002 (Cat. No. 1130) 154447-38-8
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7

(29) ApexBio Compounds for PIK3CB Gene

Compound Action Cas Number
740 Y-P PI 3-kinase activator,cell permeable 1236188-16-1
AS-252424 PI3Kγ inhibitor,novel and potent 900515-16-4
AS-604850 PI3Kγ inhibitor,selective and ATP-competitve 648449-76-7
AZD6482 PI3Kβ inhibitor,potent and selective 1173900-33-8
BAY 80-6946 (Copanlisib) PI3K inhibitor 1032568-63-0
BEZ235 (NVP-BEZ235) PI3K/mTOR inhibitor,ATP-competitve 915019-65-7
BKM120 Inhibitor of pan-Class I PI3K 944396-07-0
CAY10505 Potent PI3Kγ inhibitor 1218777-13-9
CH5132799 Class I PI3K inhibitor 1007207-67-1
CZC24832 Selective PI3K-γ inhibitor 1159824-67-5
GDC-0941 PI3K inhibitor,potent and selective 957054-30-7
GSK1059615 PI3K and mTOR inhibitor,potent and reversible 958852-01-2
GSK2126458 PI3K/mTOR inhibitor 1086062-66-9
INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective 1224844-38-5
NVP-BGT226 PI3K/mTOR inhibitor,selective and novel 1245537-68-1
PF-04691502 PI3K/mTOR (FRAP) inhibitor 1013101-36-4
PI-103 Class I PI3K, mTOR and DNA-PK inhibitor 371935-74-9
PIK-293 900185-01-5
PIK-294 900185-02-6
PIK-75 Inhibitor of PI3K isoform p110α 372196-77-5
PIK-90 PI3K inhibitor,potent selective 677338-12-4
PIK-93 PI3Kγ/PI4KIIIβ/PI3Kα inhibitor 593960-11-3
PKI-402 PI3K inhibitor,selective, reversible and ATP-competitive 1173204-81-3
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
Quercetin Antitumor agent 117-39-5
Quercetin dihydrate PLA2 and PI 3-kinase inhibitor 6151-25-3
TGX-221 PI3Kβ inhibitor,potent,selective and ATP competitive 663619-89-4
VS-5584 (SB2343) MTOR/P13K inhibitor,potent and selective 1246560-33-7
ZSTK474 Potent PI3K inhibitor 475110-96-4
genes like me logo Genes that share compounds with PIK3CB: view

Drug Products

Transcripts for PIK3CB Gene

Unigene Clusters for PIK3CB Gene

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CB Gene

No ASD Table

Relevant External Links for PIK3CB Gene

GeneLoc Exon Structure for
PIK3CB
ECgene alternative splicing isoforms for
PIK3CB

Expression for PIK3CB Gene

mRNA expression in normal human tissues for PIK3CB Gene

Protein differential expression in normal tissues from HIPED for PIK3CB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.9) and Lung (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIK3CB Gene



SOURCE GeneReport for Unigene cluster for PIK3CB Gene Hs.239818

mRNA Expression by UniProt/SwissProt for PIK3CB Gene

P42338-PK3CB_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with PIK3CB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PIK3CB Gene

Orthologs for PIK3CB Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3CB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIK3CB 35
  • 93.18 (n)
  • 96.64 (a)
PIK3CB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3CB 35
  • 93.96 (n)
  • 97.29 (a)
PIK3CB 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3cb 35
  • 88.44 (n)
  • 95.86 (a)
Pik3cb 16
Pik3cb 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIK3CB 35
  • 99.81 (n)
  • 100 (a)
PIK3CB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3cb 35
  • 88.69 (n)
  • 95.89 (a)
oppossum
(Monodelphis domestica)
Mammalia PIK3CB 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3CB 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIK3CB 35
  • 80.2 (n)
  • 87.12 (a)
PIK3CB 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIK3CB 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3cb 35
  • 71.98 (n)
  • 78.25 (a)
zebrafish
(Danio rerio)
Actinopterygii pik3cb 35
  • 66.82 (n)
  • 69.03 (a)
pik3cb 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pi3K92E 37
  • 37 (a)
Pi3K92E 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for PIK3CB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIK3CB Gene

ENSEMBL:
Gene Tree for PIK3CB (if available)
TreeFam:
Gene Tree for PIK3CB (if available)

Paralogs for PIK3CB Gene

Paralogs for PIK3CB Gene

genes like me logo Genes that share paralogs with PIK3CB: view

Variants for PIK3CB Gene

Sequence variations from dbSNP and Humsavar for PIK3CB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2230462 - 138,691,020(-) GGGCA(G/T)TTTCT reference, missense
rs725111 -- 138,690,314(-) TGTCA(A/G)AAAAA intron-variant
rs168633 -- 138,776,917(+) gactc(C/T)acctc intron-variant
rs726527 -- 138,690,901(+) GTTCA(A/G)AAAAA intron-variant
rs727352 -- 138,774,902(-) TGCCA(G/T)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3CB Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
esv271132 CNV Insertion 20981092
esv269442 CNV Insertion 20981092
esv2571713 CNV Deletion 19546169

Variation tolerance for PIK3CB Gene

Residual Variation Intolerance Score: 2.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3CB Gene

Human Gene Mutation Database (HGMD)
PIK3CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3CB Gene

Disorders for PIK3CB Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIK3CB Gene - From: DISEASES

Disorder Aliases PubMed IDs
laryngeal benign neoplasm
  • laryngeal tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PIK3CB

Genetic Association Database (GAD)
PIK3CB
Human Genome Epidemiology (HuGE) Navigator
PIK3CB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIK3CB
genes like me logo Genes that share disorders with PIK3CB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3CB Gene

Publications for PIK3CB Gene

  1. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. (PMID: 8246984) Hu P. … Schlessinger J. (Mol. Cell. Biol. 1993) 2 3 4 67
  2. The role of PI 3-kinase p110beta in AKT signally, cell survival, and proliferation in human prostate cancer cells. (PMID: 20058239) Hill K.M. … De Marzo A.M. (Prostate 2010) 3 23
  3. Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. (PMID: 20103642) Edgar K.A. … Belvin M. (Cancer Res. 2010) 3 23
  4. Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle. (PMID: 20107106) Ribel-Madsen R. … Vaag A. (Diabetes 2010) 3 23
  5. Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase. (PMID: 18285463) MarquAcs M. … Carrera A.C. (Mol. Cell. Biol. 2008) 3 23

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