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Aliases for PIK3C3 Gene

Aliases for PIK3C3 Gene

  • Phosphatidylinositol 3-Kinase, Catalytic Subunit Type 3 2 3
  • Phosphatidylinositol 3-Kinase P100 Subunit 3 4
  • Phosphoinositide-3-Kinase, Class 3 2 3
  • PtdIns-3-Kinase Type 3 3 4
  • PI3-Kinase Type 3 3 4
  • EC 4 63
  • PI3K Type 3 3 4
  • HVps34 3 4
  • VPS34 3 4
  • Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 3
  • Phosphoinositide-3-Kinase Class 3 4
  • EC 2.7.1 63

External Ids for PIK3C3 Gene

Previous GeneCards Identifiers for PIK3C3 Gene

  • GC18P039741
  • GC18P039321
  • GC18P039423
  • GC18P037787
  • GC18P037789
  • GC18P039535
  • GC18P036394

Summaries for PIK3C3 Gene

GeneCards Summary for PIK3C3 Gene

PIK3C3 (Phosphatidylinositol 3-Kinase, Catalytic Subunit Type 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include protein kinase activity and 1-phosphatidylinositol-3-kinase activity. An important paralog of this gene is PIK3CB.

UniProtKB/Swiss-Prot for PIK3C3 Gene

  • Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.

Tocris Summary for PIK3C3 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C3 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C3 Gene

Genomics for PIK3C3 Gene

Regulatory Elements for PIK3C3 Gene

Genomic Location for PIK3C3 Gene

41,955,206 bp from pter
42,087,830 bp from pter
132,625 bases
Plus strand

Genomic View for PIK3C3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C3 Gene

Proteins for PIK3C3 Gene

  • Protein details for PIK3C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 3-kinase catalytic subunit type 3
    Protein Accession:
    Secondary Accessions:
    • Q15134

    Protein attributes for PIK3C3 Gene

    887 amino acids
    Molecular mass:
    101549 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3R4. Interacts with BECN2.

    Three dimensional structures from OCA and Proteopedia for PIK3C3 Gene

neXtProt entry for PIK3C3 Gene

Proteomics data for PIK3C3 Gene at MOPED

Post-translational modifications for PIK3C3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIK3C3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIK3C3 (PIK3C3)

Domains for PIK3C3 Gene

Suggested Antigen Peptide Sequences for PIK3C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NEB9
  • Contains 1 C2 PI3K-type domain.
  • Contains 1 PI3K/PI4K domain.
  • Contains 1 PIK helical domain.
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3C3: view

Function for PIK3C3 Gene

Molecular function for PIK3C3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
UniProtKB/Swiss-Prot Function: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.

Enzyme Numbers (IUBMB) for PIK3C3 Gene

Gene Ontology (GO) - Molecular Function for PIK3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 14617358
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with PIK3C3: view
genes like me logo Genes that share phenotypes with PIK3C3: view

Animal Models for PIK3C3 Gene

MGI Knock Outs for PIK3C3:

Animal Model Products

miRNA for PIK3C3 Gene

miRTarBase miRNAs that target PIK3C3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3C3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PIK3C3 Gene

Localization for PIK3C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C3 Gene

Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PIK3C3 Gene COMPARTMENTS Subcellular localization image for PIK3C3 gene
Compartment Confidence
endosome 5
cytosol 3
vacuole 3
lysosome 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PIK3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome IDA 14617358
GO:0005829 cytosol TAS --
GO:0005930 axoneme ISS --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PIK3C3: view

Pathways for PIK3C3 Gene

genes like me logo Genes that share pathways with PIK3C3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PIK3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IEA --
GO:0000910 cytokinesis IMP 20208530
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006644 phospholipid metabolic process TAS --
genes like me logo Genes that share ontologies with PIK3C3: view

Compounds for PIK3C3 Gene

(5) Tocris Compounds for PIK3C3 Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator [1236188-16-1]
PF 05212384 Potent and selective dual PI 3-K/mTOR inhibitor [1197160-78-3]
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-79-4]
PI 828 PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) [942289-87-4]
Quercetin Non-selective PI 3-kinase inhibitor [117-39-5]

(28) ApexBio Compounds for PIK3C3 Gene

Compound Action Cas Number
A66 highly specific and selective p110alpha inhibitor [1166227-08-2]
AS-605240 Potent and selective inhibitor of PI 3-kinase beta.[648450-29-7]
AZD6482 Potent and selective inhibitor of PI 3-kinase beta. [1173900-33-8]
BEZ235 (NVP-BEZ235) imidazoquinoline derivative inhibiting both PI3K and mTOR kinases [915019-65-7]
BKM120 small-molecule inhibitor of pan-Class I PI3K [944396-07-0]
BYL-719 selective PI3Kalfa inhibitor [1217486-61-7]
CAL-101 (Idelalisib, GS-1101) p110delta selective PI3K inhibitor [870281-82-6]
CAL-130 novel PI3K inhibitor. [1431697-74-3]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
CZC24832 selective inhibitor of PI3Kgamma [1159824-67-5]
GDC-0941 PI3K inhibitor. [957054-30-7]
IC-87114 selectively inhibits PI3Ksigma [371242-69-2]
IPI-145 (INK1197) orally bioavailable, highly selective and potent small molecule inhibitor of PI3K [1201438-56-3]
LY 294002 selective PI3K inhibitor with a 2.7-fold greater potency than quercetin. [154447-36-6]
NVP-BGT226 suppresses the activation of the AKT/FRAP(mTOR) signal cascade. [1245537-68-1]
PF-04691502 potent and selective dual PI3K/mTOR (FRAP) inhibitor [1013101-36-4]
PI-103 potent inhibitor against recombinant PI3K [371935-74-9]
PIK-75 blocks production of PIP2 and/or PIP3 [372196-77-5]
PIK-90 selectively inhibits different subsets of four class I PI3K [677338-12-4]
PIK-93 novel and potent inhibitor of both PI3Kgamma and PI4KIIIbeta [593960-11-3]
PKI-402 selective, reversible, ATP-competitive, equipotent class I PI3K inhibitor [1173204-81-3]
SAR245409 (XL765) active against class I PI3K. [1349796-36-6]
TG100-115 inhibits PI3Kgamma and -delta [677297-51-7]
TGX-221 [663619-89-4]
VS-5584 (SB2343) all class I PI3K isoforms [1246560-33-7]
XL147 ATP-competitive inhibitor of class I PI3K isoforms. [956958-53-5]
XL765 mixed mTOR/PI3k inhibitor [1123889-87-1]
ZSTK474 binds to the ATP-binding site of Class PI3K and inhibits PI3K activity. [475110-96-4]

(385) HMDB Compounds for PIK3C3 Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 1,3-bisphosphate
  • D-myo-Inositol 1,3-bisphosphate
1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Not Available
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(1) Drugbank Compounds for PIK3C3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs

(5) Novoseek inferred chemical compound relationships for PIK3C3 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 3-phosphate 88.9 3
phosphatidylinositol 65.3 1
phosphoinositide 60.1 2
rapamycin 52.3 3
lipid 11.9 1
genes like me logo Genes that share compounds with PIK3C3: view

Transcripts for PIK3C3 Gene

Unigene Clusters for PIK3C3 Gene

Phosphatidylinositol 3-kinase, catalytic subunit type 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3C3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - - - -
SP3: -

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e
SP1: - - - - -
SP2: - - - - -
SP4: -
SP5: - - - -
SP7: -
SP8: - - - - -
SP10: - - - - - - - -

Relevant External Links for PIK3C3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIK3C3 Gene

mRNA expression in normal human tissues for PIK3C3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIK3C3 Gene

SOURCE GeneReport for Unigene cluster for PIK3C3 Gene Hs.464971

mRNA Expression by UniProt/SwissProt for PIK3C3 Gene

Tissue specificity: Ubiquitously expressed, with a highest expression in skeletal muscle.
genes like me logo Genes that share expressions with PIK3C3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PIK3C3 Gene

Orthologs for PIK3C3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIK3C3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIK3C3 35
  • 99.66 (n)
  • 100 (a)
PIK3C3 36
  • 100 (a)
(Bos Taurus)
Mammalia PIK3C3 35
  • 92.71 (n)
  • 98.87 (a)
PIK3C3 36
  • 99 (a)
(Canis familiaris)
Mammalia PIK3C3 35
  • 93.76 (n)
  • 98.99 (a)
PIK3C3 36
  • 99 (a)
(Mus musculus)
Mammalia Pik3c3 35
  • 87.75 (n)
  • 97.97 (a)
Pik3c3 16
Pik3c3 36
  • 98 (a)
(Monodelphis domestica)
Mammalia PIK3C3 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia PIK3C3 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Pik3c3 35
  • 87 (n)
  • 98.08 (a)
(Gallus gallus)
Aves PIK3C3 35
  • 82.39 (n)
  • 93.68 (a)
PIK3C3 36
  • 89 (a)
(Anolis carolinensis)
Reptilia PIK3C3 36
  • 95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11237 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3c3 35
  • 77.31 (n)
  • 91.71 (a)
(Danio rerio)
Actinopterygii pik3c3 35
  • 73.63 (n)
  • 85.52 (a)
pik3c3 36
  • 88 (a)
wufc13g06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010273 35
  • 41.33 (n)
  • 29.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K59F 35
  • 58.99 (n)
  • 61.76 (a)
Pi3K59F 36
  • 55 (a)
Pi3K59F 37
  • 61 (a)
(Caenorhabditis elegans)
Secernentea vps-34 35
  • 50.83 (n)
  • 41.57 (a)
vps-34 36
  • 38 (a)
vps-34 37
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL113C 35
  • 47.72 (n)
  • 39.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 35
  • 48.13 (n)
  • 39.35 (a)
VPS34 36
  • 37 (a)
VPS34 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18645g 35
  • 47.98 (n)
  • 38.65 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9995 35
(Glycine max)
eudicotyledons Gma.2544 35
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS34 35
  • 53.23 (n)
  • 45.77 (a)
(Hordeum vulgare)
Liliopsida Hv.11305 35
(Oryza sativa)
Liliopsida Os.11111 35
Os05g0180600 35
  • 51.98 (n)
  • 44.94 (a)
(Triticum aestivum)
Liliopsida Ta.28795 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00656 35
  • 48.62 (n)
  • 45.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pik3 35
  • 53.36 (n)
  • 46.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5903 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3927 36
  • 59 (a)
Species with no ortholog for PIK3C3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PIK3C3 Gene

Gene Tree for PIK3C3 (if available)
Gene Tree for PIK3C3 (if available)

Paralogs for PIK3C3 Gene

Paralogs for PIK3C3 Gene

genes like me logo Genes that share paralogs with PIK3C3: view

Variants for PIK3C3 Gene

Sequence variations from dbSNP and Humsavar for PIK3C3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs9651 -- 42,081,184(+) ACCAC(G/T)TTAGG utr-variant-3-prime
rs52911 -- 41,974,975(-) TCAAA(A/C/G/T)TGACA intron-variant
rs474605 -- 42,032,756(+) TGACC(A/G)TCCAT intron-variant
rs486125 -- 42,061,891(+) GCATT(C/T)TACAC intron-variant
rs488202 -- 42,079,019(+) cattc(A/G)tgtat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C3 Gene

Variant ID Type Subtype PubMed ID
nsv909566 CNV Gain 21882294
esv34153 CNV Loss 18971310
nsv909567 CNV Gain 21882294
nsv909568 CNV Gain 21882294
nsv507870 CNV Insertion 20534489
esv2717009 CNV Deletion 23290073
esv2674644 CNV Deletion 23128226
esv1001271 CNV Insertion 20482838
esv2717010 CNV Deletion 23290073
esv2316444 CNV Deletion 18987734
esv2717011 CNV Deletion 23290073
esv2717012 CNV Deletion 23290073
esv1518239 CNV Deletion 17803354
nsv131226 CNV Loss 16902084
nsv833631 CNV Loss 17160897

Relevant External Links for PIK3C3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C3 Gene

Disorders for PIK3C3 Gene

(1) University of Copenhagen DISEASES for PIK3C3 Gene

Relevant External Links for PIK3C3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PIK3C3: view

No data available for UniProtKB/Swiss-Prot for PIK3C3 Gene

Publications for PIK3C3 Gene

  1. Human VPS34 and p150 are Rab7 interacting partners. (PMID: 14617358) Stein M.P. … Wandinger-Ness A. (Traffic 2003) 3 4 23
  2. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. (PMID: 20208530) Sagona A.P. … Stenmark H. (Nat. Cell Biol. 2010) 3 4 23
  3. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. (PMID: 7628435) Volinia S. … Waterfield M.D. (EMBO J. 1995) 2 3 4
  4. SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34. (PMID: 18725540) Mallo G.V. … Brumell J.H. (J. Cell Biol. 2008) 3 23
  5. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PMID: 18843052) Itakura E. … Mizushima N. (Mol. Biol. Cell 2008) 3 23

Products for PIK3C3 Gene

  • antibodies-online proteins for PIK3C3
  • antibodies-online antibodies for PIK3C3
  • antibodies-online kits for PIK3C3

Sources for PIK3C3 Gene

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