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Aliases for PIK3C2G Gene

Aliases for PIK3C2G Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma 2 3
  • Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide 2 3
  • PtdIns-3-Kinase C2 Subunit Gamma 3 4
  • PI3K-C2-Gamma 3 4
  • EC 2.7.1.154 4 64
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma Polypeptide 3
  • Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
  • Phosphoinositide 3-Kinase-C2-Gamma 4
  • PTDINS-3-Kinase C2 Gamma 3
  • PI3K-C2GAMMA 3
  • EC 2.7.1 64

External Ids for PIK3C2G Gene

Summaries for PIK3C2G Gene

Entrez Gene Summary for PIK3C2G Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for PIK3C2G Gene

PIK3C2G (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and ERK Signaling. GO annotations related to this gene include phosphatidylinositol binding and 1-phosphatidylinositol-4-phosphate 3-kinase activity. An important paralog of this gene is PIK3CB.

UniProtKB/Swiss-Prot for PIK3C2G Gene

  • Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).

Tocris Summary for PIK3C2G Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C2G Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2G Gene

Genomics for PIK3C2G Gene

Genomic Location for PIK3C2G Gene

Start:
18,242,978 bp from pter
End:
18,648,418 bp from pter
Size:
405,441 bases
Orientation:
Plus strand

Genomic View for PIK3C2G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3C2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2G Gene

Regulatory Elements for PIK3C2G Gene

Proteins for PIK3C2G Gene

  • Protein details for PIK3C2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75747-P3C2G_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
    Protein Accession:
    O75747
    Secondary Accessions:
    • A1L3U0

    Protein attributes for PIK3C2G Gene

    Size:
    1445 amino acids
    Molecular mass:
    165715 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIK3C2G Gene

neXtProt entry for PIK3C2G Gene

Proteomics data for PIK3C2G Gene at MOPED

Selected DME Specific Peptides for PIK3C2G Gene

Post-translational modifications for PIK3C2G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIK3C2G Gene

Domains for PIK3C2G Gene

UniProtKB/Swiss-Prot:

P3C2G_HUMAN
Domain:
  • Contains 1 C2 domain.:
    • O75747
  • Contains 1 C2 PI3K-type domain.:
    • O75747
  • Contains 1 PI3K-RBD domain.:
    • O75747
  • Contains 1 PI3K/PI4K domain.:
    • O75747
  • Contains 1 PIK helical domain.:
    • O75747
  • Contains 1 PX (phox homology) domain.:
    • O75747
Family:
  • Belongs to the PI3/PI4-kinase family.:
    • O75747
genes like me logo Genes that share domains with PIK3C2G: view

Function for PIK3C2G Gene

Molecular function for PIK3C2G Gene

GENATLAS Biochemistry: phosphatidylinositol 3-kinase class 2,gamma polypeptide,expressed in normal breast,liver,prostate and other tissues
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
UniProtKB/Swiss-Prot Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).

Enzyme Numbers (IUBMB) for PIK3C2G Gene

Gene Ontology (GO) - Molecular Function for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016303 1-phosphatidylinositol-3-kinase activity NAS 9878262
genes like me logo Genes that share ontologies with PIK3C2G: view
genes like me logo Genes that share phenotypes with PIK3C2G: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIK3C2G Gene

Localization for PIK3C2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2G Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3C2G Gene COMPARTMENTS Subcellular localization image for PIK3C2G gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3C2G: view

Pathways for PIK3C2G Gene

genes like me logo Genes that share pathways with PIK3C2G: view

Interacting Proteins for PIK3C2G Gene

Gene Ontology (GO) - Biological Process for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006935 chemotaxis IEA --
GO:0008150 biological_process ND --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process NAS 9878262
genes like me logo Genes that share ontologies with PIK3C2G: view

Compounds for PIK3C2G Gene

(5) Tocris Compounds for PIK3C2G Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator [1236188-16-1]
AS 605240 Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor [648450-29-7]
CZC 24832 Selective inhibitor of PI 3-Kinase gamma [1159824-67-5]
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
Quercetin Non-selective PI 3-kinase inhibitor [117-39-5]

(2) HMDB Compounds for PIK3C2G Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with PIK3C2G: view

Transcripts for PIK3C2G Gene

Unigene Clusters for PIK3C2G Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2G Gene

No ASD Table

Relevant External Links for PIK3C2G Gene

GeneLoc Exon Structure for
PIK3C2G
ECgene alternative splicing isoforms for
PIK3C2G

Expression for PIK3C2G Gene

mRNA expression in normal human tissues for PIK3C2G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIK3C2G Gene

This gene is overexpressed in Stomach (16.5), Liver (8.7), Skin - Not Sun Exposed (Suprapubic) (6.9), Skin - Sun Exposed (Lower leg) (6.2), and Breast - Mammary Tissue (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIK3C2G Gene

SOURCE GeneReport for Unigene cluster for PIK3C2G Gene Hs.22500

mRNA Expression by UniProt/SwissProt for PIK3C2G Gene

O75747-P3C2G_HUMAN
Tissue specificity: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.
genes like me logo Genes that share expressions with PIK3C2G: view

Orthologs for PIK3C2G Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3C2G 36
  • 98.45 (n)
  • 97.43 (a)
PIK3C2G 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIK3C2G 36
  • 87.58 (n)
  • 84.14 (a)
PIK3C2G 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3C2G 36
  • 88.94 (n)
  • 85.13 (a)
PIK3C2G 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3c2g 36
  • 79.88 (n)
  • 73.28 (a)
Pik3c2g 16
Pik3c2g 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3c2g 36
  • 78.65 (n)
  • 72.19 (a)
chicken
(Gallus gallus)
Aves PIK3C2G 36
  • 66.49 (n)
  • 57.89 (a)
PIK3C2G 37
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330514 36
  • 47.95 (n)
  • 40.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea piki-1 37
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 37
  • 20 (a)
OneToMany
Species with no ortholog for PIK3C2G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIK3C2G Gene

ENSEMBL:
Gene Tree for PIK3C2G (if available)
TreeFam:
Gene Tree for PIK3C2G (if available)

Paralogs for PIK3C2G Gene

Paralogs for PIK3C2G Gene

genes like me logo Genes that share paralogs with PIK3C2G: view

Variants for PIK3C2G Gene

Sequence variations from dbSNP and Humsavar for PIK3C2G Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs475137 -- 18,633,172(+) atatt(C/T)cattg intron-variant
rs475222 -- 18,633,200(+) aaaat(G/T)aataa intron-variant
rs477949 -- 18,633,498(+) ctggt(A/G)gggta intron-variant
rs482703 -- 18,635,213(+) TTCTC(C/T)TCCTC intron-variant
rs501379 -- 18,648,083(+) ACTTC(C/T)GGGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2G Gene

Variant ID Type Subtype PubMed ID
nsv898837 CNV Gain 21882294
nsv832343 CNV Gain 17160897
nsv832344 CNV Loss 17160897
nsv898846 CNV Loss 21882294
nsv898847 CNV Loss 21882294
nsv627 CNV Loss 18451855
nsv438194 CNV Loss 16468122
esv2674487 CNV Deletion 23128226
esv2650294 CNV Deletion 19546169
esv2745610 CNV Deletion 23290073
esv2745611 CNV Deletion 23290073
esv2745612 CNV Deletion 23290073
esv1542857 CNV Deletion 17803354
nsv8926 CNV Loss 18304495
nsv437727 CNV Loss 16327808
nsv437728 CNV Loss 16327808
esv267505 CNV Insertion 20981092
esv274546 CNV Insertion 20981092
esv268773 CNV Insertion 20981092
esv23982 CNV Loss 19812545
esv2672387 CNV Deletion 23128226
esv1370525 CNV Insertion 17803354
nsv520574 CNV Loss 19592680
nsv521707 CNV Loss 19592680
nsv628 CNV Insertion 18451855

Relevant External Links for PIK3C2G Gene

HapMap Linkage Disequilibrium report
PIK3C2G
Human Gene Mutation Database (HGMD)
PIK3C2G

Disorders for PIK3C2G Gene

Relevant External Links for PIK3C2G

Genetic Association Database (GAD)
PIK3C2G
Human Genome Epidemiology (HuGE) Navigator
PIK3C2G
genes like me logo Genes that share disorders with PIK3C2G: view

No data available for UniProtKB/Swiss-Prot for PIK3C2G Gene

Publications for PIK3C2G Gene

  1. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. (PMID: 9878262) Rozycka M. … Fry M.J. (Genomics 1998) 2 3 4 23
  2. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. (PMID: 17991425) Daimon M. … Kato T. (Biochem. Biophys. Res. Commun. 2008) 3 4 49
  3. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) RuaA+o G. … Hanks S. (Clin. Chim. Acta 2009) 3 49
  4. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. (PMID: 17893707) Jungerius B.J. … Sinke R.J. (Mol. Psychiatry 2008) 3 49
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 49

Products for PIK3C2G Gene

Sources for PIK3C2G Gene

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