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Aliases for PIGR Gene

Aliases for PIGR Gene

  • Polymeric Immunoglobulin Receptor 2 3 5
  • Hepatocellular Carcinoma-Associated Protein TB6 4
  • Poly-Ig Receptor 4
  • PIgR 4

External Ids for PIGR Gene

Previous GeneCards Identifiers for PIGR Gene

  • GC01M205761
  • GC01M202813
  • GC01M203745
  • GC01M204185
  • GC01M203335
  • GC01M205168
  • GC01M207101
  • GC01M177799

Summaries for PIGR Gene

Entrez Gene Summary for PIGR Gene

  • This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for PIGR Gene

PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include Periampullary Adenocarcinoma and Protein-Energy Malnutrition. Among its related pathways are Innate Immune System and Integrated Breast Cancer Pathway. GO annotations related to this gene include polymeric immunoglobulin receptor activity. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot for PIGR Gene

  • This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Gene Wiki entry for PIGR Gene

Additional gene information for PIGR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGR Gene

Genomics for PIGR Gene

Regulatory Elements for PIGR Gene

Enhancers for PIGR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H206917 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +23.4 23396 11 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 CDCA4P4 EIF2D MAPKAPK2 ENSG00000271680 CD46 PIGR FCAMR RPL7AP20 IL20 IL19
GH01H207017 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -80.2 -80203 18 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF766 FOS DEK EIF2D C4BPA C4BPB FCAMR PIGR FCMR CDCA4P4 RPL7AP20 IL20 PFKFB2
GH01H206966 1.4 Ensembl ENCODE dbSUPER 12.5 -24.4 -24392 7 HDAC1 BATF RAD21 YY1 ETV6 ATF7 RUNX3 IKZF2 SMARCA5 JUNB PIGR FCMR IL20 IL24 IL10 IL19 MAPKAPK2 ENSG00000271680 C1orf116 FCAMR
GH01H206722 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +222.8 222779 2 TBP SIN3A BRCA1 RAD21 RFX5 YY1 RCOR1 FOS DEK EGR2 MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 GC01M206749
GH01H207004 1.5 Ensembl ENCODE dbSUPER 11.3 -61.3 -61338 7 HDGF PKNOX1 ARNT ARID4B SIN3A BRCA1 ZNF2 ZNF766 GATA2 ZNF143 PIGR FCMR FCAMR IL24 IL20 PFKFB2 MAPKAPK2 IL19 C4BPB TRP-TGG5-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIGR on UCSC Golden Path with GeneCards custom track

Genomic Location for PIGR Gene

Chromosome:
1
Start:
206,928,518 bp from pter
End:
206,946,466 bp from pter
Size:
17,949 bases
Orientation:
Minus strand

Genomic View for PIGR Gene

Genes around PIGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGR Gene

Proteins for PIGR Gene

  • Protein details for PIGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01833-PIGR_HUMAN
    Recommended name:
    Polymeric immunoglobulin receptor
    Protein Accession:
    P01833
    Secondary Accessions:
    • Q68D81
    • Q8IZY7

    Protein attributes for PIGR Gene

    Size:
    764 amino acids
    Molecular mass:
    83284 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PIGR Gene

neXtProt entry for PIGR Gene

Post-translational modifications for PIGR Gene

  • N-glycosylation is not necessary for Ig binding.
  • Glycosylation at Asn83, Asn90, posLast=135135, posLast=186186, posLast=421421, Asn469, and posLast=499499
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PIGR

No data available for DME Specific Peptides for PIGR Gene

Domains & Families for PIGR Gene

Gene Families for PIGR Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for PIGR Gene

Suggested Antigen Peptide Sequences for PIGR Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIGR: view

No data available for UniProtKB/Swiss-Prot for PIGR Gene

Function for PIGR Gene

Molecular function for PIGR Gene

GENATLAS Biochemistry:
immunoglobulin polymeric (poly-Ig) receptor,transmembrane secretory complement
UniProtKB/Swiss-Prot Function:
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Phenotypes From GWAS Catalog for PIGR Gene

Gene Ontology (GO) - Molecular Function for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001792 polymeric immunoglobulin receptor activity IDA 22022593
genes like me logo Genes that share ontologies with PIGR: view
genes like me logo Genes that share phenotypes with PIGR: view

Animal Models for PIGR Gene

MGI Knock Outs for PIGR:

Animal Model Products

CRISPR Products

miRNA for PIGR Gene

miRTarBase miRNAs that target PIGR

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PIGR
  • Applied Biological Materials Clones for PIGR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIGR Gene

Localization for PIGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGR Gene

Cell membrane; Single-pass type I membrane protein.
Secretory component: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIGR gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
nucleus 2
cytosol 2
golgi apparatus 2
endosome 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2920039
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PIGR: view

Pathways & Interactions for PIGR Gene

genes like me logo Genes that share pathways with PIGR: view

Pathways by source for PIGR Gene

Gene Ontology (GO) - Biological Process for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0001895 retina homeostasis IEP 23580065
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IDA 22022593
GO:0007173 epidermal growth factor receptor signaling pathway IDA 22022593
GO:0038093 Fc receptor signaling pathway IDA 22022593
genes like me logo Genes that share ontologies with PIGR: view

No data available for SIGNOR curated interactions for PIGR Gene

Drugs & Compounds for PIGR Gene

(11) Drugs for PIGR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for PIGR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIGR: view

Transcripts for PIGR Gene

Unigene Clusters for PIGR Gene

Polymeric immunoglobulin receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PIGR
  • Applied Biological Materials Clones for PIGR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PIGR Gene

No ASD Table

Relevant External Links for PIGR Gene

GeneLoc Exon Structure for
PIGR
ECgene alternative splicing isoforms for
PIGR

Expression for PIGR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIGR Gene

This gene is overexpressed in Colon - Transverse (x26.3), Minor Salivary Gland (x10.5), and Small Intestine - Terminal Ileum (x5.5).

Protein differential expression in normal tissues from HIPED for PIGR Gene

This gene is overexpressed in Milk (25.3), Pancreatic juice (15.6), and Lavage (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIGR Gene



NURSA nuclear receptor signaling pathways regulating expression of PIGR Gene:

PIGR

SOURCE GeneReport for Unigene cluster for PIGR Gene:

Hs.497589

Evidence on tissue expression from TISSUES for PIGR Gene

  • Intestine(5)
  • Liver(4.5)
  • Bone marrow(4.3)
  • Saliva(4.3)
  • Lung(4.2)
  • Kidney(3.3)
  • Stomach(3.1)
  • Gall bladder(2.5)
genes like me logo Genes that share expression patterns with PIGR: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIGR Gene

Orthologs for PIGR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGR 33 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia PIGR 33 34
  • 79.05 (n)
cow
(Bos Taurus)
Mammalia PIGR 33 34
  • 76.68 (n)
mouse
(Mus musculus)
Mammalia Pigr 33 16 34
  • 75.98 (n)
rat
(Rattus norvegicus)
Mammalia Pigr 33
  • 75.81 (n)
oppossum
(Monodelphis domestica)
Mammalia PIGR 34
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGR 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIGR 33 34
  • 53.47 (n)
lizard
(Anolis carolinensis)
Reptilia PIGR 34
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495453 33
  • 46.77 (n)
Species where no ortholog for PIGR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIGR Gene

ENSEMBL:
Gene Tree for PIGR (if available)
TreeFam:
Gene Tree for PIGR (if available)

Paralogs for PIGR Gene

Paralogs for PIGR Gene

genes like me logo Genes that share paralogs with PIGR: view

Variants for PIGR Gene

Sequence variations from dbSNP and Humsavar for PIGR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs291102 Uncertain significance 206,933,133(-) AGACG(C/T)TGCTC reference, missense
rs1000484321 -- 206,946,967(+) TTATA(C/T)ACCTC upstream-variant-2KB
rs1000631681 -- 206,947,854(+) TGGTG(-/T)TTGGT upstream-variant-2KB
rs1000732463 -- 206,936,328(+) CTCCA(A/G)GCAGC intron-variant
rs1000853790 -- 206,930,134(+) CCCCA(A/G)TAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PIGR Gene

Variant ID Type Subtype PubMed ID
esv3375038 CNV insertion 20981092
nsv1010486 CNV gain 25217958
nsv468049 CNV loss 19166990
nsv549071 CNV loss 21841781

Variation tolerance for PIGR Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.31; 88.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGR Gene

Human Gene Mutation Database (HGMD)
PIGR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGR Gene

Disorders for PIGR Gene

MalaCards: The human disease database

(3) MalaCards diseases for PIGR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PIGR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIGR

Genetic Association Database (GAD)
PIGR
Human Genome Epidemiology (HuGE) Navigator
PIGR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGR
genes like me logo Genes that share disorders with PIGR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIGR Gene

Publications for PIGR Gene

  1. [Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]. (PMID: 16086865) Fan Q … Zeng YX (Ai zheng = Aizheng = Chinese journal of cancer 2005) 3 22 45 60
  2. Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. (PMID: 15530357) Hamburger AE … Bjorkman PJ (Structure (London, England : 1993) 2004) 3 4 22 60
  3. Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy. (PMID: 11579946) Narita I … Gejyo F (Internal medicine (Tokyo, Japan) 2001) 3 22 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Human Fcalpha/muR and pIgR distribute differently in intestinal tissues. (PMID: 19338768) Wang R … Zhang W (Biochemical and biophysical research communications 2009) 3 22 60

Products for PIGR Gene

  • Addgene plasmids for PIGR

Sources for PIGR Gene

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