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Aliases for PIGR Gene

Aliases for PIGR Gene

  • Polymeric Immunoglobulin Receptor 2 3
  • Hepatocellular Carcinoma-Associated Protein TB6 4
  • Poly-Ig Receptor 4
  • PIgR 4

External Ids for PIGR Gene

Previous GeneCards Identifiers for PIGR Gene

  • GC01M205761
  • GC01M202813
  • GC01M203745
  • GC01M204185
  • GC01M203335
  • GC01M205168
  • GC01M207101
  • GC01M177799

Summaries for PIGR Gene

Entrez Gene Summary for PIGR Gene

  • This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for PIGR Gene

PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include protein-energy malnutrition and hepatocellular carcinoma. Among its related pathways are IL4-mediated signaling events and Integrated Breast Cancer Pathway. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot for PIGR Gene

  • This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment

Gene Wiki entry for PIGR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGR Gene

Genomics for PIGR Gene

Regulatory Elements for PIGR Gene

Genomic Location for PIGR Gene

Start:
206,928,518 bp from pter
End:
206,946,469 bp from pter
Size:
17,952 bases
Orientation:
Minus strand

Genomic View for PIGR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGR Gene

Proteins for PIGR Gene

  • Protein details for PIGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01833-PIGR_HUMAN
    Recommended name:
    Polymeric immunoglobulin receptor
    Protein Accession:
    P01833
    Secondary Accessions:
    • Q68D81
    • Q8IZY7

    Protein attributes for PIGR Gene

    Size:
    764 amino acids
    Molecular mass:
    83284 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PIGR Gene

neXtProt entry for PIGR Gene

Proteomics data for PIGR Gene at MOPED

Post-translational modifications for PIGR Gene

  • N-glycosylation is not necessary for Ig binding.
  • Glycosylation at Asn83, Asn90, Asn135, Asn186, Asn421, Asn469, and Asn499
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PIGR Gene

Domains for PIGR Gene

Gene Families for PIGR Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for PIGR Gene

Suggested Antigen Peptide Sequences for PIGR Gene

Graphical View of Domain Structure for InterPro Entry

P01833

UniProtKB/Swiss-Prot:

PIGR_HUMAN :
  • P01833
Domain:
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with PIGR: view

Function for PIGR Gene

Molecular function for PIGR Gene

GENATLAS Biochemistry: immunoglobulin polymeric (poly-Ig) receptor,transmembrane secretory complement
UniProtKB/Swiss-Prot Function: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment

Gene Ontology (GO) - Molecular Function for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001792 polymeric immunoglobulin receptor activity IDA 22022593
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PIGR: view
genes like me logo Genes that share phenotypes with PIGR: view

Animal Models for PIGR Gene

MGI Knock Outs for PIGR:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PIGR Gene

Localization for PIGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGR Gene

Cell membrane; Single-pass type I membrane protein.
Secretory component: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGR Gene COMPARTMENTS Subcellular localization image for PIGR gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane IDA 22022593
GO:0005887 integral component of plasma membrane TAS 2920039
GO:0043235 receptor complex IDA 23382219
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PIGR: view

Pathways for PIGR Gene

genes like me logo Genes that share pathways with PIGR: view

Pathways by source for PIGR Gene

Gene Ontology (GO) - Biological Process for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0001895 retina homeostasis IEP 23580065
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IDA 22022593
GO:0007173 epidermal growth factor receptor signaling pathway IDA 22022593
GO:0038093 Fc receptor signaling pathway IDA 22022593
genes like me logo Genes that share ontologies with PIGR: view

Compounds for PIGR Gene

(15) Novoseek inferred chemical compound relationships for PIGR Gene

Compound -log(P) Hits PubMed IDs
pneumococcal 36.1 1
mannose 6-phosphate 34.5 1
leupeptin 27.1 2
cycloheximide 26.6 3
mycophenolic acid 24.1 4
genes like me logo Genes that share compounds with PIGR: view

Transcripts for PIGR Gene

mRNA/cDNA for PIGR Gene

Unigene Clusters for PIGR Gene

Polymeric immunoglobulin receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGR

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PIGR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGR Gene

No ASD Table

Relevant External Links for PIGR Gene

GeneLoc Exon Structure for
PIGR
ECgene alternative splicing isoforms for
PIGR

Expression for PIGR Gene

mRNA expression in normal human tissues for PIGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIGR Gene

This gene is overexpressed in Colon - Transverse (26.3), Minor Salivary Gland (10.5), and Small Intestine - Terminal Ileum (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIGR Gene

SOURCE GeneReport for Unigene cluster for PIGR Gene Hs.497589

genes like me logo Genes that share expressions with PIGR: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PIGR Gene

Orthologs for PIGR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGR 35
  • 99.04 (n)
  • 98.04 (a)
PIGR 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIGR 35
  • 76.68 (n)
  • 67.46 (a)
PIGR 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIGR 35
  • 79.05 (n)
  • 69.43 (a)
PIGR 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigr 35
  • 75.98 (n)
  • 66.01 (a)
Pigr 16
Pigr 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGR 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGR 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pigr 35
  • 75.81 (n)
  • 64.7 (a)
chicken
(Gallus gallus)
Aves PIGR 35
  • 53.47 (n)
  • 42.73 (a)
PIGR 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGR 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495453 35
  • 46.77 (n)
  • 36.77 (a)
Species with no ortholog for PIGR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIGR Gene

ENSEMBL:
Gene Tree for PIGR (if available)
TreeFam:
Gene Tree for PIGR (if available)

Paralogs for PIGR Gene

Paralogs for PIGR Gene

genes like me logo Genes that share paralogs with PIGR: view

Variants for PIGR Gene

Sequence variations from dbSNP and Humsavar for PIGR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11283 -- 206,928,663(+) TCTCT(A/G)GCACC utr-variant-3-prime
rs13190 -- 206,928,948(-) GGCCC(A/T)GAAGC utr-variant-3-prime
rs172361 -- 206,933,099(-) GGTTT(C/T)CGGGA synonymous-codon, reference
rs176704 -- 206,938,053(-) GTTCC(A/T)GCCTT intron-variant
rs209982 -- 206,942,216(-) AAGGT(C/G)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGR Gene

Variant ID Type Subtype PubMed ID
nsv468049 CNV Loss 19166990
esv268029 CNV Insertion 20981092

Relevant External Links for PIGR Gene

HapMap Linkage Disequilibrium report
PIGR
Human Gene Mutation Database (HGMD)
PIGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGR Gene

Disorders for PIGR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PIGR Gene including...

Search for PIGR Gene in MalaCards »

(18) Novoseek inferred disease relationships for PIGR Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 42.1 5
nephropathy iga 38.9 2
protein-energy malnutrition 23.9 3
ebv infections 21.8 2
nasopharyngeal carcinoma 16.3 2

Relevant External Links for PIGR

Genetic Association Database (GAD)
PIGR
Human Genome Epidemiology (HuGE) Navigator
PIGR
genes like me logo Genes that share disorders with PIGR: view

No data available for UniProtKB/Swiss-Prot for PIGR Gene

Publications for PIGR Gene

  1. Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy. (PMID: 11579946) Narita I. … Gejyo F. (Intern. Med. 2001) 3 23 48
  2. Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. (PMID: 15530357) Hamburger A.E. … Bjorkman P.J. (Structure 2004) 3 4 23
  3. [Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]. (PMID: 16086865) Fan Q. … Zeng Y.X. (Ai Zheng 2005) 3 23 48
  4. Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2. (PMID: 15864740) Khattar N.H. … Kaetzel C.S. (J. Biomed. Sci. 2005) 3 23
  5. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. (PMID: 15972671) Schneeman T.A. … Kaetzel C.S. (J. Immunol. 2005) 3 23

Products for PIGR Gene

  • Addgene plasmids for PIGR

Sources for PIGR Gene

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