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Aliases for PIGC Gene

Aliases for PIGC Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class C 2 3 5
  • Phosphatidylinositol-Glycan Biosynthesis Class C Protein 3 4
  • PIG-C 3 4
  • GPI2 3 4
  • Phosphatidylinositol-Glycan Biosynthesis, Class C Protein 3
  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class C 3
  • Phosphatidylinositol N-Acetylglucosaminyltransferase 2
  • Phosphatidylinositol Glycan, Class C 2
  • EC 2.4.1.198 4

External Ids for PIGC Gene

Previous GeneCards Identifiers for PIGC Gene

  • GC01M169974
  • GC01M168039
  • GC01M168991
  • GC01M169649
  • GC01M169142
  • GC01M170628
  • GC01M170677
  • GC01M143634

Summaries for PIGC Gene

Entrez Gene Summary for PIGC Gene

  • This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGC Gene

PIGC (Phosphatidylinositol Glycan Anchor Biosynthesis Class C) is a Protein Coding gene. Diseases associated with PIGC include lassa fever. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include phosphatidylinositol N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot for PIGC Gene

  • Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Gene Wiki entry for PIGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGC Gene

Genomics for PIGC Gene

Regulatory Elements for PIGC Gene

Promoters for PIGC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIGC on UCSC Golden Path with GeneCards custom track

Genomic Location for PIGC Gene

Chromosome:
1
Start:
172,370,189 bp from pter
End:
172,444,090 bp from pter
Size:
73,902 bases
Orientation:
Minus strand

Genomic View for PIGC Gene

Genes around PIGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGC Gene

Proteins for PIGC Gene

  • Protein details for PIGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92535-PIGC_HUMAN
    Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
    Protein Accession:
    Q92535
    Secondary Accessions:
    • O14491

    Protein attributes for PIGC Gene

    Size:
    297 amino acids
    Molecular mass:
    33583 Da
    Quaternary structure:
    • Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.

neXtProt entry for PIGC Gene

Proteomics data for PIGC Gene at MOPED

Post-translational modifications for PIGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIGC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIGC Gene

Domains & Families for PIGC Gene

Gene Families for PIGC Gene

Protein Domains for PIGC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92535

UniProtKB/Swiss-Prot:

PIGC_HUMAN :
  • Belongs to the PIGC family.
Family:
  • Belongs to the PIGC family.
genes like me logo Genes that share domains with PIGC: view

Function for PIGC Gene

Molecular function for PIGC Gene

GENATLAS Biochemistry:
glycosylphosphatidylinositol (GPI) anchor synthesis,class C
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.
UniProtKB/Swiss-Prot Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Enzyme Numbers (IUBMB) for PIGC Gene

Phenotypes for PIGC Gene

GenomeRNAi human phenotypes for PIGC:
genes like me logo Genes that share phenotypes with PIGC: view

Animal Model Products

miRNA for PIGC Gene

miRTarBase miRNAs that target PIGC

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIGC Gene

Localization for PIGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGC Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGC Gene COMPARTMENTS Subcellular localization image for PIGC gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGC: view

Pathways & Interactions for PIGC Gene

genes like me logo Genes that share pathways with PIGC: view

UniProtKB/Swiss-Prot Q92535-PIGC_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Interacting Proteins for PIGC Gene

Selected Interacting proteins: Q92535-PIGC_HUMAN for PIGC Gene via I2D MINT

Gene Ontology (GO) - Biological Process for PIGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IEA,TAS 8806613
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PIGC: view

No data available for SIGNOR curated interactions for PIGC Gene

Drugs & Compounds for PIGC Gene

(4) Drugs for PIGC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(845) Additional Compounds for PIGC Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGC: view

Transcripts for PIGC Gene

Unigene Clusters for PIGC Gene

Phosphatidylinositol glycan anchor biosynthesis, class C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIGC Gene

No ASD Table

Relevant External Links for PIGC Gene

GeneLoc Exon Structure for
PIGC
ECgene alternative splicing isoforms for
PIGC

Expression for PIGC Gene

mRNA expression in normal human tissues for PIGC Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PIGC Gene



SOURCE GeneReport for Unigene cluster for PIGC Gene Hs.188456

genes like me logo Genes that share expression patterns with PIGC: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PIGC Gene

Orthologs for PIGC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGC 35
  • 99.1 (n)
  • 98.99 (a)
PIGC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
OneToMany
PIGC 36
  • 96 (a)
OneToMany
PIGC 35
  • 92.03 (n)
  • 95.96 (a)
dog
(Canis familiaris)
Mammalia PIGC 35
  • 90.12 (n)
  • 95.96 (a)
PIGC 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigc 16
Pigc 35
  • 86.53 (n)
  • 93.6 (a)
Pigc 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGC 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGC 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pigc 35
  • 86.53 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves PIGC 35
  • 72.52 (n)
  • 80 (a)
lizard
(Anolis carolinensis)
Reptilia PIGC 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732903 35
  • 71.28 (n)
  • 78.72 (a)
zebrafish
(Danio rerio)
Actinopterygii pigc 35
  • 59.43 (n)
  • 55.16 (a)
pigc 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005923 35
  • 47.86 (n)
  • 39.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12077 35
  • 48.07 (n)
  • 38.77 (a)
CG12077 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T20D3.8 36
  • 33 (a)
OneToOne
T20D3.8 35
  • 48.26 (n)
  • 35.14 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SETH1 35
  • 46.35 (n)
  • 36.5 (a)
rice
(Oryza sativa)
Liliopsida Os02g0622200 35
  • 46.08 (n)
  • 34.04 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02137 35
  • 43.02 (n)
  • 33.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpi2 35
  • 44.08 (n)
  • 32.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for PIGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGC Gene

ENSEMBL:
Gene Tree for PIGC (if available)
TreeFam:
Gene Tree for PIGC (if available)

Paralogs for PIGC Gene

Pseudogenes.org Pseudogenes for PIGC Gene

genes like me logo Genes that share paralogs with PIGC: view

No data available for Paralogs for PIGC Gene

Variants for PIGC Gene

Sequence variations from dbSNP and Humsavar for PIGC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_011360 -

Variation tolerance for PIGC Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.73; 94.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGC Gene

HapMap Linkage Disequilibrium report
PIGC
Human Gene Mutation Database (HGMD)
PIGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PIGC Gene

Disorders for PIGC Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIGC Gene - From: DISEASES

Disorder Aliases PubMed IDs
lassa fever
  • lf
- elite association - COSMIC cancer census association via MalaCards
Search PIGC in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIGC

Human Genome Epidemiology (HuGE) Navigator
PIGC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGC
genes like me logo Genes that share disorders with PIGC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIGC Gene

Publications for PIGC Gene

  1. PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. (PMID: 8806613) Inoue N. … Kinoshita T. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23 67
  2. Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. (PMID: 9325057) Hong Y. … Kinoshita T. (Genomics 1997) 2 3 23
  3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PMID: 10944123) Watanabe R. … Kinoshita T. (EMBO J. 2000) 3 23
  4. Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio. (PMID: 23670221) Schleinitz D. … Kovacs P. (Int J Obes (Lond) 2014) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for PIGC Gene

Sources for PIGC Gene

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