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Aliases for SERPINI2 Gene

Aliases for SERPINI2 Gene

  • Serpin Family I Member 2 2 3
  • Serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Neuroserpin), Member 2 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Pancpin), Member 2 2 3
  • Myoepithelium-Derived Serine Protease Inhibitor 3 4
  • Pancreas-Specific Protein TSA2004 3 4
  • Peptidase Inhibitor 14 3 4
  • PANCPIN 3 4
  • PI14 3 4
  • MEPI 3 4
  • Protease Inhibitor 14 3
  • TSA2004 3
  • PI-14 4

External Ids for SERPINI2 Gene

Previous HGNC Symbols for SERPINI2 Gene

  • PI14

Previous GeneCards Identifiers for SERPINI2 Gene

  • GC03M164449
  • GC03M168213
  • GC03M168561
  • GC03M168480
  • GC03M168642
  • GC03M167156

Summaries for SERPINI2 Gene

Entrez Gene Summary for SERPINI2 Gene

  • The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for SERPINI2 Gene

SERPINI2 (Serpin Family I Member 2) is a Protein Coding gene. Diseases associated with SERPINI2 include Specific Bursitis Often Of Occupational Origin and Olecranon Bursitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINI1.

Gene Wiki entry for SERPINI2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINI2 Gene

Genomics for SERPINI2 Gene

Regulatory Elements for SERPINI2 Gene

Enhancers for SERPINI2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERPINI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINI2 Gene

Chromosome:
3
Start:
167,441,789 bp from pter
End:
167,479,004 bp from pter
Size:
37,216 bases
Orientation:
Minus strand

Genomic View for SERPINI2 Gene

Genes around SERPINI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINI2 Gene

Proteins for SERPINI2 Gene

  • Protein details for SERPINI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75830-SPI2_HUMAN
    Recommended name:
    Serpin I2
    Protein Accession:
    O75830

    Protein attributes for SERPINI2 Gene

    Size:
    405 amino acids
    Molecular mass:
    46145 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH27859.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINI2 Gene

Proteomics data for SERPINI2 Gene at MOPED

Post-translational modifications for SERPINI2 Gene

  • Glycosylation at Asn 202, Asn 207, and Asn 306
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINI2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SERPINI2

No data available for DME Specific Peptides for SERPINI2 Gene

Domains & Families for SERPINI2 Gene

Gene Families for SERPINI2 Gene

Protein Domains for SERPINI2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75830

UniProtKB/Swiss-Prot:

SPI2_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINI2: view

Function for SERPINI2 Gene

genes like me logo Genes that share phenotypes with SERPINI2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINI2

CRISPR Products

miRNA for SERPINI2 Gene

miRTarBase miRNAs that target SERPINI2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINI2 Gene

Localization for SERPINI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINI2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINI2 Gene COMPARTMENTS Subcellular localization image for SERPINI2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SERPINI2 Gene

Pathways & Interactions for SERPINI2 Gene

SuperPathways for SERPINI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERPINI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity TAS 10097100
GO:0030155 regulation of cell adhesion IEA --
genes like me logo Genes that share ontologies with SERPINI2: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINI2 Gene

Drugs & Compounds for SERPINI2 Gene

No Compound Related Data Available

Transcripts for SERPINI2 Gene

Unigene Clusters for SERPINI2 Gene

Serpin peptidase inhibitor, clade I (pancpin), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINI2 Gene

No ASD Table

Relevant External Links for SERPINI2 Gene

GeneLoc Exon Structure for
SERPINI2
ECgene alternative splicing isoforms for
SERPINI2

Expression for SERPINI2 Gene

mRNA expression in normal human tissues for SERPINI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINI2 Gene

This gene is overexpressed in Pancreas (x50.5).

Protein differential expression in normal tissues from HIPED for SERPINI2 Gene

This gene is overexpressed in Pancreatic juice (32.1), Pancreas (24.8), and Fetal gut (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINI2 Gene



SOURCE GeneReport for Unigene cluster for SERPINI2 Gene Hs.445555

mRNA Expression by UniProt/SwissProt for SERPINI2 Gene

O75830-SPI2_HUMAN
Tissue specificity: Expressed in pancreas and adipose tissues.
genes like me logo Genes that share expression patterns with SERPINI2: view

Protein tissue co-expression partners for SERPINI2 Gene

Primer Products

Orthologs for SERPINI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERPINI2 35
  • 88.89 (n)
  • 84.94 (a)
SERPINI2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINI2 35
  • 89.47 (n)
  • 84.2 (a)
SERPINI2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpini2 35
  • 82.44 (n)
  • 76.73 (a)
Serpini2 16
Serpini2 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINI2 35
  • 99.42 (n)
  • 99.26 (a)
SERPINI2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpini2 35
  • 83.46 (n)
  • 77.49 (a)
oppossum
(Monodelphis domestica)
Mammalia SERPINI2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia serpini2 35
  • 67.96 (n)
  • 57.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta nec 37
  • 27 (a)
Spn2 37
  • 29 (a)
Spn43Aa 37
  • 28 (a)
Spn43Ab 37
  • 26 (a)
Spn6 37
  • 31 (a)
nec 36
  • 21 (a)
ManyToMany
Spn1 36
  • 31 (a)
ManyToMany
Spn2 36
  • 31 (a)
ManyToMany
Spn28Da 36
  • 25 (a)
ManyToMany
Spn28Db 36
  • 26 (a)
ManyToMany
Spn3 36
  • 30 (a)
ManyToMany
Spn4 36
  • 25 (a)
ManyToMany
Spn42Db 36
  • 26 (a)
ManyToMany
Spn42Dc 36
  • 24 (a)
ManyToMany
Spn42De 36
  • 27 (a)
ManyToMany
Spn43Aa 36
  • 26 (a)
ManyToMany
Spn43Ab 36
  • 25 (a)
ManyToMany
Spn47C 36
  • 23 (a)
ManyToMany
Spn6 36
  • 29 (a)
ManyToMany
Spn7 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea srp-1 37
  • 26 (a)
srp-6 37
  • 31 (a)
srp-7 37
  • 31 (a)
Species with no ortholog for SERPINI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINI2 Gene

ENSEMBL:
Gene Tree for SERPINI2 (if available)
TreeFam:
Gene Tree for SERPINI2 (if available)

Paralogs for SERPINI2 Gene

Paralogs for SERPINI2 Gene

genes like me logo Genes that share paralogs with SERPINI2: view

Variants for SERPINI2 Gene

Sequence variations from dbSNP and Humsavar for SERPINI2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9841174 - 167,467,090(+) TCATC(C/T)CTGCA reference, missense
VAR_051957 -
rs1104570 -- 167,450,209(+) TCACC(A/T)GTTAC intron-variant
rs2272138 -- 167,446,399(+) GTTGG(A/G)TTATG reference, synonymous-codon
rs2272139 -- 167,446,531(+) ATCAG(A/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINI2 Gene

Variant ID Type Subtype PubMed ID
nsv877969 CNV Loss 21882294

Variation tolerance for SERPINI2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.87; 94.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINI2 Gene

Human Gene Mutation Database (HGMD)
SERPINI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINI2 Gene

Disorders for SERPINI2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SERPINI2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
specific bursitis often of occupational origin
  • specific bursitides often of occupational origin
olecranon bursitis
  • bursitis of elbow
brachial plexus lesion
  • brachial plexus lesions
ulnar neuropathy
  • ulnar neuropathy [ambiguous]
enthesopathy
  • rheumatic diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINI2

Genetic Association Database (GAD)
SERPINI2
Human Genome Epidemiology (HuGE) Navigator
SERPINI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINI2
genes like me logo Genes that share disorders with SERPINI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINI2 Gene

Publications for SERPINI2 Gene

  1. Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells. (PMID: 9624529) Ozaki K. … Nakamura Y. (Genes Chromosomes Cancer 1998) 2 3 4 23 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. (PMID: 10992299) Chang W.S. … Wu F.Y. (Genes Chromosomes Cancer 2000) 3 23
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SERPINI2 Gene

Sources for SERPINI2 Gene

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