Aliases for SERPINI1 Gene
Aliases for SERPINI1 Gene
External Ids for SERPINI1 Gene
- HGNC: 8943
- Entrez Gene: 5274
- Ensembl: ENSG00000163536
- OMIM: 602445
- UniProtKB: Q99574
Previous HGNC Symbols for SERPINI1 Gene
- PI12
Previous GeneCards Identifiers for SERPINI1 Gene
- GC03P164743
- GC03P168506
- GC03P168855
- GC03P168774
- GC03P168936
- GC03P167453
Summaries for SERPINI1 Gene
-
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for SERPINI1 Gene
SERPINI1 (Serpin Family I Member 1) is a Protein Coding gene. Diseases associated with SERPINI1 include Encephalopathy, Familial, With Neuroserpin Inclusion Bodies and Encephalopathy. Among its related pathways are Validated targets of C-MYC transcriptional activation and Cell adhesion_Plasmin signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINI2.
UniProtKB/Swiss-Prot for SERPINI1 Gene
-
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINI1 Gene
Genomics for SERPINI1 Gene
Regulatory Elements for SERPINI1 Gene
Enhancers for SERPINI1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G167691 | 0.8 | ENCODE | 17 | -43.7 | -43686 | 0.2 | PKNOX1 BACH1 BMI1 EBF1 RELA ARID3A CBX5 EED ZNF143 ETV6 | SERPINI1 PDCD10 ZBBX HMGN1P8 GC03P167665 |
| GH03G167732 | 1.1 | ENCODE | 9.8 | -0.7 | -738 | 4.7 | HDGF PKNOX1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 | HMGN1P8 SERPINI1 PDCD10 |
| GH03G167749 | 1.1 | Ensembl ENCODE | 9.7 | +15.4 | 15355 | 1.5 | ELF3 TBP PKNOX1 FOXA2 TBL1XR1 RARA RELB CREM THAP11 MIXL1 | SERPINI1 PDCD10 LRRC77P |
| GH03G167684 | 0.6 | ENCODE | 17.1 | -50.7 | -50656 | 0.2 | CTCF ZNF654 CEBPB CEBPG RAD21 ATF4 ATF3 CEBPA SMC3 | SERPINI1 WDR49 PDCD10 ZBBX HMGN1P8 GC03P167665 |
| GH03G167882 | 0.6 | Ensembl | 10.5 | +146.9 | 146858 | 0.2 | CTCF ZNF654 ZNF362 TRIM22 RAD21 FOXA1 PRDM6 ZNF366 SMC3 | LRRC77P PDCD10 SERPINI1 MEMO1P3 ENSG00000244706 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SERPINI1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SERPINI1 gene promoter:
Regulatory Element Products
Genomic Location for SERPINI1 Gene
- Chromosome:
- 3
- Start:
- 167,735,243 bp from pter
- End:
- 167,825,569 bp from pter
- Size:
- 90,327 bases
- Orientation:
- Plus strand
Genomic View for SERPINI1 Gene
Genes around SERPINI1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26.1 by Ensembl
- 3q26.1 by Entrez Gene
- 3q26.1 by HGNC
SERPINI1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERPINI1 Gene
Proteins for SERPINI1 Gene
-
Protein details for SERPINI1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99574-NEUS_HUMAN
- Recommended name:
- Neuroserpin
- Protein Accession:
- Q99574
- A8K217
- D3DNP1
- Q6AHZ4
Protein attributes for SERPINI1 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 46427 Da
- Quaternary structure:
- No Data Available
Protein Expression for SERPINI1 Gene
Post-translational modifications for SERPINI1 Gene
Other Protein References for SERPINI1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SERPINI1 (Serpin I1)
-
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- antibodies-online Antibodies for SERPINI1: See all 120
- GeneTex SERPINI1 antibody for SERPINI1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERPINI1
Protein Products
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OriGene Purified Proteins for SERPINI1
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-
Cloud-Clone Corp. Proteins for SERPINI1
- antibodies-online Proteins for SERPINI1: See all 28
- Search antibodies-online for peptides
- GeneTex Proteins for SERPINI1
-
ProSci Proteins for SERPINI1
Assay Products
-
Cloud-Clone Corp Assay Kits for SERPINI1
- antibodies-online Kits for SERPINI1: See all 1
No data available for DME Specific Peptides for SERPINI1 Gene
Domains & Families for SERPINI1 Gene
Gene Families for SERPINI1 Gene
Protein Domains for SERPINI1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SERPINI1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99574- Family:
-
- Belongs to the serpin family.
Function for SERPINI1 Gene
Molecular function for SERPINI1 Gene
- UniProtKB/Swiss-Prot Function:
- Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IDA | 9442076 |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for SERPINI1 Gene
- MGI mutant phenotypes for SERPINI1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SERPINI1:
Animal Models for SERPINI1 Gene
- MGI Knock Outs for SERPINI1:
-
- Serpini1 tm1Dpw
Animal Model Products
-
Taconic Biosciences Mouse Models for SERPINI1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SERPINI1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SERPINI1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SERPINI1 gene
- Search ViGene Biosciences for SERPINI1
CRISPR Products
-
OriGene CRISPR knockouts for SERPINI1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINI1
- GenScript: Design CRISPR guide RNA sequences for SERPINI1
miRNA for SERPINI1 Gene
- miRTarBase miRNAs that target SERPINI1
miRNA Products
- Search ViGene Biosciences for SERPINI1
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for SERPINI1
- Browse OriGene Inhibitory RNA Products For SERPINI1
-
ViGene Biosciences ready-to-package AAV shRNAs for SERPINI1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SERPINI1
- VectorBuilder custom plasmid, inducible vectors for SERPINI1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERPINI1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SERPINI1
-
ViGene Biosciences adenoviral particle packaged cDNA for SERPINI1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SERPINI1 gene
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No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SERPINI1 Gene
Localization for SERPINI1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERPINI1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 3 |
| cytosol | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA,IDA | 17040209 |
| GO:0034774 | secretory granule lumen | IEA | -- |
| GO:0043025 | neuronal cell body | IDA | 17040209 |
| GO:0060205 | cytoplasmic vesicle lumen | IDA | 17040209 |
Pathways & Interactions for SERPINI1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell adhesion_Plasmin signaling | ||
| 2 | Validated targets of C-MYC transcriptional activation | ||
Pathways by source for SERPINI1 Gene
1 BioSystems pathway for SERPINI1 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINI1 Gene
Interacting Proteins for SERPINI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007417 | central nervous system development | TAS | 9070919 |
| GO:0007422 | peripheral nervous system development | TAS | 9070919 |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
| GO:0010976 | positive regulation of neuron projection development | IEA | -- |
No data available for SIGNOR curated interactions for SERPINI1 Gene
Transcripts for SERPINI1 Gene
mRNA/cDNA for SERPINI1 Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (92) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SERPINI1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SERPINI1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINI1
- GenScript: Design CRISPR guide RNA sequences for SERPINI1
miRNA Products
- Search ViGene Biosciences for SERPINI1
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for SERPINI1
- Browse OriGene Inhibitory RNA Products For SERPINI1
-
ViGene Biosciences ready-to-package AAV shRNAs for SERPINI1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SERPINI1
- VectorBuilder custom plasmid, inducible vectors for SERPINI1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERPINI1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||
| SP4: |
Expression for SERPINI1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Hippocampus
- Thalamus
- Cerebellum
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- XY Germ Cells Testis Cord
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Gonad
- XY Germ Cells Testis Cord
- Neurons (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for SERPINI1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.0), Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Cortex (x5.9), and Brain - Spinal cord (cervical c-1) (x4.8).
This gene is overexpressed in Vitreous humor (53.4) and Cerebrospinal fluid (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERPINI1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SERPINI1 Gene:
SERPINI1SOURCE GeneReport for Unigene cluster for SERPINI1 Gene:
Hs.478153mRNA Expression by UniProt/SwissProt for SERPINI1 Gene:
Q99574-NEUS_HUMAN
Tissue specificity:
Predominantly expressed in the brain.
Evidence on tissue expression from TISSUES for SERPINI1 Gene
- Nervous system(4.9)
- Eye(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINI1 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- head
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for SERPINI1
-
OriGene qPCR primer pairs and template standards for SERPINI1
No data available for Protein tissue co-expression partners for SERPINI1 Gene
Orthologs for SERPINI1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SERPINI1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SERPINI1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SERPINI1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Serpini1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Serpini1 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SERPINI1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SERPINI1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SERPINI1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SERPINI1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | serpini1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8488 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | serpini1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Spn42Da 34 |
|
||
| Spn4 36 35 |
|
||||
| Spn6 36 35 |
|
||||
| CG9455 36 |
|
|
|||
| Spn1 36 35 |
|
||||
| CG9460 36 |
|
|
|||
| Spn2 35 |
|
ManyToMany | |||
| Spn3 35 |
|
ManyToMany | |||
| Spn43Aa 36 35 |
|
||||
| Spn42Dc 35 |
|
ManyToMany | |||
| Spn42De 35 |
|
ManyToMany | |||
| Spn28Da 35 |
|
ManyToMany | |||
| Spn42Db 35 |
|
ManyToMany | |||
| CG6717 36 |
|
|
|||
| Spn7 35 |
|
ManyToMany | |||
| nec 36 35 |
|
||||
| Spn28Db 35 |
|
ManyToMany | |||
| Spn47C 35 |
|
ManyToMany | |||
| Spn43Ab 35 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | SRPN10 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | srp-6 36 |
|
|
|
| srp-7 36 |
|
|
|||
| srp-1 36 |
|
|
- Species where no ortholog for SERPINI1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SERPINI1 Gene
Paralogs for SERPINI1 Gene
(35) SIMAP similar genes for SERPINI1 Gene using alignment to 4 proteins:
- DKFZp686O07189
- SERPINI2
- SERPINB11
- SERPINE1
- DKFZp686D06190
- AT3
- SERPINE2
- SERPINB3
- SERPINA11
- SERPINA2
- SERPINH1
- SERPINE3
- SERPINB7
- SERPINB6
- SERPINB1
- SERPINA9
- SERPINA6
- SERPINA5
- SERPINA3
- SERPINA12
- SERPINC1
- SERPINB12
- SERPINB8
- SERPINB9
- SERPINB5
- SERPINA1
- SERPING1
- SERPIND1
- SERPINB2
- SERPINB10
- SERPINA7
- SERPINA10
- SCCA2
- SERPINB13
- SERPINB4
Variants for SERPINI1 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121909051 | Pathogenic, Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB) [MIM:604218] | 167,789,273(+) | TCTTC(C/T)CTCCA | reference, missense | |
| VAR_008521 | Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB) [MIM:604218] | ||||
| rs121909052 | Pathogenic | 167,823,019(+) | AATTC(A/G)CAAGT | reference, missense | |
| rs121909053 | Pathogenic | 167,825,265(+) | CATGG(A/G)ACGAG | reference, missense | |
| rs121909054 | Pathogenic | 167,825,264(+) | TCATG(A/G)GACGA | reference, missense |
Residual Variation Intolerance Score:
70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.57;
72.24% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SERPINI1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINI1 Gene
Disorders for SERPINI1 Gene
(10) MalaCards diseases for SERPINI1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| encephalopathy, familial, with neuroserpin inclusion bodies |
|
|
| encephalopathy |
|
|
| dementia, familial british |
|
|
| dementia |
|
|
| early-onset familial alzheimer disease |
|
Search SERPINI1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NEUS_HUMAN- Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB) [MIM:604218]: A neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death. {ECO:0000269 PubMed:10517635}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for SERPINI1
No data available for Genatlas for SERPINI1 Gene
Publications for SERPINI1 Gene
- Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study. (PMID: 17961231) Cole J.W. … Kittner S.J. (BMC Neurol 2007) 3 22 46 64
- Familial dementia caused by polymerization of mutant neuroserpin. (PMID: 10517635) Davis R.L. … Lomas D.A. (Nature 1999) 3 4 22 64
- Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26. (PMID: 9070919) Schrimpf S.P. … Sonderegger P. (Genomics 1997) 3 4 22 64
- Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
Products for SERPINI1 Gene
- R&D Systems Antibodies for SERPINI1 (Serpin I1)
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- Taconic Biosciences Mouse Models for SERPINI1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SERPINI1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SERPINI1
- antibodies-online Antibodies for SERPINI1: See all 120
- antibodies-online Kits for SERPINI1: See all 1
- antibodies-online Proteins for SERPINI1: See all 28
- Search antibodies-online for peptides
- GeneTex SERPINI1 antibody for SERPINI1
- GeneTex Proteins for SERPINI1
- ViGene Biosciences adenoviral particle packaged cDNA for SERPINI1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SERPINI1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SERPINI1 gene
- Search ViGene Biosciences for SERPINI1
- Santa Cruz Biotechnology (SCBT) Antibodies for SERPINI1
- Search Santa Cruz Biotechnology (SCBT) for SERPINI1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SERPINI1
- Horizon Cell Lines for SERPINI1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SERPINI1
- VectorBuilder custom plasmid, inducible vectors for SERPINI1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERPINI1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SERPINI1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer